{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T06:40:01Z","timestamp":1748673601978,"version":"3.41.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s13760-025-02765-4","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T01:20:41Z","timestamp":1743211241000},"page":"793-800","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Cox\u2019s hazard model for new development of medication overuse headache in pure chronic migraine patients under migraine prophylaxis"],"prefix":"10.1007","volume":"125","author":[{"given":"Alessandro","family":"Vigan\u00f2","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Petolicchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Toscano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Diani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Altieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Di Piero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"2765_CR1","doi-asserted-by":"crossref","unstructured":"Ashina S, Terwindt GM, Steiner TJ, Lee MJ, Porreca F, Tassorelli C et al (2023) Medication overuse headache. Nat Rev Dis Primers 9(1):5","DOI":"10.1038\/s41572-022-00415-0"},{"key":"2765_CR2","doi-asserted-by":"crossref","unstructured":"May A, Schulte LH (2016) Chronic migraine: risk factors, mechanisms and treatment. Nat Rev Neurol 12(8):455\u2013464","DOI":"10.1038\/nrneurol.2016.93"},{"key":"2765_CR3","doi-asserted-by":"crossref","unstructured":"Blumenfeld AM, Bloudek LM, Becker WJ, Buse DC, Varon SF, Maglinte GA et al (2013) Patterns of use and reasons for discontinuation of prophylactic medications for episodic migraine and chronic migraine: results from the second international burden of migraine study (IBMS-II). Headache 53(4):644\u2013655","DOI":"10.1111\/head.12055"},{"key":"2765_CR4","doi-asserted-by":"crossref","unstructured":"Buse DC, Manack A, Serrano D, Turkel C, Lipton RB (2010) Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry 81(4):428\u2013432","DOI":"10.1136\/jnnp.2009.192492"},{"key":"2765_CR5","doi-asserted-by":"crossref","unstructured":"Scher AI, Rizzoli PB, Loder EW (2017) Medication overuse headache: An entrenched idea in need of scrutiny. Neurology 89(12):1296\u20131304","DOI":"10.1212\/WNL.0000000000004371"},{"key":"2765_CR6","doi-asserted-by":"crossref","unstructured":"Bergman-Bock S (2018) Associations between migraine and the most common psychiatric co-morbidities. Headache 58(2):346\u2013353","DOI":"10.1111\/head.13146"},{"key":"2765_CR7","doi-asserted-by":"crossref","unstructured":"Mastria G, Vigan\u00f2 A, Corrado A, Mancini V, Pirillo C, Badini S et al (2021) Chronic Migraine Preventive Treatment by Prefrontal-Occipital Transcranial Direct Current Stimulation (tDCS): A Proof-of-Concept Study on the Effect of Psychiatric Comorbidities. Front Neurol 12","DOI":"10.3389\/fneur.2021.654900"},{"key":"2765_CR8","doi-asserted-by":"crossref","unstructured":"Bendtsen, Lars, et al.\u00a0(2014) Disability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project).\u00a0Cephalalgia\u00a0426-433.","DOI":"10.1177\/0333102413515338"},{"key":"2765_CR9","doi-asserted-by":"crossref","unstructured":"Lampl C, Thomas H, Tassorelli C, Katsarava Z, La\u00ednez JM, Lant\u00e9ri-Minet M et al (2016) Headache, depression and anxiety: associations in the Eurolight project. J Headache Pain 17:59","DOI":"10.1186\/s10194-016-0649-2"},{"key":"2765_CR10","doi-asserted-by":"crossref","unstructured":"Bogdanov VB, Bogdanova OV, Vigan\u00f2 A, Noirhomme Q, Laureys S, Dallel R et al (2019) Increased cerebral responses to salient transitions between alternating stimuli in chronic migraine with medication overuse headache and during migraine attacks. Cephalalgia 39(8):988\u2013999","DOI":"10.1177\/0333102418825359"},{"key":"2765_CR11","doi-asserted-by":"crossref","unstructured":"Diener H-C, Holle D, Solbach K, Gaul C (2016) Medication-overuse headache: risk factors, pathophysiology and management. Nat Rev Neurol 12(10):575\u2013583","DOI":"10.1038\/nrneurol.2016.124"},{"key":"2765_CR12","doi-asserted-by":"crossref","unstructured":"Schwedt TJ, Chong CD (2017) Medication Overuse Headache: Pathophysiological Insights from Structural and Functional Brain MRI Research. Headache 57(7):1173\u20131178","DOI":"10.1111\/head.13037"},{"key":"2765_CR13","doi-asserted-by":"crossref","unstructured":"Bigal ME, Serrano D, Reed M, Lipton RB (2008) Chronic migraine in the population: burden, diagnosis, and satisfaction with treatment. Neurology 71(8):559\u2013566","DOI":"10.1212\/01.wnl.0000323925.29520.e7"},{"key":"2765_CR14","doi-asserted-by":"crossref","unstructured":"Bense\u00f1or IM, Cook NR, Lee IM, Chown MJ, Hennekens CH, Buring JE (2001) Low-dose aspirin for migraine prophylaxis in women. Cephalalgia 21(3):175\u2013183","DOI":"10.1046\/j.0333-1024.2001.00194.x"},{"key":"2765_CR15","doi-asserted-by":"crossref","unstructured":"Buring JE, Peto R, Hennekens CH (1990) Low-dose aspirin for migraine prophylaxis. JAMA 264(13):1711\u20131713","DOI":"10.1001\/jama.1990.03450130083031"},{"key":"2765_CR16","doi-asserted-by":"crossref","unstructured":"Chen P-K, Wang S-J (2019) Medication Overuse and Medication Overuse Headache: Risk Factors, Comorbidities, Associated Burdens and Nonpharmacologic and Pharmacologic Treatment Approaches. Curr Pain Headache Rep 23(8):60","DOI":"10.1007\/s11916-019-0796-7"},{"key":"2765_CR17","doi-asserted-by":"crossref","unstructured":"Yan Z, Chen Y, Chen C, Li C, Diao X (2015) Analysis of risk factors for medication-overuse headache relapse: a clinic-based study in China. BMC Neurol 15:168","DOI":"10.1186\/s12883-015-0422-1"},{"key":"2765_CR18","doi-asserted-by":"crossref","unstructured":"Raggi A, Grazzi L, Ayadi R, Leonardi M, Proietti A, Schiavolin S et al (2017) Clinical and psychosocial features of frequent relapsers (FR) among patients with chronic migraine and medication overuse. Neurol Sci 38(Suppl 1):169\u2013171","DOI":"10.1007\/s10072-017-2894-9"},{"key":"2765_CR19","doi-asserted-by":"crossref","unstructured":"Di Lorenzo C, Coppola G, Curr\u00e0 A, Grieco G, Santorelli FM, Lepre C et al (2012) Cortical response to somatosensory stimulation in medication overuse headache patients is influenced by angiotensin converting enzyme (ACE) I\/D genetic polymorphism. Cephalalgia 32(16):1189\u20131197","DOI":"10.1177\/0333102412461890"},{"key":"2765_CR20","doi-asserted-by":"crossref","unstructured":"Di Lorenzo C, Di Lorenzo G, Sances G, Ghiotto N, Guaschino E, Grieco GS et al (2009) Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. J Headache Pain 10(5):349\u2013355","DOI":"10.1007\/s10194-009-0136-0"},{"key":"2765_CR21","doi-asserted-by":"crossref","unstructured":"Diener HC, Antonaci F, Braschinsky M, Evers S, Jensen R, Lainez M et al (2020) European Academy of Neurology guideline on the management of medication-overuse headache. Eur J Neurol 27(7):1102\u20131116","DOI":"10.1111\/ene.14268"},{"key":"2765_CR22","doi-asserted-by":"publisher","unstructured":"Vigan\u00f2 A, Petolicchio B, Toscano M, Ruggero S, Di Giambattista R, Puma M et al (2025) Real-world application of Short Term Psychodynamic Psychotherapy (STPP) as chronic migraine preventive therapy: Profiling responders and predictive factors. Neurol Sci. https:\/\/doi.org\/10.1007\/s10072-025-08075-0","DOI":"10.1007\/s10072-025-08075-0"},{"key":"2765_CR23","doi-asserted-by":"crossref","unstructured":"Alessiani M, Petolicchio B, De Sanctis R, Squitieri M, Di Giambattista R, Puma M et al (2022) A Propensity Score Matching Study on the Effect of OnabotulinumtoxinA Alone versus Short-Term Psychodynamic Psychotherapy Plus Drug-of-Choice as Preventive Therapy in Chronic Migraine: Effects and Predictive Factors. Eur Neurol 85(6):453\u2013459","DOI":"10.1159\/000525152"},{"key":"2765_CR24","doi-asserted-by":"publisher","unstructured":"D\u2019Amico D, Mosconi P, Genco S, Usai S, Prudenzano AM, Grazzi L, Leone M, Puca FM, Bussone G (2001) The Migraine Disability Assessment (MIDAS) questionnaire: translation and reliability of the Italian version. Cephalalgia 21(10):947\u2013952. https:\/\/doi.org\/10.1046\/j.0333-1024.2001.00277.x","DOI":"10.1046\/j.0333-1024.2001.00277.x"},{"key":"2765_CR25","doi-asserted-by":"publisher","unstructured":"Kosinski M, Bayliss MS, Bjorner JB, Ware J, Garber WH, Batenhorst AS, Cady R, Dahl\u00f6f CG, Dowson AJ, Tepper SJ (2003) A six-item short-form survey for measuring headache impact: The HIT-6. Qual Life Res 12:963\u2013974. https:\/\/doi.org\/10.1023\/a:1026119331193","DOI":"10.1023\/a:1026119331193"},{"key":"2765_CR26","doi-asserted-by":"crossref","unstructured":"Tassorelli C, Diener H-C, Dodick DW, Silberstein SD, Lipton RB, Ashina M et al (2018) Guidelines of the International Headache Society for controlled trials of preventive treatment of chronic migraine in adults. Cephalalgia 38(5):815\u2013832","DOI":"10.1177\/0333102418758283"},{"key":"2765_CR27","doi-asserted-by":"crossref","unstructured":"Sheldon R, Rose S, Ritchie D, Connolly SJ, Koshman M-L, Lee MA et al (2002) Historical criteria that distinguish syncope from seizures. J Am Coll Cardiol 40(1):142\u2013148","DOI":"10.1016\/S0735-1097(02)01940-X"},{"key":"2765_CR28","doi-asserted-by":"crossref","unstructured":"Hagen K, Albretsen C, Vilming ST, Salvesen R, Gr\u00f8nning M, Helde G et al (2011) A 4-year follow-up of patients with medication-overuse headache previously included in a randomized multicentre study. J Headache Pain 12(3):315\u2013322","DOI":"10.1007\/s10194-010-0285-1"},{"key":"2765_CR29","doi-asserted-by":"crossref","unstructured":"Zidverc-Trajkovic JJ, Pekmezovic T, Jovanovic Z, Pavlovic A, Mijajlovic M, Radojicic A et al (2018) Long-term predictors of remission in patients treated for medication-overuse headache at a specialized headache center: A prospective cohort study. Cephalalgia 38(2):265\u2013273","DOI":"10.1177\/0333102416683918"},{"key":"2765_CR30","doi-asserted-by":"crossref","unstructured":"Zidverc-Trajkovic J, Pekmezovic T, Jovanovic Z, Pavlovic A, Mijajlovic M, Radojicic A et al (2007) Medication overuse headache: clinical features predicting treatment outcome at 1-year follow-up. Cephalalgia 27(11):1219\u20131225","DOI":"10.1111\/j.1468-2982.2007.01432.x"},{"key":"2765_CR31","doi-asserted-by":"crossref","unstructured":"Baraldi C, Castro FL, Cainazzo MM, Pani L, Guerzoni S (2021) Predictors of response to erenumab after 12 months of treatment. Brain Behav 11(8)","DOI":"10.1002\/brb3.2260"},{"key":"2765_CR32","doi-asserted-by":"crossref","unstructured":"Nowaczewska M, Straburzy\u0144ski M, Meder G, Waliszewska-Pros\u00f3\u0142 M (2024) The relationship between migraine and Hashimoto\u2019s thyroiditis: a single center experience. Front Neurol 15:1370530","DOI":"10.3389\/fneur.2024.1370530"},{"key":"2765_CR33","doi-asserted-by":"crossref","unstructured":"Diener HC, Dichgans J, Scholz E, Geiselhart S, Gerber WD, Bille A (1989) Analgesic-induced chronic headache: long-term results of withdrawal therapy. J Neurol 236(1):9\u201314","DOI":"10.1007\/BF00314210"},{"key":"2765_CR34","doi-asserted-by":"crossref","unstructured":"Andrasik F, Grazzi L, Usai S, Kass S, Bussone G (2010) Disability in chronic migraine with medication overuse: treatment effects through 5 years. Cephalalgia 30(5):610\u2013614","DOI":"10.1111\/j.1468-2982.2009.01932.x"},{"key":"2765_CR35","doi-asserted-by":"crossref","unstructured":"Radat F, Creac\u2019h C, Swendsen JD, Lafittau M, Irachabal S, Dousset V, Henry P (2005) Psychiatric comorbidity in the evolution from migraine to medication overuse headache. Cephalalgia 25(7):519\u2013522","DOI":"10.1111\/j.1468-2982.2005.00910.x"},{"key":"2765_CR36","doi-asserted-by":"crossref","unstructured":"Dengler J, Heuschmann PU, Endres M, Meyer B, Rohde V, Rufenacht DA et al (2011) The rationale and design of the Giant Intracranial Aneurysm Registry: a retrospective and prospective study. Int J Stroke 6(3):266\u2013270","DOI":"10.1111\/j.1747-4949.2011.00588.x"},{"key":"2765_CR37","doi-asserted-by":"crossref","unstructured":"De Sanctis R, Tiberio P, Jacobs F, Gaudio M, Benvenuti C, Giordano L, Rescigno M (2024) Optimizing abemaciclib-induced diarrhea management in patients with breast cancer: a pragmatic 2-group study using a postbiotic microbiota stabilizer. The Oncologist 29(9):e1113\u2013e1119","DOI":"10.1093\/oncolo\/oyae101"},{"key":"2765_CR38","doi-asserted-by":"crossref","unstructured":"Fumal A, Schoenen J (2008) Current migraine management - patient acceptability and future approaches. Neuropsychiatr Dis Treat 4(6):1043\u20131057","DOI":"10.2147\/NDT.S3045"},{"key":"2765_CR39","doi-asserted-by":"crossref","unstructured":"Sarchielli P, Messina P, Cupini LM, Tedeschi G, Di Piero V, Livrea P et al (2014) Sodium valproate in migraine without aura and medication overuse headache: a randomized controlled trial. Eur Neuropsychopharmacol 24(8):1289\u20131297","DOI":"10.1016\/j.euroneuro.2014.03.010"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-025-02765-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-025-02765-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-025-02765-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T06:14:38Z","timestamp":1748672078000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13760-025-02765-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2765"],"URL":"https:\/\/doi.org\/10.1007\/s13760-025-02765-4","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"type":"print","value":"0300-9009"},{"type":"electronic","value":"2240-2993"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"2 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}