{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:56:37Z","timestamp":1787626597696,"version":"build-2736575974"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002347","name":"bundesministerium f\u00fcr bildung und forschung","doi-asserted-by":"publisher","award":["01KX2021"],"award-info":[{"award-number":["01KX2021"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008001","name":"Universit\u00e4t zu K\u00f6ln","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008001","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Residents in nursing homes for the elderly (NH) are at high risk for death from COVID-19. We investigated whether repeated non-mandatory RT-PCR SARS-CoV-2 surveillance of NH staff and visitors reduces COVID-19 incidence rates in NH residents and allows to reduce visiting restrictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This pilot study at the beginning of the COVID-19 pandemic compared a surveillance approach of regular, twice-weekly voluntary PCR testing of health-care workers (HCW) and visitors in interventional NH (INH) with a setting without regular testing in control NH (CNH). Residents were not tested routinely within this study. Testing was performed in a mobile testing site with same-day result reporting. SARS-CoV-2 incidence among residents in both INH and CNH was the primary endpoint; secondary endpoints being SARS-CoV-2 infection among visitors and HCW in INH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two INH and two CNH participated between October and December, 2020. At INH1, 787 tests of HCW and 350 tests of visitors were performed, accounting for 18.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091930) of visits. At INH2, 78 tests of HCW and 372 tests of visitors were done, i.e., 30.5% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091220) of visits. At the two INH 23 HCW and three visitors tested positive for SARS-CoV-2. COVID-19 outbreaks occurred among residents in INH1 (identified through study testing) and in CNH1. Utilization of voluntary testing was low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a real-world setting without available rapid testing, voluntary RT-PCR SARS-CoV-2 testing of HCW and visitors does not prevent COVID-19 outbreaks in NH. Complete, non-selective testing for these groups should be instituted before visiting restrictions can be reduced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>The study has been registered at ClinicalTrials.gov with the identifier: NCT04933981.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-021-01716-4","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T16:31:21Z","timestamp":1634747481000},"page":"607-616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mobile PCR-based surveillance for SARS-CoV-2 to reduce visiting restrictions in nursing homes during the COVID-19 pandemic: a pilot study"],"prefix":"10.1007","volume":"50","clinical-trial-number":[{"clinical-trial-number":"nct04933981","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9152-2469","authenticated-orcid":false,"given":"Jannik","family":"Stemler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5187-6510","authenticated-orcid":false,"given":"Theresa","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Dimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-4413","authenticated-orcid":false,"given":"Ulrike","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8805-1421","authenticated-orcid":false,"given":"Sofie","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-6437","authenticated-orcid":false,"given":"Rosanne","family":"Sprute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1224-5385","authenticated-orcid":false,"given":"Max","family":"Oberste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Wiesm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-2288","authenticated-orcid":false,"given":"Harald","family":"Rau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9979-1671","authenticated-orcid":false,"given":"Ullrich","family":"Bethe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-1578","authenticated-orcid":false,"given":"Clara","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5174-928X","authenticated-orcid":false,"given":"Martin","family":"Hellmich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1376-1792","authenticated-orcid":false,"given":"Florian","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Langebartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"1716_CR1","volume-title":"WHO Director-General's opening remarks at the media briefing on COVID-19","author":"WH Organization","year":"2020","unstructured":"Organization WH. WHO Director-General\u2019s opening remarks at the media briefing on COVID-19. Geneva: World Health Organization; 2020."},{"key":"1716_CR2","unstructured":"Increase in fatal cases of COVID-19 among long-term care facility residents in the EU\/EEA and the UK. 2020, European Centre for Disease Prevention and Control: Stockholm. https:\/\/www.ecdc.europa.eu\/en\/publications-data\/rapid-risk-assessment-increase-fatal-cases-covid-19-among-long-term-care-facility#copy-to-clipboard. Accessed 19 Oct 2021"},{"key":"1716_CR3","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.jamda.2020.05.045","volume":"21","author":"C Bonanad","year":"2020","unstructured":"Bonanad C, et al. The effect of age on mortality in patients with COVID-19: a meta-analysis with 611,583 subjects. J Am Med Dir Assoc. 2020;21:915\u20138.","journal-title":"J Am Med Dir Assoc"},{"key":"1716_CR4","unstructured":"Comas-Herrera, A., et al. Mortality associated with COVID-19 in care homes: international evidence. 2020; Available from: https:\/\/ltccovid.org\/2020\/04\/12\/mortality-associated-with-covid-19-outbreaks-in-care-homes-early-international-evidence\/. Accessed 14 Oct 2020 04 Jan 2021."},{"key":"1716_CR5","doi-asserted-by":"publisher","first-page":"24522","DOI":"10.18632\/aging.202307","volume":"12","author":"B Cangiano","year":"2020","unstructured":"Cangiano B, et al. Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests. Aging (Albany NY). 2020;12:24522.","journal-title":"Aging (Albany NY)"},{"key":"1716_CR6","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.15585\/mmwr.mm6943a5","volume":"69","author":"A Fell","year":"2020","unstructured":"Fell A, et al. SARS-CoV-2 exposure and infection among health care personnel\u2014Minnesota, March 6-July 11, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1605\u201310.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"1716_CR7","unstructured":"Heller E. Allgemeinverf\u00fcgung des Ministeriums f\u00fcr Arbeit, Gesundheit und Soziales (CoronaAVPflegeundBesuche)\u2014Schutz von Pflegeeinrichtungen vor dem Eintrag von SARS-CoV-2-Viren unter Ber\u00fccksichtigung des Rechts auf Teilhabe und sozialer Kontakte der pflegebed\u00fcrftigen Menschen. 2020, Ministerium f\u00fcr Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen: D\u00fcsseldorf. p. 2128."},{"key":"1716_CR8","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13643-020-01486-4","volume":"9","author":"P Rios","year":"2020","unstructured":"Rios P, et al. Preventing the transmission of COVID-19 and other coronaviruses in older adults aged 60 years and above living in long-term care: a rapid review. Syst Rev. 2020;9:218.","journal-title":"Syst Rev"},{"key":"1716_CR9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jmii.2020.04.003","volume":"53","author":"MY Yen","year":"2020","unstructured":"Yen MY, et al. Recommendations for protecting against and mitigating the COVID-19 pandemic in long-term care facilities. J Microbiol Immunol Infect. 2020;53:447\u201353.","journal-title":"J Microbiol Immunol Infect"},{"key":"1716_CR10","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/S1473-3099(20)30314-5","volume":"20","author":"MM B\u00f6hmer","year":"2020","unstructured":"B\u00f6hmer MM, et al. Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series. Lancet Infect Dis. 2020;20:920\u20138.","journal-title":"Lancet Infect Dis"},{"key":"1716_CR11","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41591-020-0869-5","volume":"26","author":"X He","year":"2020","unstructured":"He X, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26:672\u20135.","journal-title":"Nat Med"},{"key":"1716_CR12","doi-asserted-by":"crossref","unstructured":"See I, et al. Modeling effectiveness of testing strategies to prevent COVID-19 in nursing homes\u2014United States, 2020. Clin Infect Dis, 2021.","DOI":"10.1101\/2020.12.18.20248255"},{"key":"1716_CR13","first-page":"Cd013705","volume":"3","author":"J Dinnes","year":"2021","unstructured":"Dinnes J, et al. Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection. Cochrane Database Syst Rev. 2021;3:Cd013705.","journal-title":"Cochrane Database Syst Rev"},{"key":"1716_CR14","doi-asserted-by":"publisher","first-page":"e0089621","DOI":"10.1128\/JCM.00896-21","volume":"59","author":"M Korenkov","year":"2021","unstructured":"Korenkov M, et al. Evaluation of a rapid antigen test to detect SARS-CoV-2 infection and identify potentially infectious individuals. J Clin Microbiol. 2021;59:e0089621.","journal-title":"J Clin Microbiol"},{"key":"1716_CR15","unstructured":"Laumann KJ. Verordnung zum Schutz vor Neuinfizierungen mit dem Coronavirus SARS-CoV-2 (Coronaschutzverordnung\u2014CoronaSchVO), 2020, Ministerium f\u00fcr Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen: D\u00fcsseldorf."},{"key":"1716_CR16","unstructured":"Laumann KJ. Besondere Schutzma\u00dfnahmen vor Infektionen mit dem SARS-CoV-2-Virus in vollstation\u00e4ren Einrichtungen der Pflege, der Eingliederungshilfe und der Sozialhilfe - Allgemeinverf\u00fcgung des Ministeriums f\u00fcr Arbeit, Gesundheit und Soziales (CoronaAVEinrichtungen), 2020, Ministerium f\u00fcr Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen: D\u00fcsseldorf."},{"issue":"21","key":"1716_CR17","doi-asserted-by":"publisher","first-page":"2000531","DOI":"10.2807\/1560-7917.ES.2020.25.21.2000531","volume":"25","author":"M Augustin","year":"2020","unstructured":"Augustin M, et al. Rapid response infrastructure for pandemic preparedness in a tertiary care hospital: lessons learned from the COVID-19 outbreak in Cologne, Germany, February to March 2020. Euro Surveill. 2020;25(21):2000531.","journal-title":"Euro Surveill"},{"key":"1716_CR18","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1186\/s12879-021-06249-7","volume":"21","author":"J Stemler","year":"2021","unstructured":"Stemler J, et al. Web-based, rapid and contactless management of ambulatory patients for SARS-CoV-2-testing. BMC Infect Dis. 2021;21:535.","journal-title":"BMC Infect Dis"},{"key":"1716_CR19","doi-asserted-by":"crossref","unstructured":"Wunsch M et al. Safe and effective pool testing for SARS-CoV-2 detection available at SSRN: https:\/\/papers.ssrn.com\/sol3\/papers.cfm?abstract_id=3684470. Accessed 19 Oct 2021.","DOI":"10.2139\/ssrn.3684470"},{"key":"1716_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40249-021-00795-7","volume":"10","author":"JLL Waya","year":"2021","unstructured":"Waya JLL, et al. COVID-19 case management strategies: what are the options for Africa? Infect Dis Poverty. 2021;10:30.","journal-title":"Infect Dis Poverty"},{"key":"1716_CR21","doi-asserted-by":"publisher","first-page":"e005833","DOI":"10.1136\/bmjgh-2021-005833","volume":"6","author":"LN Patel","year":"2021","unstructured":"Patel LN, et al. Safer primary healthcare facilities are needed to protect healthcare workers and maintain essential services: lessons learned from a multicountry COVID-19 emergency response initiative. BMJ Glob Health. 2021;6:e005833.","journal-title":"BMJ Glob Health"},{"key":"1716_CR22","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1111\/jgs.16784","volume":"68","author":"JG Ouslander","year":"2020","unstructured":"Ouslander JG, Grabowski DC. COVID-19 in nursing homes: calming the perfect storm. J Am Geriatr Soc. 2020;68:2153\u201362.","journal-title":"J Am Geriatr Soc"},{"key":"1716_CR23","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1111\/jgs.16661","volume":"68","author":"HR Abrams","year":"2020","unstructured":"Abrams HR, et al. Characteristics of U.S. nursing homes with COVID-19 cases. J Am Geriatr Soc. 2020;68:1653\u20136.","journal-title":"J Am Geriatr Soc"},{"key":"1716_CR24","doi-asserted-by":"crossref","unstructured":"Rennert L, et al. Surveillance-based informative testing for detection and containment of SARS-CoV-2 outbreaks on a public university campus: an observational and modelling study. Lancet Child Adolesc Health, 2021.","DOI":"10.1016\/S2352-4642(21)00060-2"},{"key":"1716_CR25","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1016\/S2666-7568(20)30037-4","volume":"1","author":"Editorial","year":"2020","unstructured":"The Lancet Healthy Longevity. Care home staff and residents on the pandemic front line. Lancet Healthy Longev. 2020;1(2):e48","journal-title":"Lancet Healthy Longev"},{"key":"1716_CR26","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1001\/jamainternmed.2020.1562","volume":"180","author":"S Galea","year":"2020","unstructured":"Galea S, Merchant RM, Lurie N. The mental health consequences of COVID-19 and physical distancing: the need for prevention and early intervention. JAMA Intern Med. 2020;180:817\u20138.","journal-title":"JAMA Intern Med"},{"key":"1716_CR27","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1111\/jgs.16689","volume":"68","author":"Y Li","year":"2020","unstructured":"Li Y, et al. COVID-19 infections and deaths among connecticut nursing home residents: facility correlates. J Am Geriatr Soc. 2020;68:1899\u2013906.","journal-title":"J Am Geriatr Soc"},{"key":"1716_CR28","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2020.02191","author":"CM Kosar","year":"2021","unstructured":"Kosar CM, et al. COVID-19 mortality rates among nursing home residents declined from March To November 2020. Health Aff (Millwood). 2021. https:\/\/doi.org\/10.1377\/hlthaff.2020.02191.","journal-title":"Health Aff (Millwood)"},{"key":"1716_CR29","doi-asserted-by":"publisher","first-page":"e2015957","DOI":"10.1001\/jamanetworkopen.2020.15957","volume":"3","author":"DN Fisman","year":"2020","unstructured":"Fisman DN, et al. Risk factors associated with mortality among residents with coronavirus disease 2019 (COVID-19) in long-term care facilities in Ontario, Canada. JAMA Netw Open. 2020;3:e2015957.","journal-title":"JAMA Netw Open"},{"key":"1716_CR30","unstructured":"Considerations for Use of SARS-CoV-2 Antigen Testing in Nursing Homes. 2020; Available from: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/nursing-homes-antigen-testing.html. Accessed 4 Jan 2021."},{"key":"1716_CR31","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.15585\/mmwr.mm695152a3","volume":"69","author":"IW Pray","year":"2021","unstructured":"Pray IW, et al. Performance of an antigen-based test for asymptomatic and symptomatic SARS-CoV-2 testing at two university campuses\u2014Wisconsin, September-October 2020. MMWR Morb Mortal Wkly Rep. 2021;69:1642\u20137.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"7","key":"1716_CR32","doi-asserted-by":"publisher","first-page":"e311","DOI":"10.1016\/S2666-5247(21)00056-2","volume":"2","author":"VM Corman","year":"2021","unstructured":"Corman VM, et al. Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study. Lancet Microbe. 2021;2(7):e311\u2013e319.","journal-title":"Lancet Microbe"},{"key":"1716_CR33","doi-asserted-by":"crossref","unstructured":"Lanser L, et al. Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values. Infection, 2020; 1\u20133.","DOI":"10.1007\/s15010-020-01542-0"},{"key":"1716_CR34","volume-title":"COVID-19 vaccination and prioritisation strategies in the EU\/EEA, in Technical report","author":"ECDC","year":"2020","unstructured":"ECDC. COVID-19 vaccination and prioritisation strategies in the EU\/EEA, in Technical report. Stockholm: European Center for Disease Prevention and Control; 2020."},{"key":"1716_CR35","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s00281-020-00821-0","volume":"42","author":"A Ciabattini","year":"2020","unstructured":"Ciabattini A, et al. Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population. Semin Immunopathol. 2020;42:619\u201334.","journal-title":"Semin Immunopathol"},{"key":"1716_CR36","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.bbrc.2020.10.090","volume":"538","author":"T Schenkelberg","year":"2021","unstructured":"Schenkelberg T. Vaccine-induced protection in aging adults and pandemic response. Biochem Biophys Res Commun. 2021;538:218\u201320.","journal-title":"Biochem Biophys Res Commun"},{"key":"1716_CR37","doi-asserted-by":"publisher","first-page":"396","DOI":"10.15585\/mmwr.mm7011e3","volume":"70","author":"A Britton","year":"2021","unstructured":"Britton A, et al. Effectiveness of the Pfizer-BioNTech COVID-19 vaccine among residents of two skilled nursing facilities experiencing COVID-19 outbreaks\u2014Connecticut, December 2020-February 2021. MMWR Morb Mortal Wkly Rep. 2021;70:396\u2013401.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"9","key":"1716_CR38","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1016\/j.cell.2021.03.013","volume":"184","author":"WF Garcia-Beltran","year":"2021","unstructured":"Garcia-Beltran WF, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell. 2021;184(9):2372-2383.e9.","journal-title":"Cell"},{"key":"1716_CR39","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/d41586-021-00396-2","volume":"590","author":"N Phillips","year":"2021","unstructured":"Phillips N. The coronavirus is here to stay\u2014here\u2019s what that means. Nature. 2021;590:382\u20134.","journal-title":"Nature"},{"key":"1716_CR40","unstructured":"Haser\u00fcck A. Coronapandemie: Modellversuche als Ausweg. Dtsch \u00c4rztebl, 2021; 118."}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-021-01716-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-021-01716-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-021-01716-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T06:10:52Z","timestamp":1653891052000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-021-01716-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1716"],"URL":"https:\/\/doi.org\/10.1007\/s15010-021-01716-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-114537\/v1","asserted-by":"object"}]},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,20]]},"assertion":[{"value":"12 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"JS has received research grants by the Ministry of Education and Research (BMBF) for this study and from Basilea Pharmaceuticals Inc. outside the submitted work and has received travel grants by German Society for Infectious Diseases (DGI e.V.) and Meta-Alexander-Foundation. TK, VD SS, RS, MO SP, UB, CL, and FK have nothing to disclose. UW is employed at Institute of Virology, University of Cologne, and has received funding from the Ministry of Education and Research (BMBF) for this study. GW has received research grants by the Ministry of Education and Research (BMBF) for this study. HR has received research grants by the Ministry of Education and Research (BMBF) for this study. MH has received research grants by the Ministry of Education and Research (BMBF) for this study. GL has received research grants by the Ministry of Education and Research (BMBF) for development of the UHC Corona Webtool. OAC is supported by the German Federal Ministry of Research and Education, is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy\u2014CECAD, EXC 2030\u2014390661388, and has received research grants from, is an advisor to, or received lecture honoraria from Actelion, Allecra Therapeutics, Al-Jazeera Pharmaceuticals, Amplyx, Astellas, Basilea, Biosys, Cidara, Da Volterra, Entasis, F2G, Gilead, Grupo Biotoscana, Immunic, IQVIA, Janssen, Matinas, Medicines Company, MedPace, Melinta Therapeutics, Menarini, Merck\/MSD, Mylan, Nabriva, Noxxon, Octapharma, Paratek, Pfizer, PSI, Roche Diagnostics, Scynexis, and Shionogi.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee (No 20-1500_1) of the Medical Faculty of the University of Cologne. This study complied with ethical standards and all the methods were carried out in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained as part of the digital registration process at the mobile testing site. Implementation of the UHC Corona Web Tool for this study was registered with the data privacy software 2B Advice PrIME and approved by the UHC data protection body.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}