{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:59:57Z","timestamp":1767142797778,"version":"build-2238731810"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2017R1E1A1A01073021"],"award-info":[{"award-number":["NRF-2017R1E1A1A01073021"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C2392"],"award-info":[{"award-number":["HI18C2392"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s13770-020-00307-y","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T12:02:55Z","timestamp":1603886575000},"page":"253-264","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells"],"prefix":"10.1007","volume":"18","author":[{"given":"Hee-Yeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younghay","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Soo","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong-A","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Youn","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Chul","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inho","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Jae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9765-0477","authenticated-orcid":false,"given":"Joo-Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Ha","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"307_CR1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.biopha.2018.03.078","volume":"102","author":"S Patel","year":"2018","unstructured":"Patel S, Homaei A, Raju AB, Meher BR. Estrogen: the necessary evil for human health, and ways to tame it. Biomed Pharmacother. 2018;102:403\u201311.","journal-title":"Biomed Pharmacother"},{"key":"307_CR2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00223-001-1044-8","volume":"69","author":"S Khosla","year":"2001","unstructured":"Khosla S, Melton LJ 3rd, Riggs BL. Estrogens and bone health in men. Calcif Tissue Int. 2001;69:189\u201392.","journal-title":"Calcif Tissue Int"},{"key":"307_CR3","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1159\/000343074","volume":"35","author":"SC Janicki","year":"2013","unstructured":"Janicki SC, Park N, Cheng R, Schupf N, Clark LN, Lee JH. Aromatase variants modify risk for Alzheimer's disease in a multiethnic female cohort. Dement Geriatr Cogn Disord. 2013;35:340\u20136.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"307_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.tem.2010.10.002","volume":"22","author":"F Mauvais-Jarvis","year":"2011","unstructured":"Mauvais-Jarvis F. Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity. Trends Endocrinol Metab. 2011;22:24\u201333.","journal-title":"Trends Endocrinol Metab"},{"key":"307_CR5","doi-asserted-by":"publisher","first-page":"757461","DOI":"10.1155\/2014\/757461","volume":"2014","author":"F Lizcano","year":"2014","unstructured":"Lizcano F, Guzm\u00e1n G. Estrogen deficiency and the origin of obesity during menopause. Biomed Res Int. 2014;2014:757461.","journal-title":"Biomed Res Int"},{"key":"307_CR6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/aje\/kwk015","volume":"165","author":"SH Olson","year":"2007","unstructured":"Olson SH, Bandera EV, Orlow I. Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review. Am J Epidemiol. 2007;165:235\u201345.","journal-title":"Am J Epidemiol"},{"key":"307_CR7","doi-asserted-by":"publisher","first-page":"e00191","DOI":"10.1042\/BSR20150025","volume":"35","author":"I Ullah","year":"2015","unstructured":"Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells\u2014current trends and future prospective. Biosci Rep. 2015;35:e00191.","journal-title":"Biosci Rep."},{"key":"307_CR8","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/stem.3058","volume":"37","author":"SY Oh","year":"2019","unstructured":"Oh SY, Choi YM, Kim HY, Park YS, Jung SC, Park JW, et al. Application of tonsil-derived mesenchymal stem cells in tissue regeneration: concise review. Stem Cells. 2019;37:1252\u201360.","journal-title":"Stem Cells"},{"key":"307_CR9","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3109\/14653249.2012.706708","volume":"14","author":"KH Ryu","year":"2012","unstructured":"Ryu KH, Cho KA, Park HS, Kim JY, Woo SY, Jo I, et al. Tonsil-derived mesenchymal stromal cells: evaluation of biologic, immunologic and genetic factors for successful banking. Cytotherapy. 2012;14:1193\u2013202.","journal-title":"Cytotherapy"},{"key":"307_CR10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.diff.2015.08.001","volume":"90","author":"SY Kim","year":"2015","unstructured":"Kim SY, Kim YR, Park WJ, Kim HS, Jung SC, Woo SY, et al. Characterisation of insulin-producing cells differentiated from tonsil derived mesenchymal stem cells. Differentiation. 2015;90:27\u201339.","journal-title":"Differentiation"},{"key":"307_CR11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.yexcr.2014.06.007","volume":"326","author":"KH Ryu","year":"2014","unstructured":"Ryu KH, Kim SY, Kim YR, Woo SY, Sung SH, Kim HS, et al. Tonsil-derived mesenchymal stem cells alleviate concanavalin A-induced acute liver injury. Exp Cell Res. 2014;326:143\u201354.","journal-title":"Exp Cell Res"},{"key":"307_CR12","first-page":"609","volume":"19","author":"KA Cho","year":"2019","unstructured":"Cho KA, Kim YH, Park M, Kim HJ, Woo SY, Park JW, et al. Conditioned medium from human palatine tonsil mesenchymal stem cells attenuates acute graft vs. host disease in mice. Mol Med Rep. 2019;19:609\u201316.","journal-title":"Mol Med Rep."},{"key":"307_CR13","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3390\/cells8040368","volume":"8","author":"Y Lee","year":"2019","unstructured":"Lee Y, Shin SH, Cho KA, Kim YH, Woo SY, Kim HS, et al. Administration of tonsil-derived mesenchymal stem cells improves glucose tolerance in high fat diet-induced diabetic mice via insulin-like growth factor-binding protein 5-mediated endoplasmic reticulum stress modulation. Cells. 2019;8:368.","journal-title":"Cells"},{"key":"307_CR14","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.jcyt.2018.06.008","volume":"20","author":"G Kim","year":"2018","unstructured":"Kim G, Jin YM, Yu Y, Kim HY, Jo SA, Park YJ, et al. Double intratibial injection of human tonsil-derived mesenchymal stromal cells recovers postmenopausal osteoporotic bone mass. Cytotherapy. 2018;20:1013\u201327.","journal-title":"Cytotherapy"},{"key":"307_CR15","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.biomaterials.2015.06.044","volume":"65","author":"YS Park","year":"2015","unstructured":"Park YS, Kim HS, Jin YM, Yu Y, Kim HY, Park HS, et al. Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy. Biomaterials. 2015;65:140\u201352.","journal-title":"Biomaterials"},{"key":"307_CR16","first-page":"301540","volume":"2013","author":"D Zhang","year":"2013","unstructured":"Zhang D, Yang B, Zou W, Lu X, Xiong M, Wu L, et al. Estradiol synthesis and release in cultured female rat bone marrow stem cells. Biomed Res Int. 2013;2013:301540.","journal-title":"Biomed Res Int"},{"key":"307_CR17","doi-asserted-by":"publisher","first-page":"15286","DOI":"10.1038\/srep15286","volume":"5","author":"J Li","year":"2015","unstructured":"Li J, Peng X, Zeng X, Liu B, Hao Q, Yu X, et al. Estrogen secreted by mesenchymal stem cells necessarily determines their feasibility of therapeutical application. Sci Rep. 2015;5:15286.","journal-title":"Sci Rep"},{"key":"307_CR18","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45.","journal-title":"Nucleic Acids Res"},{"key":"307_CR19","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1210\/jc.2012-4302","volume":"98","author":"CW Lan","year":"2013","unstructured":"Lan CW, Chen MJ, Jan PS, Chen HF, Ho HN. Differentiation of human embryonic stem cells into functional ovarian granulosa-like cells. J Clin Endocrinol Metab. 2013;98:3713\u201323.","journal-title":"J Clin Endocrinol Metab"},{"key":"307_CR20","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s00109-016-1396-1","volume":"94","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Zeng C, Li X, Wu PL, Yin L, Yu XL, et al. IGF-I stimulates ERbeta and aromatase expression via IGF1R\/PI3K\/AKT-mediated transcriptional activation in endometriosis. J Mol Med (Berl). 2016;94:887\u201397.","journal-title":"J Mol Med (Berl)"},{"key":"307_CR21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.rvsc.2016.08.012","volume":"108","author":"SR Mishra","year":"2016","unstructured":"Mishra SR, Thakur N, Somal A, Parmar MS, Reshma R, Rajesh G, et al. Expression and localization of fibroblast growth factor (FGF) family in buffalo ovarian follicle during different stages of development and modulatory role of FGF2 on steroidogenesis and survival of cultured buffalo granulosa cells. Res Vet Sci. 2016;108:98\u2013111.","journal-title":"Res Vet Sci"},{"key":"307_CR22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1530\/EC-16-0099","volume":"6","author":"M Watanabe","year":"2017","unstructured":"Watanabe M, Ohno S, Wachi H. Effect of beta-agonist on the dexamethasone-induced expression of aromatase by the human monocyte cells. Endocr Connect. 2017;6:82\u20138.","journal-title":"Endocr Connect"},{"key":"307_CR23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1477-7827-7-37","volume":"7","author":"H Zhao","year":"2009","unstructured":"Zhao H, Innes J, Brooks DC, Reierstad S, Yilmaz MB, Lin Z, et al. A novel promoter controls Cyp19a1 gene expression in mouse adipose tissue. Reprod Biol Endocrinol. 2009;7:37.","journal-title":"Reprod Biol Endocrinol"},{"key":"307_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.biochi.2018.02.010","volume":"148","author":"AA Hudon Thibeault","year":"2018","unstructured":"Hudon Thibeault AA, Vaillancourt C, Sanderson JT. Profile of CYP19A1 mRNA expression and aromatase activity during syncytialization of primary human villous trophoblast cells at term. Biochimie. 2018;148:12\u20137.","journal-title":"Biochimie"},{"key":"307_CR25","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/S0960-0760(03)00357-1","volume":"86","author":"T Nakata","year":"2003","unstructured":"Nakata T, Takashima S, Shiotsu Y, Murakata C, Ishida H, Akinaga S, et al. Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients. J Steroid Biochem Mol Biol. 2003;86:455\u201360.","journal-title":"J Steroid Biochem Mol Biol."},{"key":"307_CR26","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3389\/fphar.2017.00368","volume":"8","author":"M Sinreih","year":"2017","unstructured":"Sinreih M, Knific T, Anko M, Hevir N, Vouk K, Jerin A, et al. The significance of the sulfatase pathway for local estrogen formation in endometrial cancer. Front Pharmacol. 2017;8:368.","journal-title":"Front Pharmacol"},{"key":"307_CR27","first-page":"2577","volume":"126","author":"V Pesiri","year":"2013","unstructured":"Pesiri V, La Rosa P, Stano P, Acconcia F. Identification of an estrogen receptor alpha non covalent ubiquitin-binding surface: role in 17beta-estradiol-induced transcriptional activity. J Cell Sci. 2013;126:2577\u201382.","journal-title":"J Cell Sci"},{"key":"307_CR28","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1172\/JCI125755","volume":"129","author":"SR Hammes","year":"2019","unstructured":"Hammes SR, Levin ER. Impact of estrogens in males and androgens in females. J Clin Invest. 2019;129:1818\u201326.","journal-title":"J Clin Invest"},{"key":"307_CR29","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1172\/JCI28550","volume":"116","author":"MN Weitzmann","year":"2006","unstructured":"Weitzmann MN, Pacifici R. Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest. 2006;116:1186\u201394.","journal-title":"J Clin Invest"},{"key":"307_CR30","doi-asserted-by":"publisher","first-page":"19198","DOI":"10.1073\/pnas.0505203102","volume":"102","author":"X Yue","year":"2005","unstructured":"Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, et al. Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. Proc Natl Acad Sci U S A. 2005;102:19198\u2013203.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"307_CR31","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.4103\/2230-8210.119504","volume":"17","author":"VP Jyotsna","year":"2013","unstructured":"Jyotsna VP. Postmenopausal hormonal therapy: current status. Indian J Endocrinol Metab. 2013;17:S45\u20139.","journal-title":"Indian J Endocrinol Metab"},{"key":"307_CR32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.steroids.2011.10.013","volume":"77","author":"C Stocco","year":"2012","unstructured":"Stocco C. Tissue physiology and pathology of aromatase. Steroids. 2012;77:27\u201335.","journal-title":"Steroids"},{"key":"307_CR33","doi-asserted-by":"publisher","first-page":"477","DOI":"10.4142\/jvs.2018.19.4.477","volume":"19","author":"CJ Park","year":"2018","unstructured":"Park CJ, Kim H, Jin J, Barakat R, Lin PC, Choi JM, et al. Porcine intestinal lymphoid tissues synthesize estradiol. J Vet Sci. 2018;19:477\u201382.","journal-title":"J Vet Sci"},{"key":"307_CR34","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1210\/endo.142.8.8322","volume":"142","author":"TS Samy","year":"2001","unstructured":"Samy TS, Kn\u00f6ferl MW, Zheng R, Schwacha MG, Bland KI, Chaudry IH. Divergent immune responses in male and female mice after trauma-hemorrhage: dimorphic alterations in T lymphocyte steroidogenic enzyme activities. Endocrinology. 2001;142:3519\u201329.","journal-title":"Endocrinology"},{"key":"307_CR35","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/0194599818801757","volume":"160","author":"RB Mitchell","year":"2019","unstructured":"Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, et al. Clinical practice guideline: tonsillectomy in children (update). Otolaryngol Head Neck Surg. 2019;160:S1\u201342.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"307_CR36","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/joa.12229","volume":"225","author":"Y Yu","year":"2014","unstructured":"Yu Y, Park YS, Kim HS, Kim HY, Jin YM, Jung SC, et al. Characterization of long-term in vitro culture-related alterations of human tonsil-derived mesenchymal stem cells: role for CCN1 in replicative senescence-associated increase in osteogenic differentiation. J Anat. 2014;225:510\u20138.","journal-title":"J Anat"},{"key":"307_CR37","first-page":"10009","volume":"10","author":"C Chu","year":"2017","unstructured":"Chu C, Zhao C, Zhang Z, Wang M, Zhang Z, Yang A, et al. Transcriptome analysis of primary aldosteronism in adrenal glands and controls. Int J Clin Exp Pathol. 2017;10:10009\u201318.","journal-title":"Int J Clin Exp Pathol"},{"key":"307_CR38","doi-asserted-by":"publisher","first-page":"44184","DOI":"10.1038\/srep44184","volume":"7","author":"M Ben Maamar","year":"2017","unstructured":"Ben Maamar M, Lesn\u00e9 L, Hennig K, Desdoits-Lethimonier C, Kilcoyne KR, Coiffec I, et al. Ibuprofen results in alterations of human fetal testis development. Sci Rep. 2017;7:44184.","journal-title":"Sci Rep"},{"key":"307_CR39","doi-asserted-by":"publisher","first-page":"19623","DOI":"10.18632\/oncotarget.24714","volume":"9","author":"N Nesheim","year":"2018","unstructured":"Nesheim N, Ellem S, Dansranjavin T, Hagenk\u00f6tter C, Berg E, Schambeck R, et al. Elevated seminal plasma estradiol and epigenetic inactivation of ESR1 and ESR2 is associated with CP\/CPPS. Oncotarget. 2018;9:19623\u201339.","journal-title":"Oncotarget"},{"key":"307_CR40","doi-asserted-by":"publisher","first-page":"6283","DOI":"10.1210\/jc.2005-0915","volume":"90","author":"F Hammer","year":"2005","unstructured":"Hammer F, Drescher DG, Schneider SB, Quinkler M, Stewart PM, Allolio B, et al. Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging. J Clin Endocrinol Metab. 2005;90:6283\u20139.","journal-title":"J Clin Endocrinol Metab"}],"updated-by":[{"DOI":"10.1007\/s13770-020-00320-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000}}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-020-00307-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-020-00307-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-020-00307-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T21:24:24Z","timestamp":1627680264000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-020-00307-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["307"],"URL":"https:\/\/doi.org\/10.1007\/s13770-020-00307-y","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"29 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2021","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s13770-020-00320-1","URL":"https:\/\/doi.org\/10.1007\/s13770-020-00320-1","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declares that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental procedures were approved by the Institutional Review Board of Ewha Womans University Mokdong Hospital (Seoul, South Korea, ECT-11-53-02).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}