{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:52:12Z","timestamp":1774623132613,"version":"3.50.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s13770-025-00780-3","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:11:20Z","timestamp":1768637480000},"page":"439-461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Umbilical Cord Mesenchymal Stem Cells and Wnt Pathway Modulation: A Novel Therapy for Liver Cirrhosis and Steatosis"],"prefix":"10.1007","volume":"23","author":[{"given":"Yanxuan","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouman","family":"Amjad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Mukamab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obed Boadi","family":"Amissah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishi","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-4225","authenticated-orcid":false,"given":"Zhiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"issue":"1","key":"780_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","volume":"129","author":"LA Adams","year":"2005","unstructured":"Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129:113\u201321.","journal-title":"Gastroenterology"},{"issue":"12","key":"780_CR2","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.cgh.2012.10.001","volume":"10","author":"DL White","year":"2012","unstructured":"White DL, Kanwal F, El-Serag HB. Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clin Gastroenterol Hepatol. 2012;10):1342-159.e2.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"780_CR3","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","volume":"81","author":"European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), & European Association for the Study of Obesity (EASO)","year":"2024","unstructured":"European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), & European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024;81:492\u2013542.","journal-title":"J Hepatol"},{"key":"780_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.777462","volume":"9","author":"G Chiabotto","year":"2021","unstructured":"Chiabotto G, Ceccotti E, Tapparo M, Camussi G, Bruno S. Human liver stem cell-derived extracellular vesicles target hepatic stellate cells and attenuate their pro-fibrotic phenotype. Front Cell Dev Biol. 2021;9:777462.","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"780_CR5","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1038\/s42255-025-01394-8","volume":"7","author":"RM Mancina","year":"2025","unstructured":"Mancina RM, Valenti L, Romeo S. Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism. Nat Metab. 2025;7:2199\u2013211.","journal-title":"Nat Metab"},{"issue":"1","key":"780_CR6","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jhep.2013.08.011","volume":"60","author":"J Dyson","year":"2014","unstructured":"Dyson J, Jaques B, Chattopadyhay D, Lochan R, Graham J, Das D, et al. Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team. J Hepatol. 2014;60:110\u20137.","journal-title":"J Hepatol"},{"key":"780_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113238","volume":"232","author":"X Li","year":"2022","unstructured":"Li X, Zhang T, Lv W, Wang H, Chen H, Xu Q, et al. Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt\/\u03b2-catenin signaling pathway in mice. Ecotoxicol Environ Saf. 2022;232:113238.","journal-title":"Ecotoxicol Environ Saf"},{"key":"780_CR8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.biochi.2023.03.001","volume":"211","author":"Q Ma","year":"2023","unstructured":"Ma Q, Yu J, Zhang X, Wu X, Deng G. Wnt\/\u03b2-catenin signaling pathway-a versatile player in apoptosis and autophagy. Biochimie. 2023;211:57\u201367.","journal-title":"Biochimie"},{"issue":"5","key":"780_CR9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1159\/000509554","volume":"9","author":"M Kudo","year":"2020","unstructured":"Kudo M. Gd-EOB-DTPA-MRI could predict WNT\/\u03b2-catenin mutation and resistance to immune checkpoint inhibitor therapy in hepatocellular carcinoma. Liver Cancer. 2020;9(5):479\u201390.","journal-title":"Liver Cancer"},{"issue":"4","key":"780_CR10","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.3390\/ijms25042073","volume":"25","author":"B Cuadra","year":"2024","unstructured":"Cuadra B, Silva V, Huang YL, Diaz Y, Rivas C, Molina C, et al. The immunoregulatory and regenerative potential of activated human stem cell secretome mitigates acute-on-chronic liver failure in a rat model. Int J Mol Sci. 2024;25:2073.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"780_CR11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13287-024-03648-w","volume":"15","author":"F Ding","year":"2024","unstructured":"Ding F, Liu Y, Li J, Wei X, Zhao J, Liu X, et al. TC14012 enhances the anti-fibrosis effects of UC-MSCs on the liver by reducing collagen accumulation and ameliorating inflammation. Stem Cell Res Ther. 2024;15:44.","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"780_CR12","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1007\/s13577-021-00593-1","volume":"34","author":"L Cheng","year":"2021","unstructured":"Cheng L, Yu P, Li F, Jiang X, Jiao X, Shen Y, et al. Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression. Hum Cell. 2021;34:1697\u2013708.","journal-title":"Hum Cell"},{"key":"780_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116133","volume":"171","author":"P Chen","year":"2024","unstructured":"Chen P, Yuan M, Yao L, Xiong Z, Liu P, Wang Z, et al. Human umbilical cord-derived mesenchymal stem cells ameliorate liver fibrosis by improving mitochondrial function via Slc25a47-Sirt3 signaling pathway. Biomed Pharm. 2024;171:116133.","journal-title":"Biomed Pharm = Biomed Pharm"},{"key":"780_CR14","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.biopha.2018.11.082","volume":"110","author":"X Cheng","year":"2019","unstructured":"Cheng X, Xu X, Chen D, Zhao F, Wang W. Therapeutic potential of targeting the Wnt\/\u03b2-catenin signaling pathway in colorectal cancer. Biomed Pharmacother. 2019;110:473\u201381.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"780_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","volume":"7","author":"J Liu","year":"2022","unstructured":"Liu J, Xiao Q, Xiao J, Niu C, Li Y, Zhang X, et al. Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 2022;7:3.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"780_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","volume":"17","author":"BT MacDonald","year":"2009","unstructured":"MacDonald BT, Tamai K, He X. Wnt\/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009;17:9\u201326.","journal-title":"Dev Cell"},{"issue":"2","key":"780_CR17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/ajg.2011.327","volume":"107","author":"Y Kawamura","year":"2012","unstructured":"Kawamura Y, Arase Y, Ikeda K, Seko Y, Imai N, Hosaka T, et al. Large-scale long-term follow-up study of Japanese patients with non-alcoholic fatty liver disease for the onset of hepatocellular carcinoma. Am J Gastroenterol. 2012;107:253\u201361.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"780_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/stcltm\/szad082","volume":"13","author":"F Korkida","year":"2024","unstructured":"Korkida F, Stamatopoulou A, Roubelakis MG. Recent advances in mesenchymal stem\/stromal cell-based therapy for alcohol-associated liver disease and non-alcoholic fatty liver disease. Stem Cells Transl Med. 2024;13:107\u201315.","journal-title":"Stem Cells Transl Med"},{"issue":"4","key":"780_CR19","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/00004836-200304000-00015","volume":"36","author":"HT S\u00f8rensen","year":"2003","unstructured":"S\u00f8rensen HT, Mellemkjaer L, Jepsen P, Thulstrup AM, Baron J, Olsen JH, et al. Risk of cancer in patients hospitalized with fatty liver: a Danish cohort study. J Clin Gastroenterol. 2003;36:356\u20139.","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"780_CR20","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/pro.4218","volume":"31","author":"PD Thomas","year":"2022","unstructured":"Thomas PD, Ebert D, Muruganujan A, Mushayahama T, Albou LP, Mi H. PANTHER: making genome-scale phylogenetics accessible to all. Protein Sci. 2022;31:8\u201322.","journal-title":"Protein Sci"},{"issue":"1","key":"780_CR21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13287-019-1204-2","volume":"10","author":"X Rong","year":"2019","unstructured":"Rong X, Liu J, Yao X, Jiang T, Wang Y, Xie F. Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt\/\u03b2-catenin pathway. Stem Cell Res Ther. 2019;10:98.","journal-title":"Stem Cell Res Ther"},{"issue":"10","key":"780_CR22","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1038\/s41588-019-0500-1","volume":"51","author":"PD Thomas","year":"2019","unstructured":"Thomas PD, Hill DP, Mi H, Osumi-Sutherland D, Van Auken K, Carbon S, et al. Gene ontology causal activity modeling (GO-CAM) moves beyond GO annotations to structured descriptions of biological functions and systems. Nat Genet. 2019;51:1429\u201333.","journal-title":"Nat Genet"},{"issue":"2","key":"780_CR23","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/bioinformatics\/btn615","volume":"25","author":"S Carbon","year":"2009","unstructured":"Carbon S, Ireland A, Mungall CJ, Shu S, Marshall B, Lewis S, et al. AmiGO: online access to ontology and annotation data. Bioinformatics. 2009;25:288\u20139.","journal-title":"Bioinformatics"},{"key":"780_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.729228","volume":"11","author":"S Trujano-Camacho","year":"2021","unstructured":"Trujano-Camacho S, de Cant\u00fa- Le\u00f3n D, Delgado-Waldo I, Coronel-Hern\u00e1ndez J, Millan-Catalan O, Hern\u00e1ndez-Sotelo D, et al. Inhibition of Wnt-\u03b2-catenin signaling by ICRT14 drug depends of post-transcriptional regulation by HOTAIR in human cervical cancer HeLa cells. Front Oncol. 2021;11:729228.","journal-title":"Front Oncol"},{"issue":"21","key":"780_CR25","doi-asserted-by":"publisher","first-page":"11629","DOI":"10.3390\/ijms222111629","volume":"22","author":"J Guti\u00e9rrez-Cuevas","year":"2021","unstructured":"Guti\u00e9rrez-Cuevas J, Santos A, Armendariz-Borunda J. Pathophysiological molecular mechanisms of obesity: a link between MAFLD and NASH with cardiovascular diseases. Int J Mol Sci. 2021;22:11629.","journal-title":"Int J Mol Sci"},{"issue":"Pt 1","key":"780_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129670","volume":"261","author":"W Xiang","year":"2024","unstructured":"Xiang W, Yin G, Liu H, Wei J, Yu X, Xie Y, et al. Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt\/\u03b2-catenin pathway. Int J Biol Macromol. 2024;129670.","journal-title":"Int J Biol Macromol"},{"issue":"10","key":"780_CR27","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.1007\/s12011-023-03565-8","volume":"201","author":"G Erdem Koc","year":"2023","unstructured":"Erdem Koc G, Gokcimen A, Sahin F. The effect of boric acid and sodium pentaborate pentahydrate-treated foreskin derived mesenchymal stem cells on liver fibrosis. Biol Trace Elem Res. 2023;201:4834\u201349.","journal-title":"Biol Trace Elem Res"},{"key":"780_CR28","doi-asserted-by":"publisher","first-page":"204201882311603","DOI":"10.1177\/20420188231160389","volume":"14","author":"B Norero","year":"2023","unstructured":"Norero B, Dufour JF. Should we undertake surveillance for HCC in patients with MAFLD? Ther Adv Endocrinol Metab. 2023;14:20420188231160388.","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"1","key":"780_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191010","volume":"13","author":"S More","year":"2018","unstructured":"More S, Yang X, Zhu Z, Bamunuarachchi G, Guo Y, Huang C, et al. Regulation of influenza virus replication by Wnt\/\u03b2-catenin signaling. PLoS One. 2018;13:e0191010.","journal-title":"PLoS ONE"},{"issue":"2","key":"780_CR30","doi-asserted-by":"publisher","first-page":"328","DOI":"10.20892\/j.issn.2095-3941.2019.0229","volume":"17","author":"D Ou","year":"2020","unstructured":"Ou D, Chen L, He J, Rong Z, Gao J, Li Z, et al. CDK11 negatively regulates Wnt\/\u03b2-catenin signaling in the endosomal compartment by affecting microtubule stability. Cancer Biol Med. 2020;17:328\u201342.","journal-title":"Cancer Biol Med"},{"issue":"1","key":"780_CR31","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1186\/s13287-025-04538-5","volume":"16","author":"A Yu","year":"2025","unstructured":"Yu A, Zhang Y, Zhong S, Yang Z, Xie M. Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt\/\u03b2-catenin pathway. Stem Cell Res Ther. 2025;16:418.","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"780_CR32","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/s12276-020-0393-1","volume":"52","author":"KY Paik","year":"2020","unstructured":"Paik KY, Kim KH, Park JH, Lee JI, Kim OH, Hong HE, et al. A novel antifibrotic strategy utilizing conditioned media obtained from miR-150-transfected adipose-derived stem cells: validation of an animal model of liver fibrosis. Exp Mol Med. 2020;52:438\u201349.","journal-title":"Exp Mol Med"},{"issue":"9","key":"780_CR33","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/apt.14261","volume":"46","author":"R Pais","year":"2017","unstructured":"Pais R, Fartoux L, Goumard C, Scatton O, Wendum D, Rosmorduc O, et al. Temporal trends, clinical patterns and outcomes of NAFLD-related HCC in patients undergoing liver resection over a 20-year period. Aliment Pharmacol Ther. 2017;46:856\u201363.","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"780_CR34","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s12020-024-03724-4","volume":"85","author":"B Pan","year":"2024","unstructured":"Pan B, Zhao Y, Chen C, Cai J, Li K, Wang Y, et al. The relationship between advanced liver fibrosis and osteoporosis in type 2 diabetes patients with MAFLD. Endocrine. 2024;85:206\u201321.","journal-title":"Endocrine"},{"issue":"1","key":"780_CR35","first-page":"32","volume":"19","author":"G Pomier-Layrargues","year":"1994","unstructured":"Pomier-Layrargues G, Gigu\u00e8re JF, Lavoie J, Perney P, Gagnon S, D\u2019Amour M, et al. Flumazenil in cirrhotic patients in hepatic coma: a randomized double-blind placebo-controlled crossover trial. Hepatology. 1994;19:32\u20137.","journal-title":"Hepatology"},{"issue":"4","key":"780_CR36","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41588-023-01335-9","volume":"55","author":"W Pu","year":"2023","unstructured":"Pu W, Zhu H, Zhang M, Pikiolek M, Ercan C, Li J, et al. Bipotent transitional liver progenitor cells contribute to liver regeneration. Nat Genet. 2023;55:651\u201364.","journal-title":"Nat Genet"},{"issue":"1","key":"780_CR37","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12935-021-01840-z","volume":"21","author":"M Razmi","year":"2021","unstructured":"Razmi M, Ghods R, Vafaei S, Sahlolbei M, Saeednejad Zanjani L, Madjd Z. Clinical and prognostic significances of cancer stem cell markers in gastric cancer patients: a systematic review and meta-analysis. Cancer Cell Int. 2021;21:139.","journal-title":"Cancer Cell Int"},{"issue":"4","key":"780_CR38","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1007\/s10620-019-05537-2","volume":"64","author":"M Sayiner","year":"2019","unstructured":"Sayiner M, Golabi P, Younossi ZM. Disease burden of hepatocellular carcinoma: a global perspective. Dig Dis Sci. 2019;64:910\u20137.","journal-title":"Dig Dis Sci"},{"issue":"5","key":"780_CR39","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3390\/cells13050404","volume":"13","author":"S Shivaramu","year":"2024","unstructured":"Shivaramu S, Maiti SK, Banu SA, Kalaiselvan E, Sharun K, Mishra M, et al. Synergistic hepatoprotective effects of mesenchymal stem cells and platelet-rich plasma in a rat model of bile duct ligation-induced liver cirrhosis. Cells. 2024;13:404.","journal-title":"Cells"},{"issue":"5","key":"780_CR40","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/HEP.0000000000000786","volume":"82","author":"X Wang","year":"2025","unstructured":"Wang X, Zhang L, Dong B. Molecular mechanisms in MASLD\/MASH-related HCC. Hepatology. 2025;82:1303\u201324.","journal-title":"Hepatology"},{"issue":"3","key":"780_CR41","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/sctm.18-0105","volume":"8","author":"Y Watanabe","year":"2019","unstructured":"Watanabe Y, Tsuchiya A, Seino S, Kawata Y, Kojima Y, Ikarashi S, et al. Mesenchymal stem cells and induced bone marrow-derived macrophages synergistically improve liver fibrosis in mice. Stem Cells Transl Med. 2019;8:271\u201384.","journal-title":"Stem Cells Transl Med"},{"issue":"1","key":"780_CR42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13008-023-00104-8","volume":"19","author":"H Xu","year":"2024","unstructured":"Xu H, Huang Y, Zhang F, Shi W, Cheng Y, Yang K, et al. Ultrasonic microbubbles promote mesenchymal stem cell homing to the fibrotic liver via upregulation of CXCR4 expression. Cell Div. 2024;19:7.","journal-title":"Cell Div"},{"issue":"12","key":"780_CR43","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1111\/liv.14675","volume":"40","author":"S Yamamura","year":"2020","unstructured":"Yamamura S, Eslam M, Kawaguchi T, Tsutsumi T, Nakano D, Yoshinaga S, et al. MAFLD identifies patients with significant hepatic fibrosis better than NAFLD. Liver Int. 2020;40:3018\u201330.","journal-title":"Liver Int"},{"issue":"5","key":"780_CR44","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s13770-025-00716-x","volume":"22","author":"S Qin","year":"2025","unstructured":"Qin S, Zhang A, Duan L, Lin F, Zhao M. Exosomes extracted from human umbilical cord MSCs contribute to osteoarthritic cartilage and chondrocytes repair through enhancing autophagy while suppressing the Wnt\/\u03b2-catenin pathway. Tissue Eng Regen Med. 2025;22:719\u201333.","journal-title":"Tissue Eng Regen Med"},{"issue":"1-2","key":"780_CR45","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11010-012-1498-1","volume":"374","author":"DY Zhang","year":"2013","unstructured":"Zhang DY, Pan Y, Zhang C, Yan BX, Yu SS, Wu DL, et al. Wnt\/\u03b2-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production. Mol Cell Biochem. 2013;374:13\u201320.","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"780_CR46","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13287-018-0816-2","volume":"9","author":"L Zhao","year":"2018","unstructured":"Zhao L, Chen S, Shi X, Cao H, Li L. A pooled analysis of mesenchymal stem cell-based therapy for liver disease. Stem Cell Res Ther. 2018;9:72.","journal-title":"Stem Cell Res Ther"},{"issue":"11","key":"780_CR47","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14287","volume":"23","author":"KL Whytock","year":"2024","unstructured":"Whytock KL, Divoux A, Sun Y, Pino MF, Yu G, Jin CA, et al. Aging human abdominal subcutaneous white adipose tissue at single cell resolution. Aging Cell. 2024;23:e14287.","journal-title":"Aging Cell"},{"issue":"1","key":"780_CR48","doi-asserted-by":"publisher","first-page":"2266147","DOI":"10.1080\/21623945.2023.2266147","volume":"12","author":"H Dong","year":"2023","unstructured":"Dong H, Qin M, Wang P, Li S, Wang X. Regulatory effects and mechanisms of exercise on activation of brown adipose tissue (BAT) and browning of white adipose tissue (WAT). Adipocyte. 2023;12:2266147.","journal-title":"Adipocyte"},{"issue":"9","key":"780_CR49","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1093\/stcltm\/szac053","volume":"11","author":"TT Li","year":"2022","unstructured":"Li TT, Wang ZR, Yao WQ, Linghu EQ, Wang FS, Shi L. Stem cell therapies for chronic liver diseases: progress and challenges. Stem Cells Transl Med. 2022;11:900\u201311.","journal-title":"Stem Cells Transl Med"},{"issue":"14","key":"780_CR50","doi-asserted-by":"publisher","first-page":"13358","DOI":"10.1021\/acsnano.3c01612","volume":"17","author":"H Cao","year":"2023","unstructured":"Cao H, Chen M, Cui X, Liu Y, Liu Y, Deng S, et al. Cell-free osteoarthritis treatment with sustained-release of chondrocyte-targeting exosomes from umbilical cord-derived mesenchymal stem cells to rejuvenate aging chondrocytes. ACS Nano. 2023;17:13358\u201376.","journal-title":"ACS Nano"},{"issue":"8","key":"780_CR51","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.3109\/21691401.2015.1105237","volume":"44","author":"Z Zhang","year":"2016","unstructured":"Zhang Z, Pu Y, Pan Q, Xu X, Yan X. Influences of keratinocyte growth factor - mesenchymal stem cells on chronic liver injury in rats. Artif Cells Nanomed Biotechnol. 2016;44:1810\u20137.","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"5","key":"780_CR52","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.jhep.2023.01.024","volume":"78","author":"E Lee","year":"2023","unstructured":"Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023;78:1048\u201362.","journal-title":"J Hepatol"},{"issue":"1","key":"780_CR53","doi-asserted-by":"publisher","first-page":"2537797","DOI":"10.1080\/0886022X.2025.2537797","volume":"47","author":"Z Li","year":"2025","unstructured":"Li Z, He F, Dai S, Yu Q, Si C, Wu F, et al. Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate AKI after cardiac surgery by facilitating miR-21-5p targeting TEAD1. Ren Fail. 2025;47:2537797.","journal-title":"Ren Fail"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-025-00780-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-025-00780-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-025-00780-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:54:52Z","timestamp":1774619692000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-025-00780-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,17]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["780"],"URL":"https:\/\/doi.org\/10.1007\/s13770-025-00780-3","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,17]]},"assertion":[{"value":"6 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Our protocol (XMXH-2025-0801) of animal experiment has got the permission of Animal center of central south university Xiangya basic medicine school. It has passed the Central South University Ethics Application Approval Number APU-2025-0174. The operator's certificate number is PXZS-2024-0077.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}