{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:15:28Z","timestamp":1785770128246,"version":"3.56.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tubulointerstitial nephritis (TIN) with IgM-positive plasma cells (IgMPC-TIN) is an inflammatory disease characterized by the infiltration of IgM and CD138 dual-positive plasma cells into the renal interstitium. Steroid treatment is effective for many cases of IgMPC-TIN. However, the optimal dose and duration of steroid therapy remain poorly understood. In the present case, IgMPC-TIN was diagnosed in a 36-year-old woman with femoral head osteonecrosis. After administration of prednisolone (PSL, 20\u00a0mg\/day), several markers of disease activity gradually decreased. The PSL dose was tapered to 5\u00a0mg\/day for one year without TIN recurrence. To avoid exacerbation of bone lesions due to prolonged administration of PSL, cyclosporine was added to PSL. Combination treatment with 5\u00a0mg\/day PSL and 100\u2013125\u00a0mg\/day cyclosporine stabilized the TIN. The patient remained stable without recurrence after further reduction and discontinuation of PSL. This case provides original evidence regarding the optimal treatment regimen for patients with IgMPC-TIN who are unsuitable for prolonged PSL administration.<\/jats:p>","DOI":"10.1007\/s13730-026-01153-y","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:26:42Z","timestamp":1785767202000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maintenance of clinical remission with cyclosporine after discontinuation of prednisolone in a patient with tubulointerstitial nephritis with IgM-positive plasma cells"],"prefix":"10.1007","volume":"15","author":[{"given":"Kazuki","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiori","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reina","family":"Suetsugu-Ishizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Matsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Iwano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5398-3667","authenticated-orcid":false,"given":"Naoki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"1153_CR1","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00467-016-3394-5","volume":"32","author":"E Joyce","year":"2017","unstructured":"Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A. Tubulointerstitial nephritis: diagnosis, treatment, and monitoring. Pediatr Nephrol. 2017;32:577\u201387.","journal-title":"Pediatr Nephrol"},{"key":"1153_CR2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s10157-021-02178-6","volume":"26","author":"N Nakaosa","year":"2022","unstructured":"Nakaosa N, Tsuboi N, Okabayashi Y, Haruhara K, Sasaki T, Tanno Y, Hirano K, Ikeda M, Miyazaki Y, Shimizu A, Yokoo T. Tubulointerstitial nephritis: a biopsy case series of 139 Japanese patients. Clin Exp Nephrol. 2022;26:435\u201344.","journal-title":"Clin Exp Nephrol"},{"key":"1153_CR3","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.1681\/ASN.2016101074","volume":"28","author":"N Takahashi","year":"2017","unstructured":"Takahashi N, Saeki T, Komatsuda A, Munemura C, Fukui T, Imai N, Homma N, Hatta T, Samejima KI, Fujimoto T, Omori H, Ito Y, Nishikawa Y, Kobayashi M, Morikawa Y, Fukushima S, Yokoi S, Mikami D, Kasuno K, Kimura H, Nemoto T, Nakamoto Y, Sada K, Sugai M, Naiki H, Yoshida H, Narita I, Saito Y, Iwano M. Tubulointerstitial nephritis with IgM-positive plasma cells. J Am Soc Nephrol. 2017;28:3688\u201398.","journal-title":"J Am Soc Nephrol"},{"key":"1153_CR4","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.ekir.2020.06.010","volume":"5","author":"N Matsuoka-Uchiyama","year":"2020","unstructured":"Matsuoka-Uchiyama N, Tsuji K, Fukushima K, Kitamura S, Uchida HA, Sugiyama H, Takahashi N, Iwano M, Wada J. Tubulointerstitial nephritis cases with IgM-positive plasma cells. Kidney Int Rep. 2020;5:1576\u201380.","journal-title":"Kidney Int Rep"},{"key":"1153_CR5","doi-asserted-by":"crossref","unstructured":"Akagi R, Ishii A, Kaneko K, Kondo N, Yokoi H, Matsubara T, Minamiguchi S, Kanno Y, Yanagita M. 2023. A report of three cases of patients with tubulointerstitial nephritis with IgM-positive plasma cells, treatment, and serum-IgM as a sensitive marker for relapse. BMC nephrology, 24(1), p.201.","DOI":"10.1186\/s12882-023-03253-8"},{"key":"1153_CR6","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.2169\/internalmedicine.7118-21","volume":"60","author":"M Minato","year":"2021","unstructured":"Minato M, Murakami T, Takahashi N, Ono H, Nishimura K, Tamaki M, Nagai K, Abe H, Iwano M, Joh K, Doi T. Glucocorticoid-dependent tubulointerstitial nephritis with IgM-positive Plasma cells presenting with intracellular crystalline inclusions within the rough endoplasmic reticulum. Intern Med. 2021;60:3129\u201336.","journal-title":"Intern Med"},{"key":"1153_CR7","doi-asserted-by":"crossref","unstructured":"Takahashi N, Yoshida H, Kimura H, Yamamoto C, Yamamoto M, Iwamura N, Matsuta K, Nishikawa S, Nishimori K, Fukushima S, Nishikawa Y, Kobayashi M, Kasuno K, Naiki H, Iwano M, Toyama T. Long-Term Outcomes of IgM-Positive Plasma Cell Tubulointerstitial Nephritis. Kidney International Reports. 2026; doi:10.1016\/j.ekir.2025.103764.","DOI":"10.1016\/j.ekir.2025.103764"},{"key":"1153_CR8","doi-asserted-by":"crossref","unstructured":"Vandewalle J, Luypaert A, De Bosscher K, Libert C. Therapeutic Mechanisms of Glucocorticoids. Trends Endocrinol Metab. 2018;29:42\u201354. 9.","DOI":"10.1016\/j.tem.2017.10.010"},{"key":"1153_CR9","doi-asserted-by":"crossref","unstructured":"Yoshikawa Y, Anzai H, Odajima K, Asakawa S, Arai S, Yamazaki O, Tamura Y, Ohashi R, Shibata S, Fujigaki Y. 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