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In addition to the zoophilic nature, there are also reports of the geophilic reservoir of this dermatophyte species.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>In this study, we present symptomatic infections with <jats:italic>N. nana<\/jats:italic> aetiology in humans reported recently in Poland. Interestingly, these cases had a non-specific clinical picture and occurred as skin lesions on the neck and foot as well as onychomycosis of the toenails. From the medical history, the patients had no contact with pigs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Diagnostics of these infections was performed with a combination of classical phenotypic and molecular genomic methods. The genomic diversity of the isolates was determined using the MP-PCR method. In vitro antifungal susceptibility tests against itraconazole, ketoconazole, terbinafine and naftifine hydrochloride were also performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>Nannizzia nana<\/jats:italic> has been identified as an etiological factor of dermatomycosis. Moreover, heterogeneity of the genomes was revealed for the obtained strains. In vitro activities of antifungal agents showed that isolates were susceptible to all tested drugs. The patients were treated with oral terbinafine and topical ketoconazole cream, which led to a complete recovery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In conclusion, the cases studied by us may indicate that the infrequency of <jats:italic>N. nana<\/jats:italic> infections may not necessarily be related to the low infectivity of this fungal agent, but they are rather associated with misdiagnosis. Furthermore, <jats:italic>N. nana<\/jats:italic> reservoirs should also be sought in soil.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-020-01416-5","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T11:02:59Z","timestamp":1585566179000},"page":"429-434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Unusual dermatomycoses caused by Nannizzia nana: the geophilic origin of human infections"],"prefix":"10.1007","volume":"48","author":[{"given":"Sebastian","family":"Gnat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"\u0141agowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Nowakiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Dyl\u0105g","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"1416_CR1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.21307\/PM-2019.58.1.049","volume":"58","author":"S Gnat","year":"2019","unstructured":"Gnat S, Nowakiewicz A, Zi\u0119ba P. 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No identification data are disclosed.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}