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It has also demonstrated adjunctive benefits in managing inflammatory oral diseases such as peri-implantitis and medication-related osteonecrosis of the jaw, where its dual regenerative and anti-inflammatory actions support both soft- and hard-tissue healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although these findings highlight broad therapeutic potential, current evidence remains limited. Most reports derive from preclinical experiments or small-scale clinical studies, and well-designed randomized controlled trials are needed to validate efficacy of PDRN and define its optimal clinical indications in evidence-based dental protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13770-025-00776-z","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:11:22Z","timestamp":1768637482000},"page":"209-220","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1192-7066","authenticated-orcid":false,"given":"Jeong-Kui","family":"Ku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pil-Young","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Kon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"key":"776_CR1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fphar.2017.00224","volume":"8","author":"F Squadrito","year":"2017","unstructured":"Squadrito F, Bitto A, Irrera N, Pizzino G, Pallio G, Minutoli L, et al. 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