{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:57:57Z","timestamp":1792821477319,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["22010901121"],"award-info":[{"award-number":["22010901121"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s13760-025-02759-2","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T23:11:33Z","timestamp":1741648293000},"page":"691-698","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer\u2019s diseases"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-7172","authenticated-orcid":false,"given":"Rizwan","family":"Qaisar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asima","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Shahid","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaea A.","family":"Alkahtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdos","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"2759_CR1","doi-asserted-by":"crossref","unstructured":"Karim, A., T. Muhammad, and R. Qaisar (2021) Prediction of Sarcopenia Using Multiple Biomarkers of Neuromuscular Junction Degeneration in Chronic Obstructive Pulmonary Disease. J Pers Med\u00a011(9)","DOI":"10.3390\/jpm11090919"},{"key":"2759_CR2","doi-asserted-by":"crossref","unstructured":"Qaisar R, Karim A and Muhammad T (2020) Plasma CAF22 Levels as a Useful Predictor of Muscle Health in Patients with Chronic Obstructive Pulmonary Disease. Biology (Basel), 9(7)","DOI":"10.3390\/biology9070166"},{"key":"2759_CR3","doi-asserted-by":"crossref","unstructured":"Qaisar R et al (2020) Circulating Biomarkers of Accelerated Sarcopenia in Respiratory Diseases. Biology (Basel),9(10)","DOI":"10.3390\/biology9100322"},{"key":"2759_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2022.104721","volume":"102","author":"A Karim","year":"2022","unstructured":"Karim A et al (2022) A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlled trial. Arch Gerontol Geriatr 102:104721","journal-title":"Arch Gerontol Geriatr"},{"key":"2759_CR5","doi-asserted-by":"crossref","unstructured":"Karim A et al (2022) A multistrain probiotic reduces sarcopenia by modulating Wnt signaling biomarkers in patients with chronic heart failure. J Cardiol","DOI":"10.1016\/j.jjcc.2022.06.006"},{"issue":"1","key":"2759_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s12877-021-02147-4","volume":"21","author":"SY Lee","year":"2021","unstructured":"Lee SY et al (2021) SPPB reference values and performance in assessing sarcopenia in community-dwelling Singaporeans - Yishun study. BMC Geriatr 21(1):213","journal-title":"BMC Geriatr"},{"issue":"10","key":"2759_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13225","volume":"19","author":"S Bhaskaran","year":"2020","unstructured":"Bhaskaran S et al (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19(10):e13225","journal-title":"Aging Cell"},{"issue":"2","key":"2759_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.11005\/jbm.2017.24.2.83","volume":"24","author":"YN Kwon","year":"2017","unstructured":"Kwon YN, Yoon SS (2017) Sarcopenia: Neurological Point of View. J Bone Metab 24(2):83\u201389","journal-title":"J Bone Metab"},{"issue":"4","key":"2759_CR9","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/s12031-022-01970-7","volume":"72","author":"A Karim","year":"2022","unstructured":"Karim A et al (2022) Evaluation of Sarcopenia Using Biomarkers of the Neuromuscular Junction in Parkinson\u2019s Disease. J Mol Neurosci 72(4):820\u2013829","journal-title":"J Mol Neurosci"},{"key":"2759_CR10","doi-asserted-by":"crossref","unstructured":"Karim A et al (2022) Elevated plasma zonulin and CAF22 are correlated with sarcopenia and functional dependency at various stages of Alzheimer's diseases. Neurosci Res","DOI":"10.1016\/j.neures.2022.08.004"},{"issue":"4\u20136","key":"2759_CR11","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1159\/000500718","volume":"47","author":"Y Moon","year":"2019","unstructured":"Moon Y et al (2019) Muscle Strength Is Independently Related to Brain Atrophy in Patients with Alzheimer\u2019s Disease. Dement Geriatr Cogn Disord 47(4\u20136):306\u2013314","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"8","key":"2759_CR12","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1136\/jnnp-2018-320106","volume":"90","author":"L Gaetani","year":"2019","unstructured":"Gaetani L et al (2019) Neurofilament light chain as a biomarker in neurological disorders. J Neurol Neurosurg Psychiatry 90(8):870\u2013881","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"2759_CR13","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1002\/jcsm.12979","volume":"13","author":"J Pratt","year":"2022","unstructured":"Pratt J et al (2022) Plasma neurofilament light levels associate with muscle mass and strength in middle-aged and older adults: findings from GenoFit. J Cachexia Sarcopenia Muscle 13(3):1811\u20131820","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2759_CR14","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3389\/fneur.2018.00710","volume":"9","author":"Y Ogawa","year":"2018","unstructured":"Ogawa Y et al (2018) Sarcopenia and Muscle Functions at Various Stages of Alzheimer Disease. Front Neurol 9:710","journal-title":"Front Neurol"},{"issue":"1","key":"2759_CR15","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1186\/s12877-019-1338-1","volume":"19","author":"S Sobestiansky","year":"2019","unstructured":"Sobestiansky S, Michaelsson K, Cederholm T (2019) Sarcopenia prevalence and associations with mortality and hospitalisation by various sarcopenia definitions in 85\u201389 year old community-dwelling men: a report from the ULSAM study. BMC Geriatr 19(1):318","journal-title":"BMC Geriatr"},{"issue":"4","key":"2759_CR16","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/ageing\/afz046","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(4):601","journal-title":"Age Ageing"},{"issue":"20","key":"2759_CR17","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"World Medical","year":"2013","unstructured":"World Medical, A. (2013) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191\u20134","journal-title":"JAMA"},{"key":"2759_CR18","doi-asserted-by":"crossref","unstructured":"Sbrignadello S, Gobl C, and Tura A (2022) Bioelectrical Impedance Analysis for the Assessment of Body Composition in Sarcopenia and Type 2 Diabetes. Nutrients\u00a014(9)","DOI":"10.3390\/nu14091864"},{"issue":"2","key":"2759_CR19","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s11136-023-03547-2","volume":"33","author":"R Qaisar","year":"2024","unstructured":"Qaisar R et al (2024) A leaky gut contributes to reduced sarcopenia-related quality of life (SarQoL) in geriatric older adults. Qual Life Res 33(2):551\u2013559","journal-title":"Qual Life Res"},{"issue":"5","key":"2759_CR20","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1093\/ageing\/afm105","volume":"36","author":"F Landi","year":"2007","unstructured":"Landi F et al (2007) HDL-cholesterol and physical performance: results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study). Age Ageing 36(5):514\u201320","journal-title":"Age Ageing"},{"key":"2759_CR21","doi-asserted-by":"crossref","unstructured":"Chen LK et al (2020) Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc, 21(3): p. 300\u2013307","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"2759_CR22","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.dadm.2019.08.002","volume":"11","author":"AL Benedet","year":"2019","unstructured":"Benedet AL et al (2019) Plasma neurofilament light associates with Alzheimer\u2019s disease metabolic decline in amyloid-positive individuals. Alzheimers Dement (Amst) 11:679\u2013689","journal-title":"Alzheimers Dement (Amst)"},{"key":"2759_CR23","doi-asserted-by":"crossref","unstructured":"Egle M et al (2021) Neurofilament light chain predicts future dementia risk in cerebral small vessel disease. J Neurol Neurosurg Psychiatry","DOI":"10.1136\/jnnp-2020-325681"},{"key":"2759_CR24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.redox.2015.04.005","volume":"5","author":"K Sataranatarajan","year":"2015","unstructured":"Sataranatarajan K et al (2015) Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype. Redox Biol 5:140\u2013148","journal-title":"Redox Biol"},{"key":"2759_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106662","volume":"189","author":"A Karim","year":"2021","unstructured":"Karim A et al (2021) Intestinal permeability marker zonulin as a predictor of sarcopenia in chronic obstructive pulmonary disease. Respir Med 189:106662","journal-title":"Respir Med"},{"issue":"6","key":"2759_CR26","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.hlc.2022.01.003","volume":"31","author":"A Karim","year":"2022","unstructured":"Karim A et al (2022) Relationship of Haptoglobin Phenotypes With Sarcopaenia in Patients With Congestive Heart Failure. Heart Lung Circ 31(6):822\u2013831","journal-title":"Heart Lung Circ"},{"issue":"1","key":"2759_CR27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13024-022-00523-1","volume":"17","author":"TE Golde","year":"2022","unstructured":"Golde TE (2022) Alzheimer\u2019s disease - the journey of a healthy brain into organ failure. Mol Neurodegener 17(1):18","journal-title":"Mol Neurodegener"},{"issue":"1","key":"2759_CR28","doi-asserted-by":"publisher","first-page":"8632","DOI":"10.1038\/s41598-021-87974-6","volume":"11","author":"R Qaisar","year":"2021","unstructured":"Qaisar R et al (2021) Prediction of sarcopenia using a battery of circulating biomarkers. Sci Rep 11(1):8632","journal-title":"Sci Rep"},{"issue":"4","key":"2759_CR29","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00198-009-1059-y","volume":"21","author":"T Lang","year":"2010","unstructured":"Lang T et al (2010) Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int 21(4):543\u201359","journal-title":"Osteoporos Int"},{"issue":"1","key":"2759_CR30","doi-asserted-by":"publisher","first-page":"56","DOI":"10.5334\/gh.943","volume":"16","author":"R Qaisar","year":"2021","unstructured":"Qaisar R et al (2021) Circulating MicroRNAs as Biomarkers of Accelerated Sarcopenia in Chronic Heart Failure. Glob Heart 16(1):56","journal-title":"Glob Heart"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-025-02759-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-025-02759-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-025-02759-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T02:14:36Z","timestamp":1748657676000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13760-025-02759-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2759"],"URL":"https:\/\/doi.org\/10.1007\/s13760-025-02759-2","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,11]]},"assertion":[{"value":"4 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}