{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:51:04Z","timestamp":1772700664969,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"FUJIFILM Wako Chemicals Europe"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s15010-018-1224-3","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T16:08:22Z","timestamp":1538064502000},"page":"217-224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Serological biomarkers of candidemia: a retrospective evaluation of three assays"],"prefix":"10.1007","volume":"47","author":[{"given":"Karl","family":"Dichtl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Seybold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-9422","authenticated-orcid":false,"given":"Johannes","family":"Wagener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"publisher","first-page":"4167","DOI":"10.1128\/JCM.01998-13","volume":"51","author":"M Bassetti","year":"2013","unstructured":"Bassetti M, Merelli M, Righi E, Diaz-Martin A, Rosello EM, Luzzati R, et al. Epidemiology, species distribution, antifungal susceptibility, and outcome of candidemia across five sites in Italy and Spain. J Clin Microbiol. 2013;51:4167\u201372.","journal-title":"J Clin Microbiol"},{"key":"1224_CR2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1128\/CMR.00029-06","volume":"20","author":"MA Pfaller","year":"2007","unstructured":"Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20:133\u201363.","journal-title":"Clin Microbiol Rev"},{"key":"1224_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1086\/421946","volume":"39","author":"H Wisplinghoff","year":"2004","unstructured":"Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39:309\u201317.","journal-title":"Clin Infect Dis"},{"key":"1224_CR4","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s00134-014-3310-z","volume":"40","author":"M Bassetti","year":"2014","unstructured":"Bassetti M, Righi E, Ansaldi F, Merelli M, Trucchi C, Cecilia T, et al. A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality. Intensive Care Med. 2014;40:839\u201345.","journal-title":"Intensive Care Med"},{"key":"1224_CR5","first-page":"105","volume":"2","author":"E Weiss","year":"2014","unstructured":"Weiss E, Timsit J-F. Management of invasive candidiasis in nonneutropenic ICU patients. Ther Adv Infect Dis. 2014;2:105\u201315.","journal-title":"Ther Adv Infect Dis"},{"key":"1224_CR6","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/cid\/cis305","volume":"54","author":"M Kollef","year":"2012","unstructured":"Kollef M, Micek S, Hampton N, Doherty JA, Kumar A. Septic shock attributed to Candida infection: importance of empiric therapy and source control. Clin Infect Dis. 2012;54:1739\u201346.","journal-title":"Clin Infect Dis"},{"key":"1224_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/1469-0691.12038","volume":"18","author":"M Cuenca-Estrella","year":"2012","unstructured":"Cuenca-Estrella M, Verweij PE, Arendrup MC, Arikan-Akdagli S, Bille J, Donnelly JP, et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: diagnostic procedures. Clin Microbiol Infect. 2012;18:9\u201318.","journal-title":"Clin Microbiol Infect"},{"key":"1224_CR8","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ1194","volume":"62","author":"PG Pappas","year":"2016","unstructured":"Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62:e1\u201350.","journal-title":"Clin Infect Dis"},{"key":"1224_CR9","doi-asserted-by":"publisher","first-page":"01909","DOI":"10.1128\/JCM.01909-17","volume":"56","author":"CJ Clancy","year":"2018","unstructured":"Clancy CJ, Nguyen MH. Diagnosing invasive candidiasis. J Clin Microbiol. 2018;56:01909.","journal-title":"J Clin Microbiol"},{"key":"1224_CR10","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1128\/JCM.37.5.1510-1517.1999","volume":"37","author":"B Sendid","year":"1999","unstructured":"Sendid B, Tabouret M, Poirot JL, Mathieu D, Fruit J, Poulain D. New enzyme immunoassays for sensitive detection of circulating Candida albicans mannan and antimannan antibodies: useful combined test for diagnosis of systemic candidiasis. J Clin Microbiol. 1999;37:1510\u20137.","journal-title":"J Clin Microbiol"},{"key":"1224_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.5858\/arpa.2014-0230-RS","volume":"140","author":"T Tran","year":"2016","unstructured":"Tran T, Beal SG. Application of the 1,3-\u03b2-d-glucan (Fungitell) assay in the diagnosis of invasive fungal infections. Arch Pathol Lab Med. 2016;140:181\u20135.","journal-title":"Arch Pathol Lab Med"},{"key":"1224_CR12","first-page":"261","volume":"18","author":"F Debusmann","year":"2008","unstructured":"Debusmann F, Schaffrinski M, R\u00fcchel R. Serologische candidose-diagnostik: vergleich von drei antigentests. Der Mikrobiologe. 2008;18:261\u20132.","journal-title":"Der Mikrobiologe"},{"key":"1224_CR13","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.diagmicrobio.2009.04.012","volume":"64","author":"FMV Lunel","year":"2009","unstructured":"Lunel FMV, Mennink-Kersten MASH, Ruegebrink D, van der Lee HAL, Donnelly JP, Blijlevens NMA, et al. Value of Candida serum markers in patients with invasive candidiasis after myeloablative chemotherapy. Diagn Microbiol Infect Dis. 2009;64:408\u201315.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"1224_CR14","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00464-18","author":"R Friedrich","year":"2018","unstructured":"Friedrich R, Rappold E, Bogdan C, Held J. Comparative analysis of the wako \u03b2-glucan test and the fungitell\u00ae assay for the diagnosis of candidemia and pneumocystis jirovecii pneumonia. J Clin Microbiol. 2018. https:\/\/doi.org\/10.1128\/JCM.00464-18 .","journal-title":"J Clin Microbiol."},{"key":"1224_CR15","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"B Pauw De","year":"2008","unstructured":"De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group. Clin Infect Dis. 2008;46:1813\u201321.","journal-title":"Clin Infect Dis"},{"key":"1224_CR16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1128\/JCM.01811-10","volume":"49","author":"MC Arendrup","year":"2011","unstructured":"Arendrup MC, Bruun B, Christensen JJ, Fuursted K, Johansen HK, Kjaeldgaard P, et al. National surveillance of fungemia in Denmark (2004 to 2009). J Clin Microbiol. 2011;49:325\u201334.","journal-title":"J Clin Microbiol"},{"key":"1224_CR17","doi-asserted-by":"publisher","first-page":"R222","DOI":"10.1186\/cc9365","volume":"14","author":"M Mikulska","year":"2010","unstructured":"Mikulska M, Calandra T, Sanguinetti M, Poulain D, Viscoli C. Third European Conference on Infections in Leukemia Group. The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia. Crit Care. 2010;14:R222.","journal-title":"Crit Care"},{"key":"1224_CR18","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1099\/0022-1317-51-5-433","volume":"51","author":"B Sendid","year":"2002","unstructured":"Sendid B, Poirot JL, Tabouret M, Bonnin A, Caillot D, Camus D, et al. Combined detection of mannanaemia and antimannan antibodies as a strategy for the diagnosis of systemic infection caused by pathogenic Candida species. J Med Microbiol. 2002;51:433\u201342.","journal-title":"J Med Microbiol"},{"key":"1224_CR19","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1007\/s100960100629","volume":"20","author":"H Yera","year":"2001","unstructured":"Yera H, Sendid B, Francois N, Camus D, Poulain D. Contribution of serological tests and blood culture to the early diagnosis of systemic candidiasis. Eur J Clin Microbiol Infect Dis. 2001;20:864\u201370.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"1224_CR20","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1128\/JCM.02473-12","volume":"51","author":"J Held","year":"2013","unstructured":"Held J, Kohlberger I, Rappold E, Busse Grawitz A, H\u00e4cker G. Comparison of (1->3)-\u03b2-d-glucan, mannan\/anti-mannan antibodies, and Cand-Tec Candida antigen as serum biomarkers for candidemia. J Clin Microbiol. 2013;51:1158\u201364.","journal-title":"J Clin Microbiol"},{"key":"1224_CR21","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1574-6976.2011.00278.x","volume":"36","author":"S Silva","year":"2012","unstructured":"Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev. 2012;36:288\u2013305.","journal-title":"FEMS Microbiol Rev"},{"key":"1224_CR22","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.2169\/internalmedicine.50.6175","volume":"50","author":"Y Lu","year":"2011","unstructured":"Lu Y, Chen Y-Q, Guo Y-L, Qin S-M, Wu C, Wang K. Diagnosis of invasive fungal disease using serum (1\u21923)-\u03b2-D-glucan: a bivariate meta-analysis. Intern Med. 2011;50:2783\u201391.","journal-title":"Intern Med"},{"key":"1224_CR23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1128\/JCM.05267-11","volume":"50","author":"A Onishi","year":"2012","unstructured":"Onishi A, Sugiyama D, Kogata Y, Saegusa J, Sugimoto T, Kawano S, et al. Diagnostic accuracy of serum 1,3-\u03b2-d-glucan for pneumocystis jiroveci pneumonia, invasive candidiasis, and invasive aspergillosis: systematic review and meta-analysis. J Clin Microbiol. 2012;50:7\u201315.","journal-title":"J Clin Microbiol"},{"key":"1224_CR24","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1093\/cid\/ciq206","volume":"52","author":"DE Karageorgopoulos","year":"2011","unstructured":"Karageorgopoulos DE, Vouloumanou EK, Ntziora F, Michalopoulos A, Rafailidis PI, Falagas ME. \u03b2-d-glucan assay for the diagnosis of invasive fungal infections: a meta-analysis. Clin Infect Dis. 2011;52:750\u201370.","journal-title":"Clin Infect Dis"},{"key":"1224_CR25","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1439-0507.2010.01953.x","volume":"54","author":"C Kratzer","year":"2011","unstructured":"Kratzer C, Graninger W, Lassnigg A, Presterl E. Design and use of Candida scores at the intensive care unit. Mycoses. 2011;54:467\u201374.","journal-title":"Mycoses"},{"key":"1224_CR26","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/01.CCM.0000202208.37364.7D","volume":"34","author":"C Le\u00f3n","year":"2006","unstructured":"Le\u00f3n C, Ruiz-Santana S, Saavedra P, Almirante B, Nolla-Salas J, Alvarez-Lerma F, et al. A bedside scoring system (\u201cCandida score\u201d) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med. 2006;34:730\u20137.","journal-title":"Crit Care Med"},{"key":"1224_CR27","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3109\/00365548.2012.657672","volume":"44","author":"NS Ku","year":"2012","unstructured":"Ku NS, Han SH, Choi JY, Kim SB, Kim H-W, Jeong SJ, et al. Diagnostic value of the serum galactomannan assay for invasive aspergillosis: it is less useful in non-haematological patients. Scand J Infect Dis. 2012;44:600\u20134.","journal-title":"Scand J Infect Dis"},{"key":"1224_CR28","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1093\/cid\/cit006","volume":"56","author":"CJ Clancy","year":"2013","unstructured":"Clancy CJ, Nguyen MH. Finding the \u201cmissing 50%\u201d of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. Clin Infect Dis. 2013;56:1284\u201392.","journal-title":"Clin Infect Dis"},{"key":"1224_CR29","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1093\/cid\/cis021","volume":"54","author":"DR Andes","year":"2012","unstructured":"Andes DR, Safdar N, Baddley JW, Playford G, Reboli AC, Rex JH, et al. Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. Clin Infect Dis. 2012;54:1110\u201322.","journal-title":"Clin Infect Dis"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-018-1224-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s15010-018-1224-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-018-1224-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T06:08:14Z","timestamp":1605074894000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s15010-018-1224-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["1224"],"URL":"https:\/\/doi.org\/10.1007\/s15010-018-1224-3","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]},"assertion":[{"value":"23 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report financial support for consumables and staff to conduct the study and temporary supply of technical equipment from FUJIFILM Wako Chemicals Europe. The funding source was not involved in the study design, in the collection, analysis and interpretation of data or in writing of the report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}