{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:14:58Z","timestamp":1774322098121,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn\u2019s disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved. From this case report, infliximab could be a rare cause of elevated kidney function and that it should be not considered a completely safe treatment or disregarded as potential cause of ATIN.<\/jats:p>","DOI":"10.1007\/s13730-024-00943-6","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T09:03:42Z","timestamp":1730538222000},"page":"266-270","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn\u2019s disease: a case report"],"prefix":"10.1007","volume":"14","author":[{"given":"Naif","family":"Alghamdi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan","family":"Alhazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad","family":"Bhutto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azhari","family":"Alhassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Kechrid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhafer","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadi","family":"Alshammari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talal","family":"Assiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ohoud","family":"Assiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Darewsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruba","family":"Qadri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser","family":"Alahmadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"943_CR1","unstructured":"Beck Jr, Laurence H, David J Salant (2018) \u201cAcute Interstitial Nephritis.\u201d Harrison\u2019s Principles of Internal Medicine, 20e Eds. J. Larry Jameson, et al. McGraw-Hill Education, 2018, https:\/\/accessmedicine.mhmedical.com\/content.aspx?bookid=2129&sectionid=252012497."},{"issue":"2","key":"943_CR2","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1093\/ecco-jcc\/jjv138","volume":"10","author":"D Corica","year":"2016","unstructured":"Corica D, Romano C. Renal involvement in inflammatory bowel diseases. J Crohns Colitis. 2016;10(2):226\u201335. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjv138.","journal-title":"J Crohns Colitis"},{"issue":"1","key":"943_CR3","doi-asserted-by":"publisher","first-page":"4260365","DOI":"10.1155\/2016\/4260365","volume":"2016","author":"Payaswini Vasanth","year":"2016","unstructured":"Vasanth Payaswini, et al. Interstitial nephritis in a patient with inflammatory bowel disease. Case Rep Nephrol. 2016;2016(1):4260365. https:\/\/doi.org\/10.1155\/2016\/4260365.","journal-title":"Case Rep Nephrol"},{"issue":"1","key":"943_CR4","doi-asserted-by":"publisher","first-page":"i1561","DOI":"10.1093\/ecco-jcc\/jjad212.0969","volume":"18","author":"Anders Forss","year":"2024","unstructured":"Forss Anders, et al. \u201cP839 acute interstitial nephritis in patients with inflammatory bowel disease treated with vedolizumab: a systematic review.\u201d J Crohn\u2019s Colitis. 2024;18(1):i1561\u20132. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad212.0969.","journal-title":"J Crohn\u2019s Colitis"},{"issue":"10","key":"943_CR5","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.2169\/internalmedicine.55.5834","volume":"55","author":"Mineto Ota","year":"2016","unstructured":"Ota Mineto, et al. Acute tubulointerstitial nephritis associated with infliximab in a patient with Crohn\u2019s disease. Int Med. 2016;55(10):1367\u201370. https:\/\/doi.org\/10.2169\/internalmedicine.55.5834.","journal-title":"Int Med"},{"issue":"7","key":"943_CR6","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1093\/ndt\/gfh832","volume":"20","author":"Michael B Stokes","year":"2005","unstructured":"Stokes Michael B, et al. Development of glomerulonephritis during anti-TNF-\u03b1 therapy for rheumatoid arthritis. Nephrol Dial Trans. 2005;20(7):1400\u20136. https:\/\/doi.org\/10.1093\/ndt\/gfh832.","journal-title":"Nephrol Dial Trans"},{"issue":"6","key":"943_CR7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.semarthrit.2007.08.003","volume":"37","author":"Michelle F Costa","year":"2008","unstructured":"Costa Michelle F, et al. Drug-induced lupus due to anti-tumor necrosis factor \u03b1 agents. Seminars Arthritis Rheumatism. 2008;37(6):381\u20137. https:\/\/doi.org\/10.1016\/j.semarthrit.2007.08.003.","journal-title":"Seminars Arthritis Rheumatism"},{"issue":"6","key":"943_CR8","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jbspin.2006.02.010","volume":"73","author":"Saint Marcoux","year":"2006","unstructured":"Marcoux Saint, Bernadette, et al. Vasculitides induced by TNF \u03b1 antagonists: a study in 39 patients in france. Joint Bone Spine. 2006;73(6):710\u20133.","journal-title":"Joint Bone Spine"},{"issue":"8","key":"943_CR9","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.mayocp.2012.04.011","volume":"87","author":"Olayemi Sokumbi","year":"2012","unstructured":"Sokumbi Olayemi, et al. Vasculitis associated with tumor necrosis factor-\u03b1 inhibitors. Mayo Clin Proceed. 2012;87(8):739\u201345.","journal-title":"Mayo Clin Proceed"},{"issue":"1","key":"943_CR10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.clim.2014.06.008","volume":"154","author":"Chao Dai","year":"2014","unstructured":"Dai Chao, et al. Interferon alpha on NZM2328.Lc1R27: enhancing autoimmunity and immune complex-mediated glomerulonephritis without end stage renal failure. Clin Immunol. 2014;154(1):66\u201371. https:\/\/doi.org\/10.1016\/j.clim.2014.06.008.","journal-title":"Clin Immunol"},{"key":"943_CR11","doi-asserted-by":"publisher","first-page":"204209862211001","DOI":"10.1177\/20420986221100118","volume":"13","author":"Shin Kashima","year":"2022","unstructured":"Kashima Shin, et al. A case report of drug-induced liver injury due to the infliximab biosimilar CT-P13 on switching from original infliximab in a patient with Crohn\u2019s disease. Ther Adv Drug Safety. 2022;13:20420986221100120. https:\/\/doi.org\/10.1177\/20420986221100118.","journal-title":"Ther Adv Drug Safety"},{"key":"943_CR12","unstructured":"Zachou, Maria, et al. \u201cInfliximab (IFX)-Biosimilar Induced Drug-Induced Liver Injury (DILI): A Case Report.\u201d Cureus, 14, 12, p. e32525."},{"issue":"1","key":"943_CR13","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1093\/mrcr\/rxad061","volume":"8","author":"Kenta Shidahara","year":"2024","unstructured":"Shidahara Kenta, et al. Infliximab biosimilar-induced lupus nephritis: a case report. Modern Rheumatol Case Rep. 2024;8(1):74\u20136. https:\/\/doi.org\/10.1093\/mrcr\/rxad061.","journal-title":"Modern Rheumatol Case Rep"},{"issue":"3","key":"943_CR14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1620\/tjem.245.149","volume":"245","author":"T Sato","year":"2018","unstructured":"Sato T, Kawasaki Y, Ito A, Izumi H, Kawamorita N, Yamashita S, Mitsuzuka K, Matsuura T, Watanabe M, Arai Y. Infliximab-induced tubulointerstitial nephritis with image findings of striated nephrogram in Crohn\u2019s disease. Tohoku J Exp Med. 2018;245(3):149\u201352. https:\/\/doi.org\/10.1620\/tjem.245.149. (PMID: 29973427).","journal-title":"Tohoku J Exp Med"},{"key":"943_CR15","doi-asserted-by":"publisher","unstructured":"Yoo Yang Jae,Chung Sang Yoon,Gu Dae Hoe,Ko Gang Jee,Pyo Heui Jung,Kwon Young Joo,Bak Young-Tae,Won Nam Hee. A Case of Late Onset-Acute Tubulointerstitial Nephritis with Infliximab and Mesalazine Treatment in a Patient with Crohn\u2019s Disease. https:\/\/doi.org\/10.4166\/kjg.2014.63.5.308","DOI":"10.4166\/kjg.2014.63.5.308"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00943-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13730-024-00943-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00943-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T03:22:37Z","timestamp":1743650557000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13730-024-00943-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,2]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["943"],"URL":"https:\/\/doi.org\/10.1007\/s13730-024-00943-6","relation":{},"ISSN":["2192-4449"],"issn-type":[{"value":"2192-4449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,2]]},"assertion":[{"value":"24 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare that they obtained consent from the patients discussed in the report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}}]}}