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Aims were: (1) to assess clinical features and differences of patients with COVID-19 and FLU, (2) to identify clinical and\/or laboratory factors associated with FLU or COVID-19 and (3) to evaluate 30-day mortality, bacterial superinfections, thrombotic events and invasive pulmonary aspergillosis (IPA) in patients with FLU versus COVID-19.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Overall, 74 patients were included (19, 25.7%, FLU and 55, 74.3%, COVID-19), median age 67\u00a0years (58\u201376). COVID-19 patients were more male (<jats:italic>p<\/jats:italic>\u2009=\u20090.013), with a lower percentage of COPD (Chronic Obstructive Pulmonary Disease) and chronic kidney disease (CKD) (<jats:italic>p<\/jats:italic>\u2009=\u20090.001 and <jats:italic>p<\/jats:italic>\u2009=\u20090.037, respectively) than FLU. SOFA score was higher (<jats:italic>p<\/jats:italic>\u2009=\u20090.020) and lymphocytes were significantly lower in FLU than in COVID-19 [395.5 <jats:italic>vs<\/jats:italic> 770.0 cells\/mmc, <jats:italic>p<\/jats:italic>\u2009=\u20090.005]. At multivariable analysis, male sex (OR 6.1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.002), age\u2009&gt;\u200965\u00a0years (OR 2.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.024) and lymphocyte count\u2009&gt;\u2009725 cells\/mmc at ICU admission (OR 5.1, p\u2009=\u20090.024) were significantly associated with COVID-19, whereas CKD and COPD were associated with FLU (OR 0.1 and OR 0.16, <jats:italic>p<\/jats:italic>\u2009=\u20090.020 and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). No differences in mortality, bacterial superinfections and thrombotic events were observed, whereas IPA was mostly associated with FLU (31.5% vs 3.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0029).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In critically ill patients, male sex, age\u2009&gt;\u200965\u00a0years and lymphocytes\u2009&gt;\u2009725 cells\/mmc are related to COVID-19. FLU is associated with a significantly higher risk of IPA than COVID-19.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-021-01624-7","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T03:40:28Z","timestamp":1622000428000},"page":"965-975","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of clinical features and outcomes in COVID-19 and influenza pneumonia patients requiring intensive care unit admission"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0832-7975","authenticated-orcid":false,"given":"A.","family":"Oliva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ceccarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Borrazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ridolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"D.\u2019Ettorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Alessandri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ruberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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