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This study aimed to determine the changing distribution of <jats:italic>Candida<\/jats:italic> species and the emergence of uncommon species.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a cross-sectional study performed in two Cairo University hospitals between 2019 and 2020. All <jats:italic>Candida<\/jats:italic> species isolates recovered from blood cultures of adults and pediatrics patients admitted to the hospitals were included. <jats:italic>Candida<\/jats:italic> isolates were identified by chromogenic <jats:italic>Candida<\/jats:italic> agar and Vitek2 YST identification card. <jats:italic>Candida kefyr<\/jats:italic> was confirmed by chip array.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>Candida<\/jats:italic> species were responsible for 1.6% of bloodstream infections in adults and 10.8% in pediatric patients. <jats:italic>C. albicans<\/jats:italic> was the most prevalent species representing 27.8% in adults and 48.3% in pediatrics. Non-albicans species (NAC) represented the most isolated <jats:italic>Candida<\/jats:italic> species among adults and pediatrics (72.2% and 51.6%, respectively) with the predominance of <jats:italic>C. tropicalis<\/jats:italic> (27.8% and 22.5%, respectively) followed by <jats:italic>C. parapsilosis<\/jats:italic> (16.7% and 10.8%, respectively). The uncommon <jats:italic>Candida<\/jats:italic>, which is <jats:italic>Candida<\/jats:italic> species other than <jats:italic>C. albicans<\/jats:italic>, <jats:italic>C. parapsilosis<\/jats:italic>, <jats:italic>C. tropicalis<\/jats:italic>, <jats:italic>C. glabrata<\/jats:italic>, and <jats:italic>C. krusei<\/jats:italic>, represents 16.6% and 14% of all candidemia in adults and pediatrics, respectively. Only one of each of <jats:italic>C. lusitaniae<\/jats:italic>, <jats:italic>C. utilis<\/jats:italic>, and <jats:italic>C. kefyr<\/jats:italic> were detected in adults. <jats:italic>C. lusitaniae<\/jats:italic> was the most frequently recovered uncommon <jats:italic>Candida<\/jats:italic> among pediatrics resulting in 6.4% of candidemia followed by <jats:italic>C. famata<\/jats:italic> (4.3%), <jats:italic>C. utilis<\/jats:italic> (2.2%), and <jats:italic>C. kefyr <\/jats:italic>(1.1%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p><jats:italic>C. albicans<\/jats:italic> is still the primary species isolated from pediatrics and adults with candidemia despite the considerable shift to the non-albicans species. <jats:italic>C. tropicalis<\/jats:italic> and <jats:italic>C. parapsilosis<\/jats:italic> are the most prevalent NAC. The increased prevalence of uncommon <jats:italic>Candida<\/jats:italic> species is alarming and necessitates a prompt stewardship program.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-022-01888-7","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T05:03:02Z","timestamp":1661490182000},"page":"389-395","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prevalence and species distribution of Candida bloodstream infection in children and adults in two teaching university hospitals in Egypt: first report of Candida kefyr"],"prefix":"10.1007","volume":"51","author":[{"given":"Nashwa Mohamed","family":"Reda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem Mostafa","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-0619","authenticated-orcid":false,"given":"Sherifa Tarek","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham Hamed A.","family":"Yousef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"1888_CR1","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1086\/378745","volume":"37","author":"O Gudlaugsson","year":"2003","unstructured":"Gudlaugsson O, Gillespie S, Lee K, Berg JV, Hu J, Messer S, et al. 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