{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:58:01Z","timestamp":1774508281382,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017M3A9E2060428"],"award-info":[{"award-number":["2017M3A9E2060428"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003662","name":"Korea Evaluation Institute of Industrial Technology","doi-asserted-by":"publisher","award":["10062127"],"award-info":[{"award-number":["10062127"]}],"id":[{"id":"10.13039\/501100003662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s13770-020-00308-x","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T18:02:50Z","timestamp":1611943370000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Nitric Oxide Produced by the Antioxidant Activity of Verapamil Improves the Acute Wound Healing Process"],"prefix":"10.1007","volume":"18","author":[{"given":"Yu Na","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang Youn","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk-Ho","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-8059","authenticated-orcid":false,"given":"Jong Won","family":"Rhie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"308_CR1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1751-7176.2011.00513.x","volume":"13","author":"WJ Elliott","year":"2011","unstructured":"Elliott WJ, Ram CV. Calcium channel blockers. J Clin Hypertens (Greenwich). 2011;13:687\u20139.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"308_CR2","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","volume":"42","author":"AV Chobanian","year":"2003","unstructured":"Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42:1206\u201352.","journal-title":"Hypertension"},{"key":"308_CR3","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1089\/acu.2010.0761","volume":"22","author":"N Joshi","year":"2010","unstructured":"Joshi N, Araque H. Blockade of calcium channels by electroacupuncture for hypertension treatment. Med Acupunct. 2010;22:243\u20137.","journal-title":"Med Acupunct"},{"key":"308_CR4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/00004630-199611000-00005","volume":"17","author":"H Doong","year":"1996","unstructured":"Doong H, Dissanayake S, Gowrishankar TR, LaBarbera MC, Lee RC. The 1996 Lindberg Award. Calcium antagonists alter cell shape and induce procollagenase synthesis in keloid and normal human dermal fibroblasts. J Burn Care Rehabil. 1996;17:497\u2013514.","journal-title":"J Burn Care Rehabil"},{"key":"308_CR5","first-page":"107","volume":"129","author":"RC Lee","year":"1994","unstructured":"Lee RC, Doong H, Jellema AF. The response of burn scars to intralesional verapamil. Rep Five Cases Arch Surg. 1994;129:107\u201311.","journal-title":"Rep Five Cases Arch Surg"},{"key":"308_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/0022-4804(90)90197-A","volume":"49","author":"RC Lee","year":"1990","unstructured":"Lee RC, Ping JA. Calcium antagonists retard extracellular matrix production in connective tissue equivalent. J Surg Res. 1990;49:463\u20136.","journal-title":"J Surg Res"},{"key":"308_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1089\/wound.2018.0798","volume":"8","author":"S Srivastava","year":"2019","unstructured":"Srivastava S, Kumari H, Singh A. Comparison of fractional co2 laser, verapamil, and triamcinolone for the treatment of keloid. Adv Wound Care (New Rochelle). 2019;8:7\u201313.","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"308_CR8","doi-asserted-by":"publisher","first-page":"620","DOI":"10.5999\/aps.2014.41.6.620","volume":"41","author":"A Trisliana Perdanasari","year":"2014","unstructured":"Trisliana Perdanasari A, Lazzeri D, Su W, Xi W, Zheng Z, Ke L, et al. Recent developments in the use of intralesional injections keloid treatment. Arch Plast Surg. 2014;41:620\u20139.","journal-title":"Arch Plast Surg"},{"key":"308_CR9","first-page":"375","volume":"31","author":"YO Kim","year":"2004","unstructured":"Kim YO, Kim SM, Jo NH, Nam TS. The effect of simultaneous steroid and verapamil injection on scar formation in the incisional wound of rat. J Korean Soc Plast Reconstr Surg. 2004;31:375\u201384.","journal-title":"J Korean Soc Plast Reconstr Surg"},{"key":"308_CR10","first-page":"1198","volume":"21","author":"H Mojiri-Forushani","year":"2018","unstructured":"Mojiri-Forushani H. The role of calcium channel blockers in wound healing. Iran J Basic Med Sci. 2018;21:1198\u20139.","journal-title":"Iran J Basic Med Sci"},{"key":"308_CR11","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1016\/j.jss.2011.02.039","volume":"169","author":"M Bagheri","year":"2011","unstructured":"Bagheri M, Jahromi BM, Mirkhani H, Solhjou Z, Noorafshan A, Zamani A, et al. Azelnidipine, a new calcium channel blocker, promotes skin wound healing in diabetic rats. J Surg Res. 2011;169:e101\u20137.","journal-title":"J Surg Res"},{"key":"308_CR12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/01.ASW.0000488666.03896.e6","volume":"29","author":"S Ashkani-Esfahani","year":"2016","unstructured":"Ashkani-Esfahani S, Hosseinabadi OK, Moezzi P, Moafpourian Y, Kardeh S, Rafiee S, et al. Verapamil, a calcium-channel blocker, improves the wound healing process in rats with excisional full-thickness skin wounds based on stereological parameters. Adv Skin Wound Care. 2016;29:271\u20134.","journal-title":"Adv Skin Wound Care"},{"key":"308_CR13","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1016\/0024-3205(95)02163-D","volume":"57","author":"Y Hattori","year":"1995","unstructured":"Hattori Y, Kasai K, So S, Hattori S, Banba N, Shimoda S. Effects of calcium channel antagonists on the induction of nitric oxide synthase in cultured cells by immunostimulants. Life Sci. 1995;57:1833\u201340.","journal-title":"Life Sci"},{"key":"308_CR14","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/01.fjc.0000205497.90765.b0","volume":"47","author":"J Ma","year":"2006","unstructured":"Ma J, Kishida S, Wang GQ, Meguro K, Imuta H, Oonuma H, et al. Comparative effects of azelnidipine and other Ca2+-channel blockers on the induction of inducible nitric oxide synthase in vascular smooth muscle cells. J Cardiovasc Pharmacol. 2006;47:314\u201321.","journal-title":"J Cardiovasc Pharmacol"},{"key":"308_CR15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s10856-019-6319-6","volume":"30","author":"S Nour","year":"2019","unstructured":"Nour S, Baheiraei N, Imani R, Khodaei M, Alizadeh A, Rabiee N, et al. A review of accelerated wound healing approaches: biomaterial-assisted tissue remodeling. J Mater Sci Mater Med. 2019;30:120.","journal-title":"J Mater Sci Mater Med"},{"key":"308_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.clindermatol.2006.09.007","volume":"25","author":"J Li","year":"2007","unstructured":"Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol. 2007;25:9\u201318.","journal-title":"Clin Dermatol"},{"key":"308_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1089-8603(02)00002-2","volume":"7","author":"A Schwentker","year":"2002","unstructured":"Schwentker A, Vodovotz Y, Weller R, Billiar TR. Nitric oxide and wound repair: role of cytokines? Nitric Oxide. 2002;7:1\u201310.","journal-title":"Nitric Oxide"},{"key":"308_CR18","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1046\/j.1523-1755.2002.00237.x","volume":"61","author":"S Frank","year":"2002","unstructured":"Frank S, Kampfer H, Wetzler C, Pfeilschifter J. Nitric oxide drives skin repair: novel functions of an established mediator. Kidney Int. 2002;61:882\u20138.","journal-title":"Kidney Int"},{"key":"308_CR19","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1097\/SAP.0b013e318172ba1f","volume":"61","author":"X Yan","year":"2008","unstructured":"Yan X, Zeng B, Chai Y, Luo C, Li X. Improvement of blood flow, expression of nitric oxide, and vascular endothelial growth factor by low-energy shockwave therapy in random-pattern skin flap model. Ann Plast Surg. 2008;61:646\u201353.","journal-title":"Ann Plast Surg"},{"key":"308_CR20","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.4049\/jimmunol.158.5.2375","volume":"158","author":"MR Sch\u00e4ffer","year":"1997","unstructured":"Sch\u00e4ffer MR, Efron PA, Thornton FJ, Klingel K, Gross SS, Barbul A. Nitric oxide, an autocrine regulator of wound fibroblast synthetic function. J Immunol. 1997;158:2375\u201381.","journal-title":"J Immunol"},{"key":"308_CR21","first-page":"H1600","volume":"277","author":"PC Lee","year":"1999","unstructured":"Lee PC, Salyapongse AN, Bragdon GA, Shears LL 2nd, Watkins SC, Edington HD, et al. Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol. 1999;277:H1600\u20138.","journal-title":"Am J Physiol"},{"key":"308_CR22","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/0022034509359125","volume":"89","author":"S Guo","year":"2010","unstructured":"Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89:219\u201329.","journal-title":"J Dent Res"},{"key":"308_CR23","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/PRS.0000000000001889","volume":"137","author":"EY Rha","year":"2016","unstructured":"Rha EY, Kim YH, Kim TJ, Yoo G, Rhie JW, Kim HJ, et al. Topical application of a silicone gel sheet with verapamil microparticles in a rabbit model of hypertrophic scar. Plast Reconstr Surg. 2016;137:144\u201351.","journal-title":"Plast Reconstr Surg"},{"key":"308_CR24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0009-8981(02)00167-5","volume":"322","author":"K Kedziora-Kornatowska","year":"2002","unstructured":"Kedziora-Kornatowska K, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kedziora J, Bartosz G. The effect of verapamil on the antioxidant defence system in diabetic kidney. Clin Chim Acta. 2002;322:105\u201312.","journal-title":"Clin Chim Acta"},{"key":"308_CR25","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/S0002-9610(02)00815-2","volume":"183","author":"MB Witte","year":"2002","unstructured":"Witte MB, Barbul A. Role of nitric oxide in wound repair. Am J Surg. 2002;183:406\u201312.","journal-title":"Am J Surg"},{"key":"308_CR26","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1161\/01.CIR.0000137969.87365.05","volume":"110","author":"JD Luo","year":"2004","unstructured":"Luo JD, Wang YY, Fu WL, Wu J, Chen AF. Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation. 2004;110:2484\u201393.","journal-title":"Circulation"},{"key":"308_CR27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/00000637-199501000-00003","volume":"34","author":"PA Clugston","year":"1995","unstructured":"Clugston PA, Vistnes MD, Perry LC, Maxwell GP, Fisher J. Evaluation of silicone-gel sheeting on early wound healing of linear incisions. Ann Plast Surg. 1995;34:12\u20135.","journal-title":"Ann Plast Surg"},{"key":"308_CR28","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.addr.2014.11.015","volume":"84","author":"D Docheva","year":"2015","unstructured":"Docheva D, M\u00fcller SA, Majewski M, Evans CH. Biologics for tendon repair. Adv Drug Deliv Rev. 2015;84:222\u201339.","journal-title":"Adv Drug Deliv Rev"},{"key":"308_CR29","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.phrs.2008.06.004","volume":"58","author":"M Sch\u00e4fer","year":"2008","unstructured":"Sch\u00e4fer M, Werner S. Oxidative stress in normal and impaired wound repair. Pharmacol Res. 2008;58:165\u201371.","journal-title":"Pharmacol Res"},{"key":"308_CR30","first-page":"205","volume":"144","author":"S Gay","year":"1978","unstructured":"Gay S, Vijanto J, Raekallio J, Penttinen R. Collagen types in early phases of wound healing in children. Acta Chir Scand. 1978;144:205\u201311.","journal-title":"Acta Chir Scand"},{"key":"308_CR31","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","volume":"16","author":"S Barrientos","year":"2008","unstructured":"Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16:585\u2013601.","journal-title":"Wound Repair Regen"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-020-00308-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13770-020-00308-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-020-00308-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T17:32:10Z","timestamp":1697736730000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13770-020-00308-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,29]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["308"],"URL":"https:\/\/doi.org\/10.1007\/s13770-020-00308-x","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,29]]},"assertion":[{"value":"22 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no financial conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal studies were performed after receiving approval of the Institutional Animal Care and Use Committee (IACUC) in Catholic University (IACUC approval No. CUMC-2018\u20130067-02).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}