{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:53:24Z","timestamp":1785549204236,"version":"3.56.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Glyphosate is a widely used herbicide that is generally considered safe; however, acute kidney injury (AKI) caused by glyphosate ingestion can be severe and require hemodialysis. We present a unique case of a 68-year-old Japanese man who developed AKI after accidental ingestion of glyphosate and required hemodialysis. Based on the clinical presentation and findings, the patient was diagnosed with renal AKI with severe tubulointerstitial damage. However, the precise pathogenesis of the tubulointerstitial damage remained unclear. An elevated beta-2 microglobulin level discovered by the urinalysis during admission raised the suspicion of tubulointerstitial nephritis caused by glyphosate. Gallium scintigraphy revealed accumulation in both kidneys. A renal biopsy revealed acute tubulointerstitial nephritis rather than acute tubular necrosis, which is commonly observed with glyphosate-induced renal injury. After initiating steroid therapy, his kidney function gradually improved and he was weaned from hemodialysis. This report is the first to describe glyphosate-induced acute tubulointerstitial nephritis that was successfully treated with immunosuppressive therapy. Furthermore, this report highlights the importance of steroid therapy for cases of persistent kidney injury after the discontinuation of agents associated with acute tubulointerstitial nephritis.<\/jats:p>","DOI":"10.1007\/s13730-024-00914-x","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:54:27Z","timestamp":1722257667000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unusual course of glyphosate-induced acute kidney injury: a case report of tubulointerstitial nephritis treated with steroids"],"prefix":"10.1007","volume":"14","author":[{"given":"Daichi","family":"Omote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Okunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narihito","family":"Tatsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Asanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"914_CR1","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/j.1553-2712.2000.tb02069.x","volume":"7","author":"HL Lee","year":"2000","unstructured":"Lee HL, Chen KW, Chi CH, Huang JJ, Tsai LM. Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: a review of 131 cases. Acad Emerg Med. 2000;7:906\u201310.","journal-title":"Acad Emerg Med"},{"key":"914_CR2","doi-asserted-by":"publisher","first-page":"349","DOI":"10.23876\/j.krcp.22.051","volume":"42","author":"AY Cho","year":"2023","unstructured":"Cho AY, Oh JH, Oh SS, Lee KY, Sun IO. Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning. Kidney Res Clin Pract. 2023;42:349\u201357.","journal-title":"Kidney Res Clin Pract"},{"key":"914_CR3","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.toxlet.2013.12.009","volume":"225","author":"K Wunnapuk","year":"2014","unstructured":"Wunnapuk K, Gobe G, Endre Z, et al. Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers. Toxicol Lett. 2014;225:192\u2013200.","journal-title":"Toxicol Lett"},{"key":"914_CR4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/1744-9987.12565","volume":"21","author":"T Ozaki","year":"2017","unstructured":"Ozaki T, Sofue T, Kuroda Y. Severe glyphosate-surfactant intoxication successfully treated with continuous hemodiafiltration and direct hemoperfusion: case report. Ther Apher Dial. 2017;21:296\u20137.","journal-title":"Ther Apher Dial"},{"key":"914_CR5","first-page":"235","volume":"16","author":"J Stella","year":"2004","unstructured":"Stella J, Ryan M. Glyphosate herbicide formulation: a potentially lethal ingestion. Emerg Med Australas. 2004;16:235\u20139.","journal-title":"Emerg Med Australas"},{"key":"914_CR6","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1007\/s10157-020-01962-0","volume":"24","author":"T Kimura","year":"2020","unstructured":"Kimura T, Yokoyama T, Tanemoto M. Renal tubular injury by glyphosate-based herbicide. Clin Exp Nephrol. 2020;24:1186.","journal-title":"Clin Exp Nephrol"},{"key":"914_CR7","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.2215\/CJN.11290821","volume":"17","author":"MA Perazella","year":"2022","unstructured":"Perazella MA, Rosner MH. Drug-induced acute kidney injury. Clin J Am Soc Nephrol. 2022;17:1220\u201333.","journal-title":"Clin J Am Soc Nephrol"},{"key":"914_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.5414\/CN10838","volume":"82","author":"R Raghavan","year":"2014","unstructured":"Raghavan R, Eknoyan G. Acute interstitial nephritis\u2013a reappraisal and update. Clin Nephrol. 2014;82:149\u201362.","journal-title":"Clin Nephrol"},{"key":"914_CR9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00467-016-3394-5","volume":"32","author":"E Joyce","year":"2017","unstructured":"Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A. Tubulointerstitial nephritis: diagnosis, treatment and monitoring. Pediatr Nephrol. 2017;32:577\u201387.","journal-title":"Pediatr Nephrol"},{"key":"914_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1093\/ndt\/gfg464","volume":"19","author":"RJ Baker","year":"2004","unstructured":"Baker RJ, Pusey CD. The changing profile of acute tubulointerstitial nephritis. Nephrol Dial Transpl. 2004;19:8\u201311.","journal-title":"Nephrol Dial Transpl"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00914-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13730-024-00914-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00914-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T03:25:34Z","timestamp":1743650734000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13730-024-00914-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["914"],"URL":"https:\/\/doi.org\/10.1007\/s13730-024-00914-x","relation":{},"ISSN":["2192-4449"],"issn-type":[{"value":"2192-4449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"16 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that no conflict of interest exists.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"Informed consent was obtained from the patient included in this case report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}