{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:35:13Z","timestamp":1793158513193,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neurol Belg"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s13760-026-03131-8","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:54:19Z","timestamp":1784084059000},"page":"1729-1734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subcortical shape alterations in spinocerebellar ataxia type 2: a longitudinal MRI-based analysis"],"prefix":"10.1007","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-7003","authenticated-orcid":false,"given":"Hatice","family":"Tataro\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130rem Ceren","family":"Ko\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00fctfi","family":"\u0130ncesu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"9","key":"3131_CR1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/acn3.437","volume":"4","author":"A Antenora","year":"2017","unstructured":"Antenora A, Rinaldi C, Roca A, Pane C, Lieto M, Sacc\u00e0 F et al (2017) The multiple faces of spinocerebellar ataxia type 2. Ann Clin Transl Neurol 4(9):687\u2013695","journal-title":"Ann Clin Transl Neurol"},{"key":"3131_CR2","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3389\/fneur.2017.00472","volume":"8","author":"LC Vel\u00e1zquez-P\u00e9rez","year":"2017","unstructured":"Vel\u00e1zquez-P\u00e9rez LC, Rodr\u00edguez-Labrada R, Fernandez-Ruiz J (2017) Spinocerebellar ataxia type 2: clinicogenetic aspects, mechanistic insights, and management approaches. Front Neurol 8:472","journal-title":"Front Neurol"},{"key":"3131_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.parkreldis.2017.06.010","volume":"42","author":"TL Monte","year":"2017","unstructured":"Monte TL, Pereira FS, Reckziegel EDR, Augustin MC, Locks-Coelho LD, Santos ASP et al (2017) Neurological phenotypes in spinocerebellar ataxia type 2: role of mitochondrial polymorphism A10398G and other risk factors. Parkinsonism Relat Disord 42:54\u201360","journal-title":"Parkinsonism Relat Disord"},{"key":"3131_CR4","doi-asserted-by":"publisher","first-page":"125273","DOI":"10.1155\/2015\/125273","volume":"2015","author":"H Park","year":"2015","unstructured":"Park H, Kim HJ, Jeon BS (2015) Parkinsonism in spinocerebellar ataxia. Biomed Res Int 2015:125273","journal-title":"Biomed Res Int"},{"issue":"2","key":"3131_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4103\/AOMD.AOMD_61_21","volume":"5","author":"DM Radhakrishnan","year":"2022","unstructured":"Radhakrishnan DM, Pillai KS, Das A, Rajan R, Srivastava AK (2022) Unraveling movement disorders in spinocerebellar ataxia. Ann Mov Disord 5(2):93\u2013105","journal-title":"Ann Mov Disord"},{"key":"3131_CR6","first-page":"682","volume":"9","author":"AT Meira","year":"2019","unstructured":"Meira AT, Arruda WO, Ono SE, Neto AC, Raskin S, Camargo CHF et al (2019) Neuroradiological findings in the spinocerebellar ataxias. Tremor Other Hyperkinet Mov (N Y) 9:682","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"issue":"9","key":"3131_CR7","doi-asserted-by":"publisher","first-page":"e01099","DOI":"10.1002\/brb3.1099","volume":"8","author":"Q Han","year":"2018","unstructured":"Han Q, Yang J, Xiong H, Shang H (2018) Voxel-based meta-analysis of gray and white matter volume abnormalities in spinocerebellar ataxia type 2. Brain Behav 8(9):e01099","journal-title":"Brain Behav"},{"issue":"7","key":"3131_CR8","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.parkreldis.2011.04.008","volume":"17","author":"G Goel","year":"2011","unstructured":"Goel G, Pal PK, Ravishankar S, Venkatasubramanian G, Jayakumar PN, Krishna N et al (2011) Gray matter volume deficits in spinocerebellar ataxia: an optimized voxel-based morphometric study. Parkinsonism Relat Disord 17(7):521\u2013527","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"3131_CR9","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1007\/s11547-024-01839-2","volume":"129","author":"M Grisoli","year":"2024","unstructured":"Grisoli M, Nigri A, Medina Carrion JP, Palermo S, Demichelis G, Giacosa C et al (2024) Tracking longitudinal thalamic volume changes during early stages of SCA1 and SCA2. Radiol Med 129(8):1215\u20131223","journal-title":"Radiol Med"},{"issue":"10","key":"3131_CR10","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1007\/s00415-016-8236-7","volume":"263","author":"DF Tate","year":"2016","unstructured":"Tate DF, Wade BS, Velez CS, Drennon AM, Bolzenius J, Gutman BA et al (2016) Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury. J Neurol 263(10):2065\u20132079","journal-title":"J Neurol"},{"issue":"12","key":"3131_CR11","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.3174\/ajnr.A4055","volume":"35","author":"E Mak","year":"2014","unstructured":"Mak E, Bergsland N, Dwyer MG, Zivadinov R, Kandiah N (2014) Subcortical atrophy is associated with cognitive impairment in mild Parkinson disease: a combined investigation of volumetric changes, cortical thickness, and vertex-based shape analysis. AJNR Am J Neuroradiol 35(12):2257\u20132264","journal-title":"AJNR Am J Neuroradiol"},{"key":"3131_CR12","doi-asserted-by":"publisher","first-page":"778807","DOI":"10.3389\/fnhum.2021.778807","volume":"15","author":"W Gu","year":"2021","unstructured":"Gu W, He R, Su H, Ren Z, Zhang L, Yuan H et al (2021) Changes in the shape and volume of subcortical structures in patients with end-stage renal disease. Front Hum Neurosci 15:778807","journal-title":"Front Hum Neurosci"},{"issue":"9","key":"3131_CR13","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1002\/hbm.25804","volume":"43","author":"Z Wang","year":"2022","unstructured":"Wang Z, Rodriguez-Moreno DV, Cycowicz YM, Amsel LV, Cheslack-Postava K, He X et al (2022) Shapes of subcortical structures in adolescents with and without familial history of substance use disorder. Hum Brain Mapp 43(9):2759\u20132770","journal-title":"Hum Brain Mapp"},{"key":"3131_CR14","doi-asserted-by":"publisher","first-page":"117209","DOI":"10.1016\/j.neuroimage.2020.117209","volume":"222","author":"L Ferrando","year":"2020","unstructured":"Ferrando L, Ventura-Campos N, Epifanio I (2020) Detecting and visualizing differences in brain structures with SPHARM and functional data analysis. NeuroImage 222:117209","journal-title":"NeuroImage"},{"key":"3131_CR15","unstructured":"Mascalchi M (2018) SCA2 Diffusion Tensor Imaging. OpenNeuro"},{"issue":"3","key":"3131_CR16","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.neuroimage.2011.02.046","volume":"56","author":"B Patenaude","year":"2011","unstructured":"Patenaude B, Smith SM, Kennedy DN, Jenkinson M (2011) A Bayesian model of shape and appearance for subcortical brain segmentation. NeuroImage 56(3):907\u2013922","journal-title":"NeuroImage"},{"key":"3131_CR17","first-page":"119384","volume":"258","author":"B Billot","year":"2023","unstructured":"Billot B, Greve DN, Puonti O, Thielscher A, Van Leemput K, Fischl B et al (2023) SynthSeg: segmentation of brain MRI scans of any contrast and resolution without retraining. NeuroImage 258:119384","journal-title":"NeuroImage"},{"key":"3131_CR18","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","volume":"92","author":"AM Winkler","year":"2014","unstructured":"Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE (2014) Permutation inference for the general linear model. NeuroImage 92:381\u2013397","journal-title":"NeuroImage"},{"key":"3131_CR19","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3389\/fnsys.2015.00140","volume":"9","author":"JS Provost","year":"2015","unstructured":"Provost JS, Hanganu A, Monchi O (2015) Neuroimaging studies of the striatum in cognition. Part I: healthy individuals. Front Syst Neurosci 9:140","journal-title":"Front Syst Neurosci"},{"key":"3131_CR20","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3389\/fnhum.2018.00250","volume":"12","author":"SC Goodroe","year":"2018","unstructured":"Goodroe SC, Starnes J, Brown TI (2018) The complex nature of hippocampal\u2013striatal interactions in spatial navigation. Front Hum Neurosci 12:250","journal-title":"Front Hum Neurosci"},{"issue":"8","key":"3131_CR21","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.3174\/ajnr.A4760","volume":"37","author":"A Klaes","year":"2016","unstructured":"Klaes A, Reckziegel E, Franca MC Jr, Rezende TJ, Vedolin LM, Jardim LB et al (2016) MR imaging in spinocerebellar ataxias: a systematic review. AJNR Am J Neuroradiol 37(8):1405\u20131412","journal-title":"AJNR Am J Neuroradiol"},{"issue":"5","key":"3131_CR22","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.4103\/0028-3886.329596","volume":"69","author":"D Tamuli","year":"2021","unstructured":"Tamuli D, Kaur M, Sethi T, Singh A, Faruq M, Jaryal AK et al (2021) Cortical and subcortical brain area atrophy in SCA1 and SCA2 patients in India: structural MRI underpinnings and correlative insight among the atrophy and disease attributes. Neurol India 69(5):1318\u20131325","journal-title":"Neurol India"},{"issue":"8","key":"3131_CR23","first-page":"576","volume":"31","author":"B Genc","year":"2024","unstructured":"Genc B, Sen S, Aslan K (2024) Brain volumetric changes in patients with spinocerebellar ataxia type-2. Ann Med Res 31(8):576\u2013581","journal-title":"Ann Med Res"}],"container-title":["Acta Neurologica Belgica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-026-03131-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-026-03131-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13760-026-03131-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:00:02Z","timestamp":1793156402000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13760-026-03131-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["3131"],"URL":"https:\/\/doi.org\/10.1007\/s13760-026-03131-8","relation":{},"ISSN":["0300-9009","2240-2993"],"issn-type":[{"value":"0300-9009","type":"print"},{"value":"2240-2993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"8 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study used publicly available, fully anonymized data obtained from the OpenNeuro repository. Ethical approval and informed consent were obtained by the original investigators at the time of data collection. Therefore, no additional ethical approval was required for this secondary analysis.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}