{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:28:56Z","timestamp":1740166136716,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s13760-021-01795-y","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T03:30:28Z","timestamp":1631071828000},"page":"1401-1406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroprotective strategies of cerebrolysin for the treatment of infants with neonatal hypoxic\u2013ischemic encephalopathy"],"prefix":"10.1007","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-4633","authenticated-orcid":false,"given":"Brian","family":"Fiani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Chacon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Jarrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Barthelmass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Covarrubias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"issue":"1","key":"1795_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5409\/wjcp.v5.i1.67","volume":"5","author":"CE Ahearne","year":"2016","unstructured":"Ahearne CE, Boylan GB, Murray DM (2016) Short and long term prognosis in perinatal asphyxia: an update. World J Clin Pediatr 5(1):67\u201374. https:\/\/doi.org\/10.5409\/wjcp.v5.i1.67","journal-title":"World J Clin Pediatr"},{"key":"1795_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.freeradbiomed.2019.02.025","volume":"142","author":"M Albrecht","year":"2019","unstructured":"Albrecht M, Zitta K, Groenendaal F, van Bel F, Peeters-Scholte C (2019) Neuroprotective strategies following perinatal hypoxia-ischemia: taking aim at NOS. Free Radic Biol Med 142:123\u2013131. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.02.025","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"1795_CR3","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1053\/j.semperi.2010.09.011","volume":"34","author":"JE Lawn","year":"2010","unstructured":"Lawn JE, Kerber K, Enweronu-Laryea C, Cousens S (2010) 36 Million neonatal deaths\u2014what is progressing and what is not? Semin Perinatol 34(6):371\u2013386. https:\/\/doi.org\/10.1053\/j.semperi.2010.09.011","journal-title":"Semin Perinatol"},{"issue":"4","key":"1795_CR4","doi-asserted-by":"publisher","first-page":"e668","DOI":"10.1542\/peds.2008-2579","volume":"123","author":"S Dzakpasu","year":"2009","unstructured":"Dzakpasu S, Joseph KS, Huang L, Allen A, Sauve R, Young D, Fetal, Infant Health Study Group of the Canadian Perinatal Surveillance S (2009) Decreasing diagnoses of birth asphyxia in Canada: fact or artifact. Pediatrics 123(4):e668-672. https:\/\/doi.org\/10.1542\/peds.2008-2579","journal-title":"Pediatrics"},{"issue":"3","key":"1795_CR5","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.clp.2016.04.002","volume":"43","author":"MA Rainaldi","year":"2016","unstructured":"Rainaldi MA, Perlman JM (2016) Pathophysiology of birth asphyxia. Clin Perinatol 43(3):409\u2013422. https:\/\/doi.org\/10.1016\/j.clp.2016.04.002","journal-title":"Clin Perinatol"},{"key":"1795_CR6","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pneurobio.2017.10.006","volume":"159","author":"B Li","year":"2017","unstructured":"Li B, Concepcion K, Meng X, Zhang L (2017) Brain-immune interactions in perinatal hypoxic\u2013ischemic brain injury. Prog Neurobiol 159:50\u201368. https:\/\/doi.org\/10.1016\/j.pneurobio.2017.10.006","journal-title":"Prog Neurobiol"},{"issue":"1\u20132","key":"1795_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0940-2993(97)80053-X","volume":"49","author":"M Schwab","year":"1997","unstructured":"Schwab M, Schaller R, Bauer R, Zwiener U (1997) Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats\u2013protective effects of Cerebrolysin. Exp Toxicol Pathol 49(1\u20132):29\u201337. https:\/\/doi.org\/10.1016\/S0940-2993(97)80053-X","journal-title":"Exp Toxicol Pathol"},{"issue":"4","key":"1795_CR8","doi-asserted-by":"publisher","first-page":"7000","DOI":"10.3390\/molecules20047000","volume":"20","author":"C Fattuoni","year":"2015","unstructured":"Fattuoni C, Palmas F, Noto A, Fanos V, Barberini L (2015) Perinatal asphyxia: a review from a metabolomics perspective. Molecules 20(4):7000\u20137016. https:\/\/doi.org\/10.3390\/molecules20047000","journal-title":"Molecules"},{"issue":"11","key":"1795_CR9","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1111\/j.1460-9568.2006.05189.x","volume":"24","author":"GD Hilton","year":"2006","unstructured":"Hilton GD, Nunez JL, Bambrick L, Thompson SM, McCarthy MM (2006) Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiol. Eur J Neurosci 24(11):3008\u20133016. https:\/\/doi.org\/10.1111\/j.1460-9568.2006.05189.x","journal-title":"Eur J Neurosci"},{"key":"1795_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/542976","volume":"2012","author":"VS Ten","year":"2012","unstructured":"Ten VS, Starkov A (2012) Hypoxic\u2013ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria. Neurol Res Int 2012:542976. https:\/\/doi.org\/10.1155\/2012\/542976","journal-title":"Neurol Res Int"},{"issue":"1","key":"1795_CR11","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/0271678X17726502","volume":"39","author":"NM Denihan","year":"2019","unstructured":"Denihan NM, Kirwan JA, Walsh BH, Dunn WB, Broadhurst DI, Boylan GB, Murray DM (2019) Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic\u2013ischaemic encephalopathy. J Cereb Blood Flow Metab 39(1):147\u2013162. https:\/\/doi.org\/10.1177\/0271678X17726502","journal-title":"J Cereb Blood Flow Metab"},{"issue":"7","key":"1795_CR12","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00702-005-0384-3","volume":"113","author":"E Schauer","year":"2006","unstructured":"Schauer E, Wronski R, Patockova J, Moessler H, Doppler E, Hutter-Paier B, Windisch M (2006) Neuroprotection of cerebrolysin in tissue culture models of brain ischemia: post lesion application indicates a wide therapeutic window. J Neural Transm (Vienna) 113(7):855\u2013868. https:\/\/doi.org\/10.1007\/s00702-005-0384-3","journal-title":"J Neural Transm (Vienna)"},{"issue":"1","key":"1795_CR13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3988\/jcn.2016.12.1.79","volume":"12","author":"SM Hassanein","year":"2016","unstructured":"Hassanein SM, Deifalla SM, El-Houssinie M, Mokbel SA (2016) Safety and efficacy of cerebrolysin in infants with communication defects due to severe perinatal brain insult: a randomized controlled clinical trial. J Clin Neurol 12(1):79\u201384. https:\/\/doi.org\/10.3988\/jcn.2016.12.1.79","journal-title":"J Clin Neurol"},{"key":"1795_CR14","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-200659","author":"A Samir","year":"2021","unstructured":"Samir A, Nasef N, Fathy K, El-Gilany AH, Yahia S (2021) Effect of cerebrolysin on neurodevelopmental outcome of high risk preterm infants: a randomized controlled trial. J Neonatal Perinat Med. https:\/\/doi.org\/10.3233\/NPM-200659","journal-title":"J Neonatal Perinat Med"},{"key":"1795_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11060545","author":"WH Chang","year":"2021","unstructured":"Chang WH, Lee J, Shin YI, Ko MH, Kim DY, Sohn MK, Kim J, Kim YH (2021) Cerebrolysin combined with rehabilitation enhances motor recovery and prevents neural network degeneration in ischemic stroke patients with severe motor deficits. J Pers Med. https:\/\/doi.org\/10.3390\/jpm11060545","journal-title":"J Pers Med"},{"issue":"15","key":"1795_CR16","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1002\/jnr.22495","volume":"88","author":"C Zhang","year":"2010","unstructured":"Zhang C, Chopp M, Cui Y, Wang L, Zhang R, Zhang L, Lu M, Szalad A, Doppler E, Hitzl M, Zhang ZG (2010) Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke. J Neurosci Res 88(15):3275\u20133281. https:\/\/doi.org\/10.1002\/jnr.22495","journal-title":"J Neurosci Res"},{"key":"1795_CR17","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fneur.2015.00198","volume":"6","author":"JO Davidson","year":"2015","unstructured":"Davidson JO, Wassink G, van den Heuij LG, Bennet L, Gunn AJ (2015) Therapeutic hypothermia for neonatal hypoxic\u2013ischemic encephalopathy\u2014where to from here? Front Neurol 6:198. https:\/\/doi.org\/10.3389\/fneur.2015.00198","journal-title":"Front Neurol"},{"issue":"2","key":"1795_CR18","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s13760-016-0743-x","volume":"117","author":"J Nasiri","year":"2017","unstructured":"Nasiri J, Safavifar F (2017) Effect of cerebrolysin on gross motor function of children with cerebral palsy: a clinical trial. Acta Neurol Belg 117(2):501\u2013505. https:\/\/doi.org\/10.1007\/s13760-016-0743-x","journal-title":"Acta Neurol Belg"},{"key":"1795_CR19","volume-title":"Cerebral palsy","author":"JL Hallman-Cooper","year":"2021","unstructured":"Hallman-Cooper JL, Rocha Cabrero F (2021) Cerebral palsy. StatPearls, Treasure Island (FL)"},{"key":"1795_CR20","unstructured":"FREQUENTLY ASKED QUESTIONS CEREBROLYSIN\u00ae. (2021). Cerebrolysin. https:\/\/www.cerebrolysin.com\/en\/cerebrolysin\/faqs\/#:~:text=The%20side%20effects%20of%20Cerebrolysin,headache%2C%20sweating%2C%20and%20nausea. Accessed 9 Aug 2021"},{"key":"1795_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008900.pub3","author":"S Cui","year":"2019","unstructured":"Cui S, Chen N, Yang M, Guo J, Zhou M, Zhu C, He L (2019) Cerebrolysin for vascular dementia. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD008900.pub3","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-021-01795-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-021-01795-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-021-01795-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T16:37:15Z","timestamp":1636735035000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13760-021-01795-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1795"],"URL":"https:\/\/doi.org\/10.1007\/s13760-021-01795-y","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"type":"print","value":"0300-9009"},{"type":"electronic","value":"2240-2993"}],"subject":[],"published":{"date-parts":[[2021,9,8]]},"assertion":[{"value":"11 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}