{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:10:04Z","timestamp":1784596204069,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s13760-025-02741-y","type":"journal-article","created":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T23:16:21Z","timestamp":1739142981000},"page":"1165-1171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Olfactory function in Wilson\u2019s disease\u2013systematic literature review"],"prefix":"10.1007","volume":"125","author":[{"given":"Jan Pawe\u0142","family":"Bembenek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Litwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Piechal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cz\u0142onkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Antos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Przyby\u0142kowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"2741_CR1","doi-asserted-by":"publisher","unstructured":"Marin C, Vilas D, Langdon C, Alobid I, L\u00f3pez-Chac\u00f3n M, Haehner A, Hummel T, Mullol J (2018) Olfactory Dysfunction in Neurodegenerative Diseases. Curr Allergy Asthma Rep 15;18(8):42. https:\/\/doi.org\/10.1007\/s11882-018-0796-4","DOI":"10.1007\/s11882-018-0796-4"},{"issue":"6","key":"2741_CR2","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/S1474-4422(17)30123-0","volume":"16","author":"RL Doty","year":"2017","unstructured":"Doty RL (2017) Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate? Lancet Neurol 16(6):478\u2013488. https:\/\/doi.org\/10.1016\/S1474-4422(17)30123-0","journal-title":"Lancet Neurol"},{"issue":"1","key":"2741_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41582-018-0097-5","volume":"15","author":"C Murphy","year":"2019","unstructured":"Murphy C (2019) Olfactory and other sensory impairments in Alzheimer disease. Nat Rev Neurol 15(1):11\u201324. https:\/\/doi.org\/10.1038\/s41582-018-0097-5","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"2741_CR4","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1002\/acn3.594","volume":"5","author":"C Viguera","year":"2018","unstructured":"Viguera C, Wang J, Mosmiller E, Cerezo A, Maragakis NJ (2018) Olfactory dysfunction in amyotrophic lateral sclerosis. Ann Clin Transl Neurol 5(8):976\u2013981. https:\/\/doi.org\/10.1002\/acn3.594","journal-title":"Ann Clin Transl Neurol"},{"issue":"6","key":"2741_CR5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrneurol.2012.80","volume":"8","author":"RL Doty","year":"2012","unstructured":"Doty RL (2012) Olfactory dysfunction in Parkinson disease. Nat Rev Neurol 8(6):329\u2013339. https:\/\/doi.org\/10.1038\/nrneurol.2012.80","journal-title":"Nat Rev Neurol"},{"issue":"5","key":"2741_CR6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.bpg.2010.07.014","volume":"24","author":"D Huster","year":"2010","unstructured":"Huster D (2010) Wilson disease. Best Pract Res Clin Gastroenterol 24(5):531\u2013539. https:\/\/doi.org\/10.1016\/j.bpg.2010.07.014","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2741_CR7","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.jhep.2011.11.007","volume":"56","author":"European Association For The Study of The Liver Disease","year":"2012","unstructured":"European Association For The Study of The Liver Disease (2012) EASL Clinical Practice Guidelines: Wilson\u2019s Disease. J Hepatol 56:671\u2013685. https:\/\/doi.org\/10.1016\/j.jhep.2011.11.007","journal-title":"J Hepatol"},{"issue":"6","key":"2741_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001256","volume":"2","author":"J Mullol","year":"2012","unstructured":"Mullol J, Alobid I, Mari\u00f1o-S\u00e1nchez F, Quint\u00f3 L, de Haro J, Bernal-Sprekelsen M, Valero A, Picado C, Marin C (2012) Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study). BMJ Open 2(6):e001256. https:\/\/doi.org\/10.1136\/bmjopen-2012-001256","journal-title":"BMJ Open"},{"issue":"7","key":"2741_CR9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1093\/chemse\/bjx025","volume":"42","author":"S Boesveldt","year":"2017","unstructured":"Boesveldt S, Postma EM, Boak D, Welge-Luessen A, Sch\u00f6pf V, Mainland JD, Martens J, Ngai J, Duffy VB (2017) Anosmia-A Clinical Review. Chem Senses 42(7):513\u2013523. https:\/\/doi.org\/10.1093\/chemse\/bjx025","journal-title":"Chem Senses"},{"issue":"5","key":"2741_CR10","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1002\/mds.22688","volume":"25","author":"L Silveira-Moriyama","year":"2010","unstructured":"Silveira-Moriyama L, Hughes G, Church A, Ayling H, Williams DR, Petrie A, Holton J, Revesz T, Kingsbury A, Morris HR, Burn DJ, Lees AJ (2010) Hyposmia in progressive supranuclear palsy. Mov Disord 25(5):570\u2013577. https:\/\/doi.org\/10.1002\/mds.22688","journal-title":"Mov Disord"},{"issue":"3","key":"2741_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4193\/Rhin09.206","volume":"48","author":"FS Mari\u00f1o-Sanchez","year":"2010","unstructured":"Mari\u00f1o-Sanchez FS, Alobid I, Cantellas S, Alberca C, Guilemany JM, Canals JM, De Haro J, Mullol J (2010) Smell training increases cognitive smell skills of wine tasters compared to the general healthy population. The WINECAT Study Rhinology 48(3):273\u2013276. https:\/\/doi.org\/10.4193\/Rhin09.206","journal-title":"The WINECAT Study Rhinology"},{"key":"2741_CR12","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3389\/fnhum.2016.00414","volume":"10","author":"SJ Banks","year":"2016","unstructured":"Banks SJ, Sreenivasan KR, Weintraub DM, Baldock D, Noback M, Pierce ME, Frasnelli J, James J, Beall E, Zhuang X, Cordes D, Leger GC (2016) Structural and Functional MRI Differences in Master Sommeliers: A Pilot Study on Expertise in the Brain. Front Hum Neurosci 10:414. https:\/\/doi.org\/10.3389\/fnhum.2016.00414","journal-title":"Front Hum Neurosci"},{"key":"2741_CR13","doi-asserted-by":"publisher","DOI":"10.1017\/9781139192446","volume-title":"Smell and taste disorders","author":"CH Hawkes","year":"2018","unstructured":"Hawkes CH, Doty RL (2018) Smell and taste disorders. Cambridge University Press"},{"key":"2741_CR14","doi-asserted-by":"publisher","first-page":"W65","DOI":"10.1371\/journal.pmed.1000100","volume":"151","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151:W65-94. https:\/\/doi.org\/10.1371\/journal.pmed.1000100","journal-title":"Ann Intern Med"},{"key":"2741_CR15","doi-asserted-by":"publisher","unstructured":"Carvalho MJ, Machado AA, Barbosa ER (2012) Analysis of smell in Wilson\u2019s disease patients. Abstracts of the Sixteenth International Congress of Parkinson\u2019s Disease and Mov Disord 27(Suppl 1), https:\/\/doi.org\/10.1002\/mds.25051","DOI":"10.1002\/mds.25051"},{"issue":"1","key":"2741_CR16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00405-018-5216-9","volume":"276","author":"N Degirmenci","year":"2019","unstructured":"Degirmenci N, Veyseller B, Hanagasi H, Bilgic B, Gurbuz D, Toprak A, Ozturan O (2019) Olfactory function and olfactory bulb volume in Wilson\u2019s disease. Eur Arch Otorhinolaryngo 276(1):139\u2013142. https:\/\/doi.org\/10.1007\/s00405-018-5216-9","journal-title":"Eur Arch Otorhinolaryngo"},{"issue":"2","key":"2741_CR17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.5603\/PJNNS.a2023.0020","volume":"57","author":"A Piechal","year":"2023","unstructured":"Piechal A, Bembenek J, Baranowska A, Litwin T, Mirowska-Guzel D, Cz\u0142onkowska A (2023) Olfactory dysfunction in patients with Wilson\u2019s Disease. Neurol Neurochir Pol 57(2):212\u2013218. https:\/\/doi.org\/10.5603\/PJNNS.a2023.0020","journal-title":"Neurol Neurochir Pol"},{"issue":"9","key":"2741_CR18","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1002\/mds.20989","volume":"21","author":"A Mueller","year":"2006","unstructured":"Mueller A, Reuner U, Landis B, Kitzler H, Reichmann H, Hummel T (2006) Extrapyramidal symptoms in Wilson\u2019s disease are associated with olfactory dysfunction. Mov Disord 21(9):1311\u20131316. https:\/\/doi.org\/10.1002\/mds.20989","journal-title":"Mov Disord"},{"issue":"3","key":"2741_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2022","volume":"11","author":"L Chen","year":"2021","unstructured":"Chen L, Wang X, Doty RL, Cao S, Yang J, Sun F, Yan X (2021) Olfactory impairment in Wilson\u2019s disease. Brain Behav 11(3):e02022. https:\/\/doi.org\/10.1002\/brb3.2022","journal-title":"Brain Behav"},{"key":"2741_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.122949","volume":"459","author":"MK Salmon","year":"2024","unstructured":"Salmon MK, Cohen WG, Hu F, Aydin A, Coskun AK, Schilsky M, Doty RL (2024) Taste and smell function in Wilson\u2019s disease. J Neurol Sci 459:122949. https:\/\/doi.org\/10.1016\/j.jns.2024.122949","journal-title":"J Neurol Sci"},{"issue":"2","key":"2741_CR21","first-page":"131","volume":"46","author":"S Boesveldt","year":"2008","unstructured":"Boesveldt S, Verbaan D, Knol DL, van Hilten JJ, Berendse HW (2008) Odour identification and discrimination in Dutch adults over 45 years. Rhinology 46(2):131\u2013136","journal-title":"Rhinology"},{"key":"2741_CR22","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.12659\/MSM.889838","volume":"19","author":"H Tekeli","year":"2013","unstructured":"Tekeli H, Altunda\u011f A, Saliho\u011flu M, Cay\u00f6n\u00fc M, Kendirli MT (2013) The applicability of the \u201cSniffin\u2019 Sticks\u201d olfactory test in a Turkish population. Med Sci Monit 19:1221\u20131226. https:\/\/doi.org\/10.12659\/MSM.889838","journal-title":"Med Sci Monit"},{"key":"2741_CR23","doi-asserted-by":"publisher","first-page":"2272691","DOI":"10.1155\/2022\/2272691","volume":"2022","author":"F Baert","year":"2022","unstructured":"Baert F, Vlaemynck G, Maselyne J, Matthys C (2022) Odor Identification by Parkinson\u2019s Disease Patients Tested by Using Sniffin\u2019 Sticks versus Natural Spices. Parkinsons Dis 2022:2272691. https:\/\/doi.org\/10.1155\/2022\/2272691","journal-title":"Parkinsons Dis"},{"key":"2741_CR24","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.neuro.2019.07.007","volume":"74","author":"L Mezzaroba","year":"2019","unstructured":"Mezzaroba L, Alfieri DF, Colado Sim\u00e3o AN, Vissoci Reiche EM (2019) The role of zinc, copper, manganese and iron in neurodegenerative diseases. Neurotoxicology 74:230\u2013241. https:\/\/doi.org\/10.1016\/j.neuro.2019.07.007","journal-title":"Neurotoxicology"},{"issue":"4","key":"2741_CR25","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jocn.2006.07.017","volume":"15","author":"S Meenakshi-Sundaram","year":"2008","unstructured":"Meenakshi-Sundaram S, Mahadevan A, Taly AB, Arunodaya GR, Swamy HS, Shankar SK (2008) Wilson\u2019s disease: a clinico-neuropathological autopsy study. J Clin Neurosci 15(4):409\u2013417. https:\/\/doi.org\/10.1016\/j.jocn.2006.07.017","journal-title":"J Clin Neurosci"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-025-02741-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-025-02741-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-025-02741-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T10:43:01Z","timestamp":1760352181000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13760-025-02741-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["2741"],"URL":"https:\/\/doi.org\/10.1007\/s13760-025-02741-y","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"assertion":[{"value":"29 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This manuscript has been approved for publication by all authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors. As this is systematic review of the literature it does not require approval of ethical committee.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}]}}