{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T01:25:44Z","timestamp":1776648344627,"version":"3.51.2"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s13760-018-01063-6","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T08:50:01Z","timestamp":1544691001000},"page":"595-599","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Relationship of leptin, growth hormone, and insulin-like growth factor levels with body mass index and disease severity in patients with fibromyalgia syndrome"],"prefix":"10.1007","volume":"120","author":[{"given":"Tuba T\u00fclay","family":"Koca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ejder","family":"Berk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet","family":"Seyithano\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burhan Fatih","family":"Ko\u00e7yi\u011fit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Demirel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"issue":"Suppl 105","key":"1063_CR1","first-page":"6","volume":"35","author":"R Talotta","year":"2017","unstructured":"Talotta R, Bazzichi L, Di Franco M, Casale R, Batticciotto A, Gerardi MC, Sarzi-Puttini P (2017) One year in review 2017: fibromyalgia. Clin Exp Rheumatol 35(Suppl 105):6\u201312","journal-title":"Clin Exp Rheumatol"},{"issue":"1:88","key":"1063_CR2","first-page":"S117-25","volume":"33","author":"A Rossi","year":"2015","unstructured":"Rossi A, Di Lollo AC, Guzzo MP, Giacomelli C, Atzeni F, Bazzichi L, Di Franco M (2015) Fibromyalgia and nutrition: what news? Clin Exp Rheumatol 33(1:88):S117-25","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"1063_CR3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2174\/1573397112666160919120530","volume":"13","author":"S Metyas","year":"2017","unstructured":"Metyas S, Rezk T, Arkfeld D, Leptich T (2017) Autoinflammation and immunomodulation in inflammatory fibromyalgia syndrome\u2014a review. Curr Rheumatol Rev 13(2):98\u2013102. \nhttps:\/\/doi.org\/10.2174\/1573397112666160919120530","journal-title":"Curr Rheumatol Rev"},{"issue":"11","key":"1063_CR4","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1007\/s00296-014-2988-0","volume":"34","author":"D Homann","year":"2014","unstructured":"Homann D, Carvalho HM, Stefanello JM, G\u00f3es SM, Lopes AL, de Oliveira AR et al (2014) Hyperleptinemia independent of body adiposity in women with fibromyalgia. Rheumatol Int 34(11):1593\u20131598. \nhttps:\/\/doi.org\/10.1007\/s00296-014-2988-0\n\n(Epub 2014 Mar 27)","journal-title":"Rheumatol Int"},{"issue":"1:88","key":"1063_CR5","first-page":"S117","volume":"33","author":"A Rossi","year":"2015","unstructured":"Rossi A, Di Lollo AC, Guzzo MP, Giacomelli C, Atzeni F, Bazzichi L, Di Franco M (2015) Fibromyalgia and nutrition: what news? Clin Exp Rheumatol 33(1:88):S117\u2013S125","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"1063_CR6","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/MED.0000000000000184","volume":"22","author":"OM Farr","year":"2015","unstructured":"Farr OM, Gavrieli A, Mantzoros CS (2015) Leptin applications in 2015: what have we learned about leptin and obesity? Curr Opin Endocrinol Diabetes Obes 22(5):353\u2013359. \nhttps:\/\/doi.org\/10.1097\/MED.0000000000000184","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"5","key":"1063_CR7","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s10528-016-9751-z","volume":"54","author":"M Wasim","year":"2016","unstructured":"Wasim M, Awan FR, Najam SS, Khan AR, Khan HN (2016) Role of leptin deficiency, inefficiency, and leptin receptors in obesity. Biochem Genet 54(5):565\u2013572. \nhttps:\/\/doi.org\/10.1007\/s10528-016-9751-z","journal-title":"Biochem Genet"},{"issue":"7","key":"1063_CR8","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1089\/jwh.2015.5509","volume":"25","author":"J Younger","year":"2016","unstructured":"Younger J, Kapphahn K, Brennan K, Sullivan SD, Stefanick ML (2016) Association of Leptin with Body Pain in Women. J Womens Health (Larchmt) 25(7):752\u2013760. \nhttps:\/\/doi.org\/10.1089\/jwh.2015.5509\n\n(Epub 2016 Mar 30)","journal-title":"J Womens Health (Larchmt)"},{"issue":"7","key":"1063_CR9","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.pain.2012.03.030","volume":"153","author":"CJ Malemud","year":"2012","unstructured":"Malemud CJ (2012) The basis for medical therapy of fibromyalgia with growth hormone. Pain 153(7):1342\u20131343. \nhttps:\/\/doi.org\/10.1016\/j.pain.2012.03.030","journal-title":"Pain"},{"key":"1063_CR10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s11926-002-0039-4","volume":"4","author":"RM Bennett","year":"2002","unstructured":"Bennett RM (2002) Adult growth hormone deficiency in patients with fibromyalgia. Curr Rheumatol Rep 4:306\u2013312","journal-title":"Curr Rheumatol Rep"},{"key":"1063_CR11","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s00296-004-0459-8","volume":"25","author":"CW Denko","year":"2005","unstructured":"Denko CW, Malemud CJ (2005) Serum growth hormone and insulin, but not insulin like growth factor levels are elevated in patients with fibromyalgia syndrome. Rheumatol Int 25:146\u2013151","journal-title":"Rheumatol Int"},{"issue":"1","key":"1063_CR12","doi-asserted-by":"publisher","first-page":"R34","DOI":"10.1186\/ar4187","volume":"15","author":"Jan L Bjersing","year":"2013","unstructured":"Bjersing JL, Erlandsson M, Bokarewa MI, Mannerkorpi K (2013) Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin? Arthritis Res Ther. Feb 27;15(1):R34. \nhttps:\/\/doi.org\/10.1186\/ar4187","journal-title":"Arthritis Research & Therapy"},{"key":"1063_CR13","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/art.1780330203","volume":"33","author":"F Wolfe","year":"1990","unstructured":"Wolfe F, Smythe HA, Yunus MB et al (1990) The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum 33:160\u201372","journal-title":"Arthritis Rheum"},{"key":"1063_CR14","first-page":"728","volume":"18","author":"CS Burckhardt","year":"1991","unstructured":"Burckhardt CS, Clark SR, Bennett RM (1991) The Fibromyalgia Impact Questionnaire: developed and validation. J Rheumatol 18:728\u2013733","journal-title":"J Rheumatol"},{"key":"1063_CR15","doi-asserted-by":"publisher","first-page":"627041","DOI":"10.1155\/2014\/627041","volume":"2014","author":"MI Bokarewa","year":"2014","unstructured":"Bokarewa MI, Erlandsson MC, Bjersing J, Dehlin M, Mannerkorpi K (2014) Smoking is associated with reduced leptin and neuropeptide Y levels and higher pain experience in patients with fibromyalgia. Mediators Inflamm 2014:627041. \nhttps:\/\/doi.org\/10.1155\/2014\/627041\n\n(Epub 2014 Aug 14)","journal-title":"Mediators Inflamm"},{"issue":"3","key":"1063_CR16","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1590\/2359-3997000000248","volume":"61","author":"Eduardo S. Paiva","year":"2017","unstructured":"Paiva ES, Andretta A, Batista ED, Lobo MMMT, Miranda RC, Nisihara R et al. Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight\/obesity. Arch Endocrinol Metab. 2017 May-Jun;61(3):249\u2013256. \nhttps:\/\/doi.org\/10.1590\/2359-3997000000248\n\n(Epub 2017 Feb 13)","journal-title":"Archives of Endocrinology and Metabolism"},{"issue":"5","key":"1063_CR17","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/1756-185X.12155","volume":"16","author":"SM Olama","year":"2013","unstructured":"Olama SM, Elsaid TO, El-Arman M (2013 Oct) Serum leptin in Egyptian patients with fibromyalgia syndrome: relation to disease severity. Int J RheumDis 16(5):583\u2013589. \nhttps:\/\/doi.org\/10.1111\/1756-185X.12155","journal-title":"Int J RheumDis"},{"key":"1063_CR18","doi-asserted-by":"publisher","unstructured":"Atao\u011flu S, Ankaral\u0131 H, Samanc\u0131 R, \u00d6z\u015fahin M, Adm\u0131\u015f \u00d6. The relations between serum leptin level with disease Activity and inflammatory markers in fibromyalgia patients. North Clin\u0130stanb. \nhttps:\/\/doi.org\/10.14744\/nci.2017.31644","DOI":"10.14744\/nci.2017.31644"},{"issue":"3","key":"1063_CR19","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11102-013-0486-0","volume":"17","author":"G Cuatrecasas","year":"2014","unstructured":"Cuatrecasas G, Alegre C, Casanueva FF (2014) GH\/IGF1 axis disturbances in the fibromyalgia syndrome: is there a rationale for GH treatment? Pituitary 17(3):277\u2013283. \nhttps:\/\/doi.org\/10.1007\/s11102-013-0486-0","journal-title":"Pituitary"},{"key":"1063_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.09.024","author":"S Neseliler","year":"2018","unstructured":"Neseliler S, Hu W, Larcher K, Zacchia M, Dadar M, Scala SG, Lamarche M, Zeighami Y, Stotland SC, Larocque M, Marliss EB, Dagher A (2018) Neurocognitive and hormonal correlates of voluntary weight loss in humans. Cell Metab. \nhttps:\/\/doi.org\/10.1016\/j.cmet.2018.09.024","journal-title":"Cell Metab"},{"issue":"6","key":"1063_CR21","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.semarthrit.2006.09.006","volume":"36","author":"KD Jones","year":"2007","unstructured":"Jones KD, Deodhar P, Lorentzen A, Bennett RM, Deodhar AA (2007) Growth hormone perturbations in fibromyalgia: a review. Semin Arthritis Rheum 36(6):357\u2013379","journal-title":"Semin Arthritis Rheum"},{"issue":"Suppl 4","key":"1063_CR22","first-page":"529","volume":"6","author":"G Cuatrecasas","year":"2009","unstructured":"Cuatrecasas G (2009) Fibromyalgic syndromes: could growth hormone therapy be beneficial? Pediatr Endocrinol Rev 6(Suppl 4):529\u2013533","journal-title":"Pediatr Endocrinol Rev"},{"key":"1063_CR23","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1471-2474-8-119","volume":"8","author":"G Cuatrecasas","year":"2007","unstructured":"Cuatrecasas G, Riudavets C, G\u00fcell MA (2007) Growth hormone as concomitant treatment in severe fibromyalgia associated with low IGF-1 serum levels. A pilot study. BMC Musculoskelet Disord 8:119","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"1063_CR24","first-page":"82","volume":"17","author":"KC Yuen","year":"2007","unstructured":"Yuen KC, Bennett RM, Hryciw CA, Cook MB, Rhoads SA, Cook DM (2007) Is further evaluation for growth hormone (GH) deficiency necessary in fibromyalgia patients with low serum insulin-like growth factor (IGF)-I levels? Growth Horm. IGF Res 17(1):82\u201388 (Epub 2007 Feb 6)","journal-title":"IGF Res"},{"key":"1063_CR25","doi-asserted-by":"publisher","first-page":"3106041","DOI":"10.1155\/2017\/3106041","volume":"2017","author":"AE Rigamonti","year":"2017","unstructured":"Rigamonti AE, Grugni G, Arreghini M, Capodaglio P, De Col A, Agosti F et al (2017) GH responsiveness to combined gh-releasing hormone and arginine administration in obese patients with fibromyalgia syndrome. Int J Endocrinol 2017:3106041. \nhttps:\/\/doi.org\/10.1155\/2017\/3106041\n\n(Epub 2017 Jun 28)","journal-title":"Int J Endocrinol"},{"issue":"4","key":"1063_CR26","doi-asserted-by":"publisher","first-page":"R162","DOI":"10.1186\/ar3902","volume":"14","author":"JL Bjersing","year":"2012","unstructured":"Bjersing JL, Dehlin M, Erlandsson M, Bokarewa MI, Mannerkorpi K (2012) Changes in pain and insulin-like growth factor 1 in fibromyalgia during exercise: the involvement of cerebrospinal inflammatory factors and neuropeptides. Arthritis Res Ther 14(4):R162. \nhttps:\/\/doi.org\/10.1186\/ar3902","journal-title":"Arthritis Res Ther"},{"key":"1063_CR27","doi-asserted-by":"publisher","unstructured":"Mannerkorpi K, Landin-Wilhelmsen K, Larsson A, Cider \u00c5, Arodell O, Bjersing JL (2017) Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia.BMC Musculoskelet Disord. 18(1):37. \nhttps:\/\/doi.org\/10.1186\/s12891-017-1402-y","DOI":"10.1186\/s12891-017-1402-y"},{"issue":"9","key":"1063_CR28","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.1210\/jc.2010-0061","volume":"95","author":"G Cuatrecasas","year":"2010","unstructured":"Cuatrecasas G, Gonzalez MJ, Alegre C, Sesmilo G, Fernandez-Sol\u00e0 J, Casanueva FF et al (2010) High prevalence of growth hormone deficiency in severe fibromyalgia syndromes. J Clin Endocrinol Metab 95(9):4331\u20137. \nhttps:\/\/doi.org\/10.1210\/jc.2010-0061\n\n(Epub 2010 Jul 14)","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-018-01063-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13760-018-01063-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-018-01063-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T20:24:24Z","timestamp":1590006264000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13760-018-01063-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,13]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["1063"],"URL":"https:\/\/doi.org\/10.1007\/s13760-018-01063-6","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,13]]},"assertion":[{"value":"5 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Regional Committee for Ethics (Number: 199) in Medical Research and conducted in compliance with Helsinki criteria.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent has been taken from the participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}