{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:31:45Z","timestamp":1759228305717,"version":"3.44.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100015064","name":"Tohoku Medical and Pharmaceutical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015064","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Seasonal influenza is prevalent globally, particularly during winter months. It is well documented that this disease causes severe, often fatal complications in hemodialysis patients. While numerous reports have focused on novel influenza viruses, there is a paucity of case reports detailing seasonal influenza viral infections in this patient population. This case presents a 71-year-old male undergoing hemodialysis who developed severe seasonal influenza A pneumonia despite receiving the influenza vaccine and early antiviral treatment. Initially presenting with fever, cough, and myalgia, the patient was diagnosed with influenza A virus infection and hospitalized due to heightened risk associated with dialysis and an elevated inflammatory response. Despite treatment with two different antiviral medications, his condition deteriorated, leading to ARDS (acute respiratory distress syndrome). The administration of steroid pulse therapy resulted in significant clinical improvement. This case underscores the severe nature of influenza virus-related illnesses in dialysis patients, even with vaccination and early antiviral intervention. It also suggests the potential benefit of early steroid pulse therapy in managing severe influenza pneumonia in high-risk individuals.<\/jats:p>","DOI":"10.1007\/s13730-024-00951-6","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:51:28Z","timestamp":1733874688000},"page":"542-546","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severe influenza A viral pneumonia in a hemodialysis patient: successful treatment with steroid pulse therapy"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-6551","authenticated-orcid":false,"given":"Hiroki","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadatoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuo","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyoshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takefumi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadayoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"951_CR1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1053\/j.ackd.2006.04.004","volume":"13","author":"SB Naqvi","year":"2006","unstructured":"Naqvi SB, Collins AJ. Infectious complications in chronic kidney disease. Adv Chronic Kidney Dis. 2006;13:199\u2013204.","journal-title":"Adv Chronic Kidney Dis"},{"key":"951_CR2","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1097\/01.ASN.0000074237.78764.D1","volume":"14","author":"M Allon","year":"2003","unstructured":"Allon M, Depner TA, Radeva M, Bailey J, Beddhu S, Butterly D, et al. Impact of dialysis dose and membrane on infection-related hospitalization and death: results of the HEMO Study. J Am Soc Nephrol. 2003;14:1863\u201370.","journal-title":"J Am Soc Nephrol"},{"key":"951_CR3","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1681\/ASN.2006040406","volume":"18","author":"BM Chavers","year":"2007","unstructured":"Chavers BM, Solid CA, Gilbertson DT, Collins AJ. Infection-related hospitalization rates in pediatric versus adult patients with end-stage renal disease in the United States. J Am Soc Nephrol. 2007;18:952\u20139.","journal-title":"J Am Soc Nephrol"},{"key":"951_CR4","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1111\/j.1523-1755.2000.00337.x","volume":"58","author":"MJ Sarnak","year":"2000","unstructured":"Sarnak MJ, Jaber BL. Mortality caused by sepsis in patients with end-stage renal disease compared with the general population. Kidney Int. 2000;58:1758\u201364.","journal-title":"Kidney Int"},{"key":"951_CR5","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1097\/00041552-199311000-00005","volume":"2","author":"B Descamps-Latscha","year":"1993","unstructured":"Descamps-Latscha B. The immune system in end-stage renal disease. Curr Opin Nephrol Hypertens. 1993;2:883\u201391.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"951_CR6","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1159\/000045713","volume":"86","author":"JA Antonen","year":"2000","unstructured":"Antonen JA, Hannula PM, Pyhala R, Saha HH, Ala-Houhala IO, Pasternack AI. Adequate seroresponse to influenza vaccination in dialysis patients. Nephron. 2000;86:56\u201361.","journal-title":"Nephron"},{"key":"951_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1080\/00365590310008749","volume":"37","author":"C Cavdar","year":"2003","unstructured":"Cavdar C, Sayan M, Sifil A, Artuk C, Yilmaz N, Bahar H, et al. The comparison of antibody response to influenza vaccination in continuous ambulatory peritoneal dialysis, hemodialysis and renal transplantation patients. Scand J Urol Nephrol. 2003;37:71\u20136.","journal-title":"Scand J Urol Nephrol"},{"key":"951_CR8","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1053\/j.ajkd.2008.11.032","volume":"54","author":"J Scharpe","year":"2009","unstructured":"Scharpe J, Peetermans WE, Vanwalleghem J, Maes B, Bammens B, Claes K, et al. Immunogenicity of a standard trivalent influenza vaccine in patients on long-term hemodialysis: an open-label trial. Am J Kidney Dis. 2009;54:77\u201385.","journal-title":"Am J Kidney Dis"},{"key":"951_CR9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1159\/000093306","volume":"26","author":"JY Song","year":"2006","unstructured":"Song JY, Cheong HJ, Ha SH, Kee SY, Jeong HW, Kim WJ. Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination. Am J Nephrol. 2006;26:206\u201311.","journal-title":"Am J Nephrol"},{"key":"951_CR10","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1016\/j.vaccine.2003.11.046","volume":"22","author":"NP Vogtlander","year":"2004","unstructured":"Vogtlander NP, Brown A, Valentijn RM, Rimmelzwaan GF, Osterhaus AD. Impaired response rates, but satisfying protection rates to influenza vaccination in dialysis patients. Vaccine. 2004;22:2199\u2013201.","journal-title":"Vaccine"},{"issue":"Suppl 3","key":"951_CR11","doi-asserted-by":"publisher","first-page":"S183","DOI":"10.1177\/089686080802803s34","volume":"28","author":"AB Hauser","year":"2008","unstructured":"Hauser AB, Stinghen AE, Kato S, Bucharles S, Aita C, Yuzawa Y, et al. Characteristics and causes of immune dysfunction related to uremia and dialysis. Perit Dial Int. 2008;28(Suppl 3):S183-187.","journal-title":"Perit Dial Int"},{"key":"951_CR12","doi-asserted-by":"crossref","unstructured":"(2013) Statement on seasonal influenza vaccine for 2013\u20132014: An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI). Can Commun Dis Rep 39:1\u201337.","DOI":"10.14745\/ccdr.v39i00a04r"},{"key":"951_CR13","first-page":"1","volume":"62","author":"Centers for Disease Control and Prevention (CDC)","year":"2013","unstructured":"Centers for Disease Control and Prevention (CDC). Prevention and control of seasonal influenza with vaccines. Recommendations of the advisory committee on immunization practices\u2014United States, 2013\u20132014. MMWR Recomm Rep. 2013;62:1\u201343.","journal-title":"MMWR Recomm Rep"},{"key":"951_CR14","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1159\/000063556","volume":"20","author":"R Vanholder","year":"2002","unstructured":"Vanholder R, Van Biesen W. Incidence of infectious morbidity and mortality in dialysis patients. Blood Purif. 2002;20:477\u201380.","journal-title":"Blood Purif"},{"key":"951_CR15","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s12916-014-0244-9","volume":"12","author":"C Remschmidt","year":"2014","unstructured":"Remschmidt C, Wichmann O, Harder T. Influenza vaccination in patients with end-stage renal disease: Systematic review and assessment of quality of evidence related to vaccine efficacy, effectiveness, and safety. BMC Med. 2014;12:244.","journal-title":"BMC Med"},{"key":"951_CR16","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.2215\/CJN.00950208","volume":"3","author":"S Kato","year":"2008","unstructured":"Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, Yuzawa Y, et al. Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol. 2008;3:1526\u201333.","journal-title":"Clin J Am Soc Nephrol"},{"key":"951_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr6908a1","volume":"69","author":"LA Grohskopf","year":"2020","unstructured":"Grohskopf LA, Alyanak E, Broder KR, Blanton LH, Fry AM, Jernigan DB, et al. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices\u2014United States, 2020\u201321 influenza season. MMWR Recomm Rep. 2020;69:1\u201324.","journal-title":"MMWR Recomm Rep"},{"key":"951_CR18","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1097\/CCM.0000000000004093","volume":"48","author":"LE Lansbury","year":"2020","unstructured":"Lansbury LE, Rodrigo C, Leonardi-Bee J, Nguyen-Van-Tam J, Shen LW. Corticosteroids as adjunctive therapy in the treatment of influenza: an updated cochrane systematic review and meta-analysis. Crit Care Med. 2020;48:e98\u2013106.","journal-title":"Crit Care Med"},{"key":"951_CR19","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1001\/jamainternmed.2020.0994","volume":"180","author":"C Wu","year":"2020","unstructured":"Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan. China JAMA Intern Med. 2020;180:934\u201343.","journal-title":"China JAMA Intern Med"},{"key":"951_CR20","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1038\/s41375-020-0848-3","volume":"34","author":"H Li","year":"2020","unstructured":"Li H, Chen C, Hu F, Wang J, Zhao Q, Gale RP, et al. Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis. Leukemia. 2020;34:1503\u201311.","journal-title":"Leukemia"},{"key":"951_CR21","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.cmi.2015.06.022","volume":"21","author":"JW Yang","year":"2015","unstructured":"Yang JW, Fan LC, Miao XY, Mao B, Li MH, Lu HW, et al. Corticosteroids for the treatment of human infection with influenza virus: a systematic review and meta-analysis. Clin Microbiol Infect. 2015;21:956\u201363.","journal-title":"Clin Microbiol Infect"},{"key":"951_CR22","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1164\/rccm.201706-1172OC","volume":"197","author":"YM Arabi","year":"2018","unstructured":"Arabi YM, Mandourah Y, Al-Hameed F, Sindi AA, Almekhlafi GA, Hussein MA, et al. Corticosteroid therapy for critically ill patients with middle east respiratory syndrome. Am J Respir Crit Care Med. 2018;197:757\u201367.","journal-title":"Am J Respir Crit Care Med"},{"issue":"105","key":"951_CR23","first-page":"S117","volume":"2024","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2024","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024;2024(105):S117\u2013314.","journal-title":"Kidney Int"},{"issue":"Suppl 1","key":"951_CR24","doi-asserted-by":"publisher","first-page":"A7","DOI":"10.1053\/j.ajkd.2021.01.002","volume":"77","author":"KL Johansen","year":"2021","unstructured":"Johansen KL, Chertow GM, Foley RN, Gilbertson DT, Herzog CA, Ishani A, et al. US renal data system 2020 annual data report: Epidemiology of kidney disease in the United States. Am J Kidney Dis. 2021;77(Suppl 1):A7\u20138.","journal-title":"Am J Kidney Dis"},{"key":"951_CR25","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/ciy866","volume":"68","author":"TM Uyeki","year":"2019","unstructured":"Uyeki TM, Bernstein HH, Bradley JS, Englund JA, File TM, Fry AM, et al. Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa. Clin Infect Dis. 2019;68:e1\u201347.","journal-title":"Clin Infect Dis"},{"key":"951_CR26","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/S0140-6736(14)62449-1","volume":"385","author":"J Dobson","year":"2015","unstructured":"Dobson J, Whitley RJ, Pocock S, Monto AS. Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. Lancet. 2015;385:1729\u201337.","journal-title":"Lancet"},{"key":"951_CR27","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s00134-017-4919-5","volume":"43","author":"D Annane","year":"2017","unstructured":"Annane D, Pastores SM, Rochwerg B, Arlt W, Balk RA, Beishuizen A, et al. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intensive Care Med. 2017;43:1751\u201363.","journal-title":"Intensive Care Med"},{"key":"951_CR28","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1007\/s00134-014-3307-7","volume":"40","author":"M Lemyze","year":"2014","unstructured":"Lemyze M, Mallat J. Understanding negative pressure pulmonary edema. Intensive Care Med. 2014;40:1140\u20133.","journal-title":"Intensive Care Med"},{"key":"951_CR29","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s00134-016-4326-3","volume":"42","author":"A Vieillard-Baron","year":"2016","unstructured":"Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, et al. Experts\u2019 opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Intensive Care Med. 2016;42:739\u201349.","journal-title":"Intensive Care Med"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00951-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13730-024-00951-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00951-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T01:38:06Z","timestamp":1757122686000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13730-024-00951-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["951"],"URL":"https:\/\/doi.org\/10.1007\/s13730-024-00951-6","relation":{},"ISSN":["2192-4449"],"issn-type":[{"type":"electronic","value":"2192-4449"}],"subject":[],"published":{"date-parts":[[2024,12,11]]},"assertion":[{"value":"6 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that no conflict of interest exists.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Informed consent was obtained from the patient in this report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}