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Alexander Vishnevsky: none to declare. Joan B. Soriano: received a grant from Novartis to conduct this trial via the Instituto de Investigaci\u00f3n Hospital Universitario de la Princesa. Stephanus J. Gans: none to declare. Danilo Joel Salazar Ore: honorarium from Novartis for conducting this clinical trial at the Hospital Nacional Cayetano Heredia. Adrian Rendon: contract from Novartis as a PI in the Monterrry Investigation Center. Charlotte Suppli Ulrik: received fees for lectures, advisory board meetings, and presentations from AZ, GSK, BI, Chiesi, TEVA, Sanofi Genzyme, Novartis and Orion Pharma outside the submitted work. Sushma Bhatnagar: none to declare. Srikanth Krishnamurthy: received honoraria\/research grants from AZ, BI, Sanofi, Novartis, Vicore Pharma, Sun Pharma, Dr. Reddys Lab, and Glenmark outside the submitted work. Kirsten Mc Harry: none declared. Tobias Welte: received research grant from German Ministry of Research and Education, German Ministry of Health; and fees for lectures\/advisory board from AZ, Biontech, Roche, GSK, Novartis, Pfizer, Johnson & Johnson, Boehringer Ingelheim, and MSD; and advisory board honorarium from Novartis. Alberto Alfredo Fernandez: received honoraria for dissertations from AZ, Novartis, and BI. Guido Junge: employee and shareholder of Novartis. Beata Mehes: employee and shareholder of Novartis. Karin Meiser: employee of Novartis. Ewa Gatlik: Employee and shareholder of Novartis. Ulrike Sommer: employee and shareholder of Novartis. Ederlon Rezende: received research grants from Novartis and fees for lectures and presentations from Pfizer, Baxter, and MSD.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}