{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:03:51Z","timestamp":1785528231416,"version":"3.56.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Y\u0131ld\u0131z Technical University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tissue Eng Regen Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Essential oils (EOs) derived from plants have been utilized for the development of various approaches in biomedical\napplications due to their superior properties. In particular, their antimicrobial, anti-inflammatory, antioxidant, and\nwound-healing effects, alongside their biocompatibility and biodegradability, have made EOs a significant\ncomplementary agent in tissue regeneration-focused applications. Initial uses of EOs focused primarily on direct\napplication and evaluation of their therapeutic efficacy; however, these approaches have been limited by issues such\nas volatility, instability, and potential for irritation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review focuses on current perspectives in tissue engineering strategies, based on the biological functions of EO,\nsuch as biocompatibility, antimicrobial, anticancer, and antioxidant properties. Based on this comprehensive\nbackground of biological functions, current studies addressing nanoparticle systems, smart delivery systems, and\nwound dressings and coatings have been analyzed to identify existing issues and strategies to tackle these\nchallenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In skin tissue engineering applications, innovative strategies such as nanoparticle encapsulation, integration into\nsmart delivery systems, and the development of wound dressings containing EO have been developed. These\nadvanced approaches offer advantages such as improved EO stability, controlled release, and enhanced efficacy,\nwhile also enriching the biofunctionality of the platform. While advanced delivery systems improve the stability of\nEOs, long-term stability under physiological and clinical conditions remains challenging. However, compared to\nconventional methods, these advancements strengthen the potential of EOs to drive tissue repair processes in a\nmore controlled and functional manner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The integration of EO-based tissue engineering with nanotechnology offers a promising approach to optimizing the\nbiological effects of these systems and enhancing the success of their application. Although challenges such as\nsafety, biomaterial interactions, and scalability persist, recent advancements are rapidly overcoming these\nobstacles. EO-based strategies hold significant potential for overcoming current limitations and advancing the field,\nparticularly in skin tissue engineering.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13770-026-00814-4","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:12:50Z","timestamp":1784272370000},"page":"771-789","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Essential Oils in Skin Tissue Engineering: Opportunities, Integration, and Overcoming Challenges"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6064-6563","authenticated-orcid":false,"given":"Elif","family":"Emekdar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0028-2453","authenticated-orcid":false,"given":"Selcen","family":"Ari Yuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-4310","authenticated-orcid":false,"given":"Azime","family":"Erarslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"814_CR1","doi-asserted-by":"publisher","first-page":"8999","DOI":"10.3390\/molecules27248999","volume":"27","author":"P Bolouri","year":"2022","unstructured":"Bolouri P, Salami R, Kouhi S, Kordi M, Asgari Lajayer B, Hadian J, et al. Applications of essential oils and plant extracts in different Industries. Molecules. 2022;27:8999.","journal-title":"Molecules"},{"key":"814_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2021.100261","volume":"17","author":"I Unalan","year":"2021","unstructured":"Unalan I, Boccaccini AR. Essential oils in biomedical applications: recent progress and future opportunities. Curr Opin Biomed Eng. 2021;17:100261.","journal-title":"Curr Opin Biomed Eng"},{"key":"814_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-024-04440-2","author":"F Fahimnia","year":"2024","unstructured":"Fahimnia F, Nemattalab M, Hesari Z. Development and characterization of a topical gel, containing lavender (Lavandula angustifolia) oil loaded solid lipid nanoparticles. BMC Complement Med Ther. 2024;24:155.","journal-title":"BMC Complement Med Ther"},{"key":"814_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34736","author":"A Bal-\u00d6zt\u00fcrk","year":"2021","unstructured":"Bal-\u00d6zt\u00fcrk A, \u00d6zkahraman B, \u00d6zba\u015f Z, Ya\u015fayan G, Tamahkar E, Alar\u00e7in E. Advancements and future directions in the antibacterial wound dressings \u2013 a review. J Biomed Mater Res B Appl Biomater. 2021;109:703-16.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"814_CR5","doi-asserted-by":"publisher","first-page":"5556838","DOI":"10.1155\/2024\/5556838","volume":"2024","author":"M Osanloo","year":"2024","unstructured":"Osanloo M, Ranjbar R, Zarenezhad E. Alginate nanoparticles containing Cuminum cyminum and Zataria multiflora essential oils with promising anticancer and antibacterial effects. Int J Biomat. 2024;2024:5556838.","journal-title":"Int J Biomat"},{"key":"814_CR6","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3390\/ma18030626","volume":"18","author":"A Robu","year":"2025","unstructured":"Robu A, Kaya MG, Antoniac A, Kaya DA, Coman AE, Marin MM, et al. The influence of basil and cinnamon essential oils on bioactive sponge composites of collagen reinforced with hydroxyapatite. Materials. 2025;18:626.","journal-title":"Materials"},{"key":"814_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cofs.2015.07.003","volume":"5","author":"C Dima","year":"2015","unstructured":"Dima C, Dima S. Essential oils in foods: extraction, stabilization, and toxicity. Curr Opin Food Sci Elsevier. 2015;5:29\u201335.","journal-title":"Curr Opin Food Sci Elsevier"},{"key":"814_CR8","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3390\/pharmaceutics17040503","volume":"17","author":"AH Kimura","year":"2025","unstructured":"Kimura AH, Dahmer D, Isawa LA, da Silva AB, Souza LM, Takata PH, et al. Hydrogel containing biogenic silver nanoparticles and Origanum vulgare essential oil for burn wounds: antimicrobial efficacy using ex vivo and in vivo methods against multidrug-resistant microorganisms. Pharmaceutics. 2025;17:503.","journal-title":"Pharmaceutics"},{"key":"814_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118590","volume":"569","author":"HS Sofi","year":"2019","unstructured":"Sofi HS, Akram T, Tamboli AH, Majeed A, Shabir N, Sheikh FA. Novel lavender oil and silver nanoparticles simultaneously loaded onto polyurethane nanofibers for wound-healing applications. Int J Pharm. 2019;569:118590.","journal-title":"Int J Pharm"},{"key":"814_CR10","doi-asserted-by":"publisher","first-page":"133559","DOI":"10.1016\/j.ijbiomac.2024.133559","volume":"1","author":"Y Qiu","year":"2024","unstructured":"Qiu Y, Yang T, Zhang H, Dai H, Gao H, Feng W, et al. The application of pH-responsive hyaluronic acid-based essential oils hydrogels with enhanced anti-biofilm and wound healing. Int J Biol Macromol. 2024;1:133559.","journal-title":"Int J Biol Macromol"},{"key":"814_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124490","volume":"241","author":"M Sathuvan","year":"2023","unstructured":"Sathuvan M, Thangam R, Cheong KL, Kang H, Liu Y. \u03ba-Carrageenan-essential oil loaded composite biomaterial film facilitates mechanosensing and tissue regenerative wound healing. Int J Biol Macromol. 2023;241:124490.","journal-title":"Int J Biol Macromol"},{"key":"814_CR12","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","volume":"46","author":"F Bakkali","year":"2008","unstructured":"Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils \u2013 a review. Food Chem Toxicol. 2008;46:446\u201375.","journal-title":"Food Chem Toxicol"},{"key":"814_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/polym14183884","author":"M R\u00e2p\u0103","year":"2022","unstructured":"R\u00e2p\u0103 M, Zaharescu T, Stefan LM, Gaid\u0103u C, St\u0103nculescu I, Constantinescu RR, et al. Bioactivity and thermal stability of collagen\u2013chitosan containing lemongrass essential oil for potential medical applications. Polymers (Basel). 2022;14:3884.","journal-title":"Polymers"},{"key":"814_CR14","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1111\/php.14072","volume":"101","author":"N Ranjbar","year":"2025","unstructured":"Ranjbar N, Osanloo M, Nasiri-Ghiri M, Zarenezhad A, Heiran R, Ghanbariasad A, et al. Investigating the protective effect of Rosa damascena nanogel on collagenase and elastase activity and UVB-induced dermal damage: a rodent model approach to skin photoaging. Photochem Photobiol. 2025;101:1443\u201353.","journal-title":"Photochem Photobiol"},{"key":"814_CR15","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.3390\/plants14121880","volume":"14","author":"S Xiao","year":"2025","unstructured":"Xiao S, Yu H, Guo Y, Cheng Y, Yao W. The antibacterial and anti-inflammatory potential of Cinnamomum camphora chvar. Borneol essential oil in vitro. Plants. 2025;14:1880.","journal-title":"Plants"},{"key":"814_CR16","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.3390\/pharmaceutics15112608","volume":"15","author":"AG Rusu","year":"2023","unstructured":"Rusu AG, Ni\u021b\u0103 LE, Ro\u0219ca I, Croitoriu A, Ghilan A, Mititelu-Tar\u021b\u0103u L, et al. Alginate-based hydrogels enriched with Lavender essential oil: evaluation of physicochemical properties, antimicrobial activity, and in vivo biocompatibility. Pharmaceutics. 2023;15:2608.","journal-title":"Pharmaceutics"},{"key":"814_CR17","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.ijbiomac.2022.12.048","volume":"226","author":"AH Rather","year":"2023","unstructured":"Rather AH, Khan RS, Wani TU, Rafiq M, Jadhav AH, Srinivasappa PM, et al. Polyurethane and cellulose acetate micro-nanofibers containing rosemary essential oil, and decorated with silver nanoparticles for wound healing application. Int J Biol Macromol 2023;226:690\u2013705.","journal-title":"Int J Biol Macromol Elsevier"},{"key":"814_CR18","doi-asserted-by":"publisher","first-page":"125073","DOI":"10.1016\/j.ijbiomac.2023.125073","volume":"15","author":"N Torabiardekani","year":"2023","unstructured":"Torabiardekani N, Karami F, Khorram M, Zare A, Kamkar M, Zomorodian K, et al. Encapsulation of Zataria multiflora essential oil in polyvinyl alcohol\/chitosan\/gelatin thermo-responsive hydrogel: synthesis, physico-chemical properties, and biological investigations. Int J Biol Macromol. 2023;15:125073.","journal-title":"Int J Biol Macromol"},{"key":"814_CR19","doi-asserted-by":"crossref","unstructured":"Osanloo M, Noori F, Varaa N, Tavassoli A, Goodarzi A, Moghaddam MT, et al. The wound healing effect of polycaprolactone-chitosan scaffold coated with a gel containing Zataria multiflora Boiss. volatile oil nanoemulsions. BMC Complement Med Ther. 2024;24:56.","DOI":"10.1186\/s12906-024-04352-1"},{"key":"814_CR20","doi-asserted-by":"publisher","first-page":"129931","DOI":"10.1016\/j.ijbiomac.2024.129931","volume":"262","author":"E Soleiman-Dehkordi","year":"2024","unstructured":"Soleiman-Dehkordi E, Reisi-Vanani V, Hosseini S, Lorigooini Z, Zvareh VA, Farzan M, et al. Multilayer PVA\/gelatin nanofibrous scaffolds incorporated with Tanacetum polycephalum essential oil and amoxicillin for skin tissue engineering application. Int J Biol Macromol. 2024;262:129931.","journal-title":"Int J Biol Macromol"},{"key":"814_CR21","doi-asserted-by":"publisher","DOI":"10.1177\/22808000231221067","author":"EF Ediz","year":"2024","unstructured":"Ediz EF, G\u00fcne\u015f C, Demirel Kars M, Avc\u0131 A. In vitro assessment of Momordica charantia\/Hypericum perforatum oils loaded PCL\/collagen fibers: novel scaffold for tissue engineering. J Appl Biomater Funct Mater. 2024;22:22808000231221067.","journal-title":"J Appl Biomater Funct Mater"},{"key":"814_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28176258","author":"J Salas-Oropeza","year":"2023","unstructured":"Salas-Oropeza J, Rodriguez-Monroy MA, Jimenez-Estrada M, Perez-Torres A, Castell-Rodriguez AE, Becerril-Millan R, et al. Essential oil of Bursera morelensis promotes cell migration on fibroblasts: in vitro assays. Molecules. 2023;28:6258.","journal-title":"Molecules"},{"key":"814_CR23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1007\/s12010-023-04530-w","volume":"196","author":"V Sadaiyandi","year":"2024","unstructured":"Sadaiyandi V, Ramalingam R, Arunachalam KD, Jt D. Essential oils infused poly-\u03b5-caprolactone\/gelatin electrospun nanofibrous mats: biocompatibility and antibacterial study. Appl Biochem Biotechnol. 2024;196:296\u2013313.","journal-title":"Appl Biochem Biotechnol"},{"key":"814_CR24","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.3390\/molecules29092080","volume":"29","author":"X Zhang","year":"2024","unstructured":"Zhang X, Lin X, Cao J, Xie G, Yang X, Liu B, et al. Application of Cinnamomum burmannii essential oil in promoting wound healing. Molecules. 2024;29:2080.","journal-title":"Molecules"},{"key":"814_CR25","doi-asserted-by":"publisher","first-page":"122280","DOI":"10.1016\/j.ijpharm.2022.122280","volume":"628","author":"SA Alsakhawy","year":"2022","unstructured":"Alsakhawy SA, Baghdadi HH, El-Shenawy MA, Sabra SA, El-Hosseiny LS. Encapsulation of Thymus vulgaris essential oil in caseinate\/gelatin nanocomposite hydrogel: in vitro antibacterial activity and in vivo wound healing potential. Int J Pharm. 2022;628:122280.","journal-title":"Int J Pharm"},{"key":"814_CR26","doi-asserted-by":"publisher","first-page":"124414","DOI":"10.1016\/j.colsurfa.2020.124414","volume":"589","author":"K Khezri","year":"2020","unstructured":"Khezri K, Farahpour MR, Mounesi Rad S. Efficacy of Mentha pulegium essential oil encapsulated into nanostructured lipid carriers as an in vitro antibacterial and infected wound healing agent. Colloids Surf A Physicochem Eng Asp. 2020;589:124414.","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"key":"814_CR27","doi-asserted-by":"publisher","first-page":"130386","DOI":"10.1016\/j.ijbiomac.2024.130386","volume":"263","author":"N Meng","year":"2024","unstructured":"Meng N, Zhou C, Sun Z, Chen X, Xiong S, Tao M, et al. Tailored gelatin methacryloyl-based hydrogel with near-infrared responsive delivery of Qiai essential oils boosting reactive oxygen species scavenging, antimicrobial, and anti-inflammatory activities for diabetic wound healing. Int J Biol Macromol. 2024;263:130386.","journal-title":"Int J Biol Macromol"},{"key":"814_CR28","doi-asserted-by":"publisher","first-page":"102501","DOI":"10.1016\/j.jddst.2021.102501","volume":"63","author":"G El Fawal","year":"2021","unstructured":"El Fawal G, Hong H, Mo X, Wang H. Fabrication of scaffold based on gelatin and polycaprolactone (PCL) for wound dressing application. J Drug Deliv Sci Technol. 2021;63:102501.","journal-title":"J Drug Deliv Sci Technol"},{"key":"814_CR29","doi-asserted-by":"publisher","first-page":"134565","DOI":"10.1016\/j.ijbiomac.2024.134565","volume":"277","author":"CS Miranda","year":"2024","unstructured":"Miranda CS, Marinho E, Seabra CL, Evenou C, Lamartine J, Fromy B, et al. Antimicrobial, antioxidant and cytocompatible coaxial wet-spun fibers made of polycaprolactone and cellulose acetate loaded with essential oils for wound care. Int J Biol Macromol. 2024;277:134565.","journal-title":"Int J Biol Macromol"},{"key":"814_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/polym13213753","author":"JI Castro","year":"2021","unstructured":"Castro JI, Valencia-Llano CH, Zapata MEV, Restrepo YJ, Hernandez JHM, Navia-Porras DP, et al. Chitosan\/polyvinyl alcohol\/tea tree essential oil composite films for biomedical applications. Polymers (Basel). 2021;13:3753.","journal-title":"Polymers"},{"key":"814_CR31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/iwj.12049","volume":"12","author":"LJ Bessa","year":"2015","unstructured":"Bessa LJ, Fazii P, Di Giulio M, Cellini L. Bacterial isolates from infected wounds and their antibiotic susceptibility pattern: some remarks about wound infection. Int Wound J. 2015;12:47\u201352.","journal-title":"Int Wound J"},{"key":"814_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/bioengineering12010089","volume":"12","author":"C Ersanli","year":"2025","unstructured":"Ersanli C, Skoufos I, Fotou K, Tzora A, Bayon Y, Mari D, et al. Release profile and antibacterial activity of Thymus sibthorpii essential oil-incorporated, optimally stabilized type I collagen hydrogels. Bioengineering. 2025;12:89.","journal-title":"Bioengineering"},{"key":"814_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13765-024-00859-w","author":"EA Kotb","year":"2024","unstructured":"Kotb EA, El-Shiekh RA, Hassan M, Abd-Elsalam WH, El Tanbouly N, El Senousy AS. Potential anti-acne loaded nanogel formulations of Origanum majorana L. and Chrysanthemum morifolium Ramat. essential oils. Appl Biol Chem. 2024;67:9.","journal-title":"Appl Biol Chem"},{"key":"814_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/nano13050844","author":"R Uhl\u00ed\u0159ov\u00e1","year":"2023","unstructured":"Uhl\u00ed\u0159ov\u00e1 R, Langov\u00e1 D, Bendov\u00e1 A, Gross M, Skoumalov\u00e1 P, M\u00e1rov\u00e1 I. Antimicrobial activity of gelatin nanofibers enriched by essential oils against Cutibacterium acnes and Staphylococcus epidermidis. Nanomaterials (Basel). 2023;13:844.","journal-title":"Nanomaterials"},{"key":"814_CR35","doi-asserted-by":"publisher","first-page":"120288","DOI":"10.1016\/j.ijpharm.2021.120288","volume":"15","author":"S Barzegar","year":"2021","unstructured":"Barzegar S, Zare MR, Shojaei F, Zareshahrabadi Z, Koohi-Hosseinabadi O, Saharkhiz MJ, et al. Core-shell chitosan\/PVA-based nanofibrous scaffolds loaded with Satureja mutica or Oliveria decumbens essential oils as enhanced antimicrobial wound dressing. Int J Pharm. 2021;15:120288.","journal-title":"Int J Pharm"},{"key":"814_CR36","first-page":"218","volume":"6","author":"A Valizadeh","year":"2021","unstructured":"Valizadeh A, Abdollahi A, Ranjbar N, Kelidari HR, Sereshti H, Osanloo M. Antibacterial effects of impregnated scaffolds with solid lipid nanoparticles gels containing three essential oils against standard and clinical strains of Pseudomonas aeruginosa and Staphylococcus aureus. Nanomedicine Res J. 2021;6:218\u201327.","journal-title":"Nanomedicine Res J"},{"key":"814_CR37","doi-asserted-by":"crossref","unstructured":"Rahmani H, Ghanbariasad A, Meshkibaf MH, Molazade A, Heiran R, Safari M, et al. Chitosan nanoparticles containing \u03b1-pinene and Rosmarinus officinalis L. essential oil: effects on human melanoma cells\u2019 viability and expression of apoptosis-involved genes. Polymer Bulletin 2024; 81: 2505-23.","DOI":"10.1007\/s00289-023-04839-w"},{"key":"814_CR38","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jare.2021.06.003","volume":"34","author":"K Fatima","year":"2021","unstructured":"Fatima K, Masood N, Ahmad Wani Z, Meena A, Luqman S. Neomenthol prevents the proliferation of skin cancer cells by restraining tubulin polymerization and hyaluronidase activity. J Adv Res Elsevier. 2021;34:93\u2013107.","journal-title":"J Adv Res Elsevier"},{"key":"814_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.857256","author":"K Fatima","year":"2022","unstructured":"Fatima K, Luqman S, Meena A. Carvacrol arrests the proliferation of hypopharyngeal carcinoma cells by suppressing ornithine decarboxylase and hyaluronidase activities. Front Nutr. 2022:9:857256.","journal-title":"Front Nutr"},{"key":"814_CR40","doi-asserted-by":"crossref","unstructured":"Nasra S, Meghani N, Kumar A. Nanoemulsion-based system as a novel and promising approach for enhancing the antimicrobial and Antitumoral activity of Thymus vulgaris (L.) oil in human hepatocellular carcinoma cells. Appl Biochem Biotechnol. 2024;196:949-70.","DOI":"10.1007\/s12010-023-04571-1"},{"key":"814_CR41","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1021\/acsnano.8b09496","volume":"13","author":"H Ma","year":"2019","unstructured":"Ma H, Zhou Q, Chang J, Wu C. Grape seed-inspired smart hydrogel scaffolds for melanoma therapy and wound healing. ACS Nano. 2019;13:4302\u201311.","journal-title":"ACS Nano"},{"key":"814_CR42","doi-asserted-by":"publisher","first-page":"065012","DOI":"10.1088\/1748-605X\/acfc9d","volume":"18","author":"Z Iyigundogdu","year":"2023","unstructured":"Iyigundogdu Z, Petek BS, Capkin Yurtsever M, Ceylan S. Melissa officinalis essential oil loaded polycaprolactone membranes: evaluation of antimicrobial activities and cytocompatibility for tissue engineering applications. Biomed Mater. 2023;18:065012.","journal-title":"Biomed Mater"},{"key":"814_CR43","doi-asserted-by":"publisher","first-page":"105285","DOI":"10.1016\/j.jddst.2023.105285","volume":"92","author":"M Emami","year":"2024","unstructured":"Emami M, Zomorodian K, Yazdanpanah S, Ghasemi Y, Mirzaei E, Derakhshan MA. Multifunctional bi-layer collagen nanofiber-collagen\/PLLA\/Zataria multiflora essential oil nanofiber for wound healing: antibacterial, antifungal and antioxidant properties. J Drug Deliv Sci Technol. 2024;92:105285.","journal-title":"J Drug Deliv Sci Technol"},{"key":"814_CR44","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/antiox12020273","volume":"12","author":"S Perteghella","year":"2023","unstructured":"Perteghella S, Garzoni A, Invernizzi A, Sorrenti M, Boselli C, Icaro Cornaglia A, et al. Nanoemulsions of clove oil stabilized with chitosan oleate\u2014antioxidant and wound-healing activity. Antioxidants. 2023;12:12.","journal-title":"Antioxidants"},{"key":"814_CR45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/ma16041438","volume":"16","author":"MD Berechet","year":"2023","unstructured":"Berechet MD, Gaidau C, Ne\u0161i\u0107 A, Constantinescu RR, Simion D, Niculescu O, et al. Antioxidant and antimicrobial properties of hydrolysed collagen nanofibers loaded with ginger essential oil. Materials. 2023;16:16.","journal-title":"Materials"},{"key":"814_CR46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/cosmetics10010008","volume":"10","author":"SM Saraiva","year":"2023","unstructured":"Saraiva SM, Crespo AM, Vaz F, Filipe M, Santos D, Jacinto TA, et al. Development and characterization of thermal water gel comprising Helichrysum italicum essential oil-loaded chitosan nanoparticles for skin care. Cosmetics. 2023;10:8.","journal-title":"Cosmetics"},{"key":"814_CR47","doi-asserted-by":"crossref","unstructured":"da Silva Souza Campanholi K, Sonchini Gon\u00e7alves R, Bassi da Silva J, Said dos Santos R, Carla de Oliveira M, Barbosa de Souza Ferreira S, et al. Thermal stimuli-responsive topical platform based on copaiba oil-resin: design and performance upon ex-vivo human skin. J Mol Liq. Elsevier; 2022; 361:119625.","DOI":"10.1016\/j.molliq.2022.119625"},{"key":"814_CR48","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jconrel.2017.03.023","volume":"253","author":"P Sahu","year":"2017","unstructured":"Sahu P, Kashaw SK, Jain S, Sau S, Iyer AK. Assessment of penetration potential of pH responsive double walled biodegradable nanogels coated with eucalyptus oil for the controlled delivery of 5-fluorouracil: in vitro and ex vivo studies. J Controll Release. 2017;253:122\u201336.","journal-title":"J Controll Release"},{"key":"814_CR49","doi-asserted-by":"publisher","first-page":"102069","DOI":"10.1016\/j.mtchem.2024.102069","volume":"1","author":"MH Hashempur","year":"2024","unstructured":"Hashempur MH, Karami F, Khoshnam M, Zomorodian K, Zare A, Jafari M, et al. Enrichment of creatine-gelatin cryogel with Zataria multiflora essential oil and titanium dioxide nanoparticles as a potential wound dressing. Mater Today Chem. 2024;1:102069.","journal-title":"Mater Today Chem"},{"key":"814_CR50","doi-asserted-by":"publisher","first-page":"112833","DOI":"10.1016\/j.jece.2024.112833","volume":"12","author":"R Monfared-Hajishirkiaee","year":"2024","unstructured":"Monfared-Hajishirkiaee R, Ehtesabi H, Latifi H. Peppermint essential oil and ZnO nanoparticles: a green and effective combination for a cooling bilayer patch with antibacterial activity. J Environ Chem Eng. 2024;12:112833.","journal-title":"J Environ Chem Eng"},{"key":"814_CR51","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.ijbiomac.2022.12.036","volume":"226","author":"A Rezaei","year":"2023","unstructured":"Rezaei A, Ehtesabi H, Ebrahimi S. Incorporation of Saqez essential oil into polyvinyl alcohol\/chitosan bilayer hydrogel as a potent wound dressing material. Int J Biol Macromol. 2023;226:383\u201396.","journal-title":"Int J Biol Macromol"},{"key":"814_CR52","doi-asserted-by":"publisher","first-page":"2223018","DOI":"10.1080\/10667857.2023.2223018","volume":"38","author":"CR Ustundag","year":"2023","unstructured":"Ustundag CR, Piskin MB. Investigation of electrospun poly (\u03b5-caprolactone) fiber mats loaded with Calophyllum inophyllum essential oil for wound dressing applications: Morphology, drug release and in vitro evaluation. Mater Technol. 2023;38:2223018.","journal-title":"Mater Technol"},{"key":"814_CR53","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.ijbiomac.2018.12.085","volume":"125","author":"NT Ardekani","year":"2019","unstructured":"Ardekani NT, Khorram M, Zomorodian K, Yazdanpanah S, Veisi H, Veisi H. Evaluation of electrospun poly (vinyl alcohol)-based nanofiber mats incorporated with Zataria multiflora essential oil as potential wound dressing. Int J Biol Macromol. 2019;125:743\u201350.","journal-title":"Int J Biol Macromol"},{"key":"814_CR54","doi-asserted-by":"crossref","unstructured":"Wang H, Liu Y, Cai K, Zhang B, Tang S, Zhang W, et al. Antibacterial polysaccharide-based hydrogel dressing containing plant essential oil for burn wound healing. Burns Trauma. 2021;9:tkab041.","DOI":"10.1093\/burnst\/tkab041"},{"key":"814_CR55","doi-asserted-by":"publisher","first-page":"2305078","DOI":"10.1002\/advs.202305078","volume":"11","author":"F Wang","year":"2024","unstructured":"Wang F, Sun Q, Li Y, Xu R, Li R, Wu D, et al. Hydrogel encapsulating wormwood essential oil with broad-spectrum antibacterial and immunomodulatory properties for infected diabetic wound healing. Advan Sci. 2024;11:2305078.","journal-title":"Advan Sci"},{"key":"814_CR56","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.3390\/pharmaceutics13111939","volume":"13","author":"M R\u00e2p\u0103","year":"2021","unstructured":"R\u00e2p\u0103 M, Gaidau C, Mititelu-Tartau L, Berechet MD, Berbecaru AC, Rosca I, et al. Bioactive collagen hydrolysate-chitosan\/essential oil electrospun nanofibers designed for medical wound dressings. Pharmaceutics. 2021;13:1939.","journal-title":"Pharmaceutics"},{"key":"814_CR57","first-page":"111352","volume":"1","author":"K Huang","year":"2020","unstructured":"Huang K, Jinzhong Z, Zhu T, Morsi Y, Aldalbahi A, et al. PLCL\/Silk fibroin based antibacterial nano wound dressing encapsulating oregano essential oil: fabrication, characterization and biological evaluation. Colloids Surf B. 2020;1:111352.","journal-title":"Colloids Surf, B"},{"key":"814_CR58","first-page":"28","volume":"8","author":"O Ruxandra Vasile","year":"2023","unstructured":"Ruxandra Vasile O, Stanciulescu A, Trusca RD, Nicoara AI, Holban AM, Stoica AE, et al. ZnO@esential oils based sodium alginate\/silk fibroin\/hyaluronic acid scaffolds for wound applications. Annals Academy Romanian Sci Series Phy. 2023;8:28.","journal-title":"Annals Academy Romanian Sci Series Phy"},{"key":"814_CR59","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.3390\/ma13071682","volume":"13","author":"BS Vasile","year":"2020","unstructured":"Vasile BS, Birca AC, Musat MC, Holban AM. Wound dressings coated with silver nanoparticles and essential oils for the management of wound infections. Materials. 2020;13:1682.","journal-title":"Materials"},{"key":"814_CR60","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3390\/gels11050364","volume":"11","author":"W Jiang","year":"2025","unstructured":"Jiang W, Toufouki S, Mahmood S, Ahmad A, Yohannes A, Xiang Y, et al. Development of liposome-based hydrogel patches incorporating essential oils of African plants and deep eutectic solvents. Gels. 2025;11:364.","journal-title":"Gels"},{"key":"814_CR61","doi-asserted-by":"publisher","first-page":"132108","DOI":"10.1016\/j.ijbiomac.2024.132108","volume":"1","author":"JC Borges","year":"2024","unstructured":"Borges JC, de Almeida Campos LA, Kretzschmar EA, Cavalcanti IM. Incorporation of essential oils in polymeric films for biomedical applications. Int J Biol Macromol. 2024;1:132108.","journal-title":"Int J Biol Macromol"},{"key":"814_CR62","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3389\/fbioe.2020.00563","volume":"25","author":"Z Dajic Stevanovic","year":"2020","unstructured":"Dajic Stevanovic Z, Sieniawska E, Glowniak K, Obradovic N, Pajic-Lijakovic I. Natural macromolecules as carriers for essential oils: From extraction to biomedical application. Front Bioeng Biotechnol. 2020;25:563.","journal-title":"Front Bioeng Biotechnol"},{"key":"814_CR63","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.3390\/pharmaceutics14091799","volume":"14","author":"I Partheniadis","year":"2022","unstructured":"Partheniadis I, Stathakis G, Tsalavouti D, Hein\u00e4m\u00e4ki J, Nikolakakis I. Essential oil\u2014loaded nanofibers for pharmaceutical and biomedical applications: a systematic mini-review. Pharmaceutics. 2022;14:1799.","journal-title":"Pharmaceutics"},{"key":"814_CR64","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1080\/21691401.2019.1582539","volume":"47","author":"K Khezri","year":"2019","unstructured":"Khezri K, Farahpour MR, Mounesi Rad S. Accelerated infected wound healing by topical application of encapsulated Rosemary essential oil into nanostructured lipid carriers. Artif Cells Nanomed Biotechnol. 2019;47:980\u20138.","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"814_CR65","first-page":"80","volume":"62","author":"HA El Banna","year":"2018","unstructured":"El Banna HA, El Zorba H, Hossny A, Kamel W. Comparative efficacy of Grotto cream with Fucidin cream on normal and diabetic wound models in rats. Indian J Physiol Pharmacol. 2018;62:80\u20136.","journal-title":"Indian J Physiol Pharmacol"},{"key":"814_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopen.2017.04.001","volume":"5","author":"X Han","year":"2017","unstructured":"Han X, Beaumont C, Stevens N. Chemical composition analysis and in vitro biological activities of ten essential oils in human skin cells. Biochimie Open. 2017;5:1\u20137.","journal-title":"Biochimie Open"}],"container-title":["Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-026-00814-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13770-026-00814-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13770-026-00814-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:19:11Z","timestamp":1785521951000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13770-026-00814-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["814"],"URL":"https:\/\/doi.org\/10.1007\/s13770-026-00814-4","relation":{},"ISSN":["1738-2696","2212-5469"],"issn-type":[{"value":"1738-2696","type":"print"},{"value":"2212-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"12 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this paper.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no animal experiments carried out for this article.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}