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Our data from a regional referral center for AE in southwest Germany suggest rising regional incidence for AE (annual incidence per 100,000 population 2004\u20132011: 0.12; 2012\u20132019: 0.20) and emerging urban AE (of 7 cases of AE in Freiburg city dwellers none was diagnosed before 2012) calling for an intensification of\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    and AE surveillance and of AE prevention measures.\n                  <\/jats:p>","DOI":"10.1007\/s15010-020-01479-4","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T12:03:43Z","timestamp":1594901023000},"page":"923-927","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Spatial distribution and incidence trend of human alveolar echinococcosis in southwest Germany: increased incidence and urbanization of the disease?"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-8442","authenticated-orcid":false,"given":"Matthias C.","family":"Mueller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Peyerl-Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried V.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"1479_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10344-005-0100-5","volume":"51","author":"A K\u00f6nig","year":"2005","unstructured":"K\u00f6nig A, Romig T, Thoma D, Kellermann K. Drastic increase in the prevalence of Echinococcus multilocularis in foxes (Vulpes vulpes) in southern Bavaria, Germany. Eur J Wildl Res. 2005;51:277\u201382. https:\/\/doi.org\/10.1007\/s10344-005-0100-5.","journal-title":"Eur J Wildl Res"},{"key":"1479_CR2","first-page":"185","volume":"36","author":"T Romig","year":"1999","unstructured":"Romig T, Bilger B, Dinkel A, Merli M, Mackenstedt U. Echinococcus multilocularis in animal hosts: new data from western Europe. Helminthologia. 1999;36:185\u201391.","journal-title":"Helminthologia"},{"key":"1479_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.pt.2003.11.011","volume":"20","author":"P Deplazes","year":"2004","unstructured":"Deplazes P, Hegglin D, Gloor S, Romig T. Wilderness in the city: the urbanization of Echinococcus multilocularis. Trends Parasitol. 2004;20:77\u201384. https:\/\/doi.org\/10.1016\/j.pt.2003.11.011.","journal-title":"Trends Parasitol"},{"key":"1479_CR4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1017\/s0031182099005351","volume":"120","author":"S Hofer","year":"2000","unstructured":"Hofer S, Gloor S, M\u00fcller U, Mathis A, Hegglin D, Deplazes P. High prevalence of Echinococcus multilocularis in urban red foxes (Vulpes vulpes) and voles (Arvicola terrestris) in the city of Z\u00fcrich, Switzerland. Parasitology. 2000;120:135\u201342. https:\/\/doi.org\/10.1017\/s0031182099005351.","journal-title":"Parasitology"},{"key":"1479_CR5","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.vetpar.2015.07.036","volume":"213","author":"DA Vuitton","year":"2015","unstructured":"Vuitton DA, Demonmerot F, Knapp J, Richou C, Grenouillet F, Chauchet A, Vuitton L, Bresson-Hadni S, Millon L. Clinical epidemiology of human AE in Europe. Vet Parasitol. 2015;213:110\u201320. https:\/\/doi.org\/10.1016\/j.vetpar.2015.07.036.","journal-title":"Vet Parasitol"},{"key":"1479_CR6","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3201\/eid1306.061074","volume":"13","author":"A Schweiger","year":"2007","unstructured":"Schweiger A, Ammann RW, Candinas D, Clavien P-A, Eckert J, Gottstein B, Halkic N, Muellhaupt B, Prinz BM, Reichen J, Tarr PE, Torgerson PR, Deplazes P. Human alveolar echinococcosis after fox population increase, Switzerland. Emerg Infect Dis. 2007;13:878\u201382. https:\/\/doi.org\/10.3201\/eid1306.061074.","journal-title":"Emerg Infect Dis"},{"key":"1479_CR7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s15010-017-1094-0","volume":"46","author":"J Schmidberger","year":"2018","unstructured":"Schmidberger J, Kratzer W, Stark K, Gr\u00fcner B, Echinococcosis Working Group. Alveolar echinococcosis in Germany, 1992\u20132016. 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