{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:06:07Z","timestamp":1791489967226,"version":"4.3.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2024-00512879"],"award-info":[{"award-number":["RS-2024-00512879"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020621","name":"Seoul St. Mary's Hospital, Catholic University of Korea","doi-asserted-by":"publisher","award":["ZC23EISI0773"],"award-info":[{"award-number":["ZC23EISI0773"]}],"id":[{"id":"10.13039\/501100020621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["R202101500"],"award-info":[{"award-number":["R202101500"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["R202101500"],"award-info":[{"award-number":["R202101500"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s13770-025-00755-4","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T10:03:49Z","timestamp":1757412229000},"page":"1173-1183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effects of Mesenchymal Stem Cell-Derived Exosomes on the Attenuation of Dry Eye Disease in Sj\u00f6gren Syndrome Animal Model"],"prefix":"10.1007","volume":"22","author":[{"given":"Youngseo","family":"Jeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soojung","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jeong","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmin","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Uk","family":"Beak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-9376","authenticated-orcid":false,"given":"So-Hyang","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"755_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.47","volume":"2","author":"P Brito-Zer\u00f3n","year":"2016","unstructured":"Brito-Zer\u00f3n P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, et al. Sj\u00f6gren syndrome. Nat Rev Dis Primers. 2016;2:16047.","journal-title":"Nat Rev Dis Primers"},{"key":"755_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s10238-021-00728-6","volume":"22","author":"S Negrini","year":"2022","unstructured":"Negrini S, Emmi G, Greco M, Borro M, Sardanelli F, Murdaca G, et al. Sj\u00f6gren\u2019s syndrome: a systemic autoimmune disease. Clin Exp Med. 2022;22:9\u201325.","journal-title":"Clin Exp Med"},{"key":"755_CR3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/joim.13032","volume":"287","author":"A Bj\u00f6rk","year":"2020","unstructured":"Bj\u00f6rk A, Mofors J, Wahren-Herlenius M. Environmental factors in the pathogenesis of primary Sj\u00f6gren\u2019s syndrome. J Intern Med. 2020;287:475\u201392.","journal-title":"J Intern Med"},{"key":"755_CR4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00018-020-03600-0","volume":"78","author":"LA Costa","year":"2021","unstructured":"Costa LA, Eiro N, Fraile M, Gonzalez LO, Sa\u00e1 J, Garcia-Portabella P, et al. Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses. Cell Mol Life Sci. 2021;78:447\u201367.","journal-title":"Cell Mol Life Sci"},{"key":"755_CR5","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/s41419-023-06239-4","volume":"14","author":"A Walewska","year":"2023","unstructured":"Walewska A, Janucik A, Tynecka M, Moniuszko M, Eljaszewicz A. Mesenchymal stem cells under epigenetic control - the role of epigenetic machinery in fate decision and functional properties. Cell Death Dis. 2023;14:720.","journal-title":"Cell Death Dis"},{"key":"755_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","volume":"4","author":"MF Pittenger","year":"2019","unstructured":"Pittenger MF, Discher DE, P\u00e9ault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019;4:22.","journal-title":"NPJ Regen Med"},{"key":"755_CR7","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/00055735-200012000-00016","volume":"11","author":"MC Carnahan","year":"2000","unstructured":"Carnahan MC, Goldstein DA. Ocular complications of topical, peri-ocular, and systemic corticosteroids. Curr Opin Ophthalmol. 2000;11:478\u201383.","journal-title":"Curr Opin Ophthalmol"},{"key":"755_CR8","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jtos.2014.12.001","volume":"13","author":"GN Foulks","year":"2015","unstructured":"Foulks GN, Forstot SL, Donshik PC, Forstot JZ, Goldstein MH, Lemp MA, et al. Clinical guidelines for management of dry eye associated with sj\u00f6gren disease. Ocul Surf. 2015;13:118\u201332.","journal-title":"Ocul Surf"},{"key":"755_CR9","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.3390\/ijms24021039","volume":"24","author":"S Shin","year":"2023","unstructured":"Shin S, Yoon SG, Kim M, Cheon EJ, Jeon Y, Lee HJ, et al. The effect of mesenchymal stem cells on dry eye in sjogren syndrome mouse model. Int J Mol Sci. 2023;24:1039.","journal-title":"Int J Mol Sci"},{"key":"755_CR10","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3390\/cells8070727","volume":"8","author":"LM Doyle","year":"2019","unstructured":"Doyle LM, Wang MZ. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells. 2019;8:727.","journal-title":"Cells"},{"key":"755_CR11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.actbio.2020.11.001","volume":"119","author":"P Lou","year":"2021","unstructured":"Lou P, Liu S, Xu X, Pan C, Lu Y, Liu J. Extracellular vesicle-based therapeutics for the regeneration of chronic wounds: current knowledge and future perspectives. Acta Biomater. 2021;119:42\u201356.","journal-title":"Acta Biomater"},{"key":"755_CR12","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.3390\/pharmaceutics15041167","volume":"15","author":"KY Wu","year":"2023","unstructured":"Wu KY, Ahmad H, Lin G, Carbonneau M, Tran SD. Mesenchymal stem cell-derived exosomes in ophthalmology: a comprehensive review. Pharmaceutics. 2023;15:1167.","journal-title":"Pharmaceutics"},{"key":"755_CR13","doi-asserted-by":"publisher","first-page":"5194","DOI":"10.1167\/iovs.18-24803","volume":"59","author":"R Samaeekia","year":"2018","unstructured":"Samaeekia R, Rabiee B, Putra I, Shen X, Park YJ, Hematti P, et al. Effect of human corneal mesenchymal stromal cell-derived exosomes on corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2018;59:5194\u2013200.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"755_CR14","doi-asserted-by":"publisher","first-page":"5738510","DOI":"10.1155\/2019\/5738510","volume":"2019","author":"H Tao","year":"2019","unstructured":"Tao H, Chen X, Cao H, Zheng L, Li Q, Zhang K, et al. Mesenchymal stem cell-derived extracellular vesicles for corneal wound repair. Stem Cells Int. 2019;2019:5738510.","journal-title":"Stem Cells Int"},{"key":"755_CR15","doi-asserted-by":"publisher","first-page":"104200","DOI":"10.1016\/j.isci.2022.104200","volume":"25","author":"Z Yu","year":"2022","unstructured":"Yu Z, Hao R, Du J, Wu X, Chen X, Zhang Y, et al. A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles. iScience. 2022;25:104200.","journal-title":"iScience"},{"key":"755_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101606","volume":"11","author":"H Kang","year":"2022","unstructured":"Kang H, Bae YH, Kwon Y, Kim S, Park J. Extracellular vesicles generated using bioreactors and their therapeutic effect on the acute kidney injury model. Adv Healthc Mater. 2022;11: e2101606.","journal-title":"Adv Healthc Mater"},{"key":"755_CR17","doi-asserted-by":"publisher","first-page":"10119","DOI":"10.3390\/ijms251810119","volume":"25","author":"HJ Kang","year":"2024","unstructured":"Kang HJ, Yun S, Shin SH, Youn DH, Son GH, Lee JJ, et al. Tuberculous pleural effusion-derived exosomal miR-130b-3p and miR-423-5p promote the proliferation of lung cancer cells via cyclin D1. Int J Mol Sci. 2024;25:10119.","journal-title":"Int J Mol Sci"},{"key":"755_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031115","author":"JS Han","year":"2021","unstructured":"Han JS, Kim SE, Jin JQ, Park NR, Lee JY, Kim HL, et al. Tear-derived exosome proteins are increased in patients with thyroid eye disease. Int J Mol Sci. 2021;22:1115.","journal-title":"Int J Mol Sci"},{"key":"755_CR19","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1167\/iovs.19-27469","volume":"60","author":"HJ Lee","year":"2019","unstructured":"Lee HJ, Shin S, Yoon SG, Cheon EJ, Chung SH. The effect of chloroquine on the development of dry eye in Sj\u00f6gren syndrome animal model. Invest Ophthalmol Vis Sci. 2019;60:3708\u201316.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"755_CR20","first-page":"221","volume":"21","author":"MA Lemp","year":"1995","unstructured":"Lemp MA. Report of the National Eye Institute\/Industry workshop on clinical trials in dry eyes. Clao J. 1995;21:221\u201332.","journal-title":"Clao J"},{"key":"755_CR21","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0030-4220(74)90417-4","volume":"37","author":"JS Greenspan","year":"1974","unstructured":"Greenspan JS, Daniels TE, Talal N, Sylvester RA. The histopathology of Sj\u00f6gren\u2019s syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974;37:217\u201329.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"755_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1472-6831-13-51","volume":"13","author":"J Xuan","year":"2013","unstructured":"Xuan J, Shen L, Malyavantham K, Pankewycz O, Ambrus JL Jr, Suresh L. Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren\u2019s syndrome. BMC Oral Health. 2013;13:51.","journal-title":"BMC Oral Health"},{"key":"755_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1089\/jop.2019.0060","volume":"36","author":"LM Periman","year":"2020","unstructured":"Periman LM, Perez VL, Saban DR, Lin MC, Neri P. The immunological basis of dry eye disease and current topical treatment options. J Ocul Pharmacol Ther. 2020;36:137\u201346.","journal-title":"J Ocul Pharmacol Ther"},{"key":"755_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076121","volume":"8","author":"DA Schaumberg","year":"2013","unstructured":"Schaumberg DA, Uchino M, Christen WG, Semba RD, Buring JE, Li JZ. Patient reported differences in dry eye disease between men and women: impact, management, and patient satisfaction. PLoS ONE. 2013;8:e76121.","journal-title":"PLoS ONE"},{"key":"755_CR25","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.2147\/OPTH.S279051","volume":"14","author":"LM Periman","year":"2020","unstructured":"Periman LM, Mah FS, Karpecki PM. A review of the mechanism of action of cyclosporine A: the role of cyclosporine A in dry eye disease and recent formulation developments. Clin Ophthalmol. 2020;14:4187\u2013200.","journal-title":"Clin Ophthalmol"},{"key":"755_CR26","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1080\/09273948.2017.1341988","volume":"27","author":"CA Cutolo","year":"2019","unstructured":"Cutolo CA, Barabino S, Bonzano C, Traverso CE. The use of topical corticosteroids for treatment of dry eye syndrome. Ocul Immunol Inflamm. 2019;27:266\u201375.","journal-title":"Ocul Immunol Inflamm"},{"key":"755_CR27","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.clae.2015.04.004","volume":"38","author":"BK Moscovici","year":"2015","unstructured":"Moscovici BK, Holzchuh R, Sakassegawa-Naves FE, Hoshino-Ruiz DR, Albers MB, Santo RM, et al. Treatment of sj\u00f6gren\u2019s syndrome dry eye using 0.03% tacrolimus eye drop: Prospective double-blind randomized study. Cont Lens Anterior Eye. 2015;38:373\u20138.","journal-title":"Cont Lens Anterior Eye"},{"key":"755_CR28","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1001\/archopht.118.9.1264","volume":"118","author":"SE Moss","year":"2000","unstructured":"Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol. 2000;118:1264\u20138.","journal-title":"Arch Ophthalmol"},{"key":"755_CR29","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/S0161-6420(99)90171-9","volume":"106","author":"P Marsh","year":"1999","unstructured":"Marsh P, Pflugfelder SC. Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sj\u00f6gren syndrome. Ophthalmology. 1999;106:811\u20136.","journal-title":"Ophthalmology"},{"key":"755_CR30","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1182\/blood-2011-11-391144","volume":"120","author":"J Xu","year":"2012","unstructured":"Xu J, Wang D, Liu D, Fan Z, Zhang H, Liu O, et al. Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sj\u00f6gren syndrome. Blood. 2012;120:3142\u201351.","journal-title":"Blood"},{"key":"755_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbrc.2016.02.058","volume":"472","author":"Z Stickney","year":"2016","unstructured":"Stickney Z, Losacco J, McDevitt S, Zhang Z, Lu B. Development of exosome surface display technology in living human cells. Biochem Biophys Res Commun. 2016;472:53\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"755_CR32","doi-asserted-by":"publisher","first-page":"4389","DOI":"10.1038\/s41467-021-24384-2","volume":"12","author":"M Mathieu","year":"2021","unstructured":"Mathieu M, N\u00e9vo N, Jouve M, Valenzuela JI, Maurin M, Verweij FJ, et al. Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9. Nat Commun. 2021;12:4389.","journal-title":"Nat Commun"},{"key":"755_CR33","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s12026-014-8490-7","volume":"58","author":"S Levy","year":"2014","unstructured":"Levy S. Function of the tetraspanin molecule CD81 in B and T cells. Immunol Res. 2014;58:179\u201385.","journal-title":"Immunol Res"},{"key":"755_CR34","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1186\/s13287-021-02541-0","volume":"12","author":"B Li","year":"2021","unstructured":"Li B, Xing Y, Gan Y, He J, Hua H. Labial gland-derived mesenchymal stem cells and their exosomes ameliorate murine Sj\u00f6gren\u2019s syndrome by modulating the balance of Treg and Th17 cells. Stem Cell Res Ther. 2021;12:478.","journal-title":"Stem Cell Res Ther"},{"key":"755_CR35","doi-asserted-by":"publisher","first-page":"14521","DOI":"10.1038\/s41598-020-71337-8","volume":"10","author":"C Yu","year":"2020","unstructured":"Yu C, Chen P, Xu J, Liu Y, Li H, Wang L, et al. hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye. Sci Rep. 2020;10:14521.","journal-title":"Sci Rep"},{"key":"755_CR36","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.3390\/cancers12082110","volume":"12","author":"JC Schroeder","year":"2020","unstructured":"Schroeder JC, Puntigam L, Hofmann L, Jeske SS, Beccard IJ, Doescher J, et al. Circulating exosomes inhibit B cell proliferation and activity. Cancers (Basel). 2020;12:2110.","journal-title":"Cancers (Basel)"},{"key":"755_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.871096","volume":"13","author":"Y Xing","year":"2022","unstructured":"Xing Y, Li B, He J, Hua H. Labial gland mesenchymal stem cell derived exosomes-mediated miRNA-125b attenuates experimental sjogren\u2019s syndrome by targeting PRDM1 and suppressing plasma Cells. Front Immunol. 2022;13: 871096.","journal-title":"Front Immunol"},{"key":"755_CR38","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.3390\/pharmaceutics15051486","volume":"15","author":"S An","year":"2023","unstructured":"An S, Anwar K, Ashraf M, Lee H, Jung R, Koganti R, et al. Wound-healing effects of mesenchymal stromal cell secretome in the cornea and the role of exosomes. Pharmaceutics. 2023;15:1486.","journal-title":"Pharmaceutics"},{"key":"755_CR39","first-page":"11742","volume":"9","author":"JO Jin","year":"2013","unstructured":"Jin JO, Yu Q. T Cell-associated cytokines in the pathogenesis of sj\u00f6gren\u2019s syndrome. J Clin Cell Immunol. 2013;9:11742.","journal-title":"J Clin Cell Immunol."},{"key":"755_CR40","doi-asserted-by":"publisher","first-page":"5218","DOI":"10.1167\/iovs.15-17003","volume":"56","author":"HS Aluri","year":"2015","unstructured":"Aluri HS, Kublin CL, Thotakura S, Armaos H, Samizadeh M, Hawley D, et al. Role of matrix metalloproteinases 2 and 9 in lacrimal gland disease in animal models of Sj\u00f6gren\u2019s syndrome. Invest Ophthalmol Vis Sci. 2015;56:5218\u201328.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"755_CR41","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jtos.2015.10.004","volume":"14","author":"NL Lanza","year":"2016","unstructured":"Lanza NL, Valenzuela F, Perez VL, Galor A. The matrix metalloproteinase 9 point-of-care test in dry eye. Ocul Surf. 2016;14:189\u201395.","journal-title":"Ocul Surf"},{"key":"755_CR42","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1002\/pmic.201000422","volume":"11","author":"F Raimondo","year":"2011","unstructured":"Raimondo F, Morosi L, Chinello C, Magni F, Pitto M. Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery. Proteomics. 2011;11:709\u201320.","journal-title":"Proteomics"},{"key":"755_CR43","doi-asserted-by":"publisher","first-page":"1417758","DOI":"10.3389\/fimmu.2024.1417758","volume":"15","author":"M Liu","year":"2024","unstructured":"Liu M, Wen Z, Zhang T, Zhang L, Liu X, Wang M. The role of exosomal molecular cargo in exosome biogenesis and disease diagnosis. Front Immunol. 2024;15:1417758.","journal-title":"Front Immunol"},{"key":"755_CR44","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.jtos.2017.05.007","volume":"15","author":"DM Rassi","year":"2017","unstructured":"Rassi DM, De Paiva CS, Dias LC, M\u00f3dulo CM, Adriano L, Fantucci MZ, et al. Micrornas in ocular surface and dry eye diseases. Ocul Surf. 2017;15:660\u20139.","journal-title":"Ocul Surf"},{"key":"755_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.107899","volume":"191","author":"M Ma","year":"2020","unstructured":"Ma M, Li B, Zhang M, Zhou L, Yang F, Ma F, et al. Therapeutic effects of mesenchymal stem cell-derived exosomes on retinal detachment. Exp Eye Res. 2020;191:107899.","journal-title":"Exp Eye Res"},{"key":"755_CR46","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/j.ymthe.2020.04.020","volume":"28","author":"H Kim","year":"2020","unstructured":"Kim H, Lee MJ, Bae EH, Ryu JS, Kaur G, Kim HJ, et al. Comprehensive molecular profiles of functionally effective MSC-derived extracellular vesicles in immunomodulation. Mol Ther. 2020;28:1628\u201344.","journal-title":"Mol Ther"},{"key":"755_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.65.12.1","volume":"65","author":"G Wang","year":"2024","unstructured":"Wang G, Zhu Y, Liu Y, Yang M, Zeng L. Mesenchymal stem cells-derived exosomal miR-223-3p alleviates ocular surface damage and inflammation by downregulating Fbxw7 in dry eye models. Invest Ophthalmol Vis Sci. 2024;65:1.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"755_CR48","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jtos.2023.03.002","volume":"28","author":"L Wang","year":"2023","unstructured":"Wang L, Wang X, Chen Q, Wei Z, Xu X, Han D, et al. MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1\/TAB2\/NF-\u03baB pathway. Ocul Surf. 2023;28:131\u201340.","journal-title":"Ocul Surf"},{"key":"755_CR49","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj9617","volume":"8","author":"T Zhou","year":"2022","unstructured":"Zhou T, He C, Lai P, Yang Z, Liu Y, Xu H, et al. miR-204-containing exosomes ameliorate GVHD-associated dry eye disease. Sci Adv. 2022;8:eabj9617.","journal-title":"Sci Adv"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-025-00755-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-025-00755-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-025-00755-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T06:02:49Z","timestamp":1763791369000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-025-00755-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["755"],"URL":"https:\/\/doi.org\/10.1007\/s13770-025-00755-4","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]},"assertion":[{"value":"22 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"So-Hyang Chung has patents issued and pending to The Catholic University of Korea, Industry-Academic Cooperation Foundation, and Jaesung Park has patents issued and pending to POSTECH Research and Business Development Foundation. Other authors declare that they have no known conflict of interest that could have influenced the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures were performed according to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research and the experimental protocol was approved by the Institutional Animal Care and Use Committee (IACUC no. 2023-0202-01).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}