{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:55:51Z","timestamp":1782262551036,"version":"3.54.5"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s13760-020-01552-7","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T06:40:44Z","timestamp":1606372844000},"page":"1823-1830","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The correlation between carbamazepine and valproic acid monotherapy with serum adiponectin and carnitine"],"prefix":"10.1007","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1662-5534","authenticated-orcid":false,"given":"Fatma","family":"\u015eim\u015fek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ceylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"K\u0131z\u0131ltun\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"\u0130yig\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"1552_CR1","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1080\/14740338.2019.1625887","volume":"18","author":"B Miziak","year":"2019","unstructured":"Miziak B, Chro\u015bci\u0144ska-Krawczyk M, Czuczwar SJ (2019) An update on the problem of osteoporosis in people with epilepsy taking antiepileptic drugs. Expert Opin Drug Saf 18:679\u2013689","journal-title":"Expert Opin Drug Saf"},{"key":"1552_CR2","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.4236\/abb.2012.38136","volume":"3","author":"GM Koksal","year":"2012","unstructured":"Koksal GM (2012) Oxidative stress and its complications in human health. Adv Biosci Biotechnol 3:1113\u20131115","journal-title":"Adv Biosci Biotechnol"},{"key":"1552_CR3","first-page":"365","volume-title":"T Treatment of Epilepsy. Principles and practice","author":"E Wyllie","year":"2006","unstructured":"Wyllie E (2006) T Treatment of Epilepsy. Principles and practice, 4th edn. Lippincott Williams and Wilkins, Philadelphia, pp 365\u2013372","edition":"4"},{"key":"1552_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1159\/000197868","volume":"71","author":"A Verrotti","year":"2009","unstructured":"Verrotti A, La Torre R, Trotta D, Mohn A, Chiarelli F (2009) Valproate-induced insulin resistance and obesity in children. Horm Res 71:125\u2013131","journal-title":"Horm Res"},{"key":"1552_CR5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1467-789X.2010.00800.x","volume":"12","author":"A Verrotti","year":"2011","unstructured":"Verrotti A, D\u2019Egidio C, Mohn A, Coppola G, Chiarelli F (2011) Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications. Obes Rev 12:32\u201343","journal-title":"Obes Rev"},{"key":"1552_CR6","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1136\/jnnp-2012-303688","volume":"84","author":"WO Pickrell","year":"2013","unstructured":"Pickrell WO, Lacey AS, Thomas RH, Smith PE, Rees MI (2013) Weight change associated with antiepileptic drugs. J Neurol Neurosurg Psychiatry 84:796\u2013799","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1552_CR7","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1177\/0269881117715608","volume":"31","author":"S Akg\u00fcn","year":"2017","unstructured":"Akg\u00fcn S, K\u00f6ken T, Kahraman A (2017) Evaluation of adiponectin and leptin levels and oxidative stress in bipolar disorder patients with metabolic syndrome treated by valproic acid. J Psychopharmacol 31:1453\u20131459","journal-title":"J Psychopharmacol"},{"key":"1552_CR8","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1172\/JCI29126","volume":"116","author":"K Takashi","year":"2006","unstructured":"Takashi K, Toshimasa Y, Naoto K, Kazou H, Kohjiro U, Kazuyuki T (2006) Adiponectin and adiponectin receptors in ins\u00fclin resistance, diabetes, and the metabolic syndrome. J Clin Investig 116:1784\u20131792","journal-title":"J Clin Investig"},{"key":"1552_CR9","doi-asserted-by":"publisher","first-page":"s64","DOI":"10.1210\/jc.2008-1613","volume":"93","author":"N Rasouli","year":"2008","unstructured":"Rasouli N, Kern PA (2008) Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 93:s64\u2013s73","journal-title":"J Clin Endocrinol Metab"},{"key":"1552_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1467-789X.2005.00159.x","volume":"6","author":"AS Lihn","year":"2005","unstructured":"Lihn AS, Pedersen SB, Richelsen B (2005) Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev 6:13\u201321","journal-title":"Obes Rev"},{"key":"1552_CR11","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.clineuro.2018.05.005","volume":"170","author":"I Kulhas Celik","year":"2018","unstructured":"Kulhas Celik I, Tasdemir HA, Ince H, Celik H, Sungur M (2018) Evaluation ofserum free carnitine\/acylcarnitine levels and left ventricular systolic functions in children with idiopathic epilepsy receiving valproic acid. Clin Neurol Neurosurg 170:106\u2013112","journal-title":"Clin Neurol Neurosurg"},{"key":"1552_CR12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.eplepsyres.2019.03.009","volume":"153","author":"P Haznedar","year":"2019","unstructured":"Haznedar P, Do\u011fan \u00d6, Albayrak P, \u00d6z Tun\u00e7er G, Teber S, Deda G, Eminoglu FT (2019) Effects of levetiracetam and valproic acid treatment on liver function tests, plasma free carnitine and lipid peroxidation in childhood epilepsies. Epilepsy Res 153:7\u201313","journal-title":"Epilepsy Res"},{"key":"1552_CR13","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2174\/1570159X12666140923205715","volume":"12","author":"B Martinc","year":"2014","unstructured":"Martinc B, Grabnar I, Vovk T (2014) Antioxidants as a preventive treatment for epileptic process: a review of the current status. Curr Neuropharmacol 12:527\u2013550","journal-title":"Curr Neuropharmacol"},{"key":"1552_CR14","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1126\/science.7901908","volume":"262","author":"JT Coyle","year":"1993","unstructured":"Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate and neurodegenerative disorder. Science 262:689\u2013693","journal-title":"Science"},{"key":"1552_CR15","first-page":"590","volume":"6","author":"MK Pandey","year":"2012","unstructured":"Pandey MK, Mittra P, Maheshwari M (2012) The lipid peroxidation product as a marker of oxidative stress in epilepsy. J Clin Diagn Res 6:590\u2013592","journal-title":"J Clin Diagn Res"},{"key":"1552_CR16","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/j.1528-1167.2011.03316.x","volume":"53","author":"YC Chuang","year":"2012","unstructured":"Chuang YC, Chuang HY, Lin TK, Chang CC, Lu CH, Chang WN et al (2012) Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis: antiepileptic drugs and atherosclerosis. Epilepsia 53:120\u2013128","journal-title":"Epilepsia"},{"key":"1552_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0378-4274(01)00415-5","volume":"125","author":"ZK Binienda","year":"2001","unstructured":"Binienda ZK, Ali SF (2001) Neuroprotective role of l-carnitine in the 3-nitropropionic acid induced neurotoxicity. Toxicol Lett 125:67\u201373","journal-title":"Toxicol Lett"},{"key":"1552_CR18","first-page":"105","volume":"30","author":"J Campistol","year":"2000","unstructured":"Campistol J, Chavez B, Vilaseca MA, Artuch R (2000) Antiepileptic drugs and carnitine. Rev Neurol 30:105\u2013109","journal-title":"Rev Neurol"},{"key":"1552_CR19","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1177\/088307389801301104","volume":"13","author":"M Castro-Gago","year":"1998","unstructured":"Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, Couceiro J, Cami\u00f1a F, Rodr\u00edguez-Segade S (1998) Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital. J Child Neurol 13:546\u2013549","journal-title":"J Child Neurol"},{"key":"1552_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s005990050060","volume":"29","author":"A Verrotti","year":"1999","unstructured":"Verrotti A, Greco R, Morgese G, Chiarelli F (1999) Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. Int J Clin Lab Res 29:36\u201340","journal-title":"Int J Clin Lab Res"},{"key":"1552_CR21","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S0022-3476(05)80306-3","volume":"119","author":"G Hug","year":"1991","unstructured":"Hug G, McGraw CA, Bates SR, Landrigan EA (1991) Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children. J Pediatr 119:799\u2013802","journal-title":"J Pediatr"},{"key":"1552_CR22","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1017\/S0317167100021879","volume":"24","author":"C Corman","year":"1997","unstructured":"Corman C, Leung N, Gubermen A (1997) Weight gain in epileptic patient during treatment with valproic acid: a retrospective study. Can J Neurol Sci 24:240\u2013244","journal-title":"Can J Neurol Sci"},{"key":"1552_CR23","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1177\/088307380201700405","volume":"17","author":"A Verrotti","year":"2002","unstructured":"Verrotti A, Basciani F, De Simone M, Trotta D, Morgese G, Chiarelli F (2002) Insulin resistance in epileptic girls who gain weight after therapy with valproic acit. J Child Neurol 17:265\u2013268","journal-title":"J Child Neurol"},{"key":"1552_CR24","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1172\/JCI10842","volume":"106","author":"BB Kahn","year":"2000","unstructured":"Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473\u2013481","journal-title":"J Clin Invest"},{"key":"1552_CR25","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1530\/eje.0.1480293","volume":"148","author":"JJ Diez","year":"2003","unstructured":"Diez JJ, Iglesias P (2003) The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 148:293\u2013300","journal-title":"Eur J Endocrinol"},{"key":"1552_CR26","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.yebeh.2006.02.008","volume":"8","author":"V Pylvanen","year":"2006","unstructured":"Pylvanen V, Pakarinen A, Knip M, Isojarvi J (2006) \u0130ns\u00fclin-related metabolic changes during treatment with valproate in patients with epilepsy. Epilepsy Behav 8:643\u2013648","journal-title":"Epilepsy Behav"},{"key":"1552_CR27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0920-1211(03)00091-3","volume":"55","author":"GJ Luef","year":"2003","unstructured":"Luef GJ, Lechleitner M, Bauer G, Trinka E, Hengster P (2003) Valproic acid modulates islet cell ins\u00fclin secretion: a possible mechanism of weight gain in epilepsy patients. Epilepsy Res 55:53\u201358","journal-title":"Epilepsy Res"},{"key":"1552_CR28","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1212\/01.wnl.0000187074.27586.d1","volume":"65","author":"R Greco","year":"2005","unstructured":"Greco R, Latini G, Chiarelli F, Iannetti P, Verrotti A (2005) Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acit. Neurolgy 65:1808\u20131809","journal-title":"Neurolgy"},{"key":"1552_CR29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1528-1167.2007.01460.x","volume":"49","author":"M Rauchenzauner","year":"2008","unstructured":"Rauchenzauner M, Haberlandt E, Scholl-Burgi S, Ernst B, Hoppichler F, Karall D et al (2008) Adiponectin and visfatin concentrations in children treated with valproic acid. Epilepsia 49:353\u2013357","journal-title":"Epilepsia"},{"key":"1552_CR30","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1210\/en.2005-1030","volume":"147","author":"L Qiao","year":"2006","unstructured":"Qiao L, Schaack J, Shao J (2006) Supression of Adiponectin gene expression by histone deacetylase inhibit\u00f6r Valproic acid. Endocrinology 147:865\u2013874","journal-title":"Endocrinology"},{"key":"1552_CR31","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1007\/s00228-018-2517-2","volume":"74","author":"KP Grootens","year":"2018","unstructured":"Grootens KP, Meijer A, Hartong EG, Doornbos B, Bakker PR, Al Hadithy A, Hoogerheide KN, Overmeire F, Marijnissen RM, Ruhe HG (2018) Weight changes associated with antiepileptic mood stabilizers in the treatment of bipolar disorder. Eur J Clin Pharmacol 74:1485\u20131489","journal-title":"Eur J Clin Pharmacol"},{"key":"1552_CR32","first-page":"82","volume":"44","author":"H Caksen","year":"2003","unstructured":"Caksen H, Deda G, Berbero\u011flu M, I\u00e7a\u011fasio\u011flu D, Turan EB (2003) Serum leptin levels in children receiving long-term carbamazepine. Acta Paediatr Taiwan 44:82\u201383","journal-title":"Acta Paediatr Taiwan"},{"key":"1552_CR33","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/372425a0","volume":"372","author":"Y Zhang","year":"1994","unstructured":"Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425\u2013432","journal-title":"Nature"},{"key":"1552_CR34","first-page":"230","volume":"53","author":"A Verrotti","year":"1999","unstructured":"Verrotti A, Basciani F, Morresi S, de Martino M, Morgese G, Chiarelli F (1999) Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid. Am Acad Neurol 53:230\u2013232","journal-title":"Am Acad Neurol"},{"key":"1552_CR35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ejpn.2008.05.005","volume":"13","author":"SA Hamed","year":"2009","unstructured":"Hamed SA, Fida NM, Hamed EA (2009) States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. Eur J Paediatr Neurol 13:261\u2013268","journal-title":"Eur J Paediatr Neurol"},{"key":"1552_CR36","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1528-1157.1986.tb03584.x","volume":"27","author":"LC Laub","year":"1986","unstructured":"Laub LC, Paetzke-Brunner I, Jaeger G (1986) Serum carnitine during valproic acit therapy. Epilepsia 27:559\u2013552","journal-title":"Epilepsia"},{"key":"1552_CR37","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/j.1528-1157.1990.tb05387.x","volume":"31","author":"E Beghi","year":"1990","unstructured":"Beghi E, Bizzi A, Codegoni AM, Trevisan D, Torri W (1990) Valproate, carnitine metabolism and biochemical indicators of liver function. Epilepsia 31:346\u2013352","journal-title":"Epilepsia"},{"key":"1552_CR38","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1177\/08830738030180080201","volume":"18","author":"S Kurul","year":"2003","unstructured":"Kurul S, Dirik E, IIscan A (2003) Serum carnitine levels during oxcarbazepine and carbamazepine monotherapies in children with epilepsy. J Child Neurol 18:552\u2013554","journal-title":"J Child Neurol"},{"key":"1552_CR39","first-page":"999","volume":"145","author":"G Opala","year":"1991","unstructured":"Opala G, Winter S, Vance C, Vance H, Hutchison HT, Linn LS (1991) The effect of valproic acid on plasma carnitine levels. Am J Dis Child 145:999\u20131001","journal-title":"Am J Dis Child"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-020-01552-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-020-01552-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-020-01552-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T16:37:21Z","timestamp":1636735041000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13760-020-01552-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,26]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1552"],"URL":"https:\/\/doi.org\/10.1007\/s13760-020-01552-7","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,26]]},"assertion":[{"value":"19 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work. We declare that we have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The approval for the study was obtained from the Atat\u00fcrk university local ethics committee (1\/10\/12.03.2012).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}