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Recently, DnaJ heat shock protein family (Hsp40) member B9 (DNAJB9) detected by liquid chromatography-tandem mass spectrometry (LC-MS\/MS) was discovered to be a sensitive and specific biomarker for FGN. This report presents the first documented case of recurrent congophilic FGN, a rare glomerular disease with features resembling amyloidosis, occurring two years and eight months after a renal transplant. Diagnosis of both primary and recurrent FGN was confirmed through DNAJB9 detection using advanced laser microdissection and LC-MS\/MS techniques. The recurrent FGN exhibited features consistent with amyloidosis, including CR positivity, characteristic microscopic findings, and fibrils on electron microscopy with a 9 to 15\u00a0nm diameter. This case demonstrates that FGN could recur in the transplanted kidney as congophilic GN with characteristic findings of amyloidosis, and it is difficult, if not impossible, to render a correct diagnosis without LC-MS\/MS or immunohistochemistry.<\/jats:p>","DOI":"10.1007\/s13730-025-01064-4","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T03:10:58Z","timestamp":1769137858000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Congophilic fibrillary glomerulonephritis recurrence post-renal transplant: diagnostic challenges and proteomic insights"],"prefix":"10.1007","volume":"15","author":[{"given":"Hiroshi","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-6117","authenticated-orcid":false,"given":"Michiko","family":"Nagamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Shintani-domoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Kawanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Ishino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Sumiyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"issue":"5","key":"1064_CR1","first-page":"301","volume":"18","author":"E Rosenmann","year":"1977","unstructured":"Rosenmann E, Eliakim M. 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