{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:10:53Z","timestamp":1789416653963,"version":"build-2803163510"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s13760-021-01864-2","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T22:02:28Z","timestamp":1641420148000},"page":"823-825","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Herpes simplex encephalitis in the context of immune checkpoint inhibitors: a complex interplay"],"prefix":"10.1007","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5999-9889","authenticated-orcid":false,"given":"Sof\u00eda","family":"Lallana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5624-638X","authenticated-orcid":false,"given":"Daniel","family":"S\u00e1nchez-Tejerina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-4767","authenticated-orcid":false,"given":"Cristina","family":"Auger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-8412","authenticated-orcid":false,"given":"Ana","family":"Callejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-7627","authenticated-orcid":false,"given":"Jordi","family":"Rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-0721","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Cobo-Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"1864_CR1","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1001\/jamaoncol.2018.3923","volume":"4","author":"DY Wang","year":"2018","unstructured":"Wang DY, Salem JE, Cohen JV et al (2018) Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis. JAMA Oncol 4:1721\u20131728. https:\/\/doi.org\/10.1001\/jamaoncol.2018.3923","journal-title":"JAMA Oncol"},{"key":"1864_CR2","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1093\/cid\/civ051","volume":"60","author":"FC Chow","year":"2015","unstructured":"Chow FC, Glaser CA, Sheriff H et al (2015) Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics. Clin Infect Dis 60:1377\u20131383. https:\/\/doi.org\/10.1093\/cid\/civ051","journal-title":"Clin Infect Dis"},{"key":"1864_CR3","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1007\/s00415-010-5600-x","volume":"257","author":"D Livorsi","year":"2010","unstructured":"Livorsi D, Anderson E, Qureshi S et al (2010) Brainstem encephalitis: an unusual presentation of herpes simplex virus infection. J Neurol 257:1432\u20131437. https:\/\/doi.org\/10.1007\/s00415-010-5600-x","journal-title":"J Neurol"},{"key":"1864_CR4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jns.2012.11.002","volume":"325","author":"AG Shaikh","year":"2013","unstructured":"Shaikh AG, Termsarasab P, Riley DE, Katirji B (2013) The floccular syndrome in herpes simplex type 1 encephalitis. J Neurol Sci 325:154\u2013155. https:\/\/doi.org\/10.1016\/j.jns.2012.11.002","journal-title":"J Neurol Sci"},{"key":"1864_CR5","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1016\/j.cmi.2018.01.030","volume":"24","author":"G Redelman-Sidi","year":"2018","unstructured":"Redelman-Sidi G, Michielin O, Cervera C et al (2018) ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (immune checkpoint inhibitors, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors). Clin Microbiol Infect 24:S95\u2013S107. https:\/\/doi.org\/10.1016\/j.cmi.2018.01.030","journal-title":"Clin Microbiol Infect"},{"key":"1864_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/microorganisms9040778","volume":"9","author":"T Murata","year":"2021","unstructured":"Murata T (2021) Human herpesvirus and the immune checkpoint pd-1\/pd-l1 pathway: disorders and strategies for survival. Microorganisms 9:1\u20138. https:\/\/doi.org\/10.3390\/microorganisms9040778","journal-title":"Microorganisms"},{"key":"1864_CR7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.cmi.2017.12.003","volume":"24","author":"H Picchi","year":"2018","unstructured":"Picchi H, Mateus C, Chouaid C et al (2018) Infectious complications associated with the use of immune checkpoint inhibitors in oncology: reactivation of tuberculosis after anti PD-1 treatment. Clin Microbiol Infect 24:216\u2013218","journal-title":"Clin Microbiol Infect"},{"key":"1864_CR8","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/s41591-019-0523-2","volume":"25","author":"DB Johnson","year":"2019","unstructured":"Johnson DB, McDonnell WJ, Gonzalez-Ericsson PI et al (2019) A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis. Nat Med 25:1243\u20131250. https:\/\/doi.org\/10.1038\/s41591-019-0523-2","journal-title":"Nat Med"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-021-01864-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-021-01864-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-021-01864-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T21:37:09Z","timestamp":1654551429000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13760-021-01864-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1864"],"URL":"https:\/\/doi.org\/10.1007\/s13760-021-01864-2","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"15 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Cobo-Calvo has received grant from Instituto de Salud Carlos III, Spain; JR19\/00007. Lallana, S\u00e1nchez-Tejerina, Auger, Callejo and Rio have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"We confirm that we have read the journal\u2019s position on issues concerning ethical publication and that this report is consistent with these guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent for publication of their clinical details and\/or clinical images was obtained from the patient. A copy of the consent form is available for review.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}