{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T04:31:35Z","timestamp":1774758695447,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T00:00:00Z","timestamp":1443571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s15010-015-0837-z","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T10:39:52Z","timestamp":1443609592000},"page":"729-738","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Bacteremic pneumococcal pneumonia: clinical outcomes and preliminary results of inflammatory response"],"prefix":"10.1007","volume":"43","author":[{"given":"J. M.","family":"Bordon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fernandez-Botran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. L.","family":"Wiemken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Peyrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Uriarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. W.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rodriquez-Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Rane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. E.","family":"Binford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Uppatla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cavallazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Blasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Aliberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. I.","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fazeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rahmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ayesu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,9,30]]},"reference":[{"key":"837_CR1","volume-title":"Pneumonia, with special reference to pneumococcus lobar pneumonia","author":"R Heffron","year":"1939","unstructured":"Heffron R. Pneumonia, with special reference to pneumococcus lobar pneumonia. Cambridge: Harvard University Press; 1939."},{"key":"837_CR2","first-page":"CD000422","volume":"1","author":"S Moberley","year":"2013","unstructured":"Moberley S, et al. Vaccines for preventing pneumococcal infection in adults. Cochrane Database Syst Rev. 2013;1:CD000422.","journal-title":"Cochrane Database Syst Rev"},{"key":"837_CR3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1056\/NEJMoa1209165","volume":"369","author":"MR Griffin","year":"2013","unstructured":"Griffin MR, et al. U.S. hospitalizations for pneumonia after a decade of pneumococcal vaccination. New Engl J Med. 2013;369:155\u201363.","journal-title":"New Engl J Med"},{"key":"837_CR4","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1056\/NEJM200003093421002","volume":"342","author":"JP Nuorti","year":"2000","unstructured":"Nuorti JP, et al. Cigarette smoking and invasive pneumococcal disease. Active bacterial core surveillance team. New Engl J Med. 2000;342:681\u20139.","journal-title":"New Engl J Med"},{"key":"837_CR5","first-page":"210","volume":"79","author":"DM Musher","year":"2000","unstructured":"Musher DM, et al. Bacteremic and nonbacteremic pneumococcal pneumonia. Prospect Study Med. 2000;79:210\u201321.","journal-title":"Prospect Study Med"},{"key":"837_CR6","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1086\/420821","volume":"38","author":"JH Song","year":"2004","unstructured":"Song JH, et al. Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: a study by the Asian network for surveillance of resistant pathogens. Clin Infect Dis Off Publ Infect Dis Soc Am. 2004;38:1570\u20138.","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"key":"837_CR7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1183\/09031936.00128107","volume":"32","author":"C Garcia-Vidal","year":"2008","unstructured":"Garcia-Vidal C, et al. Early mortality in patients with community-acquired pneumonia: causes and risk factors. Eur Respir J. 2008;32:733\u20139.","journal-title":"Eur Respir J"},{"key":"837_CR8","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1017\/S0950268810002402","volume":"139","author":"SH Lin","year":"2011","unstructured":"Lin SH, et al. Outcomes of hospitalized patients with bacteraemic and non-bacteraemic community-acquired pneumonia caused by Streptococcus pneumoniae. Epidemiol Infect. 2011;139:1307\u201316.","journal-title":"Epidemiol Infect"},{"key":"837_CR9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/jama.1996.03530260048030","volume":"275","author":"MJ Fine","year":"1996","unstructured":"Fine MJ, et al. Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA J Am Med Assoc. 1996;275:134\u201341.","journal-title":"JAMA J Am Med Assoc"},{"key":"837_CR10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2466-14-128","volume":"14","author":"A Capelastegui","year":"2014","unstructured":"Capelastegui A, et al. Pneumococcal pneumonia: differences according to blood culture results. BMC Pulm Med. 2014;14:128.","journal-title":"BMC Pulm Med"},{"key":"837_CR11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jinf.2012.08.011","volume":"66","author":"CI Kang","year":"2013","unstructured":"Kang CI, et al. Risk factors and pathogenic significance of bacteremic pneumonia in adult patients with community-acquired pneumococcal pneumonia. J Infect. 2013;66:34\u201340.","journal-title":"J Infect"},{"key":"837_CR12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1378\/chest.07-1322","volume":"133","author":"J Bordon","year":"2008","unstructured":"Bordon J, et al. The presence of pneumococcal bacteremia does not influence clinical outcomes in patients with community-acquired pneumonia: results from the Community-Acquired Pneumonia Organization (CAPO) international cohort study. Chest. 2008;133:618\u201324.","journal-title":"Chest"},{"key":"837_CR13","first-page":"368","volume":"10","author":"TJ Marrie","year":"2003","unstructured":"Marrie TJ, Low DE, De Carolis E. A comparison of bacteremic pneumococcal pneumonia with nonbacteremic community-acquired pneumonia of any etiology\u2013results from a Canadian multicentre study. Can Respir J J Can Thorac Soc. 2003;10:368\u201374.","journal-title":"Can Respir J J Can Thorac Soc"},{"key":"837_CR14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1378\/chest.08-1216","volume":"135","author":"T Lisboa","year":"2009","unstructured":"Lisboa T, et al. Radiologic progression of pulmonary infiltrates predicts a worse prognosis in severe community-acquired pneumonia than bacteremia. Chest. 2009;135:165\u201372.","journal-title":"Chest"},{"key":"837_CR15","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1001\/archinte.161.6.848","volume":"161","author":"JA Ramirez","year":"2001","unstructured":"Ramirez JA, Bordon J. Early switch from intravenous to oral antibiotics in hospitalized patients with bacteremic community-acquired Streptococcus pneumoniae pneumonia. Arch Intern Med. 2001;161:848\u201350.","journal-title":"Arch Intern Med"},{"key":"837_CR16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.it.2007.06.002","volume":"28","author":"N Borregaard","year":"2007","unstructured":"Borregaard N, Sorensen OE, Theilgaard-Monch K. Neutrophil granules: a library of innate immunity proteins. Trends Immunol. 2007;28:340\u20135.","journal-title":"Trends Immunol"},{"key":"837_CR17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1189\/jlb.0804442","volume":"78","author":"FR Sheppard","year":"2005","unstructured":"Sheppard FR, et al. Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation. J Leukoc Biol. 2005;78:1025\u201342.","journal-title":"J Leukoc Biol"},{"key":"837_CR18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1183\/09031936.02.00295102","volume":"20","author":"G Antunes","year":"2002","unstructured":"Antunes G, et al. Systemic cytokine levels in community-acquired pneumonia and their association with disease severity. Eur Respir J. 2002;20:990\u20135.","journal-title":"Eur Respir J"},{"key":"837_CR19","first-page":"e76","volume":"17","author":"J Bordon","year":"2013","unstructured":"Bordon J, et al. Understanding the roles of cytokines and neutrophil activity and neutrophil apoptosis in the protective vs. deleterious inflammatory response in pneumonia. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. 2013;17:e76\u201383.","journal-title":"Int J Infect Dis IJID Off Publ Int Soc Infect Dis"},{"key":"837_CR20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","volume":"17","author":"J Grommes","year":"2011","unstructured":"Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med. 2011;17:293\u2013307.","journal-title":"Mol Med"},{"key":"837_CR21","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1164\/rccm.200603-350OC","volume":"175","author":"FW Arnold","year":"2007","unstructured":"Arnold FW, et al. A worldwide perspective of atypical pathogens in community-acquired pneumonia. Am J Respir Crit Care Med. 2007;175:1086\u201393.","journal-title":"Am J Respir Crit Care Med"},{"key":"837_CR22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1378\/chest.124.1.121","volume":"124","author":"FW Arnold","year":"2003","unstructured":"Arnold FW, et al. Hospitalization for community-acquired pneumonia: the pneumonia severity index vs. clinical judgment. Chest. 2003;124:121\u20134.","journal-title":"Chest"},{"key":"837_CR23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1056\/NEJM199701233360402","volume":"336","author":"MJ Fine","year":"1997","unstructured":"Fine MJ, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. New Engl Jo Med. 1997;336:243\u201350.","journal-title":"New Engl Jo Med"},{"key":"837_CR24","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1164\/ajrccm.163.7.at1010","volume":"163","author":"MS Niederman","year":"2001","unstructured":"Niederman MS, et al. Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med. 2001;163:1730\u201354.","journal-title":"Am J Respir Crit Care Med"},{"key":"837_CR25","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/aje\/kwh090","volume":"159","author":"G Zou","year":"2004","unstructured":"Zou G. A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004;159:702\u20136.","journal-title":"Am J Epidemiol"},{"key":"837_CR26","doi-asserted-by":"crossref","first-page":"e1000159","DOI":"10.1371\/journal.ppat.1000159","volume":"4","author":"YJ Lu","year":"2008","unstructured":"Lu YJ, et al. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog. 2008;4:e1000159.","journal-title":"PLoS Pathog"},{"key":"837_CR27","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jcrc.2013.04.016","volume":"28","author":"JM Pereira","year":"2013","unstructured":"Pereira JM, et al. Can we predict pneumococcal bacteremia in patients with severe community-acquired pneumonia? J Crit Care. 2013;28:970\u20134.","journal-title":"J Crit Care"},{"key":"837_CR28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1365-2796.2008.01934.x","volume":"264","author":"M Christ-Crain","year":"2008","unstructured":"Christ-Crain M, et al. Use of B-type natriuretic peptide in the risk stratification of community-acquired pneumonia. J Intern Med. 2008;264:166\u201376.","journal-title":"J Intern Med"},{"key":"837_CR29","doi-asserted-by":"crossref","first-page":"e62612","DOI":"10.1371\/journal.pone.0062612","volume":"8","author":"CL Chang","year":"2013","unstructured":"Chang CL, et al. Biomarkers of cardiac dysfunction and mortality from community-acquired pneumonia in adults. PLoS One. 2013;8:e62612.","journal-title":"PLoS One"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-015-0837-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s15010-015-0837-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-015-0837-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T17:40:00Z","timestamp":1559497200000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s15010-015-0837-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,30]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["837"],"URL":"https:\/\/doi.org\/10.1007\/s15010-015-0837-z","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,30]]}}}