{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:42:14Z","timestamp":1793396534333,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To investigate the effect of Pilates exercises on balance and gross motor coordination in children with Down syndrome (DS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty children with DS, aged 8 up to 10\u00a0years, were randomly divided into two groups; experimental and control groups. A designed physical therapy program was applied for both groups, while the experimental group received an additional Pilates exercise program. Balance and gross motor coordination as primary outcomes and quality of life (QoL) as secondary outcome were assessed using Biodex balance system (BBS), Bruininks Oseretsky of Motor Proficiency (BOT-2), and Pediatric quality of life inventory (PedsQL\u2122) sequentially.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Both experimental (Pilates) and control groups demonstrated significant improvements in dynamic balance, gross motor coordination, and QoL after interventions. However, comparison between groups showed significant improvement in favor of the Pilates group in all measured outcomes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Adding Pilates exercises to the designed physical therapy program could provide more significant improvements in balance, gross motor coordination, and QoL in children with DS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinical Trial gov number Identifier: NCT05928949.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s13760-024-02517-w","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T14:01:45Z","timestamp":1711980105000},"page":"1499-1505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Pilates exercises on balance and gross motor coordination in children with Down syndrome"],"prefix":"10.1007","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-5010","authenticated-orcid":false,"given":"Alaa","family":"AL-Nemr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3114-5221","authenticated-orcid":false,"given":"Shimaa","family":"Reffat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"2517_CR1","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/DMCN.14260","volume":"61","author":"AA Baburamani","year":"2019","unstructured":"Baburamani AA, Patkee PA, Arichi T, Rutherford MA (2019) New approaches to studying early brain development in Down syndrome. Dev Med Child Neurol 61:867\u2013879. https:\/\/doi.org\/10.1111\/DMCN.14260","journal-title":"Dev Med Child Neurol"},{"key":"2517_CR2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.5281\/zenodo","volume":"9","author":"AS Lengkana","year":"2019","unstructured":"Lengkana AS, Tangkudung J, Asmawi A (2019) The effect of core stability exercise (CSE) on balance in primary school students. J EducHealth Sport 9:160\u2013167. https:\/\/doi.org\/10.5281\/zenodo","journal-title":"J EducHealth Sport"},{"key":"2517_CR3","doi-asserted-by":"publisher","first-page":"897","DOI":"10.24953\/TURKJPED.2020.06.001","volume":"62","author":"SK Jafri","year":"2020","unstructured":"Jafri SK, Harman KE (2020) Neurocognitive abilities in individuals with Down syndrome-a narrative review. Turk J Pediatr 62:897\u2013905. https:\/\/doi.org\/10.24953\/TURKJPED.2020.06.001","journal-title":"Turk J Pediatr"},{"key":"2517_CR4","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1093\/PTJ\/PZZ012","volume":"99","author":"C Ma\u00efano","year":"2019","unstructured":"Ma\u00efano C, Hue O, Lepage G, Morin AJS, Tracey D, Moullec G (2019) Do exercise interventions improve balance for children and adolescents with Down syndrome? a systematic review. Phys Ther 99:507\u2013518. https:\/\/doi.org\/10.1093\/PTJ\/PZZ012","journal-title":"Phys Ther"},{"key":"2517_CR5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/J.CTIM.2012.02.005","volume":"20","author":"C Wells","year":"2012","unstructured":"Wells C, Kolt GS, Bialocerkowski A (2012) Defining Pilates exercise: a systematic review. Complement Ther Med 20:253\u2013262. https:\/\/doi.org\/10.1016\/J.CTIM.2012.02.005","journal-title":"Complement Ther Med"},{"key":"2517_CR6","doi-asserted-by":"publisher","first-page":"221","DOI":"10.36347\/sjams.2014.v02i01.0047","volume":"2","author":"L Surbala","year":"2014","unstructured":"Surbala L, Khuman P, Trivedi PB, Devanshi B, Mital V (2014) Pilates versus conventional balance training on functional balance and quality of life in elderly individuals\u202f: a randomized controlled study. Sch J App Med 2:221\u2013226. https:\/\/doi.org\/10.36347\/sjams.2014.v02i01.0047","journal-title":"Sch J App Med"},{"key":"2517_CR7","doi-asserted-by":"publisher","first-page":"161","DOI":"10.12965\/JER.150203","volume":"11","author":"JH Moon","year":"2015","unstructured":"Moon JH, Hong SM, Kim CW, Shin YA (2015) Comparison of deep and superficial abdominal muscle activity between experienced Pilates and resistance exercise instructors and controls during stabilization exercise. J Exerc Rehabil 11:161\u2013168. https:\/\/doi.org\/10.12965\/JER.150203","journal-title":"J Exerc Rehabil"},{"key":"2517_CR8","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3109\/17518423.2014.947040","volume":"19","author":"AN Dos Santos","year":"2016","unstructured":"Dos Santos AN, Serikawa SS, Rocha NACF (2016) Pilates improves lower limbs strength and postural control during quite standing in a child with hemiparetic cerebral palsy: a case report study. Dev Neurorehabil 19:226\u2013230. https:\/\/doi.org\/10.3109\/17518423.2014.947040","journal-title":"Dev Neurorehabil"},{"key":"2517_CR9","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1007\/S13760-021-01845-5\/METRICS","volume":"122","author":"H Ad\u0131guzel","year":"2022","unstructured":"Ad\u0131guzel H, Elbasan B (2022) Effects of modified Pilates on trunk, postural control, gait and balance in children with cerebral palsy: a single-blinded randomized controlled study. Acta Neurol Belg 122:903\u2013914. https:\/\/doi.org\/10.1007\/S13760-021-01845-5\/METRICS","journal-title":"Acta Neurol Belg"},{"key":"2517_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.5535\/ARM.21148","volume":"46","author":"HM Abd-Elfattah","year":"2022","unstructured":"Abd-Elfattah HM, Galal DOSM, Aly MIE, Aly SM, Elnegamy TE (2022) Effect of Pilates exercises on standing, walking, and balance in children with diplegic cerebral palsy. Ann Rehabil Med 46:45. https:\/\/doi.org\/10.5535\/ARM.21148","journal-title":"Ann Rehabil Med"},{"key":"2517_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/J.RCREU.2020.06.015","volume":"27","author":"BB Cal\u0131k","year":"2020","unstructured":"Cal\u0131k BB, Kabul EG, Korkmaz C, Tekin ZE, Yener GO, Yuksel S (2020) The efficacy of clinical Pilates exercises in children and adolescents with juvenile idiopathic arthritis: a pilot study. Revista Colombiana de Reumatolog\u00eda 27:269\u2013277. https:\/\/doi.org\/10.1016\/J.RCREU.2020.06.015","journal-title":"Revista Colombiana de Reumatolog\u00eda"},{"key":"2517_CR12","first-page":"204","volume":"2","author":"L Surbala","year":"2013","unstructured":"Surbala L, Khuman PR, Gopal Nambi S, Kalpesh S (2013) Pilates in functional balance and quality of life in subacute stroke subjects-a randomized controlled study. Int J Health Rehab Sci 2:204\u2013211","journal-title":"Int J Health Rehab Sci"},{"key":"2517_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/HSR2.98","volume":"1","author":"N Dawson","year":"2018","unstructured":"Dawson N, Dzurino D, Karleskint M, Tucker J (2018) Examining the reliability, correlation, and validity of commonly used assessment tools to measure balance. Health Sci Rep 1:e98. https:\/\/doi.org\/10.1002\/HSR2.98","journal-title":"Health Sci Rep"},{"key":"2517_CR14","unstructured":"Balance SystemTM SD\u2013Balance\u2013Physical Medicine\/Biodex. https:\/\/www.biodex.com\/physical-medicine\/products\/balance\/balance-system-sd. Accessed 27 Jul 2023"},{"key":"2517_CR15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1207\/S15327841MPEE0502_3","volume":"5","author":"WJC Cachupe","year":"2009","unstructured":"Cachupe WJC, Shifflett B, Kahanov L, Wughalter EH (2009) Reliability of biodex balance system measures. Meas Phys Educ Exerc Sci 5:97\u2013108. https:\/\/doi.org\/10.1207\/S15327841MPEE0502_3","journal-title":"Meas Phys Educ Exerc Sci"},{"key":"2517_CR16","unstructured":"Bruininks-Oseretsky Test of Motor Proficiency, Second Edition\/RehabMeasures Database. https:\/\/www.sralab.org\/rehabilitation-measures\/bruininks-oseretsky-test-motor-proficiency-second-edition. Accessed 4 Jul 2023"},{"key":"2517_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3389\/FPED.2019.00153\/BIBTEX","volume":"7","author":"J J\u00edrovec","year":"2019","unstructured":"J\u00edrovec J, Mus\u00e1lek M, Mess F (2019) Test of Motor Proficiency second edition (BOT-2): compatibility of the complete and short form and its usefulness for middle-age school children. Front Pediatr 7:153. https:\/\/doi.org\/10.3389\/FPED.2019.00153\/BIBTEX","journal-title":"Front Pediatr"},{"key":"2517_CR18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/J006V27N04_06","volume":"27","author":"JC Deitz","year":"2007","unstructured":"Deitz JC, Kartin D, Kopp K (2007) Review of the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Phys Occup Ther Pediatr 27:87\u2013102. https:\/\/doi.org\/10.1080\/J006V27N04_06","journal-title":"Phys Occup Ther Pediatr"},{"key":"2517_CR19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1352\/1944-7558-120.4.289","volume":"120","author":"MA Viecili","year":"2015","unstructured":"Viecili MA, Weiss JA (2015) Reliability and validity of the pediatric quality of life inventory with individuals with intellectual and developmental disabilities. Am J Intellect Dev Disabil 120:289\u2013301. https:\/\/doi.org\/10.1352\/1944-7558-120.4.289","journal-title":"Am J Intellect Dev Disabil"},{"key":"2517_CR20","unstructured":"PedsQL TM (Pediatric Quality of Life Inventory TM). https:\/\/www.pedsql.org\/about_pedsql.html. Accessed 4 Jul 2023"},{"key":"2517_CR21","doi-asserted-by":"publisher","first-page":"YC05","DOI":"10.7860\/JCDR\/2017\/28388.10649","volume":"11","author":"S Panibatla","year":"2017","unstructured":"Panibatla S, Kumar V, Narayan A (2017) Relationship between trunk control and balance in children with spastic cerebral palsy: a cross-sectional study. J Clin Diagn Res 11:YC05\u2013YC08. https:\/\/doi.org\/10.7860\/JCDR\/2017\/28388.10649","journal-title":"J Clin Diagn Res"},{"key":"2517_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12887-019-1791-1\/FIGURES\/2","volume":"19","author":"TW Pin","year":"2019","unstructured":"Pin TW, Butler PB, Cheung HM, Shum SL (2019) Relationship between segmental trunk control and gross motor development in typically developing infants aged from 4 to 12 months: a pilot study. BMC Pediatr 19:1\u20139. https:\/\/doi.org\/10.1186\/S12887-019-1791-1\/FIGURES\/2","journal-title":"BMC Pediatr"},{"key":"2517_CR23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.braindev.2021.09.005","volume":"44","author":"PD Jain","year":"2022","unstructured":"Jain PD, Nayak A, Karnad SD (2022) Relationship between trunk muscle strength, reaching ability and balance in children with Down syndrome\u2013A cross-sectional study. Brain Dev 44:95\u2013104. https:\/\/doi.org\/10.1016\/j.braindev.2021.09.005","journal-title":"Brain Dev"},{"key":"2517_CR24","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1007\/S11845-021-02840-8\/TABLES\/2","volume":"191","author":"S Suner-Keklik","year":"2022","unstructured":"Suner-Keklik S, Numanoglu-Akbas A, Cobanoglu G, Kafa N, Guzel NA (2022) An online Pilates exercise program is effective on proprioception and core muscle endurance in a randomized controlled trial. Ir J Med Sci 191:2133\u20132139. https:\/\/doi.org\/10.1007\/S11845-021-02840-8\/TABLES\/2","journal-title":"Ir J Med Sci"},{"key":"2517_CR25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/CCH.12815","volume":"47","author":"A Lee","year":"2021","unstructured":"Lee A, Knafl G, Knafl K, Van Riper M (2021) Quality of life in individuals with Down syndrome aged 4 to 21 years. Child Care Health Dev 47:85\u201393. https:\/\/doi.org\/10.1111\/CCH.12815","journal-title":"Child Care Health Dev"},{"key":"2517_CR26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5281\/zenodo","volume":"34","author":"KM Krishnaprasad","year":"2022","unstructured":"Krishnaprasad KM, Narayan A, Kumar KV (2022) Association between postural stability and functional abilities in children with spastic cerebral palsy. Crit Rev TM Phys Rehabil Med 34:67\u201375. https:\/\/doi.org\/10.5281\/zenodo","journal-title":"Crit Rev TM Phys Rehabil Med"},{"key":"2517_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.23736\/S0022-4707.20.10730-8","volume":"61","author":"A Ravari","year":"2020","unstructured":"Ravari A, Mirzaei T, Bahremand R, Raeisi M, Kamiab Z (2020) The effect of Pilates exercise on the happiness and depression of elderly women: a clinical trial study. J Sports Med Phys Fitness 61:131\u2013139. https:\/\/doi.org\/10.23736\/S0022-4707.20.10730-8","journal-title":"J Sports Med Phys Fitness"},{"key":"2517_CR28","doi-asserted-by":"publisher","first-page":"7793","DOI":"10.3390\/IJERPH19137793","volume":"19","author":"AR Azab","year":"2022","unstructured":"Azab AR, Kamel FH, Basha MA, Alrawaili SM, Aloraini GS, Hassan SM, Ewais NF, Elnaggar RK (2022) Impact of clinical Pilates exercise on pain, cardiorespiratory fitness, functional ability, and quality of life in children with polyarticular juvenile idiopathic arthritis. Int J Environ Res Public Health 19:7793. https:\/\/doi.org\/10.3390\/IJERPH19137793","journal-title":"Int J Environ Res Public Health"},{"key":"2517_CR29","doi-asserted-by":"publisher","first-page":"e920449","DOI":"10.12659\/MSMBR.920449","volume":"26","author":"S Rrecaj-Malaj","year":"2020","unstructured":"Rrecaj-Malaj S, Beqaj S, Krasniqi V, Qorolli M, Tufekcievski A (2020) Outcome of 24 weeks of combined schroth and pilates exercises on cobb angle, angle of trunk rotation, chest expansion, flexibility and quality of life in adolescents with idiopathic scoliosis. Med Sci Monit Basic Res 26:e920449. https:\/\/doi.org\/10.12659\/MSMBR.920449","journal-title":"Med Sci Monit Basic Res"},{"key":"2517_CR30","doi-asserted-by":"publisher","first-page":"E27254","DOI":"10.1097\/MD.0000000000027254","volume":"100","author":"Y Gou","year":"2021","unstructured":"Gou Y, Lei H, Zeng Y, Tao J, Kong W, Wu J (2021) The effect of Pilates exercise training for scoliosis on improving spinal deformity and quality of life: meta-analysis of randomized controlled trials. Medicine 100:E27254. https:\/\/doi.org\/10.1097\/MD.0000000000027254","journal-title":"Medicine"},{"key":"2517_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/FPSYT.2020.503274\/BIBTEX","volume":"11","author":"SM Mart\u00ednez-S\u00e1nchez","year":"2020","unstructured":"Mart\u00ednez-S\u00e1nchez SM, Mart\u00ednez-Garc\u00eda C, Mart\u00ednez-Garc\u00eda TE, Mungu\u00eda-Izquierdo D (2020) Psychopathology, body image and quality of life in female children and adolescents with anorexia nervosa: a pilot study on the acceptability of a Pilates program. Front Psychiatry 11:503274. https:\/\/doi.org\/10.3389\/FPSYT.2020.503274\/BIBTEX","journal-title":"Front Psychiatry"},{"key":"2517_CR32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/J.CTCP.2018.10.017","volume":"34","author":"Z Rahimimoghadam","year":"2019","unstructured":"Rahimimoghadam Z, Rahemi Z, Sadat Z, Ajorpaz NM (2019) Pilates exercises and quality of life of patients with chronic kidney disease. Complement Ther Clin Pract 34:35\u201340. https:\/\/doi.org\/10.1016\/J.CTCP.2018.10.017","journal-title":"Complement Ther Clin Pract"},{"key":"2517_CR33","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/J.EXPLORE.2019.07.010","volume":"16","author":"Z Abas\u0131yan\u0131k","year":"2020","unstructured":"Abas\u0131yan\u0131k Z, Ertekin \u00d6, Kahraman T, Yigit P, \u00d6zakba\u015f S (2020) The effects of Clinical Pilates training on walking, balance, fall risk, respiratory, and cognitive functions in persons with multiple sclerosis: a randomized controlled trial. EXPLORE 16:12\u201320. https:\/\/doi.org\/10.1016\/J.EXPLORE.2019.07.010","journal-title":"EXPLORE"},{"key":"2517_CR34","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/J.JBMT.2023.04.028","volume":"35","author":"FU Cibinello","year":"2023","unstructured":"Cibinello FU, De Jesus Neves JC, Valenciano PJ, Fujisawa DS, Camillo CAM (2023) Effects of Pilates in children and adolescents\u2014a systematic review and meta-analysis. J Bodyw Mov Ther 35:400\u2013412. https:\/\/doi.org\/10.1016\/J.JBMT.2023.04.028","journal-title":"J Bodyw Mov Ther"},{"key":"2517_CR35","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/J.APMR.2019.05.023","volume":"101","author":"E Hornsby","year":"2020","unstructured":"Hornsby E, Johnston LM (2020) Effect of Pilates intervention on physical function of children and youth: a systematic review. Arch Phys Med Rehabil 101:317\u2013328. https:\/\/doi.org\/10.1016\/J.APMR.2019.05.023","journal-title":"Arch Phys Med Rehabil"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-024-02517-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-024-02517-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-024-02517-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T11:04:05Z","timestamp":1733223845000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13760-024-02517-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["2517"],"URL":"https:\/\/doi.org\/10.1007\/s13760-024-02517-w","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]},"assertion":[{"value":"16 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The outpatient clinic of the Faculty of Physical Therapy, Cairo University was the place where Participants were recruited, based on the sixth revision of the Declaration of Helsinki 2008, regarding human experimentation and the study assigned ethical approval number; P.T.REC\/012\/004659 from the Ethical Research Committee of the Faculty of Physical Therapy, Cairo University. We received all parents' informed written consent before the children\u2019s enrollment in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}