{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:38:37Z","timestamp":1780504717476,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007471","name":"Northern Borders University","doi-asserted-by":"publisher","award":["NBU-FFR-2023-0065"],"award-info":[{"award-number":["NBU-FFR-2023-0065"]}],"id":[{"id":"10.13039\/501100007471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s13770-023-00570-9","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T11:02:24Z","timestamp":1694170944000},"page":"1053-1062","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effectiveness of Mesenchymal Stem Cell Secretome on Wound Healing: A Systematic Review and Meta-analysis"],"prefix":"10.1007","volume":"20","author":[{"given":"Cecep","family":"Suhandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Fouad Abdelwahab","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gofarana","family":"Wilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"El-Rayyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-6909","authenticated-orcid":false,"given":"Nasrul","family":"Wathoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"570_CR1","unstructured":"Wound Assessment. Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482198\/. Accessed 31 Oct 2022."},{"key":"570_CR2","doi-asserted-by":"publisher","first-page":"8278","DOI":"10.3390\/ijms22158278","volume":"22","author":"AC Afonso","year":"2021","unstructured":"Afonso AC, Oliveira D, Saavedra MJ, Borges A, Sim\u00f5es M. Biofilms in diabetic foot ulcers: impact, risk factors and control strategies. Int J Mol Sci. 2021;22:8278.","journal-title":"Int J Mol Sci"},{"key":"570_CR3","unstructured":"Wound Classification. Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554456\/. Accessed 31 Oct 2022."},{"key":"570_CR4","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1089\/wound.2017.0761","volume":"7","author":"J Larouche","year":"2018","unstructured":"Larouche J, Sheoran S, Maruyama K, Martino MM. Immune regulation of skin wound healing: mechanisms and novel therapeutic targets. Adv Wound Care. 2018;7:209\u201331.","journal-title":"Adv Wound Care"},{"key":"570_CR5","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3390\/biom11050700","volume":"11","author":"K Raziyeva","year":"2021","unstructured":"Raziyeva K, Kim Y, Zharkinbekov Z, Kassymbek K, Jimi S, Saparov A. Immunology of acute and chronic wound healing. Biomolecules. 2021;11:700.","journal-title":"Biomolecules"},{"key":"570_CR6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","volume":"34","author":"G Han","year":"2017","unstructured":"Han G, Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther. 2017;34:599\u2013610.","journal-title":"Adv Ther"},{"key":"570_CR7","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.3390\/biomedicines9091235","volume":"9","author":"V Brumberg","year":"2021","unstructured":"Brumberg V, Astrelina T, Malivanova T, Samoilov A. Modern wound dressings: hydrogel dressings. Biomedicines. 2021;9:1235.","journal-title":"Biomedicines"},{"key":"570_CR8","doi-asserted-by":"publisher","first-page":"791899","DOI":"10.3389\/fnut.2021.791899","volume":"8","author":"P Monika","year":"2022","unstructured":"Monika P, Chandraprabha MN, Rangarajan A, Waiker PV, Murthy KNC. Challenges in healing wound: role of complementary and alternative medicine. Front Nutr. 2022;8:791899.","journal-title":"Front Nutr"},{"key":"570_CR9","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1089\/wound.2012.0401","volume":"3","author":"A Sood","year":"2014","unstructured":"Sood A, Granick MS, Tomaselli NL. Wound dressings and comparative effectiveness data. Adv Wound Care. 2014;3:511\u201329.","journal-title":"Adv Wound Care"},{"key":"570_CR10","doi-asserted-by":"publisher","first-page":"5217967","DOI":"10.1155\/2017\/5217967","volume":"2017","author":"S Kanji","year":"2017","unstructured":"Kanji S, Das H. Advances of stem cell therapeutics in cutaneous wound healing and regeneration. Mediat Inflamm. 2017;2017:5217967.","journal-title":"Mediat Inflamm"},{"key":"570_CR11","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/s41392-022-01134-4","volume":"7","author":"DM Hoang","year":"2022","unstructured":"Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022;7:272.","journal-title":"Signal Transduct Target Ther"},{"key":"570_CR12","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1002\/stem.1796","volume":"32","author":"PH Oliveira","year":"2014","unstructured":"Oliveira PH, da Silva CL, Cabral JM. Concise review: genomic instability in human stem cells: current status and future challenges. Stem Cells. 2014;32:2824\u201332.","journal-title":"Stem Cells"},{"key":"570_CR13","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.3390\/polym14142929","volume":"14","author":"R Ibrahim","year":"2022","unstructured":"Ibrahim R, Mndlovu H, Kumar P, Adeyemi SA, Choonara YE. Cell secretome strategies for controlled drug delivery and wound-healing applications. Polymers. 2022;14:2929.","journal-title":"Polymers"},{"key":"570_CR14","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.4252\/wjsc.v12.i12.1529","volume":"12","author":"A Gonz\u00e1lez-Gonz\u00e1lez","year":"2020","unstructured":"Gonz\u00e1lez-Gonz\u00e1lez A, Garc\u00eda-S\u00e1nchez D, Dotta M, Rodr\u00edguez-Rey JC, P\u00e9rez-Campo FM. Mesenchymal stem cells secretome: the cornerstone of cell-free regenerative medicine. World J Stem Cells. 2020;12:1529\u201352.","journal-title":"World J Stem Cells"},{"key":"570_CR15","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.3390\/ijms18091852","volume":"18","author":"FJ Vizoso","year":"2017","unstructured":"Vizoso FJ, Eiro N, Cid S, Schneider J, Perez-Fernandez R. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Int J Mol Sci. 2017;18:1852.","journal-title":"Int J Mol Sci"},{"key":"570_CR16","doi-asserted-by":"publisher","first-page":"7038","DOI":"10.3390\/ijms21197038","volume":"21","author":"P Ahangar","year":"2020","unstructured":"Ahangar P, Mills SJ, Cowin AJ. Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair. Int J Mol Sci. 2020;21:7038.","journal-title":"Int J Mol Sci"},{"key":"570_CR17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3897\/rrpharmacology.6.49413","volume":"6","author":"LA Pokrovskaya","year":"2020","unstructured":"Pokrovskaya LA, Zubareva EV, Nadezhdin SV, Lysenko AS, Litovkina TL. Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach. Res Results Pharmacol. 2020;6:57\u201368.","journal-title":"Res Results Pharmacol"},{"key":"570_CR18","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.3390\/cells11071198","volume":"11","author":"X Guo","year":"2022","unstructured":"Guo X, Schaudinn C, Blume-Peytavi U, Vogt A, Rancan F. Effects of adipose-derived stem cells and their conditioned medium in a human ex vivo wound model. Cells. 2022;11:1198.","journal-title":"Cells"},{"key":"570_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.23937\/2469-570X\/1410045","volume":"4","author":"S Bartaula-Brevik","year":"2017","unstructured":"Bartaula-Brevik S, Bolstad A, Mustafa K, Pedersen TO. Secretome of mesenchymal stem cells grown in hypoxia accelerates wound healing and vessel formation in vitro. Int J Stem Cell Res Ther. 2017;4. https:\/\/doi.org\/10.23937\/2469-570X\/1410045","journal-title":"Int J Stem Cell Res Ther"},{"key":"570_CR20","doi-asserted-by":"publisher","first-page":"105906","DOI":"10.1016\/j.ijsu.2021.105906","volume":"88","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg. 2021;88:105906.","journal-title":"Int J Surg"},{"key":"570_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2522\/ptj.20070147","volume":"88","author":"SA Olivo","year":"2008","unstructured":"Olivo SA, Macedo LG, Gadotti IC, Fuentes J, Stanton T, Magee DJ. Scales to assess the quality of randomized controlled trials: a systematic review. Phys Ther. 2008;88:156\u201375.","journal-title":"Phys Ther"},{"key":"570_CR22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1471-2288-14-45","volume":"14","author":"CK Lo","year":"2014","unstructured":"Lo CK, Mertz D, Loeb M. Newcastle-Ottawa scale: comparing reviewers\u2019 to authors\u2019 assessments. BMC Med Res Methodol. 2014;14:45.","journal-title":"BMC Med Res Methodol"},{"key":"570_CR23","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1159\/000051263","volume":"12","author":"M Oremus","year":"2001","unstructured":"Oremus M, Wolfson C, Perrault A, Demers L, Momoli F, Moride Y. Interrater reliability of the modified Jadad quality scale for systematic reviews of Alzheimer\u2019s disease drug trials. Dement Geriatr Cogn Disord. 2001;12:232\u20136.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"570_CR24","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2147\/CLEP.S66677","volume":"6","author":"AV Margulis","year":"2014","unstructured":"Margulis AV, Pladevall M, Riera-Guardia N, Varas-Lorenzo C, Hazell L, Berkman N, et al. Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: the Newcastle-Ottawa scale and the RTI item bank. Clin Epidemiol. 2014;6:359\u201368.","journal-title":"Clin Epidemiol"},{"key":"570_CR25","unstructured":"The Nordic Cochrane Centre. Review Manager, Version 5.4; The Cochrane Collaboration: Copenhagen, Denmark, 2020."},{"key":"570_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"JP Higgins","year":"2019","unstructured":"Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions. Wiley; 2019."},{"key":"570_CR27","doi-asserted-by":"publisher","first-page":"958","DOI":"10.15562\/bmj.v10i3.2747","volume":"10","author":"MD Alinda","year":"2021","unstructured":"Alinda MD, Christopher PM, Listiawan MY, Endaryanto A, Suroto H, Rantam FA, et al. Comparative efficacy of topical adipocyte-derived mesenchymal stem cells-conditioned medium (Admsc-cm) and amniotic membrane mesenchymal stem cells-conditioned medium (amsc-cm) on chronic plantar ulcers in leprosy: a randomized controlled trial. Bali Med J. 2021;10:958\u201363.","journal-title":"Bali Med J"},{"key":"570_CR28","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/jocd.13063","volume":"19","author":"J Kim","year":"2020","unstructured":"Kim J, Kim B, Kim S, Lee YI, Kim J, Lee JH. The effect of human umbilical cord blood-derived mesenchymal stem cell media containing serum on recovery after laser treatment: a double-blinded, randomized, split-face controlled study. J Cosmet Dermatol. 2020;19:651\u20136.","journal-title":"J Cosmet Dermatol"},{"key":"570_CR29","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1080\/09546634.2019.1630701","volume":"32","author":"EM Abdel-Maguid","year":"2021","unstructured":"Abdel-Maguid EM, Awad SM, Hassan YS, El-Mokhtar MA, El-Deek HE, Mekkawy MM. Efficacy of stem cell-conditioned medium vs. platelet-rich plasma as an adjuvant to ablative fractional CO2 laser resurfacing for atrophic post-acne scars: a split-face clinical trial. J Dermatol Treat. 2021;32:242\u20139.","journal-title":"J Dermatol Treat"},{"key":"570_CR30","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13039","author":"M El-Domyati","year":"2019","unstructured":"El-Domyati M, Moftah NH, Nasif GA, Ragaie MH, Ibrahim MR, Ameen SW. Amniotic fluid-derived mesenchymal stem cell products combined with microneedling for acne scars: a split-face clinical, histological, and histometric study. J Cosmet Dermatol. 2019;18:1300\u20136","journal-title":"J Cosmet Dermatol"},{"key":"570_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/09546634.2019.1628915","volume":"32","author":"CS Park","year":"2021","unstructured":"Park CS, Park JH, Kim CR, Lee JH. Objective analysis of volume restoration in atrophic acne scars and skin pores: a split study using human stem cell-conditioned media. J Dermatol Treat. 2021;32:73\u20137.","journal-title":"J Dermatol Treat"},{"key":"570_CR32","doi-asserted-by":"publisher","first-page":"519126","DOI":"10.1155\/2013\/519126","volume":"2013","author":"BR Zhou","year":"2013","unstructured":"Zhou BR, Xu Y, Guo SL, Xu Y, Wang Y, Zhu F, et al. The effect of conditioned media of adipose-derived stem cells on wound healing after ablative fractional carbon dioxide laser resurfacing. Biomed Res Int. 2013;2013:519126.","journal-title":"Biomed Res Int"},{"key":"570_CR33","first-page":"50","volume":"4","author":"D Fife","year":"2011","unstructured":"Fife D. Practical evaluation and management of atrophic acne scars: tips for the general dermatologist. J Clin Aesthet Dermatol. 2011;4:50\u20137.","journal-title":"J Clin Aesthet Dermatol"},{"key":"570_CR34","first-page":"33","volume":"8","author":"MV Gozali","year":"2015","unstructured":"Gozali MV, Zhou B. Effective treatments of atrophic acne scars. J Clin Aesthet Dermatol. 2015;8:33\u201340.","journal-title":"J Clin Aesthet Dermatol"},{"key":"570_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/wound.2016.0696","volume":"7","author":"CD Marshall","year":"2018","unstructured":"Marshall CD, Hu MS, Leavitt T, Barnes LA, Lorenz HP, Longaker MT. Cutaneous scarring: basic science, current treatments, and future directions. Adv Wound Care. 2018;7:29\u201345.","journal-title":"Adv Wound Care"},{"key":"570_CR36","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.3390\/jcm11102744","volume":"11","author":"K Chilicka","year":"2022","unstructured":"Chilicka K, Rusztowicz M, Szygu\u0142a R, Nowicka D. Methods for the Improvement of acne scars used in dermatology and cosmetology: a review. J Clin Med. 2022;11:2744.","journal-title":"J Clin Med"},{"key":"570_CR37","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3760\/cma.j.cn501120-20200310-00145","volume":"37","author":"H Fan","year":"2021","unstructured":"Fan H, Zhang JW, Liu DJ, Liu FB. Transepidermal water loss of scar skin in three types of scar patients and its correlation with scar severity. Zhonghua Shao Shang Za Zhi. 2021;37:629\u201334.","journal-title":"Zhonghua Shao Shang Za Zhi"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-023-00570-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-023-00570-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-023-00570-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T18:12:22Z","timestamp":1699985542000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-023-00570-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["570"],"URL":"https:\/\/doi.org\/10.1007\/s13770-023-00570-9","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,8]]},"assertion":[{"value":"9 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}