{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:13:21Z","timestamp":1793171601308,"version":"4.5.0"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Red yeast rice has been used to produce alcoholic beverages and various fermented foods especially in East Asia. Since around March 2024, there have been many cases of kidney dysfunction in people who have taken certain supplements containing red yeast rice in Japan. We experienced a case of acute kidney injuries induced after taking a supplement containing red yeast rice. A 58-year-old woman was admitted to our hospital due to renal dysfunction suspected to be caused by taking the supplement Benikoji CholesteHelp<jats:sup>\u00ae<\/jats:sup>, which contains red yeast rice. With elevations of urinary tubular injury markers such as urinary \u03b22-microglobulin and <jats:italic>N<\/jats:italic>-acetyl-\u03b2-D-glucosaminidase, serum creatinine levels were elevated up to 2.75\u00a0mg\/dL. A kidney biopsy revealed a diagnosis of tubulointerstitial nephritis with lymphocytic infiltration of the interstitium, tubular atrophy, and interstitial fibrotic changes. After discontinuation of the supplement and initiation of the prednisolone treatment, renal dysfunction rapidly improved. The course of this case suggests tubular damage caused by the supplements containing red yeast rice. For early diagnosis and treatment, it should be noted that even what are regarded as nutritional health supplements can cause renal dysfunction.<\/jats:p>","DOI":"10.1007\/s13730-024-00897-9","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T11:06:13Z","timestamp":1718622373000},"page":"24-28","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Successful treatment of acute tubulointerstitial nephritis probably due to Benikoji CholesteHelp\u00ae, a supplement containing red yeast rice"],"prefix":"10.1007","volume":"14","author":[{"given":"Masayuki","family":"Maiguma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Hamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Gohda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-9747","authenticated-orcid":false,"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"897_CR1","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3390\/molecules26061619","volume":"26","author":"H Fukami","year":"2021","unstructured":"Fukami H, Higa Y, Hisano T, Asano K, Hirata T, Nishibe S. A review of red yeast rice, a traditional fermented food in Japan and East Asia: Its characteristic ingredients and application in the maintenance and improvement of health in lipid metabolism and the circulatory system. Molecules. 2021;26:1619.","journal-title":"Molecules"},{"issue":"371","key":"897_CR2","first-page":"m3109","volume":"12","author":"S Vinaya","year":"2020","unstructured":"Vinaya S. Management of hypertriglyceridemia. BMJ. 2020;12(371):m3109.","journal-title":"BMJ"},{"issue":"7","key":"897_CR3","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1039\/C3FO60575B","volume":"5","author":"H Wei-Hsuan","year":"2014","unstructured":"Wei-Hsuan H, Tzu-Ming P. A novel PPARgamma agonist monascin\u2019s potential application in diabetes prevention. Food Funct. 2014;5(7):1334\u201340.","journal-title":"Food Funct"},{"issue":"4","key":"897_CR4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2478\/10004-1254-60-2009-1992","volume":"60","author":"F Dubravka","year":"2009","unstructured":"Dubravka F, Peraica M. Toxicological properties of citrinin. Arh Hig Rada Toksikol. 2009;60(4):457\u201364.","journal-title":"Arh Hig Rada Toksikol"},{"issue":"1","key":"897_CR5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/foods10010014","volume":"10","author":"LJ Silva","year":"2020","unstructured":"Silva LJ, Pereira AM, Pena A, Lino CM. Citrinin in foods and supplements: a review of occurrence and analytical methodologies. Foods. 2020;10(1):14.","journal-title":"Foods"},{"issue":"8","key":"897_CR6","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/sj.ki.5002776","volume":"73","author":"E Gonz\u00e1lez","year":"2008","unstructured":"Gonz\u00e1lez E, Guti\u00e9rrez E, Galeano C, Chevia C, de Sequera P, Bernis C, Parra EG, Delgado R, Sanz M, Ortiz M, Goicoechea M. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int. 2008;73(8):940\u20136.","journal-title":"Kidney Int"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00897-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13730-024-00897-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00897-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T03:35:51Z","timestamp":1738380951000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13730-024-00897-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["897"],"URL":"https:\/\/doi.org\/10.1007\/s13730-024-00897-9","relation":{},"ISSN":["2192-4449"],"issn-type":[{"value":"2192-4449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]},"assertion":[{"value":"8 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors have declared no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}