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We followed the ethical standards set by the Helsinki Declaration of 1975, as revised in 2004, and the research guidelines of the Universities of Freiburg and Cologne. Written informed consent was obtained from the patients at the University Medical Center Cologne. The institutional review board of the University Medical Center Freiburg considered the investigation as evaluation of service within a quality assurance program and waived the need for written informed consent. The study is registered in the German Clinical Trials Registry (DRKS00005045).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"A.J.K. has received payments for lectures from BD Biosciences, bioM\u00e9rieux, MSD Sharp & Dohme, Limbach Gruppe SE, and ViiV Healthcare and travel support from Janssen-Cilag. H.S. has received grants or research support from the Bundesministerium f\u00fcr Bildung und Forschung (BMBF), Germany, the German Centre for Infection Research (DZIF), Basilea, Novartis and Pfizer, has been a consultant for Astellas, AstraZeneca, Basilea, Cubist, Novartis, Pfizer, Tetraphase, and The Medicines Company, and has received payments for lectures from MSD, Novartis and Pfizer. S.R. has received payments for lectures from Pfizer and MSD Sharp & Dohme, as well as travel support from Astellas and MSD Sharp & Dohme. W.V.K., A.F.W., J.S and H.C.S report no conflicts.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}