{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:49:44Z","timestamp":1792453784373,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s13770-021-00337-0","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T10:03:10Z","timestamp":1624874590000},"page":"663-670","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Intra-Articular Atelocollagen Injection for the Treatment of Articular Cartilage Defects in Rabbit Model"],"prefix":"10.1007","volume":"18","author":[{"given":"Dong Sam","family":"Suh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Chul","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hun","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"337_CR1","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/bip.20871","volume":"89","author":"J Glowacki","year":"2008","unstructured":"Glowacki J, Mizuno S. Collagen scaffolds for tissue engineering. Biopolymers. 2008;89:338\u201344.","journal-title":"Biopolymers"},{"key":"337_CR2","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.cpm.2009.08.001","volume":"26","author":"KG Cornwell","year":"2009","unstructured":"Cornwell KG, Landsman A, James KS. Extracellular matrix biomaterials for soft tissue repair. Clin Podiatr Med Surg. 2009;26:507\u201323.","journal-title":"Clin Podiatr Med Surg"},{"key":"337_CR3","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1007\/s00270-011-0218-7","volume":"35","author":"RJ Owen","year":"2012","unstructured":"Owen RJ, Nation PN, Polakowski R, Biliske JA, Tiege PB, Griffith IJ. A preclinical study of the safety and efficacy of occlusin 500 artificial embolization device in sheep. Cardiovasc Intervent Radiol. 2012;35:636\u201344.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"337_CR4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.22203\/eCM.v009a09","volume":"9","author":"LC Hughes","year":"2005","unstructured":"Hughes LC, Archer CW, ap Gwynn I. The ultrastructure of mouse articular cartilage: collagen orientation and implications for tissue functionality. A polarised light and scanning electron microscope Studt and review. Eur Cell Mater. 2005;9:68\u201384.","journal-title":"Eur Cell Mater"},{"key":"337_CR5","first-page":"113","volume":"138","author":"CA Poole","year":"1984","unstructured":"Poole CA, Flint MH, Beaumont BW. Morphological and functional interrelationships of articular cartilage matrices. J Anat. 1984;138:113\u201338.","journal-title":"J Anat"},{"key":"337_CR6","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1177\/1941738109350438","volume":"1","author":"AJ Sophia Fox","year":"2009","unstructured":"Sophia Fox AJ, Bedi A, Rodeo SA. The basic science of articular cartilage: structure, composition, and function. Sports Health. 2009;1:461\u20138.","journal-title":"Sports Health"},{"key":"337_CR7","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.joca.2013.04.021","volume":"21","author":"R Fujioka","year":"2013","unstructured":"Fujioka R, Aoyama T, Takakuwa T. The layered structure of the articular surface. Osteoarthritis Cartilage. 2013;21:1092\u20138.","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"337_CR8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1302\/0301-620X.77B3.7744937","volume":"77","author":"R Teshima","year":"1995","unstructured":"Teshima R, Otsuka T, Takasu N, Yamagata N, Yamamoto K. Structure of the most superficial layer of articular cartilage. J Bone Joint Surg Br. 1995;77:460-4.","journal-title":"Bone Joint Surg Br"},{"key":"337_CR9","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1242\/jcs.105.4.975","volume":"105","author":"RJ Wardale","year":"1993","unstructured":"Wardale RJ, Duance VC. Quantification and immunolocalisation of porcine articular and growth plate cartilage collagens. J Cell Sci. 1993;105:975\u201384.","journal-title":"J Cell Sci"},{"issue":"5","key":"337_CR10","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1302\/0301-620X.73B5.1894669","volume":"73","author":"AK Jeffery","year":"1991","unstructured":"Jeffery AK, Blunn GW, Archer CW, Bentley G. Three-dimensional collagen architecture in bovine articular cartilage. J Bone Joint Surg Br. 1991;73:795\u2013801.","journal-title":"J Bone Joint Surg Br"},{"key":"337_CR11","unstructured":"Polacek M. The secretome of cartilage, chondrocytes and chondroprogenitors: implications for cell transplantation strategies. 2011. https:\/\/munin.uit.no\/bitstream\/handle\/10037\/3010\/thesis.pdf?sequence=1&isAllowed=y."},{"key":"337_CR12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.7326\/0003-4819-133-8-200010170-00016","volume":"133","author":"DT Felson","year":"2000","unstructured":"Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Osteoarthritis: new insights Part 1: the disease and its risk factors. Ann Intern Med. 2000;133:635\u201346.","journal-title":"Ann Intern Med"},{"key":"337_CR13","first-page":"487","volume":"47","author":"JA Buckwalter","year":"1998","unstructured":"Buckwalter JA, Mankin HJ. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect. 1998;47:487\u2013504.","journal-title":"Instr Course Lect"},{"key":"337_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/284873","volume":"2013","author":"M Maldonado","year":"2013","unstructured":"Maldonado M, Nam J. The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. Biomed Res Int. 2013;2013:284873.","journal-title":"Biomed Res Int"},{"key":"337_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1749-799X-3-29","volume":"3","author":"JP Wu","year":"2008","unstructured":"Wu JP, Kirk TB, Zheng MH. Study of the collagen structure in the superficial zone and physiological state of articular cartilage using a 3D confocal imaging technique. J Orthop Surg Res. 2008;3:29.","journal-title":"J Orthop Surg Res."},{"key":"337_CR16","doi-asserted-by":"publisher","first-page":"546","DOI":"10.2174\/138945010791011866","volume":"11","author":"X Chevalier","year":"2010","unstructured":"Chevalier X. Intra-articular treatments for osteoarthritis: new perspectives. Curr Drug Targets. 2010;11:546\u201360.","journal-title":"Curr Drug Targets"},{"issue":"3","key":"337_CR17","first-page":"538","volume":"86","author":"CT Wang","year":"2004","unstructured":"Wang CT, Lin J, Chang CJ, Lin YT, Hou SM. Therapeutic effects of hyaluronic acid on osteoarthritis of the kneeA meta-analysis of randomized controlled trials. J Bone Joint Surg Am. 2004;86:538-45.","journal-title":"J Joint Surg Am"},{"key":"337_CR18","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1177\/0363546504273510","volume":"33","author":"JW Alford","year":"2005","unstructured":"Alford JW, Cole BJ. Cartilage restoration, Part 1: basic science, historical perspective, patient evaluation, and treatment options. Am J Sports Med. 2005;33:295\u2013306.","journal-title":"Am J Sports Med"},{"issue":"1","key":"337_CR19","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s007760300016","volume":"8","author":"T Abe","year":"2003","unstructured":"Abe T, Yamada H, Nakajima H, Kikuchi T, Takaishi H, Tadakuma T, et al. Repair of full-thickness cartilage defects using liposomal transforming growth factor-\u03b21. J Orthop Sci. 2003;8:92-101.","journal-title":"J Orthop Sci"},{"key":"337_CR20","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/jor.20787","volume":"27","author":"M Hurtig","year":"2009","unstructured":"Hurtig M, Chubinskaya S, Dickey J, Rueger D. BMP-7 protects against progression of cartilage degeneration after impact injury. J Orthop Res. 2009;27:602-11.","journal-title":"J Orthop Res"},{"key":"337_CR21","doi-asserted-by":"publisher","first-page":"595","DOI":"10.2106\/00004623-198870040-00017","volume":"70","author":"SW O\u2019Driscoll","year":"1988","unstructured":"O\u2019Driscoll SW, Keeley FW, Salter RB. Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion A follow-up report at one year. J Bone Joint Surg Am. 1988;70:595\u2013606.","journal-title":"J Bone Joint Surg Am"},{"key":"337_CR22","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.2106\/00004623-198668070-00008","volume":"68","author":"SW O\u2019Driscoll","year":"1986","unstructured":"O\u2019Driscoll SW, Keeley FW, Salter RB. The chondrogenic potential of free autogenous periosteal grafts for biological resurfacing of major full-thickness defects in joint surfaces under the influence of continuous passive motion an experimental investigation in the rabbit. J Bone Joint Surg Am. 1986;68:1017\u201335.","journal-title":"J Bone Joint Surg Am"},{"key":"337_CR23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1159\/000147272","volume":"143","author":"S Pineda","year":"1992","unstructured":"Pineda S, Pollack A, Stevenson S, Goldberg V, Caplan A. A semiquantitative scale for histologic grading of articular cartilage repair. Acta Anat (Basel). 1992;143:335\u201340.","journal-title":"Acta Anat"},{"issue":"1","key":"337_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.joca.2009.08.009","volume":"18","author":"M Rutgers","year":"2010","unstructured":"Rutgers M, van Pelt MJ, Dhert WJ, Creemers LB, Saris DB. Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage. Osteoarthritis Cartilage. 2010;18:12\u201323.","journal-title":"Osteoarthritis Cartilage"},{"key":"337_CR25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.2106\/00004623-199404000-00013","volume":"76","author":"S Wakitani","year":"1994","unstructured":"Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI, et al. 1994 Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am. 1994;76:579\u201392.","journal-title":"J Bone Joint Surg Am."},{"key":"337_CR26","doi-asserted-by":"publisher","first-page":"578","DOI":"10.2519\/jospt.2003.33.10.578","volume":"33","author":"JA Buckwalter","year":"2003","unstructured":"Buckwalter JA. Sports, joint injury, and posttraumatic osteoarthritis. J Orthop Sports Phys Ther. 2003;33:578\u201388.","journal-title":"J Orthop Sports Phys Ther"},{"issue":"6","key":"337_CR27","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1053\/joca.2002.0801","volume":"10","author":"EB Hunziker","year":"2002","unstructured":"Hunziker EB. Articular cartilage repair: basic science and clinical progress a review of the current status and prospects. Osteoarthritis Cartilage. 2002;10:432\u201363.","journal-title":"Osteoarthritis Cartilage"},{"key":"337_CR28","doi-asserted-by":"publisher","first-page":"205s","DOI":"10.1083\/jcb.91.3.205s","volume":"91","author":"ED Hay","year":"1981","unstructured":"Hay ED. Extracellular matrix. J Cell Biol. 1981;91:205s\u201323.","journal-title":"J Cell Biol"},{"issue":"6281","key":"337_CR29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/346281a0","volume":"346","author":"Y Yamaguchi","year":"1990","unstructured":"Yamaguchi Y, Mann DM, Ruoslahti E. Negative regulation of transforming growth factor-\u03b2 by the proteoglycan decorin. Nature. 1990;346:281\u20134.","journal-title":"Nature"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-021-00337-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-021-00337-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-021-00337-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T17:40:09Z","timestamp":1627753209000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-021-00337-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,28]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["337"],"URL":"https:\/\/doi.org\/10.1007\/s13770-021-00337-0","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,28]]},"assertion":[{"value":"10 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the ethics committee [Sewon Cellontech Institutional Animal Care and Use Committee (IACUC)] for animal experimentation and followed all institutional guidelines for the care and treatment of experimental animals (IACUC No. SC-IACUC-12\u2013005).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}