{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:29:24Z","timestamp":1763810964731,"version":"3.37.3"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT","award":["2017M3A9B3063636"],"award-info":[{"award-number":["2017M3A9B3063636"]}]},{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["2019R1I1A1A01060308"],"award-info":[{"award-number":["2019R1I1A1A01060308"]}],"id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RP-Grant 2021 of Ewha Womans University."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s13770-022-00489-7","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T12:14:59Z","timestamp":1667304899000},"page":"1283-1294","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transplantation of Differentiated Tonsil-Derived Mesenchymal Stem Cells Ameliorates Murine Duchenne Muscular Dystrophy via Autophagy Activation"],"prefix":"10.1007","volume":"19","author":[{"given":"Saeyoung","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyeon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Hwa","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoonji","family":"Yum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3174-8965","authenticated-orcid":false,"given":"Sung-Chul","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"489_CR1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3390\/ijms22010255","volume":"22","author":"SX Sui","year":"2021","unstructured":"Sui SX, Williams LJ, Holloway-Kew KL, Hyde KN, Pasco JA. Skeletal muscle health and cognitive function: a narrative review. Int J Mol Sci. 2021;22:255.","journal-title":"Int J Mol Sci"},{"key":"489_CR2","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3390\/ijms21051830","volume":"21","author":"H Yamakawa","year":"2020","unstructured":"Yamakawa H, Kusumoto D, Hashimoto H, Yuasa S. Stem cell aging in skeletal muscle regeneration and disease. Int J Mol Sci. 2020;21:1830.","journal-title":"Int J Mol Sci"},{"key":"489_CR3","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1039\/C8LC00553B","volume":"18","author":"GA Truskey","year":"2018","unstructured":"Truskey GA. Development and application of human skeletal muscle microphysiological systems. Lab Chip. 2018;18:3061\u201373.","journal-title":"Lab Chip"},{"key":"489_CR4","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3892\/ijmm.2016.2536","volume":"37","author":"S Park","year":"2016","unstructured":"Park S, Choi Y, Jung N, Yu Y, Ryu KH, Kim HS, et al. Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration. Int J Mol Med. 2016;37:1209\u201320.","journal-title":"Int J Mol Med"},{"key":"489_CR5","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.febslet.2015.03.031","volume":"589","author":"Y Nakamura","year":"2015","unstructured":"Nakamura Y, Miyaki S, Ishitobi H, Matsuyama S, Nakasa T, Kamei N, et al. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Lett. 2015;589:1257\u201365.","journal-title":"FEBS Lett"},{"key":"489_CR6","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.12659\/MSM.913362","volume":"24","author":"QQ Wang","year":"2018","unstructured":"Wang QQ, Jing XM, Bi YZ, Cao XF, Wang YZ, Li YX, et al. Human umbilical cord Wharton\u2019s jelly derived mesenchymal stromal cells may attenuate sarcopenia in aged mice induced by hindlimb suspension. Med Sci Monit. 2018;24:9272\u201381.","journal-title":"Med Sci Monit"},{"key":"489_CR7","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/stem.3058","volume":"37","author":"SY Oh","year":"2019","unstructured":"Oh SY, Choi YM, Kim HY, Park YS, Jung SC, Park JW, et al. Application of tonsil-derived mesenchymal stem cells in tissue regeneration: concise review. Stem Cells. 2019;37:1252\u201360.","journal-title":"Stem Cells"},{"key":"489_CR8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/joa.12229","volume":"225","author":"Y Yu","year":"2014","unstructured":"Yu Y, Park YS, Kim HS, Kim HY, Jin YM, Jung SC, et al. Characterization of long-term in vitro culture-related alterations of human tonsil-derived mesenchymal stem cells: role for CCN1 in replicative senescence-associated increase in osteogenic differentiation. J Anat. 2014;225:510\u20138.","journal-title":"J Anat"},{"key":"489_CR9","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.3390\/ijms22115772","volume":"22","author":"HJ Lee","year":"2021","unstructured":"Lee HJ, Jung H, Kim DK. IDO and CD40 may be key molecules for immunomodulatory capacity of the primed tonsil-derived mesenchymal stem cells. Int J Mol Sci. 2021;22:5772.","journal-title":"Int J Mol Sci"},{"key":"489_CR10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/jpc.12868","volume":"51","author":"EM Yiu","year":"2015","unstructured":"Yiu EM, Kornberg AJ. Duchenne muscular dystrophy. J Paediatr Child Health. 2015;51:759\u201364.","journal-title":"J Paediatr Child Health"},{"key":"489_CR11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/mus.21211","volume":"39","author":"CF Spurney","year":"2009","unstructured":"Spurney CF, Gordish-Dressman H, Guerron AD, Sali A, Pandey GS, Rawat R, et al. Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures. Muscle Nerve. 2009;39:591\u2013602.","journal-title":"Muscle Nerve"},{"key":"489_CR12","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1073\/pnas.0811599106","volume":"106","author":"JE Rooney","year":"2009","unstructured":"Rooney JE, Gurpur PB, Burkin DJ. Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2009;106:7991\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"489_CR13","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.stemcr.2018.01.023","volume":"10","author":"MA Aminzadeh","year":"2018","unstructured":"Aminzadeh MA, Rogers RG, Fournier M, Tobin RE, Guan X, Childers MK, et al. Exosome-mediated benefits of cell therapy in mouse and human models of Duchenne muscular dystrophy. Stem Cell Reports. 2018;10:942\u201355.","journal-title":"Stem Cell Reports"},{"key":"489_CR14","doi-asserted-by":"crossref","first-page":"14454","DOI":"10.1038\/ncomms14454","volume":"8","author":"NE Bengtsson","year":"2017","unstructured":"Bengtsson NE, Hall JK, Odom GL, Phelps MP, Andrus CR, Hawkins RD, et al. Muscle-specific CRISPR\/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy. Nat Commun. 2017;8:14454.","journal-title":"Nat Commun"},{"key":"489_CR15","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","volume":"20","author":"KR Parzych","year":"2014","unstructured":"Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 2014;20:460\u201373.","journal-title":"Antioxid Redox Signal"},{"key":"489_CR16","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/cdd.2016.70","volume":"23","author":"E Fiacco","year":"2016","unstructured":"Fiacco E, Castagnetti F, Bianconi V, Madaro L, De Bardi M, Nazio F, D\u2019Amico A, Bertini E, Cecconi F, Puri PL, Latella L. Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles. Cell Death Differ. 2016;23:1839\u201349.","journal-title":"Cell Death Differ"},{"key":"489_CR17","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.159","volume":"3","author":"C De Palma","year":"2012","unstructured":"De Palma C, Morisi F, Cheli S, Pambianco S, Cappello V, Vezzoli M, et al. Autophagy as a new therapeutic target in Duchenne muscular dystrophy. Cell Death Dis. 2012;3:e418.","journal-title":"Cell Death Dis"},{"key":"489_CR18","doi-asserted-by":"crossref","first-page":"12864","DOI":"10.1073\/pnas.1509536112","volume":"112","author":"NP Whitehead","year":"2015","unstructured":"Whitehead NP, Kim MJ, Bible KL, Adams ME, Froehner SC. A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy. Proc Natl Acad Sci U S A. 2015;112:12864\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"489_CR19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","volume":"146","author":"DC Rubinsztein","year":"2011","unstructured":"Rubinsztein DC, Marino G, Kroemer G. Autophagy and aging. Cell. 2011;146:682\u201395.","journal-title":"Cell"},{"key":"489_CR20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13395-015-0046-6","volume":"5","author":"S Schiaffino","year":"2015","unstructured":"Schiaffino S, Rossi AC, Smerdu V, Leinwand LA, Reggiani C. Developmental myosins: expression patterns and functional significance. Skelet Muscle. 2015;5:22.","journal-title":"Skelet Muscle"},{"key":"489_CR21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.semcdb.2017.11.010","volume":"72","author":"JM Hern\u00e1ndez-Hern\u00e1ndez","year":"2017","unstructured":"Hern\u00e1ndez-Hern\u00e1ndez JM, Garc\u00eda-Gonz\u00e1lez EG, Brun CE, Rudnicki MA. The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration. Semin Cell Dev Biol. 2017;72:10\u20138.","journal-title":"Semin Cell Dev Biol"},{"key":"489_CR22","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1038\/s41467-021-22305-x","volume":"12","author":"A Farini","year":"2021","unstructured":"Farini A, Sitzia C, Villa C, Cassani B, Tripodi L, Legato M, et al. Defective dystrophic thymus determines degenerative changes in skeletal muscle. Nat Commun. 2021;12:2099.","journal-title":"Nat Commun"},{"key":"489_CR23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cmet.2009.10.008","volume":"10","author":"E Masiero","year":"2009","unstructured":"Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M, et al. Autophagy is required to maintain muscle mass. Cell Metab. 2009;10:507\u201315.","journal-title":"Cell Metab"},{"key":"489_CR24","doi-asserted-by":"crossref","unstructured":"Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021;17:1\u2013382.","DOI":"10.1080\/15548627.2020.1797280"},{"key":"489_CR25","doi-asserted-by":"crossref","first-page":"8110","DOI":"10.1096\/fj.201802488R","volume":"33","author":"M van Putten","year":"2019","unstructured":"van Putten M, Putker K, Overzier M, Adamzek WA, Pasteuning-Vuhman S, Plomp JJ, et al. Natural disease history of the D2 -mdx mouse model for Duchenne muscular dystrophy. FASEB J. 2019;33:8110\u201324.","journal-title":"FASEB J"},{"key":"489_CR26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3390\/genes11080837","volume":"11","author":"C Sun","year":"2020","unstructured":"Sun C, Shen L, Zhang Z, Xie X. Therapeutic strategies for Duchenne muscular dystrophy: an update. Genes (Basel). 2020;11:837.","journal-title":"Genes (Basel)"},{"key":"489_CR27","volume":"9","author":"S Yao","year":"2021","unstructured":"Yao S, Chen Z, Yu Y, Zhang N, Jiang H, Zhang G, et al. Current pharmacological strategies for duchenne muscular dystrophy. Front Cell Dev Biol. 2021;9:689533.","journal-title":"Front Cell Dev Biol"},{"key":"489_CR28","volume":"9","author":"C Happi Mbakam","year":"2022","unstructured":"Happi Mbakam C, Lamothe G, Tremblay JP. Therapeutic strategies for dystrophin replacement in duchenne muscular dystrophy. Front Med (Lausanne). 2022;9:859930.","journal-title":"Front Med (Lausanne)"},{"key":"489_CR29","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.3390\/ijms17111867","volume":"17","author":"N Jung","year":"2016","unstructured":"Jung N, Park S, Choi Y, Park JW, Hong YB, Park HH, et al. Tonsil-derived mesenchymal stem cells differentiate into a Schwann cell phenotype and promote peripheral nerve regeneration. Int J Mol Sci. 2016;17:1867.","journal-title":"Int J Mol Sci"},{"key":"489_CR30","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3390\/ijms23020715","volume":"23","author":"JY Kim","year":"2022","unstructured":"Kim JY, Park S, Oh SY, Nam YH, Choi YM, Choi Y, et al. Density-dependent differentiation of tonsil-derived mesenchymal stem cells into parathyroid-hormone-releasing cells. Int J Mol Sci. 2022;23:715.","journal-title":"Int J Mol Sci"},{"key":"489_CR31","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/mus.25763","volume":"57","author":"S Park","year":"2018","unstructured":"Park S, Choi Y, Kwak G, Hong YB, Jung N, Kim J, et al. Application of differentiated human tonsil-derived stem cells to trembler-J mice. Muscle Nerve. 2018;57:478\u201386.","journal-title":"Muscle Nerve"},{"key":"489_CR32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biomaterials.2018.11.037","volume":"193","author":"V Bansal","year":"2019","unstructured":"Bansal V, De D, An J, Kang TM, Jeong HJ, Kang JS, et al. Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells. Biomaterials. 2019;193:30\u201346.","journal-title":"Biomaterials"},{"key":"489_CR33","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/term.1914","volume":"11","author":"W Chen","year":"2017","unstructured":"Chen W, Xie M, Yang B, Bharadwaj S, Song L, Liu G, et al. Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. J Tissue Eng Regen Med. 2017;11:334\u201341.","journal-title":"J Tissue Eng Regen Med"},{"key":"489_CR34","volume":"9","author":"M Ganassi","year":"2020","unstructured":"Ganassi M, Badodi S, Wanders K, Zammit PS, Hughes SM. Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis Elife. 2020;9:e60445.","journal-title":"Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis Elife"},{"key":"489_CR35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00401-012-1024-2","volume":"125","author":"H Tajsharghi","year":"2013","unstructured":"Tajsharghi H, Oldfors A. Myosinopathies: pathology and mechanisms. Acta Neuropathol. 2013;125:3\u201318.","journal-title":"Acta Neuropathol"},{"key":"489_CR36","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1242\/jeb.099127","volume":"217","author":"W Herzog","year":"2014","unstructured":"Herzog W. The role of titin in eccentric muscle contraction. J Exp Biol. 2014;217:2825\u201333.","journal-title":"J Exp Biol"},{"key":"489_CR37","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1745-7270.2008.00418.x","volume":"40","author":"Y Guo","year":"2008","unstructured":"Guo Y, Xiao P, Lei S, Deng F, Xiao GG, Liu Y, et al. How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes. Acta Biochim Biophys Sin (Shanghai). 2008;40:426\u201336.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"489_CR38","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2174\/1389202921999200716103758","volume":"21","author":"J Li","year":"2020","unstructured":"Li J, Zhang Y. Li J, Zhang Y, Yang C, Rong R. Discrepant mRNA and protein expression in immune cells. Curr Genomics. 2020;21:560\u20133.","journal-title":"Curr Genomics"},{"key":"489_CR39","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1159\/000374033","volume":"35","author":"J Yu","year":"2015","unstructured":"Yu J, Su X, Zhu C, Pan Q, Yang J, Ma J, et al. GFP labeling and hepatic differentiation potential of human placenta-derived mesenchymal stem cells. Cell Physiol Biochem. 2015;35:2299\u2013308.","journal-title":"Cell Physiol Biochem"},{"key":"489_CR40","doi-asserted-by":"crossref","first-page":"1659275","DOI":"10.1155\/2016\/1659275","volume":"2016","author":"I Islam","year":"2016","unstructured":"Islam I, Sriram G, Li M, Zou Y, Li L, Handral HK, et al. In Vitro osteogenic potential of green fluorescent protein labelled human embryonic stem cell-derived osteoprogenitors. Stem Cells Int. 2016;2016:1659275.","journal-title":"Stem Cells Int"},{"key":"489_CR41","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1038\/s41467-020-18131-2","volume":"11","author":"S Swist","year":"2020","unstructured":"Swist S, Unger A, Li Y, V\u00f6ge A, von Frieling-Salewsky M, Sk\u00e4rl\u00e9n \u00c5. Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin. Nat Commun. 2020;11:4479.","journal-title":"Nat Commun"},{"key":"489_CR42","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1093\/hmg\/ddu249","volume":"23","author":"C Moorwood","year":"2014","unstructured":"Moorwood C, Barton ER. Caspase-12 ablation preserves muscle function in the mdx mouse. Hum Mol Genet. 2014;23:5325\u201341.","journal-title":"Hum Mol Genet"},{"key":"489_CR43","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/mt.2008.149","volume":"16","author":"GL Odom","year":"2008","unstructured":"Odom GL, Gregorevic P, Allen JM, Finn E, Chamberlain JS. Microutrophin delivery through rAAV6 increases lifespan and improves muscle function in dystrophic dystrophin\/utrophin-deficient mice. Mol Ther. 2008;16:1539\u201345.","journal-title":"Mol Ther"},{"key":"489_CR44","doi-asserted-by":"crossref","DOI":"10.1117\/1.3598842","volume":"16","author":"BR Klyen","year":"2011","unstructured":"Klyen BR, Shavlakadze T, Radley-Crabb HG, Grounds MD, Sampson DD. Identification of muscle necrosis in the mdx mouse model of duchenne muscular dystrophy using three-dimensional optical coherence tomography. J Biomed Opt. 2011;16:076013.","journal-title":"J Biomed Opt"},{"key":"489_CR45","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3892\/ijmm.2017.2898","volume":"39","author":"S Park","year":"2017","unstructured":"Park S, Choi Y, Jung N, Kim J, Oh S, Yu Y, et al. Autophagy induction in the skeletal myogenic differentiation of human tonsil-derived mesenchymal stem cells. Int J Mol Med. 2017;39:831\u201340.","journal-title":"Int J Mol Med"},{"key":"489_CR46","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/molecules24091838","volume":"24","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Zhang Y, Jin XF, Zhou XH, Dong XH, Yu WT, et al. The role of astragaloside IV against cerebral ischemia\/reperfusion injury: suppression of apoptosis via promotion of p62-LC3-autophagy. Molecules. 2019;24:1838.","journal-title":"Molecules"},{"key":"489_CR47","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3390\/cells1030284","volume":"1","author":"JP Decuypere","year":"2012","unstructured":"Decuypere JP, Parys JB, Bultynck G. Regulation of the autophagic bcl-2\/beclin 1 interaction. Cells. 2012;1:284\u2013312.","journal-title":"Cells"},{"key":"489_CR48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymeth.2014.11.021","volume":"75","author":"P Jiang","year":"2015","unstructured":"Jiang P, Mizushima N. LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells. Methods. 2015;75:13\u20138.","journal-title":"Methods"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-022-00489-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-022-00489-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-022-00489-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T09:41:11Z","timestamp":1669023671000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-022-00489-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["489"],"URL":"https:\/\/doi.org\/10.1007\/s13770-022-00489-7","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"type":"print","value":"1738-2696"},{"type":"electronic","value":"2212-5469"}],"subject":[],"published":{"date-parts":[[2022,11,1]]},"assertion":[{"value":"28 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"The study protocol was approved by the Ewha Womans University Medical Center (EWUMC) institutional review board (IRB number: ECT-2011\u201309-003). All the experimental procedures were reviewed and approved by the ethics committee for animal research at Ewha Woman\u2019s University (EUM20-051). Informed Consent Statement: Informed written consent was obtained from all the patients participating in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}