{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:10Z","timestamp":1790279110494,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s13760-018-0912-1","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T11:47:47Z","timestamp":1523879267000},"page":"289-296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of diffusion tensor imaging changes and neurocognitive effects of asymptomatic vitamin B12 deficiency"],"prefix":"10.1007","volume":"118","author":[{"given":"Ali Zeynal Abidin","family":"Tak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Dayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hac\u0131 Taner","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"912_CR1","first-page":"4525","volume":"20","author":"BG \u00c7okal","year":"2016","unstructured":"\u00c7okal BG, G\u00fcne\u015f HN, G\u00fcler SK, Yolda\u015f TK (2016) Visual and somotosensory evoked potentials in asymptomatic patients with vitamin B12 deficiency. Eur Rev Med Pharmacol Sci 20:4525\u20134529","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"912_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3945\/ajcn.111.013243","volume":"94","author":"EA Yetley","year":"2011","unstructured":"Yetley EA, Pfeiffer CM, Phinney KW, Bailey RL, Blackmore S, Bock JL, Brody LC, Carmel R, Curtin LR, Durazo-Arvizu RA, Eckfeldt JH, Green R, Gregory JF, Hoofnagle AN, Jacobsen DW, Jacques PF, Lacher DA, Molloy AM, Massaro J, Mills JL, Nexo E, Rader JI, Selhub J, Sempos C, Shane B, Stabler S, Stover P, Tamura T, Tedstone A, Thorpe SJ, Coates PM, Johnson CL, Picciano MF (2011) Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr 94(1):313\u2013321","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"912_CR3","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1503\/cmaj.1031155","volume":"171","author":"E Andres","year":"2004","unstructured":"Andres E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, Noblet-Dick M, Maloisel F, Schlienger JL, Blickle JL (2004) Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 171(3):251\u2013259","journal-title":"CMAJ"},{"key":"912_CR4","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.ypmed.2004.04.047","volume":"39","author":"M Wolters","year":"2004","unstructured":"Wolters M, Str\u00f6hle A, Hahn A (2004) Cobalamin: a critical vitamin in the elderly. Prev Med 39:1256\u20131266","journal-title":"Prev Med"},{"key":"912_CR5","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0950-3536(05)80220-3","volume":"8","author":"R Green","year":"1995","unstructured":"Green R (1995) Metabolite assays in cobalamin and folate deficiency. Baillieres Clin Haematol 8:533\u2013566","journal-title":"Baillieres Clin Haematol"},{"issue":"5","key":"912_CR6","first-page":"979","volume":"67","author":"R Oh","year":"2003","unstructured":"Oh R, Brown DL (2003) Vitamin B12 deficiency. Am Fam Physician 67(5):979\u2013994","journal-title":"Am Fam Physician"},{"issue":"3","key":"912_CR7","first-page":"199","volume":"8","author":"M Maralcan","year":"2004","unstructured":"Maralcan M, Ellidokuz E (2004) Vitamin B12 Eksikli\u011fi. G\u00fcncel Gastroenteroloji 8(3):199\u2013204","journal-title":"G\u00fcncel Gastroenteroloji"},{"key":"912_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00234-013-1306-y","volume":"56","author":"PK Gupta","year":"2014","unstructured":"Gupta PK, Garg RK, Gupta RK, Malhotra HS, Paliwal VK, Rathore RKS, Verma R, Singh MK, Rai Y, Pandey CM (2014) Diffusion tensor tractography and neuropsychological assessment in patients with vitamin B12 deficiency. Neuroradiology 56:97\u2013106","journal-title":"Neuroradiology"},{"key":"912_CR9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0306-9877(91)90181-W","volume":"34","author":"J Dommisse","year":"1991","unstructured":"Dommisse J (1991) Subtle vitamin B12 deficiency and psychiatry: a largely unnoticed but devastating relationship? Med Hypotheses 34:131\u2013140","journal-title":"Med Hypotheses"},{"key":"912_CR10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1136\/jnnp.2008.149286","volume":"80","author":"LM Lau de","year":"2009","unstructured":"de Lau LM, Smith AD, Refsum H, Johnston C, Breteler MM (2009) Plasma vitamin B12 status and cerebral white-matter lesions. J Neurol Neurosurg Psychiatry 80:149\u2013157","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"912_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jns.2005.03.009","volume":"233","author":"A Miller","year":"2005","unstructured":"Miller A, Korem M, Almog R, Galboiz Y (2005) Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurol Sci 233:93\u201397","journal-title":"J Neurol Sci"},{"key":"912_CR12","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/S0197-4580(01)00318-9","volume":"23","author":"O Abe","year":"2002","unstructured":"Abe O, Aoki S, Hayashi N, Yamada H, Kunimatsu A, Mori H, Yoshikawa T, Okubo T, Ohtomo K (2002) Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis. Neurobiol Aging 23:433\u2013441","journal-title":"Neurobiol Aging"},{"key":"912_CR13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4306\/pi.2008.5.1.36","volume":"5","author":"JM Kim","year":"2008","unstructured":"Kim JM, Kim SW, Shin IS, Yang SJ, Park WY, Kim SJ, Shin HY, Yoon JS (2008) Folate, vitamin b(12), and homocysteine as risk factors for cognitive decline in the elderly. Psychiatry Investig 5:36\u201340","journal-title":"Psychiatry Investig"},{"issue":"6","key":"912_CR14","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1093\/ageing\/31.6.440","volume":"31","author":"JH Williams","year":"2002","unstructured":"Williams JH, Pereira EA, Budge MM, Bradley KM (2002) Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people. Age Ageing 31(6):440\u2013444","journal-title":"Age Ageing"},{"key":"912_CR15","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/jnr.20547","volume":"81","author":"RK Gupta","year":"2005","unstructured":"Gupta RK, Hasan KM, Trivedi R, Pradhan M, Das V, Parikh NA, Narayana PA (2005) Diffusion tensor imaging of the developing human cerebrum. J Neurosci Res 81:172\u2013178","journal-title":"J Neurosci Res"},{"issue":"6","key":"912_CR16","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.acra.2014.02.009","volume":"21","author":"HT Bulut","year":"2014","unstructured":"Bulut HT, Yildirim A, Ekmekci B, Gunbey HP (2014) The diagnostic and grading value of diffusion tensor imaging in patients with carpal tunnel syndrome. Acad Radiol 21(6):767\u2013773","journal-title":"Acad Radiol"},{"key":"912_CR17","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.yebeh.2016.07.015","volume":"62","author":"B Ekmekci","year":"2016","unstructured":"Ekmekci B, Bulut HT, G\u00fcm\u00fc\u015fta\u015f F, Y\u0131ld\u0131r\u0131m A, Ku\u015ftepe A (2016) The relationship between white matter abnormalities and cognitive functions in new-onset juvenile myoclonic epilepsy. Epilepsy Behav 62:166\u2013170","journal-title":"Epilepsy Behav"},{"issue":"1","key":"912_CR18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, Johnston C, Engbaek F, Schneede J, McPartlin C, Scott JM (2004) Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 50(1):3\u201332","journal-title":"Clin Chem"},{"key":"912_CR19","first-page":"273","volume":"13","author":"C G\u00fcngen","year":"2002","unstructured":"G\u00fcngen C, Ertan T, Eker E, Ya\u015far R, Engin F (2002) Standardize Mini Mental Test\u2019in T\u00fcrk toplumunda hafif demans tan\u0131s\u0131nda ge\u00e7erlilik ve g\u00fcvenilirli\u011fi. T\u00fcrk Psikiyatri Dergisi 13:273\u2013281","journal-title":"T\u00fcrk Psikiyatri Dergisi"},{"key":"912_CR20","first-page":"166","volume":"13","author":"K Selekler","year":"2010","unstructured":"Selekler K, Cang\u00f6z B, Ulu\u00e7 S (2010) Montreal Bili\u015fsel De\u011ferlendirme \u00d6l\u00e7e\u011fi (MOB\u0130D)\u2019nin hafif bili\u015fsel bozukluk ve Alzheimer hastalar\u0131n\u0131 ay\u0131rt edebilme g\u00fcc\u00fcn\u00fcn incelenmesi. Turk J Geriatr 13:166\u2013171","journal-title":"Turk J Geriatr"},{"key":"912_CR21","first-page":"196","volume":"29","author":"\u00d6 \u00d6ktem","year":"1992","unstructured":"\u00d6ktem \u00d6 (1992) S\u00f6zel Bellek S\u00fcre\u00e7leri Testi (SBST)\u2014Bir \u00d6n \u00c7al\u0131\u015fma. N\u00f6ropsikiyatri Ar\u015fivi 29:196\u2013206","journal-title":"N\u00f6ropsikiyatri Ar\u015fivi"},{"key":"912_CR22","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1080\/13607863.2010.536133","volume":"15","author":"P Kurt","year":"2011","unstructured":"Kurt P, Yener G, Oguz M (2011) Impaired digit span can predict further cognitive decline in older people with subjective memory complaint: a preliminary result. Aging Ment Health 15:364\u2013369","journal-title":"Aging Ment Health"},{"key":"912_CR23","unstructured":"Bing\u00f6l A, Ero\u011flu G, Haktan\u0131r I (1994) T\u00fcrk toplumunda s\u00f6zel ak\u0131c\u0131l\u0131k becerisi; bir standardizasyon \u00e7al\u0131\u015fmas\u0131. 15. Ulusal N\u00f6roloji Kongresi; Adana"},{"issue":"2","key":"912_CR24","first-page":"73","volume":"10","author":"B Cang\u00f6z","year":"2007","unstructured":"Cang\u00f6z B, Karako\u00e7 E, Selekler K (2007) \u0130z S\u00fcrme Testi\u2019nin 50 ya\u015f \u00fczeri T\u00fcrk yeti\u015fkin ve ya\u015fl\u0131 \u00f6rneklemi i\u00e7in standardizasyon \u00e7al\u0131\u015fmas\u0131. Turk J Geriatr 10(2):73\u201382","journal-title":"Turk J Geriatr"},{"issue":"33","key":"912_CR25","first-page":"33","volume":"9","author":"\u00d6 \u00d6ktem","year":"1994","unstructured":"\u00d6ktem \u00d6 (1994) N\u00f6ropsikolojik Testler ve N\u00f6ropsikolojik De\u011ferlendirme. T\u00fcrk Psikoloji Dergisi 9(33):33\u201344","journal-title":"T\u00fcrk Psikoloji Dergisi"},{"key":"912_CR26","first-page":"215","volume":"3","author":"S Karaka\u015f","year":"2000","unstructured":"Karaka\u015f S, Karaka\u015f HM (2000) Y\u00f6netici i\u015flevlerin ara\u015ft\u0131r\u0131lmas\u0131nda multidisipliner yakla\u015f\u0131m: bili\u015fsel psikolojiden n\u00f6roradyolojiye. Klinik psikiyatri 3:215\u2013227","journal-title":"Klinik psikiyatri"},{"issue":"12","key":"912_CR27","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1111\/j.1460-9568.2010.07251.x","volume":"31","author":"JP Aggleton","year":"2010","unstructured":"Aggleton JP, O\u2019Mara SM, Vann SD, Wright NF, Tsanov M, Erichsen JT (2010) Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions. Eur J Neurosci 31(12):2292\u20132307","journal-title":"Eur J Neurosci"},{"key":"912_CR28","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1136\/jnnp.64.1.131","volume":"64","author":"M Taylor","year":"1998","unstructured":"Taylor M, David AS (1998) Agenesis of the corpus callosum: a United Kingdom series of 56 cases. J Neurol Neurosurg Psychiatry 64:131\u2013134","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"912_CR29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10072-010-0419-x","volume":"32","author":"C Blundo","year":"2011","unstructured":"Blundo C, Marin D, Ricci M (2011) Vitamin B12 deficiency associated with symptoms of frontotemporal dementia. Neurol Sci 32:101\u2013105","journal-title":"Neurol Sci"},{"key":"912_CR30","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/geronb\/56.6.P327","volume":"56","author":"E Calvaresi","year":"2001","unstructured":"Calvaresi E, Bryan J (2001) B vitamins, cognition and aging: a review. J Gerontol B Psychol Sci Soc Sci 56:327\u2013339","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"912_CR31","doi-asserted-by":"publisher","first-page":"872","DOI":"10.3174\/ajnr.A3785","volume":"35","author":"PK Gupta","year":"2014","unstructured":"Gupta PK, Gupta RK, Garg RK, Rai Y, Roy B, Pandey CM, Malhotra HS, Narayana PA (2014) DTI correlates of cognition in conventional MRI of normal-appearing brain in patients with clinical features of subacute combined degeneration and biochemically proven vitamin B (12) deficiency. Am J Neuroradiol 35:872\u2013877","journal-title":"Am J Neuroradiol"},{"issue":"5","key":"912_CR32","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.mri.2015.02.012","volume":"33","author":"B Roy","year":"2015","unstructured":"Roy B, Trivedi R, Garg RK, Gupta PK, Tyagi R, Gupta RK (2015) Assessment of functional and structural damage in brain parenchyma in patients with vitamin B12 deficiency: a longitudinal perfusion and diffusion tensor imaging study. Magn Reson Imaging 33(5):537\u2013543","journal-title":"Magn Reson Imaging"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13760-018-0912-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-018-0912-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-018-0912-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T23:19:06Z","timestamp":1555370346000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13760-018-0912-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["912"],"URL":"https:\/\/doi.org\/10.1007\/s13760-018-0912-1","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]},"assertion":[{"value":"25 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Ethics committee approval was taken for this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics committee approval"}},{"value":"Written informed consent was taken from the patients participating in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"External, independent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Peer review"}},{"value":"The authors reported no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}