{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:40:29Z","timestamp":1772628029490,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s15010-021-01587-9","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T06:04:49Z","timestamp":1614578689000},"page":"677-684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-682X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Porta-Etessam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n J.","family":"N\u00fa\u00f1ez-Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Gonz\u00e1lez Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Fernandez-Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C.","family":"Viana-Llamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charbel Maroun","family":"Eid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aitor","family":"Uribarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Manuel","family":"Becerra-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Garc\u00eda","family":"Aguado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Rondano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Alfonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex Fernando Castro","family":"Mej\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Raposeiras","family":"Roubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martino","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Feltes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Mat\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Cortese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Buz\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge J\u00e1tiva","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"1587_CR1","first-page":"262","volume":"73","author":"LN Margallo","year":"2020","unstructured":"Margallo LN, Diaz M, Lim PP. 2019 Novel coronavirus pandemic: what do we know? Medicine. 2020;73:262\u20134.","journal-title":"Medicine"},{"key":"1587_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102512","author":"AR Morrison","year":"2020","unstructured":"Morrison AR, Johnson JM, Griebe KM, et al. Clinical characteristics and predictors of survival in adults with coronavirus disease 2019 receiving tocilizumab. J Autoimmun. 2020. https:\/\/doi.org\/10.1016\/j.jaut.2020.102512.","journal-title":"J Autoimmun"},{"key":"1587_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14273","author":"\u00c1 Beltr\u00e1n-Corbellini","year":"2020","unstructured":"Beltr\u00e1n-Corbellini \u00c1, Chico-Garc\u00eda JL, Mart\u00ednez-Poles J, et al. Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study. Eur J Neurol. 2020. https:\/\/doi.org\/10.1111\/ene.14273.","journal-title":"Eur J Neurol"},{"key":"1587_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3389\/fpubh.2020.00243","volume":"8","author":"P G\u00f3mez-Iglesias","year":"2020","unstructured":"G\u00f3mez-Iglesias P, Porta-Etessam J, Montalvo T, et al. An online observational study of patients with olfactory and gustory alterations secondary to SARS-CoV-2 infection. Front Public Health. 2020;8:243. https:\/\/doi.org\/10.3389\/fpubh.2020.00243.","journal-title":"Front Public Health"},{"key":"1587_CR5","doi-asserted-by":"publisher","first-page":"S101","DOI":"10.5455\/JPMA.20","volume":"70","author":"D Kanwar","year":"2020","unstructured":"Kanwar D, Baig AM, Wasay M. Neurological manifestations of COVID-19. J Pak Med Assoc. 2020;70:S101\u20133. https:\/\/doi.org\/10.5455\/JPMA.20.","journal-title":"J Pak Med Assoc"},{"key":"1587_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105007","author":"M Cataldi","year":"2020","unstructured":"Cataldi M, Pignataro G, Taglialatela M. Neurobiology of coronaviruses: Potential relevance for COVID-19. Neurobiol Dis. 2020. https:\/\/doi.org\/10.1016\/j.nbd.2020.105007.","journal-title":"Neurobiol Dis"},{"key":"1587_CR7","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6675.10.3174\/ajnr.A6675","author":"MFVV Arag\u00e3o","year":"2020","unstructured":"Arag\u00e3o MFVV, Leal MC, Cartaxo Filho OQ, Fonseca TM, Valen\u00e7a MM. Anosmia in COVID-19 associated with injury to the olfactory bulbs evident on MRI. AJNR Am J Neuroradiol. 2020. https:\/\/doi.org\/10.3174\/ajnr.A6675.10.3174\/ajnr.A6675.","journal-title":"AJNR Am J Neuroradiol."},{"key":"1587_CR8","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/jmv.25915","volume":"92","author":"A Paniz-Mondolfi","year":"2020","unstructured":"Paniz-Mondolfi A, Bryce C, Grimes Z, et al. Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). J Med Virol. 2020;92:699\u2013702. https:\/\/doi.org\/10.1002\/jmv.25915.","journal-title":"J Med Virol"},{"key":"1587_CR9","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/alr.22592","volume":"10","author":"CH Yan","year":"2020","unstructured":"Yan CH, Faraji F, Prajapati DP, Ostrander BT, DeConde AS. Self-reported olfactory loss associates with outpatient clinical course in COVID-19. Int Forum Allergy Rhinol. 2020;10:821\u201331. https:\/\/doi.org\/10.1002\/alr.22592.","journal-title":"Int Forum Allergy Rhinol"},{"key":"1587_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05965-1","author":"JR Lechien","year":"2020","unstructured":"Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical present2ation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020. https:\/\/doi.org\/10.1007\/s00405-020-05965-1.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1587_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2020.04.006","author":"T Klopfenstein","year":"2020","unstructured":"Klopfenstein T, Kadiane-Oussou NJ, Toko L, Royer PY, Lepiller Q, Gendrin V, Zayet S. Features of anosmia in COVID-19. Med Mal Infect. 2020. https:\/\/doi.org\/10.1016\/j.medmal.2020.04.006.","journal-title":"Med Mal Infect"},{"key":"1587_CR12","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/s41591-020-0916-2","volume":"26","author":"C Menni","year":"2020","unstructured":"Menni C, Valdes AM, Freidin MB, et al. Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat Med. 2020;26:1037\u201340. https:\/\/doi.org\/10.1038\/s41591-020-0916-2.","journal-title":"Nat Med"},{"key":"1587_CR13","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","volume":"77","author":"L Mao","year":"2020","unstructured":"Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77:683\u201390. https:\/\/doi.org\/10.1001\/jamaneurol.2020.1127.","journal-title":"JAMA Neurol"},{"key":"1587_CR14","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3389\/fimmu.2016.00475","volume":"7","author":"F Imamura","year":"2016","unstructured":"Imamura F, Hasegawa-Ishii S. Environmental toxicants-induced immune responses in the olfactory mucosa. Front Immunol. 2016;7:475. https:\/\/doi.org\/10.3389\/fimmu.2016.00475.","journal-title":"Front Immunol."},{"key":"1587_CR15","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1289\/ehp.8854","volume":"114","author":"Z Islam","year":"2006","unstructured":"Islam Z, Harkema JR, Pestka JJ. Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. Environ Health Perspect. 2006;114:1099\u2013107. https:\/\/doi.org\/10.1289\/ehp.8854.","journal-title":"Environ Health Perspect"},{"key":"1587_CR16","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00441-014-1848-2","volume":"357","author":"K Kanaya","year":"2014","unstructured":"Kanaya K, Kondo K, Suzukawa K, Sakamoto T, Kikuta S, Okada K, et al. Innate immune responses and neuroepithelial degeneration and regeneration in the mouse olfactory mucosa induced by intranasal administration of Poly(I:C). Cell Tissue Res. 2014;357:279\u201399. https:\/\/doi.org\/10.1007\/s00441-014-1848-2.","journal-title":"Cell Tissue Res"},{"key":"1587_CR17","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1002\/lary.22190","volume":"121","author":"B Sultan","year":"2011","unstructured":"Sultan B, May LA, Lane AP. The role of TNF-alpha in inflammatory olfactory loss. Laryngoscope. 2011;121:2481\u20136. https:\/\/doi.org\/10.1002\/lary.22190.","journal-title":"Laryngoscope"},{"key":"1587_CR18","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fnins.2014.00182.PMID:25018692;PMCID:PMC4071289","volume":"26","author":"JH Brann","year":"2014","unstructured":"Brann JH, Firestein SJ. A lifetime of neurogenesis in the olfactory system. Front Neurosci. 2014;26:182. https:\/\/doi.org\/10.3389\/fnins.2014.00182.PMID:25018692;PMCID:PMC4071289.","journal-title":"Front Neurosci"},{"key":"1587_CR19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/BF01175561","volume":"8","author":"GA Graziadei","year":"1979","unstructured":"Graziadei GA, Graziadei PP. Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy. J Neurocytol. 1979;8:197\u2013213. https:\/\/doi.org\/10.1007\/BF01175561.","journal-title":"J Neurocytol"},{"key":"1587_CR20","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.nrl.2020.03.001","volume":"35","author":"J Mat\u00edas-Guiu","year":"2020","unstructured":"Mat\u00edas-Guiu J, Gomez-Pinedo U, Montero-Escribano P, Gomez-Iglesias P, Porta-Etessam J, Matias-Guiu JA. Should we expect neurological symptoms in the SARS-CoV-2 epidemic? Es esperable que haya cuadros neurol\u00f3gicos por la pandemia por SARS-CoV-2? Neurologia. 2020;35:170\u20135. https:\/\/doi.org\/10.1016\/j.nrl.2020.03.001.","journal-title":"Neurologia"},{"key":"1587_CR21","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/jmv.25728","volume":"92","author":"YC Li","year":"2020","unstructured":"Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020;92:552\u20135. https:\/\/doi.org\/10.1002\/jmv.25728.","journal-title":"J Med Virol"},{"key":"1587_CR22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.4161\/viru.2.4.16138","volume":"2","author":"U Kalinke","year":"2011","unstructured":"Kalinke U, Bechmann I, Detje CN. Host strategies against virus entry via the olfactory system. Virulence. 2011;2:367\u201370. https:\/\/doi.org\/10.4161\/viru.2.4.16138.","journal-title":"Virulence"},{"key":"1587_CR23","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.mehy.2010.02.023","volume":"75","author":"JA Majde","year":"2010","unstructured":"Majde JA. Neuroinflammation resulting from covert brain invasion by common viruses\u2014a potential role in local and global neurodegeneration. Med Hypotheses. 2010;75:204\u201313. https:\/\/doi.org\/10.1016\/j.mehy.2010.02.023.","journal-title":"Med Hypotheses"},{"key":"1587_CR24","doi-asserted-by":"publisher","first-page":"E368","DOI":"10.1073\/pnas.1521463112","volume":"113","author":"C Tesoriero","year":"2016","unstructured":"Tesoriero C, Codita A, Zhang MD, et al. H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep-wake regulatory neurons in mice. Proc Natl Acad Sci U S A. 2016;113:E368\u201377. https:\/\/doi.org\/10.1073\/pnas.1521463112.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1587_CR25","doi-asserted-by":"publisher","first-page":"e01099","DOI":"10.1128\/JVI.01099-17","volume":"91","author":"DL Wheeler","year":"2017","unstructured":"Wheeler DL, Athmer J, Meyerholz DK, Perlman S. Murine olfactory bulb interneurons survive infection with a neurotropic coronavirus. J Virol. 2017;91:e01099-e1117. https:\/\/doi.org\/10.1128\/JVI.01099-17.","journal-title":"J Virol."},{"key":"1587_CR26","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/chemse\/26.8.953","volume":"26","author":"SL Youngentob","year":"2001","unstructured":"Youngentob SL, Schwob JE, Saha S, Manglapus G, Jubelt B. Functional consequences following infection of the olfactory system by intranasal infusion of the olfactory bulb line variant (OBLV) of mouse hepatitis strain JHM. Chem Senses. 2001;26:953\u201363. https:\/\/doi.org\/10.1093\/chemse\/26.8.953.","journal-title":"Chem Senses"},{"key":"1587_CR27","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa240","author":"RW Paterson","year":"2020","unstructured":"Paterson RW, Brown RL, Benjamin L, et al. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. 2020. https:\/\/doi.org\/10.1093\/brain\/awaa240.","journal-title":"Brain"},{"key":"1587_CR28","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.25.009084","author":"DH Brann","year":"2020","unstructured":"Brann DH, Tsukahara T, Weinreb C, Logan DW, Datta SR. Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients. BioRxiv. 2020. https:\/\/doi.org\/10.1101\/2020.03.25.009084.","journal-title":"BioRxiv"},{"key":"1587_CR29","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1126\/science.abd2985","volume":"370","author":"L Cantuti-Castelvetri","year":"2020","unstructured":"Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, \u00d6sterlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020;370:856\u201360. https:\/\/doi.org\/10.1126\/science.abd2985.","journal-title":"Science"},{"key":"1587_CR30","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.08.084996","author":"M Chen","year":"2020","unstructured":"Chen M, Shen W, Rowan NR, Kulaga H, Hillel A, Ramanathan M, Lane AP. Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication. BioRxiv. 2020. https:\/\/doi.org\/10.1101\/2020.05.08.084996.","journal-title":"BioRxiv"},{"key":"1587_CR31","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.acra.2020.04.002","volume":"27","author":"MK Galougahi","year":"2020","unstructured":"Galougahi MK, Ghorbani J, Bakhshayeshkaram M, Naeini AS, Haseli S. Olfactory bulb magnetic resonance imaging in SARS-CoV-2-induced anosmia: the first report. Acad Radiol. 2020;27:892\u20133. https:\/\/doi.org\/10.1016\/j.acra.2020.04.002.","journal-title":"Acad Radiol"},{"key":"1587_CR32","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.0832","author":"M Eliezer","year":"2020","unstructured":"Eliezer M, Hautefort C, Hamel AL, et al. Sudden and complete olfactory loss function as a possible symptom of COVID-19. JAMA Otolaryngol Head Neck Surg. 2020. https:\/\/doi.org\/10.1001\/jamaoto.2020.0832.","journal-title":"JAMA Otolaryngol Head Neck Surg."},{"key":"1587_CR33","doi-asserted-by":"publisher","first-page":"34320","DOI":"10.1074\/jbc.M002814200","volume":"275","author":"R Lin","year":"2000","unstructured":"Lin R, Mamane Y, Hiscott J. Multiple regulatory domains control IRF-7 activity in response to virus infection. J Biol Chem. 2000;275:34320\u20137. https:\/\/doi.org\/10.1074\/jbc.M002814200.","journal-title":"J Biol Chem"},{"key":"1587_CR34","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","volume":"20","author":"MZ Tay","year":"2020","unstructured":"Tay MZ, Poh CM, R\u00e9nia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020;20:363\u201374. https:\/\/doi.org\/10.1038\/s41577-020-0311-8.","journal-title":"Nat Rev Immunol"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-021-01587-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-021-01587-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-021-01587-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T13:12:27Z","timestamp":1627391547000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-021-01587-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1587"],"URL":"https:\/\/doi.org\/10.1007\/s15010-021-01587-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-158894\/v1","asserted-by":"object"}]},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]},"assertion":[{"value":"30 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they no have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}