{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:43:08Z","timestamp":1792172588544,"version":"4.4.0"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1A2C3004850"],"award-info":[{"award-number":["2022R1A2C3004850"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2024-00405381"],"award-info":[{"award-number":["RS-2024-00405381"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2023-00257290"],"award-info":[{"award-number":["RS-2023-00257290"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00246418"],"award-info":[{"award-number":["RS-2023-00246418"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00275407"],"award-info":[{"award-number":["RS-2023-00275407"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and ICT, Ministry of Health & Welfare","award":["21C0703L1"],"award-info":[{"award-number":["21C0703L1"]}]},{"name":"Ministry of Science and ICT, Ministry of Trade, Industry and Energy, Ministry of Health & Welfare, The Ministry of Food and Drug Safety","award":["HX23C1734"],"award-info":[{"award-number":["HX23C1734"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s13770-024-00690-w","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:35:08Z","timestamp":1736750108000},"page":"167-180","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Regenerative Functions of Regulatory T Cells and Current Strategies Utilizing Mesenchymal Stem Cells in Immunomodulatory Tissue Regeneration"],"prefix":"10.1007","volume":"22","author":[{"given":"Jinsung","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin Bacero","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-8301","authenticated-orcid":false,"given":"Soo-Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"690_CR1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.actbio.2017.01.056","volume":"53","author":"Z Julier","year":"2017","unstructured":"Julier Z, Park AJ, Briquez PS, Martino MM. Promoting tissue regeneration by modulating the immune system. Acta Biomater. 2017;53:13\u201328.","journal-title":"Acta Biomater"},{"key":"690_CR2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13223-018-0278-1","volume":"14","author":"JS Marshall","year":"2018","unstructured":"Marshall JS, Warrington R, Watson W, Kim HL. An introduction to immunology and immunopathology. Allergy Asthma Clin Immunol. 2018;14:49.","journal-title":"Allergy Asthma Clin Immunol"},{"key":"690_CR3","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3390\/ijms22052668","volume":"22","author":"YJ Su","year":"2021","unstructured":"Su YJ, Wang PW, Weng SW. The role of mitochondria in immune-cell-mediated tissue regeneration and ageing. Int J Mol Sci. 2021;22:2668.","journal-title":"Int J Mol Sci"},{"key":"690_CR4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.semcdb.2009.04.009","volume":"20","author":"SA Eming","year":"2009","unstructured":"Eming SA, Hammerschmidt M, Krieg T, Roers A. Interrelation of immunity and tissue repair or regeneration. Semin Cell Dev Biol. 2009;20:517\u201327.","journal-title":"Semin Cell Dev Biol"},{"key":"690_CR5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12033-021-00430-8","volume":"64","author":"M Masoomikarimi","year":"2022","unstructured":"Masoomikarimi M, Salehi M. Modulation of the immune system promotes tissue regeneration. Mol Biotechnol. 2022;64:599\u2013610.","journal-title":"Mol Biotechnol"},{"key":"690_CR6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fimmu.2018.00585","volume":"9","author":"J Li","year":"2018","unstructured":"Li J, Tan J, Martino MM, Lui KO. Regulatory t-cells: Potential regulator of tissue repair and regeneration. Front Immunol. 2018;9:585.","journal-title":"Front Immunol"},{"key":"690_CR7","doi-asserted-by":"crossref","first-page":"10878","DOI":"10.1073\/pnas.1834400100","volume":"100","author":"EA Green","year":"2003","unstructured":"Green EA, Gorelik L, McGregor CM, Tran EH, Flavell RA. Cd4+cd25+ t regulatory cells control anti-islet cd8+ t cells through tgf-beta-tgf-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A. 2003;100:10878\u201383.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"690_CR8","doi-asserted-by":"crossref","first-page":"a022236","DOI":"10.1101\/cshperspect.a022236","volume":"9","author":"S Sanjabi","year":"2017","unstructured":"Sanjabi S, Oh SA, Li MO. Regulation of the immune response by tgf-\u03b2: From conception to autoimmunity and infection. Cold Spring Harb Perspect Biol. 2017;9:a022236.","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"690_CR9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.immuni.2008.03.003","volume":"28","author":"MO Li","year":"2008","unstructured":"Li MO, Flavell RA. Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity. 2008;28:468\u201376.","journal-title":"Immunity"},{"key":"690_CR10","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/nm.2542","volume":"17","author":"Y Liu","year":"2011","unstructured":"Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, Xu X, et al. Mesenchymal stem cell-based tissue regeneration is governed by recipient t lymphocytes via ifn-\u03b3 and tnf-\u03b1. Nat Med. 2011;17:1594\u2013601.","journal-title":"Nat Med"},{"key":"690_CR11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1517\/14712598.2014.896333","volume":"14","author":"C Li","year":"2014","unstructured":"Li C, Sun J, Gong Y, Ding X, Ruan H, Ye L, et al. Transforming growth factor-\u03b21-induced treg cells inhibit the absorption of tissue-engineered cartilage caused by endogenous ifn-\u03b3 and tnf-\u03b1. Expert Opin Biol Ther. 2014;14:573\u201381.","journal-title":"Expert Opin Biol Ther"},{"key":"690_CR12","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cell.2013.10.054","volume":"155","author":"D Burzyn","year":"2013","unstructured":"Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, et al. A special population of regulatory t cells potentiates muscle repair. Cell. 2013;155:1282\u201395.","journal-title":"Cell"},{"key":"690_CR13","first-page":"49","volume":"10","author":"S Knoedler","year":"2023","unstructured":"Knoedler S, Knoedler L, Kauke-Navarro M, Rinkevich Y, Hundeshagen G, Harhaus L, et al. Regulatory t cells in skin regeneration and wound healing. Mil Med Res. 2023;10:49.","journal-title":"Mil Med Res"},{"key":"690_CR14","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.3389\/fimmu.2019.01889","volume":"10","author":"I Pacella","year":"2019","unstructured":"Pacella I, Piconese S. Immunometabolic checkpoints of treg dynamics: adaptation to microenvironmental opportunities and challenges. Front Immunol. 2019;10:1889.","journal-title":"Front Immunol"},{"key":"690_CR15","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/stem.3151","volume":"38","author":"N Negi","year":"2020","unstructured":"Negi N, Griffin MD. Effects of mesenchymal stromal cells on regulatory t cells: current understanding and clinical relevance. Stem Cells. 2020;38:596\u2013605.","journal-title":"Stem Cells"},{"key":"690_CR16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1517\/14712598.8.5.569","volume":"8","author":"SS Iyer","year":"2008","unstructured":"Iyer SS, Rojas M. Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies. Expert Opin Biol Ther. 2008;8:569\u201381.","journal-title":"Expert Opin Biol Ther"},{"key":"690_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052472","author":"CR Harrell","year":"2021","unstructured":"Harrell CR, Djonov V, Volarevic V. The cross-talk between mesenchymal stem cells and immune cells in tissue repair and regeneration. Int J Mol Sci. 2021;22:2472.","journal-title":"Int J Mol Sci"},{"key":"690_CR18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/lt.25049","volume":"24","author":"M Gazdic","year":"2018","unstructured":"Gazdic M, Markovic BS, Arsenijevic A, Jovicic N, Acovic A, Harrell CR, et al. Crosstalk between mesenchymal stem cells and t regulatory cells is crucially important for the attenuation of acute liver injury. Liver Transpl. 2018;24:687\u2013702.","journal-title":"Liver Transpl"},{"key":"690_CR19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/scrt216","volume":"4","author":"P Luz-Crawford","year":"2013","unstructured":"Luz-Crawford P, Kurte M, Bravo-Alegr\u00eda J, Contreras R, Nova-Lamperti E, Tejedor G, et al. Mesenchymal stem cells generate a cd4+cd25+foxp3+ regulatory t cell population during the differentiation process of th1 and th17 cells. Stem Cell Res Ther. 2013;4:65.","journal-title":"Stem Cell Res Ther"},{"key":"690_CR20","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1172\/JCI124614","volume":"129","author":"FR D'Alessio","year":"2019","unstructured":"D\u2019Alessio FR, Kurzhagen JT, Rabb H. Reparative t lymphocytes in organ injury. J Clin Invest. 2019;129:2608\u201318.","journal-title":"J Clin Invest"},{"key":"690_CR21","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1159\/000484295","volume":"43","author":"C Zhang","year":"2017","unstructured":"Zhang C, Li L, Feng K, Fan D, Xue W, Lu J. \u201cRepair\u201d treg cells in tissue injury. Cell Physiol Biochem. 2017;43:2155\u201369.","journal-title":"Cell Physiol Biochem"},{"key":"690_CR22","doi-asserted-by":"crossref","first-page":"7863","DOI":"10.1038\/s41467-024-51353-2","volume":"15","author":"B Nayer","year":"2024","unstructured":"Nayer B, Tan JL, Alshoubaki YK, Lu YZ, Legrand JMD, Lau S, et al. Local administration of regulatory t cells promotes tissue healing. Nat Commun. 2024;15:7863.","journal-title":"Nat Commun"},{"key":"690_CR23","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/s41423-023-01036-7","volume":"20","author":"J Wang","year":"2023","unstructured":"Wang J, Zhao X, Wan YY. Intricacies of tgf-\u03b2 signaling in treg and th17 cell biology. Cell Mol Immunol. 2023;20:1002\u201322.","journal-title":"Cell Mol Immunol"},{"key":"690_CR24","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.3389\/fimmu.2019.01954","volume":"10","author":"C Schlundt","year":"2019","unstructured":"Schlundt C, Reinke S, Geissler S, Bucher CH, Giannini C, M\u00e4rdian S, et al. Individual effector\/regulator t cell ratios impact bone regeneration. Front Immunol. 2019;10:1954.","journal-title":"Front Immunol"},{"key":"690_CR25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","volume":"8","author":"DA Vignali","year":"2008","unstructured":"Vignali DA, Collison LW, Workman CJ. How regulatory t cells work. Nat Rev Immunol. 2008;8:523\u201332.","journal-title":"Nat Rev Immunol"},{"key":"690_CR26","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/apm.12706","volume":"125","author":"G Sun","year":"2017","unstructured":"Sun G, Wang Z, Ti Y, Wang Y, Wang J, Zhao J, et al. Stat3 promotes bone fracture healing by enhancing the foxp3 expression and the suppressive function of regulatory t cells. APMIS. 2017;125:752\u201360.","journal-title":"APMIS"},{"key":"690_CR27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3389\/fimmu.2018.00657","volume":"9","author":"RK Srivastava","year":"2018","unstructured":"Srivastava RK, Dar HY, Mishra PK. Immunoporosis: immunology of osteoporosis-role of t cells. Front Immunol. 2018;9:657.","journal-title":"Front Immunol"},{"key":"690_CR28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2021.12.006","volume":"140","author":"M Li","year":"2022","unstructured":"Li M, Yin H, Yan Z, Li H, Wu J, Wang Y, et al. The immune microenvironment in cartilage injury and repair. Acta Biomater. 2022;140:23\u201342.","journal-title":"Acta Biomater"},{"key":"690_CR29","volume":"240","author":"M Dai","year":"2020","unstructured":"Dai M, Sui B, Hua Y, Zhang Y, Bao B, Lin Q, et al. A well defect-suitable and high-strength biomimetic squid type ii gelatin hydrogel promoted in situ costal cartilage regeneration via dynamic immunomodulation and direct induction manners. Biomaterials. 2020;240: 119841.","journal-title":"Biomaterials"},{"key":"690_CR30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2021.100193","volume":"3","author":"LE Keller","year":"2021","unstructured":"Keller LE, Tait Wojno ED, Begum L, Fortier LA. Regulatory t cells provide chondroprotection through increased timp1, il-10 and il-4, but cannot mitigate the catabolic effects of il-1\u03b2 and il-6 in a tri-culture model of osteoarthritis. Osteoarthr Cartil Open. 2021;3:100193.","journal-title":"Osteoarthr Cartil Open"},{"key":"690_CR31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108858","volume":"108","author":"F Rezaei Kahmini","year":"2022","unstructured":"Rezaei Kahmini F, Shahgaldi S, Azimi M, Mansourabadi AH. Emerging therapeutic potential of regulatory t (treg) cells for rheumatoid arthritis: New insights and challenges. Int Immunopharmacol. 2022;108: 108858.","journal-title":"Int Immunopharmacol"},{"key":"690_CR32","doi-asserted-by":"crossref","first-page":"E2585","DOI":"10.1073\/pnas.1800618115","volume":"115","author":"M Panduro","year":"2018","unstructured":"Panduro M, Benoist C, Mathis D. T(reg) cells limit ifn-\u03b3 production to control macrophage accrual and phenotype during skeletal muscle regeneration. Proc Natl Acad Sci U S A. 2018;115:E2585\u201393.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"690_CR33","volume":"10","author":"A Castiglioni","year":"2015","unstructured":"Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, et al. Foxp3+ t cells recruited to sites of sterile skeletal muscle injury regulate the fate of satellite cells and guide effective tissue regeneration. PLoS ONE. 2015;10:e0128094.","journal-title":"PLoS ONE"},{"key":"690_CR34","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.cmet.2023.08.010","volume":"35","author":"M Becker","year":"2023","unstructured":"Becker M, Joseph SS, Garcia-Carrizo F, Tom RZ, Opaleva D, Serr I, et al. Regulatory t cells require il6 receptor alpha signaling to control skeletal muscle function and regeneration. Cell Metab. 2023;35:1736-51.e7.","journal-title":"Cell Metab"},{"key":"690_CR35","volume":"10","author":"YF Chen","year":"2022","unstructured":"Chen YF, Lee CW, Wu HH, Lin WT, Lee OK. Immunometabolism of macrophages regulates skeletal muscle regeneration. Front Cell Dev Biol. 2022;10: 948819.","journal-title":"Front Cell Dev Biol"},{"key":"690_CR36","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1126\/scitranslmed.3009925","volume":"6","author":"SA Villalta","year":"2014","unstructured":"Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, et al. Regulatory t cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med. 2014;6:258.","journal-title":"Sci Transl Med."},{"key":"690_CR37","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2353\/ajpath.2009.080422","volume":"174","author":"Y Allenbach","year":"2009","unstructured":"Allenbach Y, Solly S, Gr\u00e9goire S, Dubourg O, Salomon B, Butler-Browne G, et al. Role of regulatory t cells in a new mouse model of experimental autoimmune myositis. Am J Pathol. 2009;174:989\u201398.","journal-title":"Am J Pathol"},{"key":"690_CR38","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.31557\/APJCP.2021.22.11.3447","volume":"22","author":"SH Aliyah","year":"2021","unstructured":"Aliyah SH, Ardiyan YN, Mardhiyah I, Herdini C, Dwianingsih EK, Aning S, et al. The distribution of m2 macrophage and treg in nasopharyngeal carcinoma tumor tissue and the correlation with tnm status and clinical stage. Asian Pac J Cancer Prev. 2021;22:3447\u201353.","journal-title":"Asian Pac J Cancer Prev"},{"key":"690_CR39","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.4049\/jimmunol.1502139","volume":"196","author":"A Nosbaum","year":"2016","unstructured":"Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, et al. Cutting edge: regulatory t cells facilitate cutaneous wound healing. J Immunol. 2016;196:2010\u20134.","journal-title":"J Immunol"},{"key":"690_CR40","doi-asserted-by":"crossref","first-page":"20696","DOI":"10.1073\/pnas.2000372117","volume":"117","author":"H Shime","year":"2020","unstructured":"Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, et al. Proenkephalin(+) regulatory t cells expanded by ultraviolet b exposure maintain skin homeostasis with a healing function. Proc Natl Acad Sci U S A. 2020;117:20696\u2013705.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"690_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032299","author":"RD de Ruiter","year":"2023","unstructured":"de Ruiter RD, Wisse LE, Schoenmaker T, Yaqub M, S\u00e1nchez-Duffhues G, Eekhoff EMW, et al. TGF-beta induces activin a production in dermal fibroblasts derived from patients with fibrodysplasia ossificans progressiva. Int J Mol Sci. 2023;24:2299.","journal-title":"Int J Mol Sci."},{"key":"690_CR42","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.7150\/thno.32734","volume":"9","author":"J Li","year":"2019","unstructured":"Li J, Yang KY, Tam RCY, Chan VW, Lan HY, Hori S, et al. Regulatory t-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. Theranostics. 2019;9:4324\u201341.","journal-title":"Theranostics"},{"key":"690_CR43","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nn.4528","volume":"20","author":"Y Dombrowski","year":"2017","unstructured":"Dombrowski Y, O\u2019Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, et al. Regulatory t cells promote myelin regeneration in the central nervous system. Nat Neurosci. 2017;20:674\u201380.","journal-title":"Nat Neurosci"},{"key":"690_CR44","first-page":"9826426","volume":"2022","author":"Y Wang","year":"2022","unstructured":"Wang Y, Xue F, Li Y, Lin L, Wang Y, Zhao S, et al. Programming of regulatory t cells in situ for nerve regeneration and long-term patency of vascular grafts. Research (Wash D C). 2022;2022:9826426.","journal-title":"Research (Wash D C)"},{"key":"690_CR45","doi-asserted-by":"crossref","first-page":"893","DOI":"10.7150\/ijbs.39725","volume":"16","author":"C Hu","year":"2020","unstructured":"Hu C, Wu Z, Li L. Mesenchymal stromal cells promote liver regeneration through regulation of immune cells. Int J Biol Sci. 2020;16:893\u2013903.","journal-title":"Int J Biol Sci"},{"key":"690_CR46","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1111\/jgh.12653","volume":"29","author":"L Xu","year":"2014","unstructured":"Xu L, Gong Y, Wang B, Shi K, Hou Y, Wang L, et al. Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis b virus cirrhosis: regulation of treg\/th17 cells. J Gastroenterol Hepatol. 2014;29:1620\u20138.","journal-title":"J Gastroenterol Hepatol"},{"key":"690_CR47","first-page":"53","volume":"9","author":"KJ Wu","year":"2023","unstructured":"Wu KJ, Qian QF, Zhou JR, Sun DL, Duan YF, Zhu X, et al. Regulatory t cells (tregs) in liver fibrosis. Cell Death Discov. 2023;9:53.","journal-title":"Cell Death Discov"},{"key":"690_CR48","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/imr.12172","volume":"259","author":"J Barbi","year":"2014","unstructured":"Barbi J, Pardoll D, Pan F. Treg functional stability and its responsiveness to the microenvironment. Immunol Rev. 2014;259:115\u201339.","journal-title":"Immunol Rev"},{"key":"690_CR49","doi-asserted-by":"crossref","first-page":"1269577","DOI":"10.3389\/fnins.2024.1269577","volume":"18","author":"J Wang","year":"2024","unstructured":"Wang J, Deng G, Wang S, Li S, Song P, Lin K, et al. Enhancing regenerative medicine: the crucial role of stem cell therapy. Front Neurosci. 2024;18:1269577.","journal-title":"Front Neurosci"},{"key":"690_CR50","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3324\/haematol.11240","volume":"92","author":"C Prevosto","year":"2007","unstructured":"Prevosto C, Zancolli M, Canevali P, Zocchi MR, Poggi A. Generation of cd4+ or cd8+ regulatory t cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica. 2007;92:881\u20138.","journal-title":"Haematologica."},{"key":"690_CR51","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2119\/molmed.2010.00098","volume":"17","author":"Y-H Kim","year":"2011","unstructured":"Kim Y-H, Wee Y-M, Choi M-Y, Lim D-G, Kim S-C, Han D-J. Interleukin (il)-10 induced by cd11b+ cells and il-10-activated regulatory t cells play a role in immune modulation of mesenchymal stem cells in rat islet allografts. Mol Med. 2011;17:697\u2013708.","journal-title":"Mol Med"},{"key":"690_CR52","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.0105-2896.2006.00407.x","volume":"212","author":"YY Wan","year":"2006","unstructured":"Wan YY, Flavell RA. The roles for cytokines in the generation and maintenance of regulatory t cells. Immunol Rev. 2006;212:114\u201330.","journal-title":"Immunol Rev"},{"key":"690_CR53","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3324\/haematol.2012.074088","volume":"98","author":"C Scott\u00e0","year":"2013","unstructured":"Scott\u00e0 C, Esposito M, Fazekasova H, Fanelli G, Edozie FC, Ali N, et al. Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human cd4(+)cd25(+)foxp3(+) t regulatory cell subpopulations. Haematologica. 2013;98:1291\u20139.","journal-title":"Haematologica"},{"key":"690_CR54","doi-asserted-by":"crossref","first-page":"10676","DOI":"10.1038\/s41598-021-90115-8","volume":"11","author":"JS Do","year":"2021","unstructured":"Do JS, Zwick D, Kenyon JD, Zhong F, Askew D, Huang AY, et al. Mesenchymal stromal cell mitochondrial transfer to human induced t-regulatory cells mediates foxp3 stability. Sci Rep. 2021;11:10676.","journal-title":"Sci Rep"},{"key":"690_CR55","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2249.2009.03874.x","volume":"156","author":"K English","year":"2009","unstructured":"English K, Ryan JM, Tobin L, Murphy MJ, Barry FP, Mahon BP. Cell contact, prostaglandin e(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of cd4+cd25(high) forkhead box p3+ regulatory t cells. Clin Exp Immunol. 2009;156:149\u201360.","journal-title":"Clin Exp Immunol"},{"key":"690_CR56","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.intimp.2014.02.038","volume":"20","author":"N Pang","year":"2014","unstructured":"Pang N, Zhang F, Ma X, Zhu Y, Zhao H, Xin Y, et al. Tgf-\u03b2\/smad signaling pathway regulates th17\/treg balance during echinococcus multilocularis infection. Int Immunopharmacol. 2014;20:248\u201357.","journal-title":"Int Immunopharmacol"},{"key":"690_CR57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1101029","volume":"188","author":"P Kalinski","year":"2012","unstructured":"Kalinski P. Regulation of immune responses by prostaglandin e2. J Immunol. 2012;188:21\u20138.","journal-title":"J Immunol"},{"key":"690_CR58","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s13287-017-0744-6","volume":"8","author":"B Wang","year":"2017","unstructured":"Wang B, Lin Y, Hu Y, Shan W, Liu S, Xu Y, et al. Mtor inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing cox-2 and pge(2). Stem Cell Res Ther. 2017;8:292.","journal-title":"Stem Cell Res Ther"},{"key":"690_CR59","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.4049\/jimmunol.1402898","volume":"195","author":"P Hsu","year":"2015","unstructured":"Hsu P, Santner-Nanan B, Hu M, Skarratt K, Lee CH, Stormon M, et al. Il-10 potentiates differentiation of human induced regulatory t cells via stat3 and foxo1. J Immunol. 2015;195:3665\u201374.","journal-title":"J Immunol"},{"key":"690_CR60","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202154096","volume":"23","author":"UF Prodjinotho","year":"2022","unstructured":"Prodjinotho UF, Gres V, Henkel F, Lacorcia M, Dandl R, Haslbeck M, et al. Helminthic dehydrogenase drives pge(2) and il-10 production in monocytes to potentiate treg induction. EMBO Rep. 2022;23:e54096.","journal-title":"EMBO Rep"},{"key":"690_CR61","doi-asserted-by":"publisher","DOI":"10.22541\/au.171722001.19584616\/v1","author":"Z Tang","year":"2024","unstructured":"Tang Z, Yang F, Shen J, Wu H, Hong H, Wang Y, et al. Mesenchymal stromal cells over-expression mutant il-2 enhance treg function in cia mice. Authorea Preprints. 2024. https:\/\/doi.org\/10.22541\/au.171722001.19584616\/v1.","journal-title":"Authorea Preprints."},{"key":"690_CR62","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s42003-021-02995-1","volume":"5","author":"MA Al-Aghbar","year":"2022","unstructured":"Al-Aghbar MA, Jainarayanan AK, Dustin ML, Roffler SR. The interplay between membrane topology and mechanical forces in regulating t cell receptor activity. Commun Biol. 2022;5:40.","journal-title":"Commun Biol"},{"key":"690_CR63","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3390\/biom13081194","volume":"13","author":"J Guo","year":"2023","unstructured":"Guo J, Xu Z, Gunderson RC, Xu B, Michie SA. Lfa-1\/icam-1 adhesion pathway mediates the homeostatic migration of lymphocytes from peripheral tissues into lymph nodes through lymphatic vessels. Biomolecules. 2023;13:1194.","journal-title":"Biomolecules."},{"key":"690_CR64","volume":"8","author":"ZX Yang","year":"2013","unstructured":"Yang ZX, Han ZB, Ji YR, Wang YW, Liang L, Chi Y, et al. Cd106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One. 2013;8: e59354.","journal-title":"PLoS ONE"},{"key":"690_CR65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13287-015-0021-5","volume":"6","author":"EF Cahill","year":"2015","unstructured":"Cahill EF, Tobin LM, Carty F, Mahon BP, English K. Jagged-1 is required for the expansion of cd4+ cd25+ foxp3+ regulatory t cells and tolerogenic dendritic cells by murine mesenchymal stromal cells. Stem Cell Res Ther. 2015;6:19.","journal-title":"Stem Cell Res Ther"},{"key":"690_CR66","doi-asserted-by":"crossref","first-page":"8437","DOI":"10.2147\/OTT.S221340","volume":"12","author":"J Cai","year":"2019","unstructured":"Cai J, Wang D, Zhang G, Guo X. The role of pd-1\/pd-l1 axis in treg development and function: implications for cancer immunotherapy. Onco Targets Ther. 2019;12:8437\u201345.","journal-title":"Onco Targets Ther"},{"key":"690_CR67","doi-asserted-by":"crossref","first-page":"44486","DOI":"10.1038\/srep44486","volume":"7","author":"HJ Lee","year":"2017","unstructured":"Lee HJ, Kim SN, Jeon MS, Yi T, Song SU. Icosl expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory t cells. Sci Rep. 2017;7:44486.","journal-title":"Sci Rep"},{"key":"690_CR68","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/ten.tea.2013.0673","volume":"21","author":"Y Liu","year":"2015","unstructured":"Liu Y, Yang R, Shi S. Systemic infusion of mesenchymal stem cells improves cell-based bone regeneration via upregulation of regulatory t cells. Tissue Eng Part A. 2015;21:498\u2013509.","journal-title":"Tissue Eng Part A"},{"key":"690_CR69","volume":"11","author":"A Schmidt","year":"2016","unstructured":"Schmidt A, Eriksson M, Shang MM, Weyd H, Tegn\u00e9r J. Comparative analysis of protocols to induce human cd4+foxp3+ regulatory t cells by combinations of il-2, tgf-beta, retinoic acid, rapamycin and butyrate. PLoS ONE. 2016;11:e0148474.","journal-title":"PLoS ONE"},{"key":"690_CR70","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1515\/biol-2021-0118","volume":"16","author":"R Li","year":"2021","unstructured":"Li R, Wang R, Zhong S, Asghar F, Li T, Zhu L, et al. Tgf-\u03b21-overexpressing mesenchymal stem cells reciprocally regulate th17\/treg cells by regulating the expression of ifn-\u03b3. Open Life Sci. 2021;16:1193\u2013202.","journal-title":"Open Life Sci"},{"key":"690_CR71","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/dna.2017.3735","volume":"37","author":"C Wang","year":"2018","unstructured":"Wang C, Lv D, Zhang X, Ni ZA, Sun X, Zhu C. Interleukin-10-overexpressing mesenchymal stromal cells induce a series of regulatory effects in the inflammatory system and promote the survival of endotoxin-induced acute lung injury in mice model. DNA Cell Biol. 2018;37:53\u201361.","journal-title":"DNA Cell Biol"},{"key":"690_CR72","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1159\/000489689","volume":"46","author":"B Tang","year":"2018","unstructured":"Tang B, Li X, Liu Y, Chen X, Li X, Chu Y, et al. The therapeutic effect of icam-1-overexpressing mesenchymal stem cells on acute graft-versus-host disease. Cell Physiol Biochem. 2018;46:2624\u201335.","journal-title":"Cell Physiol Biochem"},{"key":"690_CR73","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s13287-023-03594-z","volume":"14","author":"X Bai","year":"2023","unstructured":"Bai X, Chen T, Li Y, Ge X, Qiu C, Gou H, et al. Pd-l1 expression levels in mesenchymal stromal cells predict their therapeutic values for autoimmune hepatitis. Stem Cell Res Ther. 2023;14:370.","journal-title":"Stem Cell Res Ther"},{"key":"690_CR74","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/j.1582-4934.2011.01509.x","volume":"16","author":"S Schu","year":"2012","unstructured":"Schu S, Nosov M, O\u2019Flynn L, Shaw G, Treacy O, Barry F, et al. Immunogenicity of allogeneic mesenchymal stem cells. J Cell Mol Med. 2012;16:2094\u2013103.","journal-title":"J Cell Mol Med"},{"key":"690_CR75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","volume":"19","author":"S Gurung","year":"2021","unstructured":"Gurung S, Perocheau D, Touramanidou L, Baruteau J. The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Commun Signal. 2021;19:47.","journal-title":"Cell Commun Signal"},{"key":"690_CR76","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/cells9041059","volume":"9","author":"F Franco da Cunha","year":"2020","unstructured":"Franco da Cunha F, Andrade-Oliveira V, Candido de Almeida D, Borges da Silva T, de Souza Naffah, Breda C, Costa Cruz M, et al. Extracellular vesicles isolated from mesenchymal stromal cells modulate cd4(+) t lymphocytes toward a regulatory profile. Cells. 2020;9:1059.","journal-title":"Cells"},{"key":"690_CR77","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.3727\/096368915X687543","volume":"24","author":"A Del Fattore","year":"2015","unstructured":"Del Fattore A, Luciano R, Pascucci L, Goffredo BM, Giorda E, Scapaticci M, et al. Immunoregulatory effects of mesenchymal stem cell-derived extracellular vesicles on t lymphocytes. Cell Transplant. 2015;24:2615\u201327.","journal-title":"Cell Transplant"},{"key":"690_CR78","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1089\/scd.2013.0479","volume":"23","author":"B Zhang","year":"2014","unstructured":"Zhang B, Yin Y, Lai RC, Tan SS, Choo AB, Lim SK. Mesenchymal stem cells secrete immunologically active exosomes. Stem Cells Dev. 2014;23:1233\u201344.","journal-title":"Stem Cells Dev"},{"key":"690_CR79","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biomaterials.2019.02.006","volume":"200","author":"S Zhang","year":"2019","unstructured":"Zhang S, Teo KYW, Chuah SJ, Lai RC, Lim SK, Toh WS. Msc exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis. Biomaterials. 2019;200:35\u201347.","journal-title":"Biomaterials"},{"key":"690_CR80","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.7150\/thno.21072","volume":"8","author":"S Cosenza","year":"2018","unstructured":"Cosenza S, Toupet K, Maumus M, Luz-Crawford P, Blanc-Brude O, Jorgensen C, et al. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis. Theranostics. 2018;8:1399\u2013410.","journal-title":"Theranostics"},{"key":"690_CR81","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/jcmm.17086","volume":"26","author":"X Tian","year":"2022","unstructured":"Tian X, Wei W, Cao Y, Ao T, Huang F, Javed R, et al. Gingival mesenchymal stem cell-derived exosomes are immunosuppressive in preventing collagen-induced arthritis. J Cell Mol Med. 2022;26:693\u2013708.","journal-title":"J Cell Mol Med"},{"key":"690_CR82","doi-asserted-by":"crossref","first-page":"24120","DOI":"10.1038\/srep24120","volume":"6","author":"M Di Trapani","year":"2016","unstructured":"Di Trapani M, Bassi G, Midolo M, Gatti A, Kamga PT, Cassaro A, et al. Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on t, b and nk cell functions. Sci Rep. 2016;6:24120.","journal-title":"Sci Rep"},{"key":"690_CR83","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41420-021-00534-9","volume":"7","author":"J Lu","year":"2021","unstructured":"Lu J, Wang W, Li P, Wang X, Gao C, Zhang B, et al. Mir-146a regulates regulatory t cells to suppress heart transplant rejection in mice. Cell Death Discov. 2021;7:165.","journal-title":"Cell Death Discov"},{"key":"690_CR84","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12974-016-0712-6","volume":"13","author":"J Heyn","year":"2016","unstructured":"Heyn J, Luchting B, Hinske LC, H\u00fcbner M, Azad SC, Kreth S. Mir-124a and mir-155 enhance differentiation of regulatory t cells in patients with neuropathic pain. J Neuroinflammation. 2016;13:248.","journal-title":"J Neuroinflammation"},{"key":"690_CR85","doi-asserted-by":"crossref","first-page":"2993043","DOI":"10.1155\/2021\/2993043","volume":"2021","author":"T Teshima","year":"2021","unstructured":"Teshima T, Yuchi Y, Suzuki R, Matsumoto H, Koyama H. Immunomodulatory effects of canine adipose tissue mesenchymal stem cell-derived extracellular vesicles on stimulated cd4(+) t cells isolated from peripheral blood mononuclear cells. J Immunol Res. 2021;2021:2993043.","journal-title":"J Immunol Res"},{"key":"690_CR86","volume":"34","author":"F Xu","year":"2022","unstructured":"Xu F, Fei Z, Dai H, Xu J, Fan Q, Shen S, et al. Mesenchymal stem cell-derived extracellular vesicles with high pd-l1 expression for autoimmune diseases treatment. Adv Mater. 2022;34: e2106265.","journal-title":"Adv Mater"},{"key":"690_CR87","volume":"232","author":"Z Wei","year":"2019","unstructured":"Wei Z, Qiao S, Zhao J, Liu Y, Li Q, Wei Z, et al. Mirna-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury. Life Sci. 2019;232: 116632.","journal-title":"Life Sci"},{"key":"690_CR88","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.drudis.2016.06.005","volume":"21","author":"RJ Bose","year":"2016","unstructured":"Bose RJ, Lee SH, Park H. Biofunctionalized nanoparticles: an emerging drug delivery platform for various disease treatments. Drug Discov Today. 2016;21:1303\u201312.","journal-title":"Drug Discov Today"},{"key":"690_CR89","doi-asserted-by":"crossref","first-page":"12100","DOI":"10.1038\/s41598-017-12121-z","volume":"7","author":"FDC Gon\u00e7alves","year":"2017","unstructured":"Gon\u00e7alves FDC, Luk F, Korevaar SS, Bouzid R, Paz AH, L\u00f3pez-Iglesias C, et al. Membrane particles generated from mesenchymal stromal cells modulate immune responses by selective targeting of pro-inflammatory monocytes. Sci Rep. 2017;7:12100.","journal-title":"Sci Rep"},{"key":"690_CR90","volume":"35","author":"N Su","year":"2023","unstructured":"Su N, Villicana C, Barati D, Freeman P, Luo Y, Yang F. Stem cell membrane-coated microribbon scaffolds induce regenerative innate and adaptive immune responses in a critical-size cranial bone defect model. Adv Mater. 2023;35:e2208781.","journal-title":"Adv Mater"},{"key":"690_CR91","doi-asserted-by":"crossref","first-page":"11401","DOI":"10.1007\/s12274-023-5877-6","volume":"16","author":"C Gu","year":"2023","unstructured":"Gu C, Yang S, Liu X, Jin Y, Yu Y, Lu L. A biomimetic adipocyte mesenchymal stem cell membrane-encapsulated drug delivery system for the treatment of rheumatoid arthritis. Nano Res. 2023;16:11401\u201310.","journal-title":"Nano Res"},{"key":"690_CR92","volume":"161","author":"L Fan","year":"2023","unstructured":"Fan L, Wei A, Gao Z, Mu X. Current progress of mesenchymal stem cell membrane-camouflaged nanoparticles for targeted therapy. Biomed Pharmacother. 2023;161:114451.","journal-title":"Biomed Pharmacother"},{"key":"690_CR93","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s13770-021-00364-x","volume":"18","author":"J Hahm","year":"2021","unstructured":"Hahm J, Kim J, Park J. Strategies to enhance extracellular vesicle production. Tissue Eng Regen Med. 2021;18:513\u201324.","journal-title":"Tissue Eng Regen Med"},{"key":"690_CR94","volume":"9","author":"J Kim","year":"2024","unstructured":"Kim J, Kim JS, Kim D, Bello AB, Kim BJ, Cha BH, et al. Therapeutic potential of mesenchymal stem cells from human ipsc-derived teratomas for osteochondral defect regeneration. Bioeng Transl Med. 2024;9:e10629.","journal-title":"Bioeng Transl Med"},{"key":"690_CR95","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40824-023-00371-0","volume":"27","author":"N Prakash","year":"2023","unstructured":"Prakash N, Kim J, Jeon J, Kim S, Arai Y, Bello AB, et al. Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (mscs) from pluripotent stem cells (pscs). Biomater Res. 2023;27:31.","journal-title":"Biomater Res"},{"key":"690_CR96","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1359-6446(03)02953-2","volume":"9","author":"AJ Chirino","year":"2004","unstructured":"Chirino AJ, Ary ML, Marshall SA. Minimizing the immunogenicity of protein therapeutics. Drug Discov Today. 2004;9:82\u201390.","journal-title":"Drug Discov Today"},{"key":"690_CR97","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13287-017-0511-8","volume":"8","author":"D Gerace","year":"2017","unstructured":"Gerace D, Martiniello-Wilks R, Nassif NT, Lal S, Steptoe R, Simpson AM. Crispr-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success? Stem Cell Res Ther. 2017;8:62.","journal-title":"Stem Cell Res Ther"},{"key":"690_CR98","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41577-019-0248-y","volume":"20","author":"YE Bar-Ephraim","year":"2020","unstructured":"Bar-Ephraim YE, Kretzschmar K, Clevers H. Organoids in immunological research. Nat Rev Immunol. 2020;20:279\u201393.","journal-title":"Nat Rev Immunol"},{"key":"690_CR99","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tips.2023.06.010","volume":"44","author":"FW Pun","year":"2023","unstructured":"Pun FW, Ozerov IV, Zhavoronkov A. Ai-powered therapeutic target discovery. Trends Pharmacol Sci. 2023;44:561\u201372.","journal-title":"Trends Pharmacol Sci"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-024-00690-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-024-00690-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-024-00690-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T11:26:08Z","timestamp":1738668368000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-024-00690-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":99,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["690"],"URL":"https:\/\/doi.org\/10.1007\/s13770-024-00690-w","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"21 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no financial conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"There are no animal experiments carried out for this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}