{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:15:56Z","timestamp":1790104556418,"version":"4.0.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T00:00:00Z","timestamp":1646524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T00:00:00Z","timestamp":1646524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The diagnostic accuracy of the interferon-gamma release assay (IGRA) in immunosuppressed patients remains unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A systematic review and meta-analysis were performed for diagnostic test accuracy of IGRA in tuberculosis (TB) infection among people living with HIV (PLWHIV). Summary estimates of sensitivity and specificity were calculated using both univariate and bivariate models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The meta-analysis included 45 of the 1,242 first-screened articles. The total number of PLWHIV was 6,525; 3,467 had TB disease, including 806 cases of LTBI and 2,661 cases of active TB. The overall diagnostic odds ratio (DOR) of IGRA in the diagnosis of TB disease was 10.0 (95% confidence interval (CI) 5.59, 25.07), with an area under the curve (AUC) of 0.729. The DOR was better for QFT (14.2 (95%CI 4.359, 46.463)) than T-SPOT (10.0 (95%CI 3.866 26.033)). The sensitivity and specificity of QFT and T-SPOT were 0.663 (95%CI 0.471, 0.813), 0.867 (95%CI 0.683 0.942), and 0.604 (95%CI 0.481, 0.715), 0.862 (95%CI 0.654, 0.954), respectively, in the bivariate model. The sensitivity of IGRA in the diagnosis of LTBI was 0.64 (95%CI 0.61, 0.66).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>IGRA was useful in the diagnostic of TB disease in PLWHIV, and QFT showed a better tendency of DOR than T-SPOT. IGRA showed a limited effect to rule out LTBI in PLWHIV.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-022-01789-9","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T07:02:13Z","timestamp":1646550133000},"page":"597-606","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Diagnostic accuracy of the interferon-gamma release assay in acquired immunodeficiency syndrome patients with suspected tuberculosis infection: a meta-analysis"],"prefix":"10.1007","volume":"50","author":[{"given":"Hao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Takamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seitarou","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Horita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,6]]},"reference":[{"key":"1789_CR1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/ciw694","volume":"64","author":"DM Lewinsohn","year":"2017","unstructured":"Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, et al. Official American Thoracic Society\/Infectious Diseases Society of America\/Centers for Disease Control and Prevention Clinical Practice Guidelines: diagnosis of tuberculosis in adults and children. Clin Infect Dis. 2017;64:e1\u201333. https:\/\/doi.org\/10.1093\/cid\/ciw694.","journal-title":"Clin Infect Dis"},{"key":"1789_CR2","doi-asserted-by":"publisher","first-page":"e0241789","DOI":"10.1371\/journal.pone.0241789","volume":"15","author":"B Sanogo","year":"2020","unstructured":"Sanogo B, Ouermi AS, Barro M, Millogo A, Ouattara ABI, Abdoul Salam O, Nacro B. Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children. PLoS ONE. 2020;15:e0241789. https:\/\/doi.org\/10.1371\/journal.pone.0241789.","journal-title":"PLoS ONE"},{"key":"1789_CR3","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1016\/j.ijid.2019.01.048","volume":"80s","author":"G Gualano","year":"2019","unstructured":"Gualano G, Mencarini P, Lauria FN, Palmieri F, Mfinanga S, Mwaba P, Chakaya J, Zumla A, Ippolito G. Tuberculin skin test - Outdated or still useful for Latent TB infection screening? Int J Infect Dis. 2019;80s:S20-s22. https:\/\/doi.org\/10.1016\/j.ijid.2019.01.048.","journal-title":"Int J Infect Dis"},{"key":"1789_CR4","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.ijid.2020.02.011","volume":"92s","author":"P Mwaba","year":"2020","unstructured":"Mwaba P, Chakaya JM, Petersen E, Wejse C, Zumla A, Kapata N. Advancing new diagnostic tests for latent tuberculosis infection due to multidrug-resistant strains of Mycobacterium tuberculosis - End of the road? Int J Infect Dis. 2020;92s:S69-s71. https:\/\/doi.org\/10.1016\/j.ijid.2020.02.011.","journal-title":"Int J Infect Dis"},{"key":"1789_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta23230","volume":"23","author":"Y Takwoingi","year":"2019","unstructured":"Takwoingi Y, Whitworth H, Rees-Roberts M, Badhan A, Partlett C, Green N, Boakye A, Lambie H, Marongiu L, Jit M, et al. Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation. Health Technol Assess. 2019;23:1\u2013152. https:\/\/doi.org\/10.3310\/hta23230.","journal-title":"Health Technol Assess"},{"key":"1789_CR6","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12879-017-2301-4","volume":"17","author":"P Auguste","year":"2017","unstructured":"Auguste P, Tsertsvadze A, Pink J, Court R, McCarthy N, Sutcliffe P, Clarke A. Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis. BMC Infect Dis. 2017;17:200. https:\/\/doi.org\/10.1186\/s12879-017-2301-4.","journal-title":"BMC Infect Dis"},{"key":"1789_CR7","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/s1473-3099(20)30276-0","volume":"20","author":"G Zhou","year":"2020","unstructured":"Zhou G, Luo Q, Luo S, Teng Z, Ji Z, Yang J, Wang F, Wen S, Ding Z, Li L, et al. Interferon-\u03b3 release assays or tuberculin skin test for detection and management of latent tuberculosis infection: a systematic review and meta-analysis. Lancet Infect Dis. 2020;20:1457\u201369. https:\/\/doi.org\/10.1016\/s1473-3099(20)30276-0.","journal-title":"Lancet Infect Dis"},{"key":"1789_CR8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1183\/09031936.00114810","volume":"37","author":"M Sester","year":"2011","unstructured":"Sester M, Sotgiu G, Lange C, Giehl C, Girardi E, Migliori GB, Bossink A, Dheda K, Diel R, Dominguez J, et al. Interferon-\u03b3 release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. Eur Respir J. 2011;37:100\u201311. https:\/\/doi.org\/10.1183\/09031936.00114810.","journal-title":"Eur Respir J"},{"key":"1789_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jctube.2016.05.005","volume":"4","author":"AJ Caulfield","year":"2016","unstructured":"Caulfield AJ, Wengenack NL. Diagnosis of active tuberculosis disease: from microscopy to molecular techniques. J Clin Tuberc Other Mycobact Dis. 2016;4:33\u201343. https:\/\/doi.org\/10.1016\/j.jctube.2016.05.005.","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"1789_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188631","volume":"12","author":"TN Doan","year":"2017","unstructured":"Doan TN, Eisen DP, Rose MT, Slack A, Stearnes G, McBryde ES. Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: a latent-class analysis. PLoS ONE. 2017;12: e0188631. https:\/\/doi.org\/10.1371\/journal.pone.0188631.","journal-title":"PLoS ONE"},{"key":"1789_CR11","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/2046-4053-2-82","volume":"2","author":"MM Leeflang","year":"2013","unstructured":"Leeflang MM, Deeks JJ, Takwoingi Y, Macaskill P. Cochrane diagnostic test accuracy reviews. Syst Rev. 2013;2:82. https:\/\/doi.org\/10.1186\/2046-4053-2-82.","journal-title":"Syst Rev"},{"key":"1789_CR12","unstructured":"University hospital Medical Information Network. https:\/\/upload.umin.ac.jp\/cgi-bin\/ctr\/ctr_view_reg.cgi?recptno=R000052187. Accessed 1 Oct 2021."},{"key":"1789_CR13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","volume":"155","author":"PF Whiting","year":"2011","unstructured":"Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MM, Sterne JA, Bossuyt PM. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155:529\u201336. https:\/\/doi.org\/10.7326\/0003-4819-155-8-201110180-00009.","journal-title":"Ann Intern Med"},{"key":"1789_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fimmu.2020.02006","volume":"2020","author":"C Carranza","year":"2006","unstructured":"Carranza C, Pedraza-Sanchez S, de Oyarzabal-Mendez E, Torres M. Diagnosis for latent tuberculosis infection: new alternatives. Front Immunol. 2006;2020:11. https:\/\/doi.org\/10.3389\/fimmu.2020.02006.","journal-title":"Front Immunol"},{"key":"1789_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"J Higgins","year":"2008","unstructured":"Higgins J, Green S. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley; 2008."},{"key":"1789_CR16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.athoracsur.2004.09.040","volume":"79","author":"CM Jones","year":"2005","unstructured":"Jones CM, Athanasiou T. Summary receiver operating characteristic curve analysis techniques in the evaluation of diagnostic tests. Ann Thorac Surg. 2005;79:16\u201320. https:\/\/doi.org\/10.1016\/j.athoracsur.2004.09.040.","journal-title":"Ann Thorac Surg"},{"key":"1789_CR17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557\u201360. https:\/\/doi.org\/10.1136\/bmj.327.7414.557.","journal-title":"BMJ"},{"key":"1789_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004220","volume":"4","author":"MG Aabye","year":"2009","unstructured":"Aabye MG, Ravn P, PrayGod G, Jeremiah K, Mugomela A, Jepsen M, Faurholt D, Range N, Friis H, Changalucha J, et al. The impact of HIV infection and CD4 cell count on the performance of an interferon gamma release assay in patients with pulmonary tuberculosis. PLoS ONE. 2009;4: e4220. https:\/\/doi.org\/10.1371\/journal.pone.0004220.","journal-title":"PLoS ONE"},{"key":"1789_CR19","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.3390\/ijerph16162912","volume":"16","author":"S Adams","year":"2019","unstructured":"Adams S, Ehrlich R, Baatjies R, Dendukuri N, Wang Z, Dheda K. Evaluating latent tuberculosis infection test performance using latent class analysis in a TB and HIV endemic setting. Int J Environ Res Public Health. 2019;16:2912. https:\/\/doi.org\/10.3390\/ijerph16162912.","journal-title":"Int J Environ Res Public Health"},{"key":"1789_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.5582\/bst.2014.01032","volume":"8","author":"R Cai","year":"2014","unstructured":"Cai R, Chen J, Guan L, Sun M, Sun Y, Shen Y, Zhang R, Liu L, Lu H. Relationship between T-SPOT. TB responses and numbers of circulating CD4+ T-cells in HIV infected patients with active tuberculosis. Biosci Trends. 2014;8:163\u20138.","journal-title":"Biosci Trends"},{"key":"1789_CR21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1471-2334-10-75","volume":"10","author":"A Cattamanchi","year":"2010","unstructured":"Cattamanchi A, Ssewenyana I, Davis JL, Huang L, Worodria W, den Boon S, Yoo S, Andama A, Hopewell PC, Cao H. Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection. BMC Infect Dis. 2010;10:75. https:\/\/doi.org\/10.1186\/1471-2334-10-75.","journal-title":"BMC Infect Dis"},{"key":"1789_CR22","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1128\/jcm.02403-07","volume":"46","author":"CB Chee","year":"2008","unstructured":"Chee CB, Gan SH, Khinmar KW, Barkham TM, Koh CK, Liang S, Wang YT. Comparison of sensitivities of two commercial gamma interferon release assays for pulmonary tuberculosis. J Clin Microbiol. 2008;46:1935\u201340. https:\/\/doi.org\/10.1128\/jcm.02403-07.","journal-title":"J Clin Microbiol"},{"key":"1789_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026827","volume":"6","author":"J Chen","year":"2011","unstructured":"Chen J, Zhang R, Wang J, Liu L, Zheng Y, Shen Y, Qi T, Lu H. Interferon-gamma release assays for the diagnosis of active tuberculosis in HIV-infected patients: a systematic review and meta-analysis. PLoS ONE. 2011;6: e26827. https:\/\/doi.org\/10.1371\/journal.pone.0026827.","journal-title":"PLoS ONE"},{"key":"1789_CR24","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.1365-2249.2007.03477.x","volume":"150","author":"SA Clark","year":"2007","unstructured":"Clark SA, Martin SL, Pozniak A, Steel A, Ward B, Dunning J, Henderson DC, Nelson M, Gazzard B, Kelleher P. Tuberculosis antigen-specific immune responses can be detected using enzyme-linked immunospot technology in human immunodeficiency virus (HIV)-1 patients with advanced disease. Clin Exp Immunol. 2007;150:238\u201344. https:\/\/doi.org\/10.1111\/j.1365-2249.2007.03477.x.","journal-title":"Clin Exp Immunol"},{"key":"1789_CR25","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1097\/QAD.0b013e32832956ad","volume":"23","author":"MA Davies","year":"2009","unstructured":"Davies MA, Connell T, Johannisen C, Wood K, Pienaar S, Wilkinson KA, Wilkinson RJ, Zar HJ, Eley B, Beatty D, et al. Detection of tuberculosis in HIV-infected children using an enzyme-linked immunospot assay. AIDS. 2009;23:961\u20139. https:\/\/doi.org\/10.1097\/QAD.0b013e32832956ad.","journal-title":"AIDS"},{"key":"1789_CR26","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1136\/thx.2009.116376","volume":"64","author":"K Dheda","year":"2009","unstructured":"Dheda K, van Zyl-Smit RN, Meldau R, Meldau S, Symons G, Khalfey H, Govender N, Rosu V, Sechi LA, Maredza A, et al. Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis. Thorax. 2009;64:847\u201353. https:\/\/doi.org\/10.1136\/thx.2009.116376.","journal-title":"Thorax"},{"key":"1789_CR27","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1186\/1471-2334-11-319","volume":"11","author":"L Elzi","year":"2011","unstructured":"Elzi L, Steffen I, Furrer H, Fehr J, Cavassini M, Hirschel B, Hoffmann M, Bernasconi E, Bassetti S, Battegay M. Improved sensitivity of an interferon-gamma release assay (T-SPOT.TB\u2122) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-infection. BMC Infect Dis. 2011;11:319. https:\/\/doi.org\/10.1186\/1471-2334-11-319.","journal-title":"BMC Infect Dis"},{"key":"1789_CR28","doi-asserted-by":"publisher","first-page":"325295","DOI":"10.1155\/2011\/325295","volume":"2011","author":"A Fujita","year":"2011","unstructured":"Fujita A, Ajisawa A, Harada N, Higuchi K, Mori T. Performance of a whole-blood interferon-gamma release assay with mycobacterium RD1-specific antigens among HIV-infected persons. Clin Dev Immunol. 2011;2011:325295. https:\/\/doi.org\/10.1155\/2011\/325295.","journal-title":"Clin Dev Immunol"},{"key":"1789_CR29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/s1995-7645(13)60009-7","volume":"6","author":"G Garcia-Elorriaga","year":"2013","unstructured":"Garcia-Elorriaga G, Martinez-Velazquez M, Gaona-Flores V, del Rey-Pineda G, Gonzalez-Bonilla C. Interferon gamma in patients with HIV\/AIDS and suspicion or latent tuberculosis infection. Asian Pac J Trop Med. 2013;6:135\u20138. https:\/\/doi.org\/10.1016\/s1995-7645(13)60009-7.","journal-title":"Asian Pac J Trop Med"},{"key":"1789_CR30","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/inf.0000000000001774","volume":"37","author":"M Hormi","year":"2018","unstructured":"Hormi M, Gu\u00e9rin-El Khourouj V, Pommelet V, Jeljeli M, P\u00e9dron B, Diana JS, Faye A, Sterkers G. Performance of the QuantiFERON-TB gold assay among HIV-infected children with active tuberculosis in France. Pediatr Infect Dis J. 2018;37:339\u201344. https:\/\/doi.org\/10.1097\/inf.0000000000001774.","journal-title":"Pediatr Infect Dis J"},{"key":"1789_CR31","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3109\/00365548.2010.482942","volume":"42","author":"J Idh","year":"2010","unstructured":"Idh J, Abate E, Westman A, Elias D, Janols H, Gelaw A, Getachew A, Alemu S, Aseffa A, Britton S, et al. Kinetics of the QuantiFERON (R)-TB gold in-tube test during treatment of patients with sputum smear-positive tuberculosis in relation to initial TST result and severity of disease. Scand J Infect Dis. 2010;42:650\u20137. https:\/\/doi.org\/10.3109\/00365548.2010.482942.","journal-title":"Scand J Infect Dis"},{"key":"1789_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2172-10-31","volume":"10","author":"W Jiang","year":"2009","unstructured":"Jiang W, Shao L, Zhang Y, Zhang S, Meng C, Xu Y, Huang L, Wang Y, Wang Y, Weng X, et al. High-sensitive and rapid detection of Mycobacterium tuberculosis infection by IFN-gamma release assay among HIV-infected individuals in BCG-vaccinated area. BMC Immunol. 2009;10:31. https:\/\/doi.org\/10.1186\/1471-2172-10-31.","journal-title":"BMC Immunol"},{"key":"1789_CR33","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.5588\/ijtld.13.0239","volume":"17","author":"SR Jonnalagadda","year":"2013","unstructured":"Jonnalagadda SR, Brown E, Lohman-Payne B, Wamalwa D, Farquhar C, John-Stewart GC. Predictive value of interferon-gamma release assays for postpartum active tuberculosis in HIV-1-infected women. Int J Tuberc Lung Dis. 2013;17:1552\u20137. https:\/\/doi.org\/10.5588\/ijtld.13.0239.","journal-title":"Int J Tuberc Lung Dis"},{"key":"1789_CR34","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.diagmicrobio.2011.07.012","volume":"71","author":"BSA Kabeer","year":"2011","unstructured":"Kabeer BSA, Sikhamani R, Raja A. Comparison of interferon gamma-inducible protein-10 and interferon gamma-based QuantiFERON TB Gold assays with tuberculin skin test in HIV-infected subjects. Diagn Microbiol Infect Dis. 2011;71:236\u201343. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2011.07.012.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"1789_CR35","first-page":"S160","volume":"53","author":"N Kaswandani","year":"2018","unstructured":"Kaswandani N, Nurul D. Performance of interferon gamma release assay and tuberculin skin test for TB diagnosis in HIV infected children. Pediatr Pulmonol. 2018;53:S160\u20131.","journal-title":"Pediatr Pulmonol"},{"key":"1789_CR36","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/resp.12442","volume":"20","author":"T Khawcharoenporn","year":"2015","unstructured":"Khawcharoenporn T, Apisarnthanarak A, Phetsuksiri B, Rudeeaneksin J, Srisungngam S, Mundy LM. Tuberculin skin test and QuantiFERON-TB gold in-tube test for latent tuberculosis in Thai HIV-infected adults. Respirology. 2015;20:340\u20137. https:\/\/doi.org\/10.1111\/resp.12442.","journal-title":"Respirology"},{"key":"1789_CR37","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1186\/s12879-018-3508-8","volume":"18","author":"GB Klautau","year":"2018","unstructured":"Klautau GB, da Mota NVF, Salles MJC, Burattini MN, Rodrigues DS. Interferon-gamma release assay as a sensitive diagnostic tool of latent tuberculosis infection in patients with HIV: a cross-sectional study. BMC Infect Dis. 2018;18:585. https:\/\/doi.org\/10.1186\/s12879-018-3508-8.","journal-title":"BMC Infect Dis"},{"key":"1789_CR38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bjid.2015.10.007","volume":"20","author":"GM Kussen","year":"2016","unstructured":"Kussen GM, Dalla-Costa LM, Rossoni A, Raboni SM. Interferon-gamma release assay versus tuberculin skin test for latent tuberculosis infection among HIV patients in Brazil. Braz J Infect Dis. 2016;20:69\u201375. https:\/\/doi.org\/10.1016\/j.bjid.2015.10.007.","journal-title":"Braz J Infect Dis"},{"key":"1789_CR39","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/qai.0000000000001298","volume":"75","author":"SM LaCourse","year":"2017","unstructured":"LaCourse SM, Cranmer LM, Matemo D, Kinuthia J, Richardson BA, Horne DJ, John-Stewart G. Effect of pregnancy on interferon gamma release assay and tuberculin skin test detection of latent TB infection among HIV-infected women in a high burden setting. J Acquir Immune Defic Syndr. 2017;75:128\u201336. https:\/\/doi.org\/10.1097\/qai.0000000000001298.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"1789_CR40","first-page":"9","volume":"12","author":"T Lavender","year":"2011","unstructured":"Lavender T, Barrett A, Magee J, Ong E. Whole-blood interferon-gamma release assay in the diagnosis of active tuberculosis infection in HIV-infected and HIV-non-infected individuals: a five-year review of data. HIV Med. 2011;12:9\u20139.","journal-title":"HIV Med"},{"key":"1789_CR41","doi-asserted-by":"publisher","first-page":"422","DOI":"10.5588\/ijtld.18.0198","volume":"23","author":"S Lee","year":"2019","unstructured":"Lee S, Lee JE, Kang JS, Lee SO, Lee SH. Long-term performance of the IGRA to predict and prevent active tuberculosis development in HIV-infected patients. Int J Tuberc Lung Dis. 2019;23:422\u20137. https:\/\/doi.org\/10.5588\/ijtld.18.0198.","journal-title":"Int J Tuberc Lung Dis"},{"key":"1789_CR42","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1186\/1471-2334-10-354","volume":"10","author":"M Legesse","year":"2010","unstructured":"Legesse M, Ameni G, Mamo G, Medhin G, Bjune G, Abebe F. Performance of QuantiFERON-TB Gold In-Tube (QFTGIT) for the diagnosis of Mycobacterium tuberculosis (Mtb) infection in Afar Pastoralists, Ethiopia. BMC Infect Dis. 2010;10:354. https:\/\/doi.org\/10.1186\/1471-2334-10-354.","journal-title":"BMC Infect Dis"},{"key":"1789_CR43","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1183\/09031936.00045509","volume":"35","author":"L Leidl","year":"2010","unstructured":"Leidl L, Mayanja-Kizza H, Sotgiu G, Baseke J, Ernst M, Hirsch C, Goletti D, Toossi Z, Lange C. Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+ T-cells in HIV infection. Eur Respir J. 2010;35:619\u201326. https:\/\/doi.org\/10.1183\/09031936.00045509.","journal-title":"Eur Respir J"},{"key":"1789_CR44","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1183\/09031936.00181610","volume":"38","author":"DI Ling","year":"2011","unstructured":"Ling DI, Pai M, Davids V, Brunet L, Lenders L, Meldau R, Calligaro G, Allwood B, van Zyl-Smit R, Peter J, et al. Are interferon-\u03b3 release assays useful for diagnosing active tuberculosis in a high-burden setting? Eur Respir J. 2011;38:649\u201356. https:\/\/doi.org\/10.1183\/09031936.00181610.","journal-title":"Eur Respir J"},{"key":"1789_CR45","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00430-017-0501-6","volume":"206","author":"C Lundtoft","year":"2017","unstructured":"Lundtoft C, Awuah AA, Nausch N, Enimil A, Mayatepek E, Owusu-Dabo E, Jacobsen M. Alternative Quantiferon cytokines for diagnosis of children with active tuberculosis and HIV co-infection in Ghana. Med Microbiol Immunol. 2017;206:259\u201365. https:\/\/doi.org\/10.1007\/s00430-017-0501-6.","journal-title":"Med Microbiol Immunol"},{"key":"1789_CR46","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1080\/13102818.2009.10817622","volume":"23","author":"R Markova","year":"2009","unstructured":"Markova R, Todorova Y, Drenska R, Elenkov I, Yankova M, Stefanova D. Usefulness of interferon-gamma release assays in the diagnosis of tuberculosis infection in HIV-infected patients in Bulgaria. Biotechnol Biotechnol Equip. 2009;23:1103\u20138. https:\/\/doi.org\/10.1080\/13102818.2009.10817622.","journal-title":"Biotechnol Biotechnol Equip"},{"key":"1789_CR47","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1183\/09031936.00171509","volume":"36","author":"T Oni","year":"2010","unstructured":"Oni T, Patel J, Gideon HP, Seldon R, Wood K, Hlombe Y, Wilkinson KA, Rangaka MX, Mendelson M, Wilkinson RJ. Enhanced diagnosis of HIV-1-associated tuberculosis by relating T-SPOT.TB and CD4 counts. Eur Respir J. 2010;36:594\u2013600. https:\/\/doi.org\/10.1183\/09031936.00171509.","journal-title":"Eur Respir J"},{"key":"1789_CR48","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.jinf.2020.02.009","volume":"80","author":"E Petruccioli","year":"2020","unstructured":"Petruccioli E, Chiacchio T, Navarra A, Vanini V, Cuzzi G, Cimaglia C, Codecasa LR, Pinnetti C, Riccardi N, Palmieri F, et al. Effect of HIV-infection on QuantiFERON-plus accuracy in patients with active tuberculosis and latent infection. J Infect. 2020;80:536\u201346. https:\/\/doi.org\/10.1016\/j.jinf.2020.02.009.","journal-title":"J Infect"},{"key":"1789_CR49","doi-asserted-by":"publisher","first-page":"e2278","DOI":"10.1093\/cid\/ciaa1135,10.1093\/cid\/ciaa1135","volume":"73","author":"AC Pettit","year":"2020","unstructured":"Pettit AC, Stout JE, Belknap R, Benson CA, S\u00e9raphin MN, Lauzardo M, Horne DJ, Garfein RS, Maruri F, Ho CS. Optimal testing choice and diagnostic strategies for latent tuberculosis infection among U.S.-born people living with HIV. Clin Infect Dis. 2020;73:e2278\u201384. https:\/\/doi.org\/10.1093\/cid\/ciaa1135,10.1093\/cid\/ciaa1135.","journal-title":"Clin Infect Dis"},{"key":"1789_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002489","volume":"3","author":"E Raby","year":"2008","unstructured":"Raby E, Moyo M, Devendra A, Banda J, De Haas P, Ayles H, Godfrey-Faussett P. The effects of HIV on the sensitivity of a whole blood IFN-gamma release assay in Zambian adults with active tuberculosis. PLoS ONE. 2008;3: e2489. https:\/\/doi.org\/10.1371\/journal.pone.0002489.","journal-title":"PLoS ONE"},{"key":"1789_CR51","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1183\/09031936.00058911","volume":"39","author":"MX Rangaka","year":"2012","unstructured":"Rangaka MX, Gideon HP, Wilkinson KA, Pai M, Mwansa-Kambafwile J, Maartens G, Glynn JR, Boulle A, Fielding K, Goliath R, et al. Interferon release does not add discriminatory value to smear-negative HIV-tuberculosis algorithms. Eur Respir J. 2012;39:163\u201371. https:\/\/doi.org\/10.1183\/09031936.00058911.","journal-title":"Eur Respir J"},{"key":"1789_CR52","doi-asserted-by":"publisher","first-page":"281","DOI":"10.5588\/ijtld.11.0441","volume":"16","author":"MV Sattah","year":"2012","unstructured":"Sattah MV, Aye SS, Azen C, Kort JJ, Escalante P, Jones BE. Interferon-gamma release assay T-SPOT\u00ae.TB and HIV-related tuberculosis. Int J Tuberc Lung Dis. 2012;16:281\u20132. https:\/\/doi.org\/10.5588\/ijtld.11.0441.","journal-title":"Int J Tuberc Lung Dis"},{"key":"1789_CR53","first-page":"834","volume":"14","author":"I Sauzullo","year":"2010","unstructured":"Sauzullo I, Mengoni F, Scrivo R, Valesini G, Potenza C, Skroza N, Marocco R, Lichtner M, Vullo V, Mastroianni CM. Evaluation of QuantiFERON-TB gold in-tube in human immunodeficiency virus infection and in patient candidates for anti-tumour necrosis factor-alpha treatment. Int J Tuberc Lung Dis. 2010;14:834\u201340.","journal-title":"Int J Tuberc Lung Dis"},{"key":"1789_CR54","first-page":"153","volume":"37","author":"I Sauzullo","year":"2014","unstructured":"Sauzullo I, Mengoni F, Ermocida A, Massetti AP, D\u2019Agostino C, Russo G, Salotti A, Falciano M, Vullo V, Mastroianni CM. Interferon-gamma release assay in HIV-infected patients with active tuberculosis: impact of antituberculous drugs on host immune response. New Microbiol. 2014;37:153\u201361.","journal-title":"New Microbiol"},{"key":"1789_CR55","first-page":"14","volume":"68","author":"H Stavri","year":"2009","unstructured":"Stavri H, Ene L, Popa GL, Duiculescu D, Murgoci G, Marica C, Ulea I, Cus G, Popa MI. Comparison of tuberculin skin test with a whole-blood interferon gamma assay and ELISA, in HIV positive children and adolescents with TB. Roum Arch Microbiol Immunol. 2009;68:14\u20139.","journal-title":"Roum Arch Microbiol Immunol"},{"key":"1789_CR56","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1128\/jcm.02411-05","volume":"44","author":"SJ Tsiouris","year":"2006","unstructured":"Tsiouris SJ, Coetzee D, Toro PL, Austin J, Stein Z, El-Sadr W. Sensitivity analysis and potential uses of a novel gamma interferon release assay for diagnosis of tuberculosis. J Clin Microbiol. 2006;44:2844\u201350. https:\/\/doi.org\/10.1128\/jcm.02411-05.","journal-title":"J Clin Microbiol"},{"key":"1789_CR57","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jinf.2012.03.017","volume":"65","author":"V Vanini","year":"2012","unstructured":"Vanini V, Petruccioli E, Gioia C, Cuzzi G, Orchi N, Rianda A, Alba L, Giancola ML, Conte A, Schinin\u00e0 V, et al. IP-10 is an additional marker for tuberculosis (TB) detection in HIV-infected persons in a low-TB endemic country. J Infect. 2012;65:49\u201359. https:\/\/doi.org\/10.1016\/j.jinf.2012.03.017.","journal-title":"J Infect"},{"key":"1789_CR58","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1574-695X.2009.00610.x","volume":"57","author":"C Veldsman","year":"2009","unstructured":"Veldsman C, Kock MM, Rossouw T, Nieuwoudt M, Maeurer M, Hoosen AA, Ehlers MM. QuantiFERON-TB GOLD ELISA assay for the detection of Mycobacterium tuberculosis-specific antigens in blood specimens of HIV-positive patients in a high-burden country. FEMS Immunol Med Microbiol. 2009;57:269\u201373. https:\/\/doi.org\/10.1111\/j.1574-695X.2009.00610.x.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"1789_CR59","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1365-2249.2007.03462.x","volume":"150","author":"D Vincenti","year":"2007","unstructured":"Vincenti D, Carrara S, Butera O, Bizzoni F, Casetti R, Girardi E, Goletti D. Response to region of difference 1 (RD1) epitopes in human immunodeficiency virus (HIV)-infected individuals enrolled with suspected active tuberculosis: a pilot study. Clin Exp Immunol. 2007;150:91\u20138. https:\/\/doi.org\/10.1111\/j.1365-2249.2007.03462.x.","journal-title":"Clin Exp Immunol"},{"key":"1789_CR60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070957","volume":"8","author":"Y Yu","year":"2013","unstructured":"Yu Y, Zhao X, Wang W, Wu H, Chen M, Hua W, Wang H, Wei T, Jiao Y, Sun G, et al. Diagnostic performance of interferon-gamma releasing assay in HIV-infected patients in China. PLoS ONE. 2013;8: e70957. https:\/\/doi.org\/10.1371\/journal.pone.0070957.","journal-title":"PLoS ONE"},{"key":"1789_CR61","volume-title":"Latent tuberculosis infection: updated and consolidated guidelines for programmatic management","author":"World Health Organization","year":"2018","unstructured":"World Health Organization. Latent tuberculosis infection: updated and consolidated guidelines for programmatic management. Geneva: World Health Organization; 2018."},{"key":"1789_CR62","first-page":"E322","volume":"41","author":"I Bastian","year":"2017","unstructured":"Bastian I, Coulter C. Position statement on interferon-\u03b3 release assays for the detection of latent tuberculosis infection. Commun Dis Intell Q Rep. 2017;41:E322-e336.","journal-title":"Commun Dis Intell Q Rep"},{"key":"1789_CR63","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.jinf.2019.08.018","volume":"79","author":"G Sotgiu","year":"2019","unstructured":"Sotgiu G, Saderi L, Petruccioli E, Aliberti S, Piana A, Petrone L, Goletti D. QuantiFERON TB Gold Plus for the diagnosis of tuberculosis: a systematic review and meta-analysis. J Infect. 2019;79:444\u201353. https:\/\/doi.org\/10.1016\/j.jinf.2019.08.018.","journal-title":"J Infect"},{"key":"1789_CR64","doi-asserted-by":"publisher","first-page":"e00614","DOI":"10.1128\/jcm.00614-18","volume":"56","author":"ES Theel","year":"2018","unstructured":"Theel ES, Hilgart H, Breen-Lyles M, McCoy K, Flury R, Breeher LE, Wilson J, Sia IG, Whitaker JA, Clain J, et al. Comparison of the QuantiFERON-TB Gold Plus and QuantiFERON-TB Gold In-Tube Interferon Gamma Release Assays in Patients at Risk for Tuberculosis and in Health Care Workers. J Clin Microbiol. 2018;56:e00614\u20138. https:\/\/doi.org\/10.1128\/jcm.00614-18.","journal-title":"J Clin Microbiol"},{"key":"1789_CR65","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.tube.2017.11.014","volume":"108","author":"ED Pieterman","year":"2018","unstructured":"Pieterman ED, Liqui Lung FG, Verbon A, Bax HI, Ang CW, Berkhout J, Blaauw G, Brandenburg A, van Burgel ND, Claessen A, et al. A multicentre verification study of the QuantiFERON(\u00ae)-TB Gold Plus assay. Tuberculosis (Edinb). 2018;108:136\u201342. https:\/\/doi.org\/10.1016\/j.tube.2017.11.014.","journal-title":"Tuberculosis (Edinb)"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-022-01789-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-022-01789-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-022-01789-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T10:15:04Z","timestamp":1653905704000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-022-01789-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,6]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1789"],"URL":"https:\/\/doi.org\/10.1007\/s15010-022-01789-9","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,6]]},"assertion":[{"value":"2 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"The authors declare that no conflicts of interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}