{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:45:56Z","timestamp":1770918356356,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Schistosomiasis is a parasitic disease affecting the blood cell. As a chronic disease, schistosomiasis particularly impacts on the human host\u2019s haematological profile. We assessed here the impact of urogenital schistosomiasis on the full blood counts (FBC) as proxy diagnostic tool for schistosomiasis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A cross-sectional study was conducted among school children living in Lambar\u00e9n\u00e9, Gabon. Schistosomiasis status was determined using urine filtration technique. EDTA blood samples were analysed using a Pentra ABX 60<jats:sup>\u00ae<\/jats:sup> analyzer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Compared to their infection-free counterparts, school children infected with <jats:italic>Schistosoma haematobium<\/jats:italic> displayed an altered FBC profile, with changes in all three blood cell lines. Adjusted for praziquantel intake, soil-transmitted helminthic infections and <jats:italic>Plasmodium falciparum<\/jats:italic> infection status, schistosomiasis was independently associated with a decreasing trend of mean haemoglobin (\u03b2\u2009=\u2009\u2212\u00a00.20\u00a0g\/dL, <jats:italic>p-value<\/jats:italic>\u2009=\u20090.08) and hematocrit (\u03b2\u2009=\u2009\u2212\u00a00.61%, <jats:italic>p-value<\/jats:italic>\u2009=\u20090.06) levels, a lower mean MCV (\u03b2\u2009=\u2009\u2212\u00a01.50\u00b5m<jats:sup>3<\/jats:sup>, <jats:italic>p-value<\/jats:italic>\u2009=\u20090.02) and MCH (\u03b2\u2009=\u2009\u2212\u00a00.54\u00a0pg, <jats:italic>p-value<\/jats:italic>\u2009=\u20090.04), and higher platelet (\u03b2\u2009=\u200928.2 10<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>, <jats:italic>p-value<\/jats:italic>\u2009=\u20090.002) and leukocyte (\u03b2\u2009=\u20091.13 10<jats:sup>3<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>, <jats:italic>p-value<\/jats:italic>\u2009=\u20090.0003) counts, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Schistosomiasis is associated with a characteristic FBC profile of schoolchildren living in Lambar\u00e9n\u00e9, indicating the necessity to consider schistosomiasis as a single cause of disease, or a co-morbidity, when interpreting FBC in endemic areas.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-020-01575-5","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T04:49:22Z","timestamp":1611463762000},"page":"645-651","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Haematological changes in Schistosoma haematobium infections in school children in Gabon"],"prefix":"10.1007","volume":"49","author":[{"given":"Jean Claude","family":"Dejon-Agob\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u00f4la A.","family":"Adegnika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-1099","authenticated-orcid":false,"given":"Martin P.","family":"Grobusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"key":"1575_CR1","unstructured":"World Health Organization. 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