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We studied the characteristics of changes in T-lymphocyte subsets and their risk factors in HIV-negative patients with active tuberculosis (ATB).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>T-lymphocyte subsets in 275 HIV-negative ATB patients were quantitatively analyzed and compared with an <jats:italic>Mycobacterium<\/jats:italic><jats:italic>tuberculosis<\/jats:italic>-free control group. Single-factor and multifactor analyses of clinical and laboratory characteristics of patients were also conducted.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In ATB patients, CD4 and CD8 T-cell counts decreased, and the levels were positively interrelated (<jats:italic>r<\/jats:italic>\u2009=\u20090.655, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). After 4\u00a0weeks of antituberculosis treatment, CD4 and CD8 T-cell counts increased significantly but remained lower than in the control group. CD4 and CD8 cell counts were negatively associated with the extent of lesions detected in the chest by computed tomography (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Although not reflected in the CD4\/CD8 ratio, CD4 and CD8 cell counts differed between drug-resistant TB patients and drug-susceptible TB patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.030). The multivariate analysis showed prealbumin, alpha-1 globulin, body mass index, and platelet count were independent risk factors for decreased CD4 cell count (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while age and platelet count were independent risk factors for decreased CD8 cell count (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>CD4 and CD8 T-cell counts showed the evident value in predicting ATB severity. An increase in the CD4\/CD8 ratio may be a critical clue of drug resistance in ATB. Although the factors influencing CD4 and CD8 are not identical, our results indicated the importance of serum protein and platelets to ATB patients\u2019 immune function.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s15010-020-01451-2","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T17:02:55Z","timestamp":1590771775000},"page":"585-595","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Changes in T-lymphocyte subsets and risk factors in human immunodeficiency virus-negative patients with active tuberculosis"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-3918","authenticated-orcid":false,"given":"Kui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyu","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-4817","authenticated-orcid":false,"given":"Zhiguo","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"1451_CR1","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.4049\/jimmunol.1301373","volume":"192","author":"S Yao","year":"2014","unstructured":"Yao S, Huang D, Chen CY, Halliday L, Wang RC, Chen ZW. 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