{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:04:46Z","timestamp":1790996686644,"version":"4.1.0"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Genetic variants can affect signaling pathways that are important in the pathophysiology of Parkinson\u2019s disease (PD). Comprehending their relationship is crucial for the development of diagnostic instruments and preventative drugs for PD. We thoroughly analyzed data from 68 genome-wide association studies to uncover significant genetic variations and clarify the molecular pathways underlying the etiology of Parkinson\u2019s disease (PD) resulting from genetic variants. Six common biomarkers linked to PD were found in all 68 investigations:\n                    <jats:italic>SNCA<\/jats:italic>\n                    ,\n                    <jats:italic>TMEM175<\/jats:italic>\n                    ,\n                    <jats:italic>BST1<\/jats:italic>\n                    ,\n                    <jats:italic>RIT2<\/jats:italic>\n                    ,\n                    <jats:italic>LRRK2<\/jats:italic>\n                    , and\n                    <jats:italic>MCCC1<\/jats:italic>\n                    .\n                    <jats:italic>SNCA<\/jats:italic>\n                    (\n                    <jats:inline-formula>\n                      <jats:tex-math>$$\\uparrow$$<\/jats:tex-math>\n                    <\/jats:inline-formula>\n                    rs5019538 and\n                    <jats:inline-formula>\n                      <jats:tex-math>$$\\uparrow$$<\/jats:tex-math>\n                    <\/jats:inline-formula>\n                    rs356182),\n                    <jats:italic>LRRK2<\/jats:italic>\n                    (\n                    <jats:inline-formula>\n                      <jats:tex-math>$$\\uparrow$$<\/jats:tex-math>\n                    <\/jats:inline-formula>\n                    rs34637584 and\n                    <jats:inline-formula>\n                      <jats:tex-math>$$\\uparrow$$<\/jats:tex-math>\n                    <\/jats:inline-formula>\n                    rs76904798), and\n                    <jats:italic>SH3GL2<\/jats:italic>\n                    (\n                    <jats:inline-formula>\n                      <jats:tex-math>$$\\uparrow$$<\/jats:tex-math>\n                    <\/jats:inline-formula>\n                    rs10756907 and\n                    <jats:inline-formula>\n                      <jats:tex-math>$$\\downarrow$$<\/jats:tex-math>\n                    <\/jats:inline-formula>\n                    rs13294100) were the main biomarkers associated with PD. The clinical traits of PD, such as age at onset, cognitive progression, motor progression, composite progression, tremor dominant, and postural instability gait difficulty, have been found to be underpinned by additional biomarkers, including\n                    <jats:italic>APOE<\/jats:italic>\n                    ,\n                    <jats:italic>NTRK2<\/jats:italic>\n                    ,\n                    <jats:italic>SLCO1B3<\/jats:italic>\n                    ,\n                    <jats:italic>SLC28A3<\/jats:italic>\n                    ,\n                    <jats:italic>AQP10<\/jats:italic>\n                    ,\n                    <jats:italic>SNCAIP<\/jats:italic>\n                    ,\n                    <jats:italic>ANO2<\/jats:italic>\n                    ,\n                    <jats:italic>CADM1<\/jats:italic>\n                    ,\n                    <jats:italic>PTPRD<\/jats:italic>\n                    ,\n                    <jats:italic>GPR32<\/jats:italic>\n                    ,\n                    <jats:italic>GPR321<\/jats:italic>\n                    ,\n                    <jats:italic>SQOR<\/jats:italic>\n                    ,\n                    <jats:italic>SULT1C2<\/jats:italic>\n                    ,\n                    <jats:italic>GABRG2<\/jats:italic>\n                    ,\n                    <jats:italic>CYP4Z1<\/jats:italic>\n                    ,\n                    <jats:italic>CDH13<\/jats:italic>\n                    , and\n                    <jats:italic>FANCF<\/jats:italic>\n                    . Significant evidence was found linking genetic variants linked to an increased risk of PD to reduced dopamine production, receptor recycling, oxidoreductase activity, and increased amyloid-beta accumulation. Considerable evidence links genetic variations with a lower risk of PD due to improved synaptic vesicle signaling, neuron projection development, controlled histone methylation, and excitatory postsynaptic potential. Additionally, we found\n                    <jats:italic>MYT1L<\/jats:italic>\n                    and\n                    <jats:italic>hsa-miR-20a-5p<\/jats:italic>\n                    , which are essential for understanding the genetic variations linked to PD. These findings provide a solid underpinning for future therapeutic approaches aimed at PD, with a focus on the genetic variants and processes connected to the illness.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphic abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s13760-025-02897-7","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:49:33Z","timestamp":1759218573000},"page":"1621-1641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson\u2019s disease"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8419-7784","authenticated-orcid":false,"given":"Hai Duc","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"2897_CR1","doi-asserted-by":"publisher","first-page":"699562","DOI":"10.3389\/fnmol.2021.699562","volume":"14","author":"J Aguila","year":"2021","unstructured":"Aguila J, Cheng S, Kee N, Cao M, Wang M, Deng Q, Hedlund E (2021) Spatial RNA sequencing identifies robust markers of vulnerable and resistant human midbrain dopamine neurons and their expression in Parkinson\u2019s disease. Front Mol Neurosci 14:699562. https:\/\/doi.org\/10.3389\/fnmol.2021.699562","journal-title":"Front Mol Neurosci"},{"key":"2897_CR2","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1073\/pnas.1518553113","volume":"113","author":"B Ayoglu","year":"2016","unstructured":"Ayoglu B, Mitsios N, Kockum I, Khademi M, Zandian A, Sj\u00f6berg R, Forsstr\u00f6m B, Bredenberg J, Lima Bomfim I, Holmgren E et al (2016) Anoctamin 2 identified as an autoimmune target in multiple sclerosis. Proc Natl Acad Sci U S A 113:2188\u20132193. https:\/\/doi.org\/10.1073\/pnas.1518553113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/00004647-200204000-00001","volume":"22","author":"J Badaut","year":"2002","unstructured":"Badaut J, Lasbennes F, Magistretti PJ, Regli L (2002) Aquaporins in brain: distribution, physiology, and pathophysiology. J Cereb Blood Flow Metab 22:367\u2013378. https:\/\/doi.org\/10.1097\/00004647-200204000-00001","journal-title":"J Cereb Blood Flow Metab"},{"key":"2897_CR4","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","volume":"25","author":"G Bindea","year":"2009","unstructured":"Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, Fridman W-H, Pag\u00e8s F, Trajanoski Z, Galon J (2009) ClueGO: a cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 25:1091\u20131093. https:\/\/doi.org\/10.1093\/bioinformatics\/btp101. (%J Bioinformatics)","journal-title":"Bioinformatics"},{"key":"2897_CR5","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.stem.2016.07.001","volume":"19","author":"B Black Joshua","year":"2016","unstructured":"Black Joshua B, Adler Andrew F, Wang H-G, D\u2019Ippolito Anthony M, Hutchinson Hunter A, Reddy Timothy E, Pitt Geoffrey S, Leong Kam W, Gersbach Charles A (2016) Targeted epigenetic remodeling of endogenous loci by CRISPR\/Cas9-based transcriptional activators directly converts fibroblasts to neuronal cells. Cell Stem Cell 19:406\u2013414. https:\/\/doi.org\/10.1016\/j.stem.2016.07.001","journal-title":"Cell Stem Cell"},{"key":"2897_CR6","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1002\/mds.27659","volume":"34","author":"C Blauwendraat","year":"2019","unstructured":"Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstr\u00f8m L, Sim\u00f3n-S\u00e1nchez J, Schulte C, Sharma M, Krohn L (2019) Parkinson\u2019s disease age at onset genome-wide association study: defining heritability, genetic loci, and \u03b1-synuclein mechanisms. Mov Disord 34:866\u2013875. https:\/\/doi.org\/10.1002\/mds.27659","journal-title":"Mov Disord"},{"key":"2897_CR7","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/s1474-4422(19)30287-x","volume":"19","author":"C Blauwendraat","year":"2020","unstructured":"Blauwendraat C, Nalls MA, Singleton AB (2020) The genetic architecture of Parkinson\u2019s disease. Lancet Neurol 19:170\u2013178. https:\/\/doi.org\/10.1016\/s1474-4422(19)30287-x","journal-title":"Lancet Neurol"},{"key":"2897_CR8","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/s0140-6736(21)00218-x","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. Lancet 397:2284\u20132303. https:\/\/doi.org\/10.1016\/s0140-6736(21)00218-x","journal-title":"Lancet"},{"key":"2897_CR9","doi-asserted-by":"publisher","first-page":"e0116483","DOI":"10.1371\/journal.pone.0116483","volume":"10","author":"V Cenedese","year":"2015","unstructured":"Cenedese V, Mezzavilla M, Morgan A, Marino R, Ettorre CP, Margaglione M, Gasparini P, Menini A (2015) Assessment of the olfactory function in Italian patients with type 3 von Willebrand disease caused by a homozygous 253 kb deletion involving VWF and TMEM16B\/ANO2. PLoS ONE 10:e0116483. https:\/\/doi.org\/10.1371\/journal.pone.0116483","journal-title":"PLoS ONE"},{"key":"2897_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3267172","volume":"2020","author":"S Chamani","year":"2020","unstructured":"Chamani S, Bianconi V, Tasbandi A, Pirro M, Barreto GE, Jamialahmadi T, Sahebkar A (2020) Resolution of inflammation in neurodegenerative diseases: the role of resolvins. Mediators Inflamm 2020:3267172. https:\/\/doi.org\/10.1155\/2020\/3267172","journal-title":"Mediators Inflamm"},{"key":"2897_CR11","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/ng.3955","volume":"49","author":"D Chang","year":"2017","unstructured":"Chang D, Nalls MA, Hallgr\u00edmsd\u00f3ttir IB, Hunkapiller J, van der Brug M, Cai F, Kerchner GA, Ayalon G, Bingol B, Sheng M et al (2017) A meta-analysis of genome-wide association studies identifies 17 new Parkinson\u2019s disease risk loci. Nat Genet 49:1511\u20131516. https:\/\/doi.org\/10.1038\/ng.3955","journal-title":"Nat Genet"},{"key":"2897_CR12","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","volume":"8","author":"C-H Chin","year":"2014","unstructured":"Chin C-H, Chen S-H, Wu H-H, Ho C-W, Ko M-T, Lin C-Y (2014) CytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol 8:S11. https:\/\/doi.org\/10.1186\/1752-0509-8-S4-S11","journal-title":"BMC Syst Biol"},{"key":"2897_CR13","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1083\/jcb.200108123","volume":"156","author":"SD Conner","year":"2002","unstructured":"Conner SD, Schmid SL (2002) Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol 156:921\u2013929. https:\/\/doi.org\/10.1083\/jcb.200108123","journal-title":"J Cell Biol"},{"key":"2897_CR14","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.nbd.2015.02.005","volume":"76","author":"JJ Credle","year":"2015","unstructured":"Credle JJ, Forcelli PA, Delannoy M, Oaks AW, Permaul E, Berry DL, Duka V, Wills J, Sidhu A (2015) \u0391-synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in parkinson\u2019s disease. Neurobiol Dis 76:112\u2013125. https:\/\/doi.org\/10.1016\/j.nbd.2015.02.005","journal-title":"Neurobiol Dis"},{"key":"2897_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7070074","volume":"7","author":"K Dashtipour","year":"2017","unstructured":"Dashtipour K, Tafreshi A, Adler C, Beach T, Chen X, Serrano G, Tashiro S, Wang C (2017) Hypermethylation of synphilin-1, alpha-synuclein-interacting protein (SNCAIP) gene in the cerebral cortex of patients with sporadic Parkinson\u2019s disease. Brain Sci 7:74. https:\/\/doi.org\/10.3390\/brainsci7070074","journal-title":"Brain Sci"},{"key":"2897_CR16","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay3069","volume":"12","author":"AA Davis","year":"2020","unstructured":"Davis AA, Inman CE, Wargel ZM, Dube U, Freeberg BM, Galluppi A, Haines JN, Dhavale DD, Miller R, Choudhury FA (2020) APOE genotype regulates pathology and disease progression in synucleinopathy. Sci Transl Med 12:eaay3069. https:\/\/doi.org\/10.1126\/scitranslmed.aay3069","journal-title":"Sci Transl Med"},{"key":"2897_CR17","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2200627","author":"M Decet","year":"2023","unstructured":"Decet M, Soukup SF (2023) Endophilin-a\/SH3GL2 calcium switch for synaptic autophagy induction is impaired by a Parkinson\u2019s risk variant. Autophagy. https:\/\/doi.org\/10.1080\/15548627.2023.2200627","journal-title":"Autophagy"},{"key":"2897_CR18","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","volume":"68","author":"ER Dorsey","year":"2007","unstructured":"Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, Marshall FJ, Ravina BM, Schifitto G, Siderowf A al (2007) Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68:384. https:\/\/doi.org\/10.1212\/01.wnl.0000247740.47667.03","journal-title":"Neurology"},{"key":"2897_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.sleep.2016.06.003","volume":"31","author":"CJ Earley","year":"2017","unstructured":"Earley CJ, Uhl GR, Clemens S, Ferr\u00e9 S (2017) Connectome and molecular pharmacological differences in the dopaminergic system in restless legs syndrome (RLS): plastic changes and neuroadaptations that may contribute to augmentation. Sleep Med 31:71\u201377. https:\/\/doi.org\/10.1016\/j.sleep.2016.06.003","journal-title":"Sleep Med"},{"key":"2897_CR20","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1096\/fj.08-113902","volume":"23","author":"E Errasti-Murugarren","year":"2009","unstructured":"Errasti-Murugarren E, Molina-Arcas M, Casado FJ, Pastor-Anglada M (2009) A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum. FASEB J 23:172\u2013182. https:\/\/doi.org\/10.1096\/fj.08-113902","journal-title":"FASEB J"},{"key":"2897_CR21","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1001\/jamaneurol.2020.0428","volume":"77","author":"JN Foo","year":"2020","unstructured":"Foo JN, Chew EGY, Chung SJ, Peng R, Blauwendraat C, Nalls MA, Mok KY, Satake W, Toda T, Chao Yet al et al (2020) Identification of risk loci for Parkinson disease in Asians and comparison of risk between Asians and Europeans: a genome-wide association study. JAMA Neurol 77:746\u2013754. https:\/\/doi.org\/10.1001\/jamaneurol.2020.0428","journal-title":"JAMA Neurol"},{"key":"2897_CR22","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.parkreldis.2015.03.010","volume":"21","author":"Z Gan-Or","year":"2015","unstructured":"Gan-Or Z, Alcalay RN, Bar-Shira A, Leblond CS, Postuma RB, Ben-Shachar S, Waters C, Johnson A, Levy O, Mirelman A (2015) Genetic markers of restless legs syndrome in Parkinson disease. Parkinsonism Relat Disord 21:582\u2013585. https:\/\/doi.org\/10.1016\/j.parkreldis.2015.03.010","journal-title":"Parkinsonism Relat Disord"},{"key":"2897_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106568","volume":"199","author":"AYL Gao","year":"2024","unstructured":"Gao AYL, Montagna DR, Hirst WD, Temkin PA (2024) RIT2 regulates autophagy lysosomal pathway induction and protects against \u03b1-synuclein pathology in a cellular model of parkinson\u2019s disease. Neurobiol Dis 199:106568. https:\/\/doi.org\/10.1016\/j.nbd.2024.106568","journal-title":"Neurobiol Dis"},{"issue":"s1","key":"2897_CR24","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.3233\/jpd-179005","volume":"7","author":"M Goedert","year":"2017","unstructured":"Goedert M, Jakes R, Spillantini MG (2017) The synucleinopathies: twenty years on. J Parkinsons Dis 7(s1):S51-s69. https:\/\/doi.org\/10.3233\/jpd-179005","journal-title":"J Parkinsons Dis"},{"key":"2897_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1094265","volume":"13","author":"P Hartz","year":"2022","unstructured":"Hartz P, Fehlmann T, Wagenpfeil G, Unger MM, Bernhardt R (2022) A CYPome-wide study reveals new potential players in the pathogenesis of parkinson\u2019s disease. Front Pharmacol 13:1094265. https:\/\/doi.org\/10.3389\/fphar.2022.1094265","journal-title":"Front Pharmacol"},{"key":"2897_CR26","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1113\/jphysiol.2008.163709","volume":"587","author":"HC Hartzell","year":"2009","unstructured":"Hartzell HC, Yu K, Xiao Q, Chien LT, Qu Z (2009) Anoctamin\/TMEM16 family members are Ca2+-activated Cl- channels. J Physiol 587:2127\u20132139. https:\/\/doi.org\/10.1113\/jphysiol.2008.163709","journal-title":"J Physiol"},{"key":"2897_CR27","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1006\/bbrc.2001.5661","volume":"287","author":"S Hatakeyama","year":"2001","unstructured":"Hatakeyama S, Yoshida Y, Tani T, Koyama Y, Nihei K, Ohshiro K, Kamiie JI, Yaoita E, Suda T, Hatakeyama K (2001) Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum. Biochem Biophys Res Commun 287:814\u2013819. https:\/\/doi.org\/10.1006\/bbrc.2001.5661","journal-title":"Biochem Biophys Res Commun"},{"key":"2897_CR28","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","volume":"10","author":"K Haze","year":"1999","unstructured":"Haze K, Yoshida H, Yanagi H, Yura T, Mori K (1999) Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 10:3787\u20133799. https:\/\/doi.org\/10.1091\/mbc.10.11.3787","journal-title":"Mol Biol Cell"},{"key":"2897_CR29","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1523\/jneurosci.4390-14.2015","volume":"35","author":"P Hoerbelt","year":"2015","unstructured":"Hoerbelt P, Lindsley TA, Fleck MW (2015) Dopamine directly modulates GABAA receptors. J Neurosci 35:3525\u20133536. https:\/\/doi.org\/10.1523\/jneurosci.4390-14.2015","journal-title":"J Neurosci"},{"key":"2897_CR30","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1097\/NEN.0b013e3182632566","volume":"71","author":"A Hoshi","year":"2012","unstructured":"Hoshi A, Yamamoto T, Shimizu K, Ugawa Y, Nishizawa M, Takahashi H, Kakita A (2012) Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer disease. J Neuropathol Exp Neurol 71:750\u2013759. https:\/\/doi.org\/10.1097\/NEN.0b013e3182632566","journal-title":"J Neuropathol Exp Neurol"},{"key":"2897_CR31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/bpa.12369","volume":"27","author":"A Hoshi","year":"2017","unstructured":"Hoshi A, Tsunoda A, Tada M, Nishizawa M, Ugawa Y, Kakita A (2017) Expression of aquaporin 1 and aquaporin 4 in the temporal neocortex of patients with Parkinson\u2019s disease. Brain Pathol 27:160\u2013168. https:\/\/doi.org\/10.1111\/bpa.12369","journal-title":"Brain Pathol"},{"key":"2897_CR32","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1016\/j.cell.2022.05.021","volume":"185","author":"M Hu","year":"2022","unstructured":"Hu M, Li P, Wang C, Feng X, Geng Q, Chen W, Marthi M, Zhang W, Gao C, Reid W al (2022) Parkinson\u2019s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes. Cell 185:2292\u20132308e2220. https:\/\/doi.org\/10.1016\/j.cell.2022.05.021","journal-title":"Cell"},{"key":"2897_CR33","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","volume":"24","author":"EJ Huang","year":"2001","unstructured":"Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677\u2013736. https:\/\/doi.org\/10.1146\/annurev.neuro.24.1.677","journal-title":"Annu Rev Neurosci"},{"key":"2897_CR34","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/s0140-6736(04)17104-3","volume":"364","author":"P Ib\u00e1\u00f1ez","year":"2004","unstructured":"Ib\u00e1\u00f1ez P, Bonnet AM, D\u00e9barges B, Lohmann E, Tison F, Pollak P, Agid Y, D\u00fcrr A, Brice A (2004) Causal relation between alpha-synuclein gene duplication and familial parkinson\u2019s disease. Lancet 364:1169\u20131171. https:\/\/doi.org\/10.1016\/s0140-6736(04)17104-3","journal-title":"Lancet"},{"key":"2897_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78405-z","volume":"10","author":"T Idda","year":"2020","unstructured":"Idda T, Bonas C, Hoffmann J, Bertram J, Quinete N, Schettgen T, Fietkau K, Esser A, Stope MB, Leijs MM (2020) Metabolic activation and toxicological evaluation of polychlorinated biphenyls in drosophila melanogaster. Sci Rep 10:21587. https:\/\/doi.org\/10.1038\/s41598-020-78405-z","journal-title":"Sci Rep"},{"key":"2897_CR36","doi-asserted-by":"publisher","first-page":"F167","DOI":"10.1152\/ajprenal.00175.2023","volume":"326","author":"T Inoue","year":"2024","unstructured":"Inoue T, Umene R, Sung SJ, Tanaka S, Huang L, Yao J, Hashimoto N, Wu CH, Nakamura Y, Nishino T (2024) Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury. American Journal of Physiology-Renal Physiology 326:F167-f177. https:\/\/doi.org\/10.1152\/ajprenal.00175.2023","journal-title":"American Journal of Physiology-Renal Physiology"},{"key":"2897_CR37","doi-asserted-by":"publisher","unstructured":"Iwaki H, Blauwendraat C, Leonard HL, Kim JJ, Liu G, Maple-Gr\u00f8dem J, Corvol JC, Pihlstr\u00f8m L, van Nimwegen M Hutten SJ (2019) Genomewide association study of Parkinson\u2019s disease clinical biomarkers in 12 longitudinal patients\u2019 cohorts. Mov Disord 34: 1839\u20131850 https:\/\/doi.org\/10.1002\/mds.27845","DOI":"10.1002\/mds.27845"},{"key":"2897_CR38","doi-asserted-by":"crossref","unstructured":"Jing Q, Rebecca AB, Bradley TH, Alberto S-P (2021) Association of APOEGenotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease. Neurology 96: e2414 Doi 10.1212\/WNL.0000000000011883","DOI":"10.1212\/WNL.0000000000011883"},{"key":"2897_CR39","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1073\/pnas.1616332114","volume":"114","author":"S Jinn","year":"2017","unstructured":"Jinn S, Drolet RE, Cramer PE, Wong AH, Toolan DM, Gretzula CA, Voleti B, Vassileva G, Disa J, Tadin-Strapps M et al (2017) TMEM175 deficiency impairs lysosomal and mitochondrial function and increases \u03b1-synuclein aggregation. Proc Natl Acad Sci U S A 114:2389\u20132394. https:\/\/doi.org\/10.1073\/pnas.1616332114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2897_CR40","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.tins.2018.09.007","volume":"42","author":"ME Johnson","year":"2019","unstructured":"Johnson ME, Stecher B, Labrie V, Brundin L, Brundin P (2019) Triggers, facilitators, and aggravators: redefining Parkinson\u2019s disease pathogenesis. Trends Neurosci 42:4\u201313. https:\/\/doi.org\/10.1016\/j.tins.2018.09.007","journal-title":"Trends Neurosci"},{"issue":"5","key":"2897_CR41","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/s41593-022-01061-1","volume":"25","author":"T Kamath","year":"2022","unstructured":"Kamath T, Abdulraouf A, Burris SJ, Langlieb J, Gazestani V, Nadaf NM, Balderrama K, Vanderburg C, Macosko EZ (2022) Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson\u2019s disease. Nat Neurosci 25(5):588\u2013595. https:\/\/doi.org\/10.1038\/s41593-022-01061-1","journal-title":"Nat Neurosci"},{"key":"2897_CR42","unstructured":"Keenan AB, Torre D, Lachmann A, Leong AK, Wojciechowicz ML, Utti V, Jagodnik KM, Kropiwnicki E, Wang Z, Ma\u2019ayan AJN (2019) ChIP-X Enrichment Analysis version 3 (CHEA3) Available at: https:\/\/maayanlab.cloud\/chea3\/. Accessed Accessed on 20 December 2022"},{"key":"2897_CR43","doi-asserted-by":"crossref","unstructured":"Keenan AB, Torre D, Lachmann A, Leong AK, Wojciechowicz ML, Utti V, Jagodnik KM, Kropiwnicki E, Wang Z (2019) Ma\u2019ayan AJNar ChEA3: transcription factor enrichment analysis by orthogonal omics integration. 47: W212-W224","DOI":"10.1093\/nar\/gkz446"},{"key":"2897_CR44","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s00702-011-0591-z","volume":"118","author":"RJ Keyser","year":"2011","unstructured":"Keyser RJ, Oppon E, Carr JA, Bardien S (2011) Identification of Parkinson\u2019s disease candidate genes using CAESAR and screening of MAPT and SNCAIP in South African Parkinson\u2019s disease patients. J Neural Transm 118:889\u2013897. https:\/\/doi.org\/10.1007\/s00702-011-0591-z","journal-title":"J Neural Transm"},{"key":"2897_CR45","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1001\/jamaneurol.2020.5257","volume":"78","author":"DA Kia","year":"2021","unstructured":"Kia DA, Zhang D, Guelfi S, Manzoni C, Hubbard L, Reynolds RH, Bot\u00eda J, Ryten M, Ferrari R, Lewis PA (2021) Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets. JAMA Neurol 78:464\u2013472. https:\/\/doi.org\/10.1001\/jamaneurol.2020.5257","journal-title":"JAMA Neurol"},{"key":"2897_CR46","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1261\/rna.5980303","volume":"9","author":"AM Krichevsky","year":"2003","unstructured":"Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS (2003) A microrna array reveals extensive regulation of micrornas during brain development. RNA 9:1274\u20131281. https:\/\/doi.org\/10.1261\/rna.5980303","journal-title":"RNA"},{"key":"2897_CR47","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/mds.28787","volume":"37","author":"J Lake","year":"2022","unstructured":"Lake J, Reed X, Langston RG, Nalls MA, Gan-Or Z, Cookson MR, Singleton AB, Blauwendraat C, Leonard HL (2022) Coding and noncoding variation in LRRK2 and parkinson\u2019s disease risk. Mov Disord 37:95\u2013105. https:\/\/doi.org\/10.1002\/mds.28787","journal-title":"Mov Disord"},{"key":"2897_CR48","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1471-2350-10-98","volume":"10","author":"JC Latourelle","year":"2009","unstructured":"Latourelle JC, Pankratz N, Dumitriu A, Wilk JB, Goldwurm S, Pezzoli G, Mariani CB, DeStefano AL, Halter C, Gusella JF al (2009) Genomewide association study for onset age in Parkinson disease. BMC Med Genet 10:98. https:\/\/doi.org\/10.1186\/1471-2350-10-98","journal-title":"BMC Med Genet"},{"key":"2897_CR49","doi-asserted-by":"publisher","first-page":"1097293","DOI":"10.3389\/fnins.2023.1097293","volume":"17","author":"C Lei","year":"2023","unstructured":"Lei C, Zhongyan Z, Wenting S, Jing Z, Liyun Q, Hongyi H, Juntao Y, Qing Y (2023) Identification of necroptosis-related genes in Parkinson\u2019s disease by integrated bioinformatics analysis and experimental validation. Front Neurosci 17:1097293. https:\/\/doi.org\/10.3389\/fnins.2023.1097293","journal-title":"Front Neurosci"},{"key":"2897_CR50","doi-asserted-by":"crossref","unstructured":"Licursi V (2019) MIENTURNET (MicroRNA ENrichment TURned NETwork) Availabe at: http:\/\/userver.bio.uniroma1.it\/apps\/mienturnet\/ . Accessed Accessed on 20 December 2022","DOI":"10.1186\/s12859-019-3105-x"},{"key":"2897_CR51","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1186\/s12859-019-3105-x","volume":"20","author":"V Licursi","year":"2019","unstructured":"Licursi V, Conte F, Fiscon G, Paci P (2019) MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis. BMC Bioinformatics 20:545. https:\/\/doi.org\/10.1186\/s12859-019-3105-x","journal-title":"BMC Bioinformatics"},{"key":"2897_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31168-9","volume":"13","author":"Z Liu","year":"2022","unstructured":"Liu Z, Yang N, Dong J, Tian W, Chang L, Ma J, Guo J, Tan J, Dong A, He K (2022) Deficiency in endocannabinoid synthase DAGLB contributes to early onset parkinsonism and murine nigral dopaminergic neuron dysfunction. Nat Commun 13:3490. https:\/\/doi.org\/10.1038\/s41467-022-31168-9","journal-title":"Nat Commun"},{"key":"2897_CR53","doi-asserted-by":"publisher","first-page":"662278","DOI":"10.3389\/fneur.2021.662278","volume":"12","author":"K Markopoulou","year":"2021","unstructured":"Markopoulou K, Chase BA, Premkumar AP, Schoneburg B, Kartha N, Wei J, Yu H, Epshteyn A, Garduno L, Pham Aet al et al (2021) Variable effects of PD-risk associated SNPs and variants in Parkinsonism-associated genes on disease phenotype in a community-based cohort. Front Neurol 12:662278. https:\/\/doi.org\/10.3389\/fneur.2021.662278","journal-title":"Front Neurol"},{"key":"2897_CR54","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/s0304-3940(02)01076-5","volume":"334","author":"S Menzikov","year":"2002","unstructured":"Menzikov S, Menzikova O (2002) Interaction of pentobarbital with Gabaergic drugs acting on the Cl(-)-ATPase activity of the plasma membranes from Bream brain (Abramis brama L). Neurosci Lett 334:161\u2013164. https:\/\/doi.org\/10.1016\/s0304-3940(02)01076-5","journal-title":"Neurosci Lett"},{"key":"2897_CR55","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.neuron.2011.08.029","volume":"72","author":"I Milosevic","year":"2011","unstructured":"Milosevic I, Giovedi S, Lou X, Raimondi A, Collesi C, Shen H, Paradise S, O\u2019Toole E, Ferguson S, Cremona Oet al et al (2011) Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron 72:587\u2013601. https:\/\/doi.org\/10.1016\/j.neuron.2011.08.029","journal-title":"Neuron"},{"key":"2897_CR56","doi-asserted-by":"publisher","unstructured":"Mograbi KM, de Castro AC, de Oliveira JA, Sales PJ, Covolan L, Del Bel EA, de Souza AS (2017) Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson\u2019s disease model in mice. Physiological Rep 5. https:\/\/doi.org\/10.14814\/phy2.13081","DOI":"10.14814\/phy2.13081"},{"key":"2897_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102562","volume":"59","author":"F Nagashima","year":"2023","unstructured":"Nagashima F, Miyazaki Y, Kanemaru E, Ezaka M, Hara H, Sugiura K, Boerboom SL, Ostrom KF, Jiang W, Bloch DB ((2023)) Sulfide:quinone oxidoreductase ameliorates neurodegeneration in a murine model of Parkinson\u2019s disease. Redox Biol 59:102562. https:\/\/doi.org\/10.1016\/j.redox.2022.102562","journal-title":"Redox Biol"},{"key":"2897_CR58","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/s1474-4422(19)30320-5","volume":"18","author":"MA Nalls","year":"2019","unstructured":"Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A (2019) Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies. Lancet Neurol 18:1091\u20131102. https:\/\/doi.org\/10.1016\/s1474-4422(19)30320-5","journal-title":"Lancet Neurol"},{"key":"2897_CR59","doi-asserted-by":"publisher","first-page":"147898","DOI":"10.1016\/j.gene.2023.147898","volume":"892","author":"A Nassar","year":"2024","unstructured":"Nassar A, Kodi T, Satarker S, Gurram PC, Fayaz SM, Nampoothiri M (2024) Astrocytic transcription factors REST, YY1, and putative MicroRNAs in parkinson\u2019s disease and advanced therapeutic strategies. Gene 892:147898. https:\/\/doi.org\/10.1016\/j.gene.2023.147898","journal-title":"Gene"},{"key":"2897_CR60","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1523\/JNEUROSCI.2736-20.2020","volume":"41","author":"S Natasha","year":"2021","unstructured":"Natasha S, Anya V, Yael E-E, Elior P (2021) Differential contribution of Cadm1\u2013Cadm3 cell adhesion molecules to peripheral myelinated axons. J Neurosci 41:1393. https:\/\/doi.org\/10.1523\/JNEUROSCI.2736-20.2020","journal-title":"J Neurosci"},{"key":"2897_CR61","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1086\/432588","volume":"77","author":"SA Oliveira","year":"2005","unstructured":"Oliveira SA, Li YJ, Noureddine MA, Zuchner S, Qin X, Pericak-Vance MA, Vance JM (2005) Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. Am J Hum Genet 77:252\u2013264. https:\/\/doi.org\/10.1086\/432588","journal-title":"Am J Hum Genet"},{"key":"2897_CR62","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/brain\/awr301","volume":"135","author":"S Paris-Robidas","year":"2012","unstructured":"Paris-Robidas S, Brochu E, Sintes M, Emond V, Bousquet M, Vandal M, Pilote M, Tremblay C, Di Paolo T, Rajput AH et al (2012) Defective dentate nucleus GABA receptors in essential tremor. Brain 135:105\u2013116. https:\/\/doi.org\/10.1093\/brain\/awr301","journal-title":"Brain"},{"key":"2897_CR63","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.mad.2015.06.002","volume":"149","author":"GM Parkinson","year":"2015","unstructured":"Parkinson GM, Dayas CV, Smith DW (2015) Age-related gene expression changes in substantia nigra dopamine neurons of the rat. Mech Ageing Dev 149:41\u201349. https:\/\/doi.org\/10.1016\/j.mad.2015.06.002","journal-title":"Mech Ageing Dev"},{"key":"2897_CR64","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/s41531-021-00196-5","volume":"7","author":"CC Pedersen","year":"2021","unstructured":"Pedersen CC, Lange J, F\u00f8rland MGG, Macleod AD, Alves G, Maple-Gr\u00f8dem J (2021) A systematic review of associations between common SNCA variants and clinical heterogeneity in parkinson\u2019s disease. NPJ Parkinsons Dis 7:54. https:\/\/doi.org\/10.1038\/s41531-021-00196-5","journal-title":"NPJ Parkinsons Dis"},{"key":"2897_CR65","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.cellsig.2009.01.035","volume":"21","author":"M Philippova","year":"2009","unstructured":"Philippova M, Joshi MB, Kyriakakis E, Pfaff D, Erne P, Resink TJ (2009) A guide and guard: the many faces of T-cadherin. Cell Signal 21:1035\u20131044. https:\/\/doi.org\/10.1016\/j.cellsig.2009.01.035","journal-title":"Cell Signal"},{"key":"2897_CR66","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/ana.25274","volume":"84","author":"L Pihlstr\u00f8m","year":"2018","unstructured":"Pihlstr\u00f8m L, Blauwendraat C, Cappelletti C, Berge-Seidl V, Langmyhr M, Henriksen SP, van de Berg WDJ, Gibbs JR, Cookson MR, Singleton AB et al (2018) A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease. Ann Neurol 84:117\u2013129. https:\/\/doi.org\/10.1002\/ana.25274","journal-title":"Ann Neurol"},{"key":"2897_CR67","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3389\/fphar.2018.01273","volume":"9","author":"J Pirault","year":"2018","unstructured":"Pirault J, B\u00e4ck M (2018) Lipoxin and resolvin receptors transducing the resolution of inflammation in cardiovascular disease. Front Pharmacol 9:1273. https:\/\/doi.org\/10.3389\/fphar.2018.01273","journal-title":"Front Pharmacol"},{"key":"2897_CR68","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.tins.2021.12.002","volume":"45","author":"EM Rocha","year":"2022","unstructured":"Rocha EM, Keeney MT, Di Maio R, De Miranda BR, Greenamyre JT (2022) LRRK2 and idiopathic Parkinson\u2019s disease. Trends Neurosci 45:224\u2013236. https:\/\/doi.org\/10.1016\/j.tins.2021.12.002","journal-title":"Trends Neurosci"},{"key":"2897_CR69","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1002\/mds.23163","volume":"25","author":"OA Ross","year":"2010","unstructured":"Ross OA, Wilhoite GJ, Bacon JA, Soto-Ortolaza A, Kachergus J, Cobb SA, Puschmann A, Vilari\u00f1o-G\u00fcell C, Farrer MJ, Graff-Radford N (2010) LRRK2 variation and Parkinson\u2019s disease in African Americans. Mov Disord 25:1973\u20131976. https:\/\/doi.org\/10.1002\/mds.23163","journal-title":"Mov Disord"},{"key":"2897_CR70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249732","author":"Y Sawada","year":"2020","unstructured":"Sawada Y, Mashima E, Saito-Sasaki N, Nakamura M (2020) The role of cell adhesion molecule 1 (CADM1) in cutaneous malignancies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21249732","journal-title":"Int J Mol Sci"},{"key":"2897_CR71","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.parkreldis.2022.05.012","volume":"98","author":"C Simpson","year":"2022","unstructured":"Simpson C, Vinikoor-Imler L, Nassan FL, Shirvan J, Lally C, Dam T, Maserejian N (2022) Prevalence of ten LRRK2 variants in Parkinson\u2019s disease: a comprehensive review. Parkinsonism Relat Disord 98:103\u2013113. https:\/\/doi.org\/10.1016\/j.parkreldis.2022.05.012","journal-title":"Parkinsonism Relat Disord"},{"key":"2897_CR72","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s10038-025-01335-z","volume":"70","author":"S Sogabe","year":"2025","unstructured":"Sogabe S, Nakano H, Ogasahara Y, Cha PC, Ando Y, Taniguchi-Ikeda M, Matsumoto R, Kanagawa M, Kobayashi K, Murayama S al (2025) Regulation of MCCC1 expression by a parkinson\u2019s disease-associated intronic variant: implications for pathogenesis. J Hum Genet 70:371\u2013374. https:\/\/doi.org\/10.1038\/s10038-025-01335-z","journal-title":"J Hum Genet"},{"key":"2897_CR73","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"MG Spillantini","year":"1997","unstructured":"Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in lewy bodies. Nature 388:839\u2013840. https:\/\/doi.org\/10.1038\/42166","journal-title":"Nature"},{"key":"2897_CR74","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1038\/ng.2007.13","volume":"39","author":"P Sulem","year":"2007","unstructured":"Sulem P, Gudbjartsson DF, Stacey SN, Helgason A, Rafnar T, Magnusson KP, Manolescu A, Karason A, Palsson A, Thorleifsson G al (2007) Genetic determinants of hair, eye and skin pigmentation in Europeans. Nat Genet 39:1443\u20131452. https:\/\/doi.org\/10.1038\/ng.2007.13","journal-title":"Nat Genet"},{"key":"2897_CR75","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/7759053","volume":"2023","author":"A Szel\u0105gowski","year":"2023","unstructured":"Szel\u0105gowski A, Kozakiewicz M (2023) A glance at biogenesis and functionality of microRNAs and their role in the neuropathogenesis of Parkinson\u2019s disease. Oxid Med Cell Longev 2023:7759053. https:\/\/doi.org\/10.1155\/2023\/7759053","journal-title":"Oxid Med Cell Longev"},{"key":"2897_CR76","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1046\/j.1471-4159.2000.0741489.x","volume":"74","author":"T Takeuchi","year":"2000","unstructured":"Takeuchi T, Misaki A, Liang SB, Tachibana A, Hayashi N, Sonobe H, Ohtsuki Y (2000) Expression of T-cadherin (CDH13, H-cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells. J Neurochem 74:1489\u20131497. https:\/\/doi.org\/10.1046\/j.1471-4159.2000.0741489.x","journal-title":"J Neurochem"},{"key":"2897_CR77","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/mds.28342","volume":"36","author":"MMX Tan","year":"2021","unstructured":"Tan MMX, Lawton MA, Jabbari E, Reynolds RH, Iwaki H, Blauwendraat C, Kanavou S, Pollard MI, Hubbard L, Malek Net al et al (2021) Genome-Wide association studies of cognitive and motor progression in parkinson\u2019s disease. Mov Disord 36:424\u2013433. https:\/\/doi.org\/10.1002\/mds.28342","journal-title":"Mov Disord"},{"key":"2897_CR78","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1091\/mbc.e09-09-0801","volume":"21","author":"N Thayanidhi","year":"2010","unstructured":"Thayanidhi N, Helm JR, Nycz DC, Bentley M, Liang Y, Hay JC (2010) Alpha-synuclein delays Endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER\/Golgi snares. Mol Biol Cell 21:1850\u20131863. https:\/\/doi.org\/10.1091\/mbc.e09-09-0801","journal-title":"Mol Biol Cell"},{"key":"2897_CR79","doi-asserted-by":"publisher","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","volume":"45","author":"The UniProt Consortium","year":"2017","unstructured":"The UniProt Consortium (2017) UniProt: the universal protein knowledgebase. Nucleic Acids Res 45:D158\u2013d169. https:\/\/doi.org\/10.1093\/nar\/gkw1099","journal-title":"Nucleic Acids Res"},{"key":"2897_CR80","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1101\/gr.772403","volume":"13","author":"PD Thomas","year":"2003","unstructured":"Thomas PD, Campbell MJ, Kejariwal A, Mi H, Karlak B, Daverman R, Diemer K, Muruganujan A, Narechania A (2003) PANTHER: a library of protein families and subfamilies indexed by function. Genome Res 13:2129\u20132141. https:\/\/doi.org\/10.1101\/gr.772403","journal-title":"Genome Res"},{"key":"2897_CR81","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41582-019-0301-2","volume":"16","author":"E Tolosa","year":"2020","unstructured":"Tolosa E, Vila M, Klein C, Rascol O (2020) LRRK2 in Parkinson disease: challenges of clinical trials. Nat Rev Neurol 16:97\u2013107. https:\/\/doi.org\/10.1038\/s41582-019-0301-2","journal-title":"Nat Rev Neurol"},{"key":"2897_CR82","unstructured":"UniProt (2023) Q99962_SH3G2_HUMAN https:\/\/www.uniprot.org\/uniprotkb\/Q99962\/entry. Accessed Accessed on 11 November 2023"},{"key":"2897_CR83","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/hbm.24857","volume":"41","author":"AJM van Nuland","year":"2020","unstructured":"van Nuland AJM, den Ouden HEM, Zach H, Dirkx MFM, van Asten JJA, Scheenen TWJ, Toni I, Cools R, Helmich RC (2020) GABAergic changes in the thalamocortical circuit in parkinson\u2019s disease. Hum Brain Mapp 41:1017\u20131029. https:\/\/doi.org\/10.1002\/hbm.24857","journal-title":"Hum Brain Mapp"},{"key":"2897_CR84","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00384-6","volume":"15","author":"H Wang","year":"2020","unstructured":"Wang H, Dey KK, Chen P-C, Li Y, Niu M, Cho J-H, Wang X, Bai B, Jiao Y, Chepyala SR (2020) Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer\u2019s disease. Mol Neurodegener 15:43. https:\/\/doi.org\/10.1186\/s13024-020-00384-6","journal-title":"Mol Neurodegener"},{"key":"2897_CR85","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6621206","volume":"2021","author":"Q Wang","year":"2021","unstructured":"Wang Q, Wang Y, Zhou F, Li J, Lu G, Zhao Y (2021) Mir-20a-5p regulates MPP(+)-induced oxidative stress and neuroinflammation in HT22 cells by targeting IRF9\/NF-\u03baB axis. Evid Based Complement Alternat Med 2021:6621206. https:\/\/doi.org\/10.1155\/2021\/6621206","journal-title":"Evid Based Complement Alternat Med"},{"key":"2897_CR86","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.redox.2017.01.009","volume":"11","author":"Z Xu","year":"2017","unstructured":"Xu Z, Chu X, Jiang H, Schilling H, Chen S, Feng J (2017) Induced dopaminergic neurons: a new promise for parkinson\u2019s disease. Redox Biol 11:606\u2013612. https:\/\/doi.org\/10.1016\/j.redox.2017.01.009","journal-title":"Redox Biol"},{"key":"2897_CR87","doi-asserted-by":"publisher","first-page":"1570347","DOI":"10.3389\/fnagi.2025.1570347","volume":"17","author":"HL Xu","year":"2025","unstructured":"Xu HL, Yang Y, Chen LN, Li YJ, Cai GE, Wang YQ, Weng YH, Lin XL, Jian J, Chen XC al (2025) The impact of BST1 rs4698412 variant on parkinson\u2019s disease progression in a longitudinal study. Front Aging Neurosci 17:1570347. https:\/\/doi.org\/10.3389\/fnagi.2025.1570347","journal-title":"Front Aging Neurosci"},{"key":"2897_CR88","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13235978","author":"M Yal\u00e7in","year":"2021","unstructured":"Yal\u00e7in M, Malhan D, Basti A, Peralta AR, Ferreira JJ, Rel\u00f3gio A (2021) A computational analysis in a cohort of Parkinson\u2019s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13235978","journal-title":"Cancers (Basel)"},{"key":"2897_CR89","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neulet.2013.10.060","volume":"564","author":"D Zhai","year":"2014","unstructured":"Zhai D, Li S, Zhao Y, Lin Z (2014) SLC6A3 is a risk factor for parkinson\u2019s disease: a meta-analysis of sixteen years\u2019 studies. Neurosci Lett 564:99\u2013104. https:\/\/doi.org\/10.1016\/j.neulet.2013.10.060","journal-title":"Neurosci Lett"},{"key":"2897_CR90","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1809","volume":"12","author":"N Zhao","year":"2020","unstructured":"Zhao N, Attrebi ON, Ren Y, Qiao W, Sonustun B, Martens YA, Meneses AD, Li F, Shue F, Zheng J (2020) APOE4 exacerbates \u03b1-synuclein pathology and related toxicity independent of amyloid. Sci Transl Med 12:eaay1809. https:\/\/doi.org\/10.1126\/scitranslmed.aay1809","journal-title":"Sci Transl Med"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-025-02897-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-025-02897-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-025-02897-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T18:04:47Z","timestamp":1764180287000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13760-025-02897-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2897"],"URL":"https:\/\/doi.org\/10.1007\/s13760-025-02897-7","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"1 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All authors have given consent for the publication.\u00a0","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}