{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:17:01Z","timestamp":1790770621368,"version":"4.1.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"FUNGINOS"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among <jats:italic>Candida<\/jats:italic> spp. is mainly due to acquired <jats:italic>FKS<\/jats:italic> mutations. In this study, we report the emergence of <jats:italic>FKS<\/jats:italic>-mutant <jats:italic>Candida albicans<\/jats:italic>\/<jats:italic>glabrata<\/jats:italic> in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26\u00a0days; range 15\u201377). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.<\/jats:p>","DOI":"10.1007\/s15010-020-01475-8","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T16:03:20Z","timestamp":1594656200000},"page":"761-766","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland"],"prefix":"10.1007","volume":"48","author":[{"given":"A. 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Changes in the epidemiological landscape of invasive candidiasis. J Antimicrob Chemother. 2018;73:i4\u2013i13. https:\/\/doi.org\/10.1093\/jac\/dkx444.","journal-title":"J Antimicrob Chemother."},{"key":"1475_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/1469-0691.12039","volume":"18","author":"OA Cornely","year":"2012","unstructured":"Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O, et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect. 2012;18:19\u201337. https:\/\/doi.org\/10.1111\/1469-0691.12039.","journal-title":"Clin Microbiol Infect"},{"key":"1475_CR3","doi-asserted-by":"publisher","first-page":"7465","DOI":"10.1128\/AAC.01973-15","volume":"59","author":"RK Shields","year":"2015","unstructured":"Shields RK, Nguyen MH, Press EG, Cumbie R, Driscoll E, Pasculle AW, et al. Rate of FKS Mutations among Consecutive Candida Isolates Causing Bloodstream Infection. Antimicrob Agents Chemother. 2015;59:7465\u201370. https:\/\/doi.org\/10.1128\/AAC.01973-15.","journal-title":"Antimicrob Agents Chemother"},{"key":"1475_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.drup.2014.01.001","volume":"16","author":"MC Arendrup","year":"2013","unstructured":"Arendrup MC, Cuenca-Estrella M, Lass-Florl C, Hope WW. Breakpoints for antifungal agents: an update from EUCAST focussing on echinocandins against Candida spp. and triazoles against Aspergillus spp. Drug Resist Updat. 2013;16:81\u201395.","journal-title":"Drug Resist Updat."},{"key":"1475_CR5","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/cid\/ciu407","volume":"59","author":"ND Beyda","year":"2014","unstructured":"Beyda ND, John J, Kilic A, Alam MJ, Lasco TM, Garey KW. FKS mutant Candida glabrata: risk factors and outcomes in patients with candidemia. Clin Infect Dis. 2014;59:819\u201325. https:\/\/doi.org\/10.1093\/cid\/ciu407.","journal-title":"Clin Infect Dis"},{"key":"1475_CR6","doi-asserted-by":"publisher","first-page":"6361","DOI":"10.1128\/AAC.01451-13","volume":"57","author":"RK Shields","year":"2013","unstructured":"Shields RK, Nguyen MH, Press EG, Updike CL, Clancy CJ. Anidulafungin and micafungin MIC breakpoints are superior to that of caspofungin for identifying FKS mutant Candida glabrata strains and Echinocandin resistance. Antimicrob Agents Chemother. 2013;57:6361\u20135. https:\/\/doi.org\/10.1128\/AAC.01451-13.","journal-title":"Antimicrob Agents Chemother"},{"key":"1475_CR7","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01564-17","author":"KMT Astvad","year":"2018","unstructured":"Astvad KMT, Johansen HK, Roder BL, Rosenvinge FS, Knudsen JD, Lemming L, et al. Update from a 12-Year Nationwide Fungemia Surveillance: Increasing Intrinsic and Acquired Resistance Causes Concern. 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The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}