{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:11:25Z","timestamp":1779268285397,"version":"3.51.4"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005278","name":"University of Antioquia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Disseminated adenovirus infection is a rare but often fatal complication of hematopoietic stem cell transplantation (HSCT), particularly uncommon in the autologous setting. We report the case of a 59-year-old man with stage IVB diffuse large B-cell lymphoma who underwent autologous HSCT after multiple lines of therapy. Following conditioning regimen, he developed persistent fever, mucositis, dysuria, and gross hematuria, with imaging showing bilateral pyelonephritis, ureteritis, and cystitis. Despite broad-spectrum antibiotics, symptoms persisted. Quantitative PCR revealed rapidly rising adenovirus viremia (&gt;\u20091,000,000 copies\/mL), and renal biopsy demonstrated viral cytopathic changes on light microscopy together with focal segmental glomerulosclerosis (FSGS). The patient progressed to fulminant oliguric renal failure and died before dialysis could be initiated. This case highlights a rare presentation of adenovirus infection with renal involvement consistent with adenovirus-associated nephropathy and concurrent FSGS after autologous HSCT, highlighting the potential convergence of viral, neoplastic, and transplant-related mechanisms in catastrophic renal injury.<\/jats:p>","DOI":"10.1007\/s13730-026-01110-9","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:51:55Z","timestamp":1779267115000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adenovirus infection associated with focal segmental glomerulosclerosis following autologous hematopoietic stem cell transplantation"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8496-2708","authenticated-orcid":false,"given":"Yasser Isaac","family":"Arana-Escand\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-988X","authenticated-orcid":false,"given":"Paula Eliana","family":"Ram\u00edrez-Arboleda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-6971","authenticated-orcid":false,"given":"Lina Mar\u00eda","family":"Gaviria-Jaramillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8447-6553","authenticated-orcid":false,"given":"Mauricio Andr\u00e9s","family":"\u00c1lzate-Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-7253","authenticated-orcid":false,"given":"Oliver Gerardo","family":"Perilla-Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Ximena","family":"Lagos-Buitrago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-6214","authenticated-orcid":false,"given":"Joaqu\u00edn Roberto","family":"Rodelo-Ceballos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-2508","authenticated-orcid":false,"given":"Mayra Alejandra","family":"Estacio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-7983","authenticated-orcid":false,"given":"Alejandra","family":"Taborda-Murillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"1110_CR1","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.bbmt.2018.12.753","volume":"25","author":"P Sedl\u00e1\u010dek","year":"2019","unstructured":"Sedl\u00e1\u010dek P, et al. Incidence of adenovirus infection in hematopoietic stem cell transplantation recipients: findings from the advance study. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl. 2019;25:810\u20138. https:\/\/doi.org\/10.1016\/j.bbmt.2018.12.753.","journal-title":"Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl"},{"key":"1110_CR2","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1002\/ajh.26723","volume":"97","author":"Y Inamoto","year":"2022","unstructured":"Inamoto Y, et al. Adenovirus disease after hematopoietic cell transplantation: a Japanese transplant registry analysis. Am J Hematol. 2022;97:1568\u201379. https:\/\/doi.org\/10.1002\/ajh.26723.","journal-title":"Am J Hematol"},{"key":"1110_CR3","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1097\/01.tp.0000122421.71556.71","volume":"77","author":"B Bruno","year":"2004","unstructured":"Bruno B, et al. Adenovirus nephritis in hematopoietic stem-cell transplantation. 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This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and\/or animals participants"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"90"}}