{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:25:46Z","timestamp":1792679146786,"version":"4.5.0"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s13770-026-00810-8","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:22:49Z","timestamp":1780546969000},"page":"791-813","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Harnessing Artificial Intelligence for Regeneration of Endometrium in Asherman\u2019s Syndrome"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6240-8572","authenticated-orcid":false,"given":"Gokulnath","family":"Anbalagan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-9162","authenticated-orcid":false,"given":"Namasivaya Naveen","family":"Shanmuga Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-9887","authenticated-orcid":false,"given":"Nandakumar","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"810_CR1","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.fertnstert.2008.02.096","volume":"89","author":"D Yu","year":"2008","unstructured":"Yu D, Wong YM, Cheong Y, Xia E, Li TC. Asherman syndrome\u2014one century later. Fertil Steril. 2008;89:759\u201379.","journal-title":"Fertil Steril"},{"key":"810_CR2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.2147\/IJWH.S165474","volume":"11","author":"E Dreisler","year":"2019","unstructured":"Dreisler E, Kjer JJ. Asherman\u2019s syndrome: current perspectives on diagnosis and management. Int J Womens Health. 2019;11:191\u20138.","journal-title":"Int J Womens Health"},{"key":"810_CR3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jmig.2017.09.020","volume":"25","author":"Z Khan","year":"2018","unstructured":"Khan Z, Goldberg JM. Hysteroscopic management of Asherman\u2019s syndrome. J Minim Invasive Gynecol. 2018;25:195\u2013202.","journal-title":"J Minim Invasive Gynecol"},{"key":"810_CR4","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1186\/s12905-024-02944-0","volume":"24","author":"M Siferih","year":"2024","unstructured":"Siferih M, Gebre T, Hunduma F, Abebe A, Gebremichael A, Sewunet H, et al. Review of Asherman syndrome and its hysteroscopic treatment outcomes: experience in a low-resource setting. BMC Womens Health. 2024;24:2944.","journal-title":"BMC Womens Health"},{"key":"810_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4103\/jhrs.JHRS_64_19","volume":"13","author":"N Singh","year":"2020","unstructured":"Singh N, Shekhar B, Mohanty S, Kumar S, Seth T, Girish B. Autologous bone marrow-derived stem cell therapy for Asherman\u2019s syndrome and endometrial atrophy: a 5-year follow-up study. J Hum Reprod Sci. 2020;13:103\u201310.","journal-title":"J Hum Reprod Sci"},{"key":"810_CR6","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3390\/diagnostics10090706","volume":"10","author":"B Doroftei","year":"2020","unstructured":"Doroftei B, Dabuleanu AM, Ilie OD, Maftei R, Anton E, Simionescu G, et al. Mini-review of the new therapeutic possibilities in Asherman syndrome\u2014where are we after one hundred and twenty-six years? Diagnostics (Basel). 2020;10:706.","journal-title":"Diagnostics (Basel)"},{"key":"810_CR7","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.21037\/atm-20-3598","volume":"8","author":"SW Kim","year":"2020","unstructured":"Kim SW, Kim YY, Kim H, Ku SY. Animal models closer to intrauterine adhesive pathology. Ann Transl Med. 2020;8:1125.","journal-title":"Ann Transl Med"},{"key":"810_CR8","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s10815-020-01801-x","volume":"37","author":"A Benor","year":"2020","unstructured":"Benor A, Gay S, DeCherney A. An update on stem cell therapy for Asherman syndrome. J Assist Reprod Genet. 2020;37:1223\u20139.","journal-title":"J Assist Reprod Genet"},{"key":"810_CR9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1095\/biolreprod.114.126771","volume":"92","author":"L Mutlu","year":"2015","unstructured":"Mutlu L, Hufnagel D, Taylor HS. The endometrium as a source of mesenchymal stem cells for regenerative medicine. Biol Reprod. 2015;92:108.","journal-title":"Biol Reprod"},{"key":"810_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13191","volume":"84","author":"D Liu","year":"2020","unstructured":"Liu D, Wang J, Zhao G, Jiang P, Song M, Ding H, et al. CSF1-associated decrease in endometrial macrophages may contribute to Asherman\u2019s syndrome. Am J Reprod Immunol. 2020;84:e13191.","journal-title":"Am J Reprod Immunol"},{"key":"810_CR11","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1093\/humrep\/dey232","volume":"33","author":"X Santamaria","year":"2018","unstructured":"Santamaria X, Isaacson K, Sim\u00f3n C. Asherman\u2019s syndrome: it may not be all our fault. Hum Reprod. 2018;33:1374\u201380.","journal-title":"Hum Reprod"},{"key":"810_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41153-5","volume":"14","author":"X Santamaria","year":"2023","unstructured":"Santamaria X, Roson B, Perez-Moraga R, Venkatesan N, Pardo-Figuerez M, Gonzalez-Fernandez J, et al. Decoding the endometrial niche of Asherman\u2019s syndrome at single-cell resolution. Nat Commun. 2023;14:6291.","journal-title":"Nat Commun"},{"key":"810_CR13","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/S0015-0282(98)00036-3","volume":"69","author":"A Protopapas","year":"1998","unstructured":"Protopapas A, Shushan A. Myometrial scoring: a new technique for the management of severe Asherman\u2019s syndrome. Fertil Steril. 1998;69:860\u20134.","journal-title":"Fertil Steril"},{"key":"810_CR14","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/mrd.23523","volume":"88","author":"L de Miguel-G\u00f3mez","year":"2021","unstructured":"de Miguel-G\u00f3mez L, Romeu M, Pellicer A, Cervell\u00f3 I. Strategies for managing Asherman\u2019s syndrome and endometrial atrophy: from classical experimental models to new bioengineering approaches. Mol Reprod Dev. 2021;88:630\u201344.","journal-title":"Mol Reprod Dev"},{"key":"810_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1269382","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang Y, Tang Z, Teng X. New advances in the treatment of thin endometrium. Front Endocrinol (Lausanne). 2024;15:1269382.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"810_CR16","first-page":"215","volume":"7","author":"W Polishuk","year":"1976","unstructured":"Polishuk W, Weinstein D. The soichet intrauterine device in the treatment of intrauterine adhesions. Acta Eur Fertil. 1976;7:215\u20138.","journal-title":"Acta Eur Fertil"},{"key":"810_CR17","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s10815-014-0268-2","volume":"31","author":"S Kilic","year":"2014","unstructured":"Kilic S, Yuksel B, Pinarli F, Albayrak A, Boztok B, Delibasi T. Effect of stem cell application on Asherman syndrome: an experimental rat model. J Assist Reprod Genet. 2014;31:975\u201382.","journal-title":"J Assist Reprod Genet"},{"key":"810_CR18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.rbmo.2010.11.018","volume":"23","author":"CM March","year":"2011","unstructured":"March CM. Management of Asherman\u2019s syndrome. Reprod Biomed Online. 2011;23:63\u201376.","journal-title":"Reprod Biomed Online"},{"key":"810_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02263-3","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Shi L, Lin X, Zhou F, Xin L, Xu W, et al. Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: a pilot study. Stem Cell Res Ther. 2021;12:268.","journal-title":"Stem Cell Res Ther"},{"key":"810_CR20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.biopha.2018.03.091","volume":"102","author":"R Azizi","year":"2018","unstructured":"Azizi R, Aghebati-Maleki L, Nouri M, Marofi F, Negargar S, Yousefi M. Stem cell therapy in Asherman syndrome and thin endometrium: stem cell-based therapy. Biomed Pharmacother. 2018;102:333\u201343.","journal-title":"Biomed Pharmacother"},{"key":"810_CR21","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s13770-025-00761-6","volume":"23","author":"JY Han","year":"2026","unstructured":"Han JY, Kim YY, Choi BB, Kim SW, Ku SY. Comparative analysis of vehicles for the regeneration of mouse endometrial damage model. Tissue Eng Regen Med. 2026;23:175\u201384.","journal-title":"Tissue Eng Regen Med"},{"key":"810_CR22","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.3390\/ijms18091852","volume":"18","author":"FJ Vizoso","year":"2017","unstructured":"Vizoso FJ, Eiro N, Cid S, Schneider J, Perez-Fernandez R. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Int J Mol Sci. 2017;18:1852.","journal-title":"Int J Mol Sci"},{"key":"810_CR23","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1242\/dev.148478","volume":"144","author":"M Boretto","year":"2017","unstructured":"Boretto M, Cox B, Noben M, Hendriks N, Fassbender A, Roose H, et al. Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability. Development. 2017;144:1775\u201386.","journal-title":"Development"},{"key":"810_CR24","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.jcyt.2017.02.003","volume":"19","author":"L Gan","year":"2017","unstructured":"Gan L, Duan H, Xu Q, Tang YQ, Li JJ, Sun FQ, et al. Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions. Cytotherapy. 2017;19:603\u201316.","journal-title":"Cytotherapy"},{"key":"810_CR25","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.actbio.2020.06.029","volume":"113","author":"L Xin","year":"2020","unstructured":"Xin L, Lin X, Zhou F, Li C, Wang X, Yu H, et al. A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomater. 2020;113:252\u201366.","journal-title":"Acta Biomater"},{"key":"810_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105175","volume":"22","author":"WL Lee","year":"2021","unstructured":"Lee WL, Liu CH, Cheng M, Chang WH, Liu WM, Wang PH. Focus on the primary prevention of intrauterine adhesions: current concept and vision. Int J Mol Sci. 2021;22:5175.","journal-title":"Int J Mol Sci"},{"key":"810_CR27","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.fertnstert.2015.08.032","volume":"104","author":"I Cervell\u00f3","year":"2015","unstructured":"Cervell\u00f3 I, Gil-Sanchis C, Santamar\u00eda X, Cabanillas S, D\u00edaz A, Faus A, et al. Human CD133+ bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome. Fertil Steril. 2015;104:1552\u201360.","journal-title":"Fertil Steril"},{"key":"810_CR28","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.actbio.2021.08.025","volume":"135","author":"S Lopez-Martinez","year":"2021","unstructured":"Lopez-Martinez S, Rodriguez-Eguren A, de Miguel-Gomez L, Frances-Herrero E, Faus A, Diaz A, et al. Bioengineered endometrial hydrogels with growth factors promote tissue regeneration and restore fertility in murine models. Acta Biomater. 2021;135:128\u201339.","journal-title":"Acta Biomater"},{"key":"810_CR29","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1039\/D3MA00328K","volume":"4","author":"S Malathi","year":"2023","unstructured":"Malathi S, Sisila V, Singaravel V, Venkatesan N, Pakrudheen I, Dhanaraj R, et al. Epidermal growth factor receptor targeted doxorubicin and vitexin loaded niosomes for enhanced breast cancer therapy. Mater Adv. 2023;4:3645\u201356.","journal-title":"Mater Adv"},{"key":"810_CR30","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.26452\/ijrps.v10i4.1606","volume":"10","author":"N Nandvikar","year":"2019","unstructured":"Nandvikar N, Lala R, Shinde A. Nanostructured lipid carrier: the advanced lipid carriers. Int J Pharm Sci Res. 2019;10:3114\u201320.","journal-title":"Int J Pharm Sci Res"},{"key":"810_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0538-8","volume":"2","author":"S Leprince","year":"2019","unstructured":"Leprince S, Huberlant S, Allegre L, Warembourg S, Leteuff I, Bethry A, et al. Preliminary design of a new degradable medical device to prevent the formation and recurrence of intrauterine adhesions. Commun Biol. 2019;2:305.","journal-title":"Commun Biol"},{"key":"810_CR32","doi-asserted-by":"publisher","first-page":"597.e1","DOI":"10.1016\/j.ajog.2022.05.064","volume":"227","author":"J Sroussi","year":"2022","unstructured":"Sroussi J, Bourret A, Pourcelot AG, Thubert T, Lesavre M, Legendre G, et al. Does hyaluronic acid gel reduce intrauterine adhesions after dilation and curettage in women with miscarriage? A multicentric randomized controlled trial (HYFACO study). Am J Obstet Gynecol. 2022;227:597.e1-597.e8.","journal-title":"Am J Obstet Gynecol"},{"key":"810_CR33","doi-asserted-by":"publisher","first-page":"74","DOI":"10.4103\/GMIT.GMIT_103_19","volume":"9","author":"YQ Wang","year":"2020","unstructured":"Wang YQ, Song XH, Wu SL, Huang YZ, Yan L, Li CZ, et al. Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: a randomized clinical trial. Gynecol Minim Invasive Ther. 2020;9:74\u201380.","journal-title":"Gynecol Minim Invasive Ther"},{"key":"810_CR34","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jmig.2010.03.019","volume":"17","author":"MI Amer","year":"2010","unstructured":"Amer MI, Abd-El-Maeboud KH, Abdelfatah I, Salama FA, Abdallah AS, et al. Human amnion as a temporary biologic barrier after hysteroscopic lysis of severe intrauterine adhesions: pilot study. J Minim Invasive Gynecol. 2010;17:605\u201311.","journal-title":"J Minim Invasive Gynecol"},{"key":"810_CR35","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.jmig.2011.04.007","volume":"18","author":"SA Di Spiezio","year":"2011","unstructured":"Di Spiezio SA, Spinelli M, Bramante S, Scognamiglio M, Greco E, Guida M, et al. Efficacy of a polyethylene oxide\u2013sodium carboxymethylcellulose gel in prevention of intrauterine adhesions after hysteroscopic surgery. J Minim Invasive Gynecol. 2011;18:462\u20139.","journal-title":"J Minim Invasive Gynecol"},{"key":"810_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10328","volume":"8","author":"L Chen","year":"2022","unstructured":"Chen L, Li L, Mo Q, Zhang X, Chen C, Wu Y, et al. An injectable gelatin\/sericin hydrogel loaded with human umbilical cord mesenchymal stem cells for the treatment of uterine injury. Bioeng Transl Med. 2022;8:e10328.","journal-title":"Bioeng Transl Med"},{"key":"810_CR37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1089\/gyn.2020.0196","volume":"37","author":"J Vatanatara","year":"2021","unstructured":"Vatanatara J, Tingthanatikul Y, Lertvikool S, Hongsakorn W, et al. Alginate carboxymethylcellulose hyaluronic acid for preventing intrauterine adhesion after vacuum aspiration for first-trimester abortion: a prospective randomized controlled trial. J Gynecol Surg. 2021;37:402\u20137.","journal-title":"J Gynecol Surg"},{"key":"810_CR38","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1111\/jog.15629","volume":"49","author":"H Zhang","year":"2023","unstructured":"Zhang H, Shao L, Wang L, Gao Y, Cui W, Chu D, et al. Chitosan combined with intrauterine device prevents intrauterine adhesions after hysteroscopic adhesiolysis: a target trial emulation study. J Obstet Gynaecol Res. 2023;49:1571\u20138.","journal-title":"J Obstet Gynaecol Res"},{"key":"810_CR39","first-page":"391","volume":"324","author":"Z Nazemi","year":"2020","unstructured":"Nazemi Z, Nourbakhsh MS, Kiani S, Heydari Y, Ashtiani MK, Daemi H, et al. Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury. J Control Release. 2020;324:391\u2013403.","journal-title":"J Control Release"},{"key":"810_CR40","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1159\/000505691","volume":"85","author":"Y Liu","year":"2020","unstructured":"Liu Y, Cai J, Luo X, Wen H, Luo Y, et al. Collagen scaffold with human umbilical cord mesenchymal stem cells remarkably improves intrauterine adhesions in a rat model. Gynecol Obstet Invest. 2020;85:267\u201376.","journal-title":"Gynecol Obstet Invest"},{"key":"810_CR41","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1080\/10717544.2017.1333173","volume":"24","author":"HL Xu","year":"2017","unstructured":"Xu HL, Xu J, Zhang SS, Zhu QY, Jin BH, ZhuGe DL, et al. Temperature-sensitive heparin-modified poloxamer hydrogel with affinity to KGF facilitates the morphologic and functional recovery of the injured rat uterus. Drug Deliv. 2017;24:1361\u201372.","journal-title":"Drug Deliv"},{"key":"810_CR42","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ijbiomac.2022.07.161","volume":"219","author":"Q Hu","year":"2022","unstructured":"Hu Q, Xie N, Liao K, Huang J, Yang Q, Zhou Y, et al. An injectable thermosensitive Pluronic F127\/hyaluronic acid hydrogel loaded with human umbilical cord mesenchymal stem cells and asiaticoside microspheres for uterine scar repair. Int J Biol Macromol. 2022;219:96\u2013108.","journal-title":"Int J Biol Macromol"},{"key":"810_CR43","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1002\/sctm.18-0042","volume":"7","author":"A Navas","year":"2018","unstructured":"Navas A, Maga\u00f1a-Guerrero FS, Dom\u00ednguez-L\u00f3pez A, Ch\u00e1vez-Garc\u00eda C, Partido G, Graue-Hern\u00e1ndez EO, et al. Anti-inflammatory and anti-fibrotic effects of human amniotic membrane mesenchymal stem cells and their potential in corneal repair. Stem Cells Transl Med. 2018;7:906\u201317.","journal-title":"Stem Cells Transl Med"},{"key":"810_CR44","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.3727\/096368914X678346","volume":"23","author":"IJ Lim","year":"2014","unstructured":"Lim IJ, Phan TT. Epithelial and mesenchymal stem cells from the umbilical cord lining membrane. Cell Transplant. 2014;23:1531\u201342.","journal-title":"Cell Transplant"},{"key":"810_CR45","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3390\/cells1041061","volume":"1","author":"A Lindenmair","year":"2012","unstructured":"Lindenmair A, Hatlapatka T, Kollwig G, Hennerbichler S, Gabriel C, Wolbank S, et al. Mesenchymal stem or stromal cells from amnion and umbilical cord tissue and their potential for clinical applications. Cells. 2012;1:1064\u201388.","journal-title":"Cells"},{"key":"810_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010088","volume":"5","author":"RS Waterman","year":"2010","unstructured":"Waterman RS, Tomchuck SL, Henkle SL, Betancourt AM. A new mesenchymal stem cell paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype. PLoS ONE. 2010;5:e10088.","journal-title":"PLoS ONE"},{"key":"810_CR47","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.actbio.2019.03.032","volume":"89","author":"YY Kim","year":"2019","unstructured":"Kim YY, Park KH, Kim YJ, Kim MS, Liu HC, Rosenwaks Z, et al. Synergistic regenerative effects of functionalized endometrial stromal cells with hyaluronic acid hydrogel in a murine model of uterine damage. Acta Biomater. 2019;89:139\u201351.","journal-title":"Acta Biomater"},{"key":"810_CR48","first-page":"91","volume":"18","author":"ADS Sardo","year":"2011","unstructured":"Sardo ADS, Spinelli M, Bramante S, Scognamiglio M, Greco E, Guida M, et al. Efficacy of a polyethylene oxide\u2013sodium carboxymethylcellulose gel in prevention of intrauterine adhesions after hysteroscopic surgery. J Minim Invasive Gynecol. 2011;18:91\u20138.","journal-title":"J Minim Invasive Gynecol"},{"key":"810_CR49","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1016\/j.fertnstert.2005.04.055","volume":"84","author":"P Young","year":"2005","unstructured":"Young P, Johns A, Templeman C, Witz C, Webster B, Ferland R, et al. Reduction of postoperative adhesions after laparoscopic gynecological surgery with Oxiplex\/AP Gel: a pilot study. Fertil Steril. 2005;84:1450\u20136.","journal-title":"Fertil Steril"},{"key":"810_CR50","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","volume":"73","author":"K Yue","year":"2015","unstructured":"Yue K, Trujillo-de Santiago G, Alvarez MM, Tamayol A, Annabi N, Khademhosseini A. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials. 2015;73:254\u201371.","journal-title":"Biomaterials"},{"key":"810_CR51","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3109\/10409238.2013.770819","volume":"48","author":"J Vandooren","year":"2013","unstructured":"Vandooren J, Van den Steen PE, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade. Crit Rev Biochem Mol Biol. 2013;48:222\u201372.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"810_CR52","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.tibtech.2016.01.002","volume":"34","author":"BJ Klotz","year":"2016","unstructured":"Klotz BJ, Gawlitta D, Rosenberg AJ, Malda J, Melchels FP. Gelatin-methacryloyl hydrogels: towards biofabrication-based tissue repair. Trends Biotechnol. 2016;34:394\u2013407.","journal-title":"Trends Biotechnol"},{"key":"810_CR53","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab125.072","volume":"36","author":"N Venkatesan","year":"2021","unstructured":"Venkatesan N, Garcia EF, Costa XS, Valles CS. Polymeric scaffold loaded with CD133+ BMDSCs for endometrial regeneration in Asherman\u2019s syndrome. Hum Reprod. 2021;36:deab125.072.","journal-title":"Hum Reprod"},{"key":"810_CR54","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1163\/156856209X435835","volume":"21","author":"WJ Cho","year":"2010","unstructured":"Cho WJ, Oh SH, Lee JH. Alginate film as a novel post-surgical tissue adhesion barrier. J Biomater Sci Polym Ed. 2010;21:1365\u201375.","journal-title":"J Biomater Sci Polym Ed"},{"key":"810_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127314","volume":"255","author":"Q Shuai","year":"2023","unstructured":"Shuai Q, Liang Y, Xu X, Halbiyat Z, Wang X, Cheng J, et al. Sodium alginate hydrogel integrated with type III collagen and mesenchymal stem cell to promote endometrium regeneration and fertility restoration. Int J Biol Macromol. 2023;255:127314.","journal-title":"Int J Biol Macromol"},{"key":"810_CR56","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jmig.2017.09.006","volume":"25","author":"Y Yan","year":"2018","unstructured":"Yan Y, Xu D. The effect of adjuvant treatment to prevent and treat intrauterine adhesions: a network meta-analysis of randomized controlled trials. J Minim Invasive Gynecol. 2018;25:123\u201332.","journal-title":"J Minim Invasive Gynecol"},{"key":"810_CR57","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40824-021-00242-6","volume":"25","author":"J Ma","year":"2021","unstructured":"Ma J, Zhan H, Li W, Zhang L, Yun F, Wu R, et al. Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion. Biomater Res. 2021;25:42.","journal-title":"Biomater Res"},{"key":"810_CR58","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ijbiomac.2019.11.184","volume":"143","author":"W Qi","year":"2020","unstructured":"Qi W, Xu L, Zhao S, Zheng J, Tian Y, Qi X, et al. Controlled releasing of SDF-1\u03b1 in chitosan-heparin hydrogel for endometrium injury healing in rat model. Int J Biol Macromol. 2020;143:163\u201372.","journal-title":"Int J Biol Macromol"},{"key":"810_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1264006","volume":"11","author":"F Wu","year":"2023","unstructured":"Wu F, Lei N, Yang S, Zhou J, Chen M, Chen C, et al. Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels. Front Bioeng Biotechnol. 2023;11:1264006.","journal-title":"Front Bioeng Biotechnol"},{"key":"810_CR60","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1080\/10717544.2020.1801891","volume":"27","author":"Y Chen","year":"2020","unstructured":"Chen Y, Fei W, Zhao Y, Wang F, Zheng X, Luan X, et al. Sustained delivery of 17\u03b2-estradiol by human amniotic extracellular matrix scaffold integrated with PLGA microspheres for endometrium regeneration. Drug Deliv. 2020;27:1621\u201332.","journal-title":"Drug Deliv"},{"key":"810_CR61","doi-asserted-by":"publisher","first-page":"25065","DOI":"10.1039\/c3ra47142j","volume":"4","author":"V Nandakumar","year":"2014","unstructured":"Nandakumar V, Vettriselvi V, Doble M. Toxicity of high-glycolic poly(dl-lactic-co-glycolic acid) stabilized ruthenium nanoparticles against human promyelocytic leukemia cells. RSC Adv. 2014;4:25065\u201372.","journal-title":"RSC Adv"},{"key":"810_CR62","first-page":"186","volume":"161","author":"WB Zhang","year":"2012","unstructured":"Zhang WB, Cheng MJ, Huang YT, Jiang W, Cong Q, Zheng YF, et al. A study in vitro on differentiation of bone marrow mesenchymal stem cells into endometrial epithelial cells in mice. Eur J Obstet Gynecol Reprod Biol. 2012;161:186\u201392.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"810_CR63","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.425","volume":"4","author":"X Hu","year":"2023","unstructured":"Hu X, Wu H, Yong X, Wang Y, Yang S, Fan D, et al. Cyclical endometrial repair and regeneration: molecular mechanisms, diseases, and therapeutic interventions. MedComm. 2023;4:e425.","journal-title":"MedComm"},{"key":"810_CR64","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13287-018-0904-3","volume":"9","author":"Y Cao","year":"2018","unstructured":"Cao Y, Sun H, Zhu H, Zhu X, Tang X, Yan G, et al. Allogeneic cell therapy using umbilical cord mesenchymal stem cells on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther. 2018;9:44.","journal-title":"Stem Cell Res Ther"},{"key":"810_CR65","doi-asserted-by":"publisher","first-page":"13877","DOI":"10.1021\/acsomega.1c02117","volume":"6","author":"M Feng","year":"2021","unstructured":"Feng M, Hu S, Qin W, Tang Y, Guo R, Han L. Bioprinting of a blue light-cross-linked biodegradable hydrogel encapsulating amniotic mesenchymal stem cells for intrauterine adhesion prevention. ACS Omega. 2021;6:13877\u201387.","journal-title":"ACS Omega"},{"key":"810_CR66","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.2147\/IJN.S137237","volume":"12","author":"SS Zhang","year":"2017","unstructured":"Zhang SS, Xia WT, Xu J, Xu HL, Lu CT, Zhao YZ, et al. Three-dimensional structure micelles of heparin-poloxamer improve the therapeutic effect of 17\u03b2-estradiol on endometrial regeneration for intrauterine adhesions in a rat model. Int J Nanomed. 2017;12:4717\u201330.","journal-title":"Int J Nanomed"},{"key":"810_CR67","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1089\/ten.2005.11.974","volume":"11","author":"SF Khattak","year":"2005","unstructured":"Khattak SF, Bhatia SR, Roberts SC. Pluronic F127 as a cell encapsulation material: utilization of membrane-stabilizing agents. Tissue Eng. 2005;11:974\u201383.","journal-title":"Tissue Eng"},{"key":"810_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133458","volume":"271","author":"S Zhang","year":"2024","unstructured":"Zhang S, Jia E, Zhang W, Wang Z, Deng D, Zhang Y, et al. Injectable alginate-based zwitterionic hydrogels promoting endometrial repair and restoring fertility. Int J Biol Macromol. 2024;271:133458.","journal-title":"Int J Biol Macromol"},{"key":"810_CR69","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13287-017-0718-8","volume":"8","author":"H Yang","year":"2017","unstructured":"Yang H, Wu S, Feng R, Huang J, Liu L, Liu F, et al. Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats. Stem Cell Res Ther. 2017;8:218.","journal-title":"Stem Cell Res Ther"},{"key":"810_CR70","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1186\/s12884-022-04375-x","volume":"22","author":"R Zhu","year":"2022","unstructured":"Zhu R, Duan H, Xu W, Wang S, Gan L, Xu Q, et al. Decision tree model predicts live birth after surgery for moderate-to-severe intrauterine adhesions. BMC Pregnancy Childbirth. 2022;22:395.","journal-title":"BMC Pregnancy Childbirth"},{"key":"810_CR71","doi-asserted-by":"publisher","first-page":"1327207","DOI":"10.3389\/fbioe.2024.1327207","volume":"12","author":"B Li","year":"2024","unstructured":"Li B, Chen H, Duan H. Artificial intelligence-driven prognostic system for conception prediction and management in intrauterine adhesions following hysteroscopic adhesiolysis: a diagnostic study using hysteroscopic images. Front Bioeng Biotechnol. 2024;12:1327207.","journal-title":"Front Bioeng Biotechnol"},{"key":"810_CR72","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41591-018-0316-z","volume":"25","author":"A Esteva","year":"2019","unstructured":"Esteva A, Robicquet A, Ramsundar B, Kuleshov V, DePristo M, Chou K, et al. A guide to deep learning in healthcare. Nat Med. 2019;25:24\u20139.","journal-title":"Nat Med"},{"key":"810_CR73","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.70820","author":"VP Baiju","year":"2026","unstructured":"Baiju VP, Subash R, Venkatesan N. Integrated artificial intelligence and omics for prediction and monitoring of pre-eclampsia. Int J Gynaecol Obstet. 2026. https:\/\/doi.org\/10.1002\/ijgo.70820.","journal-title":"Int J Gynaecol Obstet"},{"key":"810_CR74","unstructured":"Hadji I, Wildes RP. What do we understand about convolutional networks? arXiv. 2018;1803.08834."},{"key":"810_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108599","volume":"192","author":"J Yang","year":"2024","unstructured":"Yang J, Pan J, Chen Y, Chen C, Huang Z. Advancing intrauterine adhesion severity prediction: integrative machine learning approach with hysteroscopic cold knife system, clinical characteristics and hematological parameters. Comput Biol Med. 2024;192:108599.","journal-title":"Comput Biol Med"},{"key":"810_CR76","first-page":"861","volume":"47","author":"Y Li","year":"2023","unstructured":"Li Y, Duan H, Wang S. An XGBoost predictive model of ongoing pregnancy in patients following hysteroscopic adhesiolysis. Reprod Biomed Online. 2023;47:861\u201372.","journal-title":"Reprod Biomed Online"},{"key":"810_CR77","first-page":"291","volume":"298","author":"K Kitaya","year":"2024","unstructured":"Kitaya K, Yasuo T, Yamaguchi T, Morita Y, Hamazaki A, Murayama S, et al. Construction of deep learning-based convolutional neural network model for automatic detection of fluid hysteroscopic endometrial micropolyps in infertile women with chronic endometritis. Eur J Obstet Gynecol Reprod Biol. 2024;298:291\u2013300.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"810_CR78","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fmre.2023.11.007","volume":"4","author":"B Li","year":"2024","unstructured":"Li B, Chen H, Duan H. Development of a one-step office hysteroscopic lightweight artificial intelligence application for subfertility risk stratification of intrauterine adhesions. Fundam Res. 2024;4:25\u201335.","journal-title":"Fundam Res"},{"key":"810_CR79","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3390\/diagnostics13050936","volume":"13","author":"M Mihara","year":"2023","unstructured":"Mihara M, Yasuo T, Kitaya K. Precision medicine for chronic endometritis: computer-aided diagnosis using deep learning model. Diagnostics. 2023;13:936.","journal-title":"Diagnostics"},{"key":"810_CR80","first-page":"2947021","volume":"2021","author":"J Li","year":"2021","unstructured":"Li J, Liu D, Qing X, Yu L, Xiang H. Deep learning-based three-dimensional transvaginal ultrasound in diagnosis of intrauterine adhesion. Sci Progr. 2021;2021:2947021.","journal-title":"Sci Progr"},{"key":"810_CR81","volume":"114","author":"B Li","year":"2024","unstructured":"Li B, Chen H, Lin X, Duan H. Multimodal learning system integrating electronic medical records and hysteroscopic images for reproductive outcome prediction and risk stratification of endometrial injury: a multicenter diagnostic study. Int J Surg. 2024;114:107708.","journal-title":"Int J Surg"},{"key":"810_CR82","doi-asserted-by":"publisher","first-page":"182521","DOI":"10.1109\/ACCESS.2020.3020322","volume":"8","author":"T Tao","year":"2020","unstructured":"Tao T, Liu K, Wang L, Wu H. Image recognition and analysis of intrauterine residues based on deep learning and semi-supervised learning. IEEE Access. 2020;8:182521\u201330.","journal-title":"IEEE Access"},{"key":"810_CR83","volume":"27","author":"Y Rezaeipour","year":"2022","unstructured":"Rezaeipour Y, Alizadeh P, Keshavarz M. Collagen scaffold impregnated with borosilicate bioactive glass for endometrial healing. Appl Mater Today. 2022;27:101727.","journal-title":"Appl Mater Today"},{"key":"810_CR84","doi-asserted-by":"publisher","first-page":"234","DOI":"10.21037\/qims-22-965","volume":"13","author":"X Zhao","year":"2023","unstructured":"Zhao X, Liu M, Wu S, Zhang B, Burjoo A, Yang Y, et al. Artificial intelligence diagnosis of intrauterine adhesion by 3D ultrasound imaging: a prospective study. Quant Imaging Med Surg. 2023;13:234\u201346.","journal-title":"Quant Imaging Med Surg"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-026-00810-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-026-00810-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-026-00810-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:07:27Z","timestamp":1785521247000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-026-00810-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":84,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["810"],"URL":"https:\/\/doi.org\/10.1007\/s13770-026-00810-8","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"13 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}