{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:19:20Z","timestamp":1790288360481,"version":"4.1.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To assess the likelihood of occult infection in patients with clinically unsuspected orthopedic implants during <jats:italic>Staphylococcus aureus<\/jats:italic> bacteremia (SAB).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a retrospective study in two Dutch hospitals, we included all patients with SAB between 2013 and 2020 with one or more orthopedic implants in whom [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT was performed. The primary outcome was the percentage of patients who had an orthopedic implant-related infection by <jats:italic>S. aureus<\/jats:italic>. We also compared clinical parameters in patients with clinically suspected and unsuspected implants.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifty-five of 191 (29%) orthopedic implants in 118 SAB patients included had clinical signs of infection. Of all 136 unsuspected implants, 5 (3%, all arthroplasties), showed increased [<jats:sup>18<\/jats:sup>F]FDG uptake around the prosthesis on [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT. The clinical course of these patients without clinically overt infection or relapse of bacteremia during follow-up of a median of 48\u00a0months (range 0\u201348), however, argued against prosthetic joint infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Although orthopedic implants are evidently a risk factor for metastatic infection during SAB, the absence of clinical symptoms obviate the need of additional investigations or prolonged antibiotic treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-022-01913-9","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T16:22:04Z","timestamp":1662654124000},"page":"743-747","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinically unsuspected orthopedic implants during S. aureus bacteremia do not require additional diagnostic work-up"],"prefix":"10.1007","volume":"51","author":[{"given":"Ilse J. E.","family":"Kouijzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. T. D.","family":"Speijker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H. J. G.","family":"Aarntzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. H. C.","family":"Rijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Somford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Maat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P. A.","family":"van Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Ten","family":"Oever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H.","family":"Gisolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"1913_CR1","doi-asserted-by":"publisher","first-page":"ofz218","DOI":"10.1093\/ofid\/ofz218","volume":"6","author":"M Honkanen","year":"2019","unstructured":"Honkanen M, Jamsen E, Karppelin M, Huttunen R, Eskelinen A, Syrjanen J. Periprosthetic joint infections as a consequence of bacteremia. Open Forum Infect Dis. 2019;6:ofz218.","journal-title":"Open Forum Infect Dis"},{"key":"1913_CR2","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.2106\/JBJS.18.01500","volume":"102","author":"GA Komnos","year":"2020","unstructured":"Komnos GA, Manrique J, Goswami K, Tan TL, Restrepo C, Sherman MB, et al. 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WR has served as consultant for Stryker (faculty work in Exeter courses) and for Materialise (for education\/surgical training).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The regional institutional ethics committee approved this study and the requirement to obtain informed consent was waived (nr 2020-7104).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}