{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:39:39Z","timestamp":1792784379983,"version":"4.5.0"},"reference-count":165,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T00:00:00Z","timestamp":1678579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T00:00:00Z","timestamp":1678579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"This work was supported by the grants sanctioned to Dr Antara Banerjee (PI) from the Chettinad Academy of Research and Education","award":["Chettinad Academy of Research and Education"],"award-info":[{"award-number":["Chettinad Academy of Research and Education"]}],"id":[{"id":"https:\/\/ror.org\/0394w2w14","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has put the world in a medical crisis for the past three years; nearly 6.3 million lives have been diminished due to the virus outbreak. This review aims to update the recent findings on COVID-19 infections from an epigenetic scenario and develop future perspectives of epi-drugs to treat the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Original research articles and review studies related to COVID-19 were searched and analyzed from the Google Scholar\/PubMed\/Medline databases mainly between 2019 and 2022 to brief the recent work.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Numerous in-depth studies of the mechanisms used by SARS-CoV-2 have been going on to minimize the consequences of the viral outburst. Angiotensin-Converting Enzyme 2 receptors and Transmembrane serine protease 2 facilitate viral entry to the host cells. Upon internalization, it uses the host machinery to replicate viral copies and alter the downstream regulation of the normal cells, causing infection-related morbidities and mortalities. In addition, several epigenetic regulations such as DNA methylation, acetylation, histone modifications, microRNA, and other factors (age, sex, etc.) are responsible for the regulations of viral entry, its immune evasion, and cytokine responses also play a major modulatory role in COVID-19 severity, which has been discussed in detail in this review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings of epigenetic regulation of viral pathogenicity open a new window for epi-drugs as a possible therapeutical approach against COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-023-02017-8","type":"journal-article","created":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T09:02:31Z","timestamp":1678611751000},"page":"1603-1618","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Epigenetic perspectives associated with COVID-19 infection and related cytokine storm: an updated review"],"prefix":"10.1007","volume":"51","author":[{"given":"Amit","family":"Dey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Vaishak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dikshita","family":"Deka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujay","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadarshini","family":"Shanmugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Peace","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim K.","family":"Duttaroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antara","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,12]]},"reference":[{"key":"2017_CR1","doi-asserted-by":"crossref","unstructured":"Nicola M, Alsafi Z, Sohrabi C, Kerwan A, Al-Jabir A, Iosifidis C, et al. The socio-economic implications of the coronavirus pandemic (COVID-19): A review. Int J Surg [Internet]. Elsevier; 2020 [cited 2022 Jun 14];78:185. Available from: \/pmc\/articles\/PMC7162753\/","DOI":"10.1016\/j.ijsu.2020.04.018"},{"key":"2017_CR2","unstructured":"WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard With Vaccination Data [Internet]. [cited 2022 Jun 14]. Available from: https:\/\/covid19.who.int\/"},{"key":"2017_CR3","doi-asserted-by":"publisher","unstructured":"Musat CA, Hadzhiivanov M, Durkowski V, Banerjee A, Chiphang A, Diwan M, et al. Observational study of clinico-radiological follow-up of COVID-19 pneumonia: a district general hospital experience in the UK. BMC Infect Dis [Internet]. BioMed Central Ltd; 2021 [cited 2022 Jun 17];21:1\u20138. Available from: https:\/\/link.springer.com\/articles\/https:\/\/doi.org\/10.1186\/s12879-021-06941-8","DOI":"10.1186\/s12879-021-06941-8"},{"key":"2017_CR4","doi-asserted-by":"publisher","unstructured":"Zhu H, Wei L, Niu P. The novel coronavirus outbreak in Wuhan, China. Glob Heal Res Policy [Internet]. BioMed Central Ltd; 2020 [cited 2022 Dec 23];5:1\u20133. Available from: https:\/\/ghrp.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/s41256-020-00135-6","DOI":"10.1186\/s41256-020-00135-6"},{"key":"#cr-split#-2017_CR5.1","doi-asserted-by":"crossref","unstructured":"Oehmke JF, Moss CB, Singh LN, Oehmke TB, Post LA. Dynamic Panel Surveillance of COVID-19 Transmission in the United States to Inform Health Policy: Observational Statistical Study. J Med Internet Res 2020;22(10)e21955 https\/\/www.jmir.org\/2020\/10\/e21955 [Internet]. Journal of Medical Internet Research","DOI":"10.2196\/21955"},{"key":"#cr-split#-2017_CR5.2","doi-asserted-by":"crossref","unstructured":"2020 [cited 2022 Jun 15];22:e21955. Available from: https:\/\/www.jmir.org\/2020\/10\/e21955","DOI":"10.2196\/21955"},{"key":"#cr-split#-2017_CR6.1","doi-asserted-by":"crossref","unstructured":"Post L, Culler K, Moss CB, Murphy RL, Achenbach CJ, Ison MG, et al. Surveillance of the Second Wave of COVID-19 in Europe: Longitudinal Trend Analyses. JMIR Public Heal Surveill 2021;7(4)e25695 https\/\/publichealth.jmir.org\/2021\/4\/e25695 [Internet]. JMIR Public Health and Surveillance","DOI":"10.2196\/25695"},{"key":"#cr-split#-2017_CR6.2","doi-asserted-by":"crossref","unstructured":"2021 [cited 2022 Jun 15];7:e25695. Available from: https:\/\/publichealth.jmir.org\/2021\/4\/e25695","DOI":"10.2196\/25695"},{"key":"2017_CR7","doi-asserted-by":"publisher","unstructured":"Banik A, Nag T, Chowdhury SR, Chatterjee R. Why Do COVID-19 Fatality Rates Differ Across Countries? An Explorative Cross-country Study Based on Select Indicators: https:\/\/doi.org\/10.1177\/0972150920929897 [Internet]. SAGE PublicationsSage India: New Delhi, India; 2020 [cited 2022 Jun 15];21:607\u201325. Available from: https:\/\/journals.sagepub.com\/doi\/https:\/\/doi.org\/10.1177\/0972150920929897","DOI":"10.1177\/0972150920929897 10.1177\/0972150920929897"},{"key":"2017_CR8","doi-asserted-by":"publisher","first-page":"102433","DOI":"10.1016\/j.jaut.2020.102433","volume":"109","author":"HA Rothan","year":"2020","unstructured":"Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:102433 (Academic Press).","journal-title":"J Autoimmun"},{"key":"2017_CR9","doi-asserted-by":"crossref","unstructured":"Baj J, Karaku\u0142a-Juchnowicz H, Teresi\u0144ski G, Buszewicz G, Ciesielka M, Sitarz R, et al. COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of Knowledge. J Clin Med [Internet]. J Clin Med; 2020 [cited 2022 Nov 11];9:1\u201322. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32516940\/","DOI":"10.3390\/jcm9061753"},{"key":"2017_CR10","doi-asserted-by":"crossref","unstructured":"Rabaan AA, Al-Ahmed SH, Muhammad J, Khan A, Sule AA, Tirupathi R, et al. Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine Storm. Vaccines [Internet]. Multidisciplinary Digital Publishing Institute (MDPI); 2021 [cited 2022 Jun 15];9. Available from: \/pmc\/articles\/PMC8145892\/","DOI":"10.3390\/vaccines9050436"},{"key":"2017_CR11","first-page":"317","volume":"10","author":"L Samavati","year":"2020","unstructured":"Samavati L, Uhal BD. ACE2, much more than just a receptor for SARS-COV-2 front cell infect microbiol. Front Media SA. 2020;10:317.","journal-title":"Front Media S.A."},{"key":"#cr-split#-2017_CR12.1","doi-asserted-by":"crossref","unstructured":"V'kovski P, Kratzel A, Steiner S, Stalder H, Thiel V. Coronavirus biology and replication: implications for SARS-CoV-2. Nat Rev Microbiol 2020 193 [Internet]. Nature Publishing Group","DOI":"10.1038\/s41579-020-00468-6"},{"key":"#cr-split#-2017_CR12.2","unstructured":"2020 [cited 2022 Jun 15];19:155-70. Available from: https:\/\/www.nature.com\/articles\/s41579-020-00468-6"},{"key":"2017_CR13","doi-asserted-by":"crossref","unstructured":"Hoffmann M, Kleine-Weber H, Schroeder S, Kr\u00fcger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell [Internet]. Elsevier; 2020 [cited 2022 Jun 15];181:271. Available from: \/pmc\/articles\/PMC7102627\/","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"2017_CR14","doi-asserted-by":"crossref","unstructured":"Ye Q, Wang B, Mao J. The pathogenesis and treatment of the `Cytokine Storm\u2019 in COVID-19. J Infect [Internet]. Elsevier; 2020 [cited 2022 Jun 16];80:607. Available from: \/pmc\/articles\/PMC7194613\/","DOI":"10.1016\/j.jinf.2020.03.037"},{"key":"2017_CR15","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.3389\/fimmu.2020.01446","volume":"11","author":"D Ragab","year":"2020","unstructured":"Ragab D, Salah Eldin H, Taeimah M, Khattab R, Salem R. The COVID-19 cytokine storm; what we know so far. Front Immunol Frontiers Media SA. 2020;11:1446.","journal-title":"Front Immunol. Frontiers Media S.A."},{"key":"2017_CR16","doi-asserted-by":"crossref","unstructured":"Wilson AG. Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol [Internet]. J Periodontol; 2008 [cited 2022 Jun 15];79:1514\u20139. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/18673005\/","DOI":"10.1902\/jop.2008.080172"},{"key":"2017_CR17","doi-asserted-by":"publisher","unstructured":"Atlante S, Mongelli A, Barbi V, Martelli F, Farsetti A, Gaetano C. The epigenetic implication in coronavirus infection and therapy. Clin Epigenetics 2020 121 [Internet]. BioMed Central; 2020 [cited 2022 Jun 15];12:1\u201312. Available from: https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/s13148-020-00946-x","DOI":"10.1186\/s13148-020-00946-x"},{"key":"2017_CR18","doi-asserted-by":"crossref","unstructured":"AbdelHamid SG, Refaat AA, Benjamin AM, Elmawardy LA, Elgendy LA, Manolly MM, et al. Deciphering epigenetic(s) role in modulating susceptibility to and severity of COVID-19 infection and\/or outcome: a systematic rapid review. Environ Sci Pollut Res Int [Internet]. Nature Publishing Group; 2021 [cited 2022 Jun 15];28:1. Available from: \/pmc\/articles\/PMC8359636\/","DOI":"10.1007\/s11356-021-15588-6"},{"key":"2017_CR19","doi-asserted-by":"crossref","unstructured":"Kgatle MM, Lawal IO, Mashabela G, Boshomane TMG, Koatale PC, Mahasha PW, et al. COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks. Front Immunol [Internet]. Frontiers Media SA; 2021 [cited 2022 Jun 15];12. Available from: \/pmc\/articles\/PMC8531724\/","DOI":"10.3389\/fimmu.2021.752380"},{"key":"2017_CR20","doi-asserted-by":"crossref","unstructured":"Mitj\u00e0 O, Clotet B. Use of anti-viral drugs to reduce COVID-19 transmission. Lancet Glob Heal [Internet]. Elsevier; 2020 [cited 2022 Jun 15];8:e639. Available from: \/pmc\/articles\/PMC7104000\/","DOI":"10.1016\/S2214-109X(20)30114-5"},{"key":"2017_CR21","doi-asserted-by":"crossref","unstructured":"Esakandari H, Nabi-Afjadi M, Fakkari-Afjadi J, Farahmandian N, Miresmaeili SM, Bahreini E. A comprehensive review of COVID-19 characteristics. Biol Proced Online [Internet]. BioMed Central; 2020 [cited 2022 Jun 15];22. Available from: \/pmc\/articles\/PMC7402395\/","DOI":"10.1186\/s12575-020-00128-2"},{"key":"2017_CR22","doi-asserted-by":"crossref","unstructured":"Pennington AF, Kompaniyets L, Summers AD, Danielson ML, Goodman AB, Chevinsky JR, et al. Risk of Clinical Severity by Age and Race\/Ethnicity among Adults Hospitalized for COVID-19 - United States, March-September 2020. Open Forum Infect Dis. Oxford University Press; 2021;8.","DOI":"10.1093\/ofid\/ofaa638"},{"key":"2017_CR23","doi-asserted-by":"publisher","unstructured":"Ghorbaninejad M, Khademi-Shirvan M, Hosseini S, Baghaban Eslaminejad M. Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation. Stem Cell Res Ther 2020 111 [Internet]. BioMed Central; 2020 [cited 2022 Jun 15];11:1\u201314. Available from: https:\/\/stemcellres.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/s13287-020-01966-3","DOI":"10.1186\/s13287-020-01966-3"},{"key":"2017_CR24","doi-asserted-by":"crossref","unstructured":"Rath S, Perikala V, Jena AB, Dandapat J. Factors regulating dynamics of angiotensin-converting enzyme-2 (ACE2), the gateway of SARS-CoV-2: Epigenetic modifications and therapeutic interventions by epidrugs. Biomed Pharmacother [Internet]. Elsevier; 2021 [cited 2022 Jun 15];143:112095. Available from: \/pmc\/articles\/PMC8403698\/","DOI":"10.1016\/j.biopha.2021.112095"},{"key":"2017_CR25","doi-asserted-by":"publisher","unstructured":"Montazersaheb S, Hosseiniyan Khatibi SM, Hejazi MS, Tarhriz V, Farjami A, Ghasemian Sorbeni F, et al. COVID-19 infection: an overview on cytokine storm and related interventions. Virol J [Internet]. BioMed Central; 2022;19:1\u201315. Available from: https:\/\/doi.org\/10.1186\/s12985-022-01814-1","DOI":"10.1186\/s12985-022-01814-1"},{"key":"2017_CR26","doi-asserted-by":"crossref","unstructured":"Nied\u017awiedzka-Rystwej P, Majchrzak A, Kurkowska S, Ma\u0142kowska P, Sierawska O, Hrynkiewicz R, et al. Immune Signature of COVID-19: In-Depth Reasons and Consequences of the Cytokine Storm. Int J Mol Sci [Internet]. Multidisciplinary Digital Publishing Institute (MDPI); 2022 [cited 2022 Nov 14];23. Available from: \/pmc\/articles\/PMC9105989\/","DOI":"10.3390\/ijms23094545"},{"key":"2017_CR27","doi-asserted-by":"crossref","unstructured":"Pelaia C, Tinello C, Vatrella A, De Sarro G, Pelaia G. Lung under attack by COVID-19-induced cytokine storm:pathogenic mechanisms and therapeutic implications. Ther Adv Respir Dis [Internet]. SAGE Publications; 2020 [cited 2022 Jun 16];14. Available from: \/pmc\/articles\/PMC7298425\/","DOI":"10.1177\/1753466620933508"},{"key":"#cr-split#-2017_CR28.1","doi-asserted-by":"crossref","unstructured":"Tay MZ, Poh CM, R\u00e9nia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol 2020 206 [Internet]. Nature Publishing Group","DOI":"10.1038\/s41577-020-0311-8"},{"key":"#cr-split#-2017_CR28.2","unstructured":"2020 [cited 2022 Jun 16];20:363-74. Available from: https:\/\/www.nature.com\/articles\/s41577-020-0311-8"},{"key":"2017_CR29","doi-asserted-by":"crossref","unstructured":"Bhaskar S, Sinha A, Banach M, Mittoo S, Weissert R, Kass JS, et al. Cytokine Storm in COVID-19\u2014Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper. Front Immunol [Internet]. Frontiers Media S.A.; 2020 [cited 2022 Jun 16];11:1648. Available from: \/pmc\/articles\/PMC7365905\/","DOI":"10.3389\/fimmu.2020.01648"},{"key":"2017_CR30","doi-asserted-by":"crossref","unstructured":"Mustafa MI, Abdelmoneim AH, Mahmoud EM, Makhawi AM. Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors. Mediators Inflamm [Internet]. Mediators Inflamm; 2020 [cited 2022 Jun 16];2020. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33029105\/","DOI":"10.21467\/preprints.139"},{"key":"2017_CR31","doi-asserted-by":"crossref","unstructured":"Huertas A, Montani D, Savale L, Pichon J, Tu L, Parent F, et al. Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)? Eur Respir J [Internet]. European Respiratory Society; 2020 [cited 2022 Jun 16];56. Available from: https:\/\/erj.ersjournals.com\/content\/56\/1\/2001634","DOI":"10.1183\/13993003.01634-2020"},{"key":"2017_CR32","unstructured":"Diamond M, Feliciano HLP, Sanghavi D, Mahapatra S. Acute Respiratory Distress Syndrome. StatsPearls[Internet] [Internet]. StatPearls Publishing; 2022 [cited 2022 Nov 7]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK436002\/"},{"key":"2017_CR33","doi-asserted-by":"crossref","unstructured":"Grasselli G, Tonetti T, Protti A, Langer T, Girardis M, Bellani G, et al. Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study. Lancet Respir Med [Internet]. Lancet Publishing Group; 2020 [cited 2022 Jun 16];8:1201\u20138. Available from: http:\/\/www.thelancet.com\/article\/S2213260020303702\/fulltext","DOI":"10.1016\/S2213-2600(20)30370-2"},{"key":"2017_CR34","doi-asserted-by":"crossref","unstructured":"Swenson KE, Swenson ER. Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury. Crit Care Clin [Internet]. Elsevier; 2021 [cited 2022 Jun 16];37:749. Available from: \/pmc\/articles\/PMC8162817\/","DOI":"10.1016\/j.ccc.2021.05.003"},{"key":"2017_CR35","first-page":"2485","volume":"12","author":"H Islam","year":"2021","unstructured":"Islam H, Chamberlain TC, Mui AL, Little JP. Elevated interleukin-10 levels in COVID-19: potentiation of pro-inflammatory responses or impaired anti-inflammatory action? Front Immunol Frontiers Media SA. 2021;12:2485.","journal-title":"Front Immunol. Frontiers Media S.A."},{"key":"2017_CR36","first-page":"263","volume":"12","author":"A Santa Cruz","year":"2021","unstructured":"Santa Cruz A, Mendes-Frias A, Oliveira AI, Dias L, Matos AR, Carvalho A, et al. Interleukin-6 Is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus 2 pneumonia. Front Immunol Frontiers Media SA. 2021;12:263.","journal-title":"Front Immunol. Frontiers Media S.A."},{"key":"2017_CR37","doi-asserted-by":"crossref","unstructured":"Gadotti AC, de Castro Deus M, Telles JP, Wind R, Goes M, Garcia Charello Ossoski R, et al. IFN-\u03b3 is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection. Virus Res [Internet]. Elsevier; 2020 [cited 2022 Jun 16];289:198171. Available from: \/pmc\/articles\/PMC7510544\/","DOI":"10.1016\/j.virusres.2020.198171"},{"key":"2017_CR38","doi-asserted-by":"crossref","unstructured":"Bunprakob S, Hemachudha P, Ruchisrisarod C, Supharatpariyakorn T, Hemachudha T. IP-10 and complement activation as friend or foe in COVID-19. Int J Immunopathol Pharmacol [Internet]. Int J Immunopathol Pharmacol; 2022 [cited 2022 Jun 16];36. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35531750\/","DOI":"10.1177\/03946320221096202"},{"key":"2017_CR39","doi-asserted-by":"crossref","unstructured":"Yang Y, Shen C, Li J, Yuan J, Wei J, Huang F, et al. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. J Allergy Clin Immunol [Internet]. Elsevier; 2020 [cited 2022 Jun 16];146:119. Available from: \/pmc\/articles\/PMC7189843\/","DOI":"10.1016\/j.jaci.2020.04.027"},{"key":"2017_CR40","doi-asserted-by":"crossref","unstructured":"Wong CK, Lam CWK, Wu AKL, Ip WK, Lee NLS, Chan IHS, et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol [Internet]. Oxford University Press; 2004 [cited 2022 Jun 16];136:95. Available from: \/pmc\/articles\/PMC1808997\/","DOI":"10.1111\/j.1365-2249.2004.02415.x"},{"key":"2017_CR41","doi-asserted-by":"crossref","unstructured":"Mahallawi WH, Khabour OF, Zhang Q, Makhdoum HM, Suliman BA. MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile. Cytokine [Internet]. Elsevier; 2018 [cited 2022 Jun 16];104:8. Available from: \/pmc\/articles\/PMC7129230\/","DOI":"10.1016\/j.cyto.2018.01.025"},{"key":"2017_CR42","doi-asserted-by":"crossref","unstructured":"Guo J, Wang S, Xia H, Shi D, Chen Y, Zheng S, et al. Cytokine Signature Associated With Disease Severity in COVID-19. Front Immunol. Frontiers Media S.A.; 2021;12:3276.","DOI":"10.3389\/fimmu.2021.681516"},{"key":"2017_CR43","doi-asserted-by":"publisher","unstructured":"Merad M, Martin JC. Author Correction: Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages (Nature Reviews Immunology, (2020), 20, 6, (355\u2013362), https:\/\/doi.org\/10.1038\/s41577-020-0331-4). Nat Rev Immunol [Internet]. Nature Research; 2020 [cited 2022 Jun 16];20:448. Available from: https:\/\/www.nature.com\/articles\/s41577-020-0331-4","DOI":"10.1038\/s41577-020-0331-4"},{"key":"#cr-split#-2017_CR44.1","doi-asserted-by":"crossref","unstructured":"Lang FM, Lee KMC, Teijaro JR, Becher B, Hamilton JA. GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches. Nat Rev Immunol 2020 208 [Internet]. Nature Publishing Group","DOI":"10.1038\/s41577-020-0357-7"},{"key":"#cr-split#-2017_CR44.2","unstructured":"2020 [cited 2022 Jun 16];20:507-14. Available from: https:\/\/www.nature.com\/articles\/s41577-020-0357-7"},{"key":"2017_CR45","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.3389\/fimmu.2020.01625","volume":"11","author":"A Bonaventura","year":"2020","unstructured":"Bonaventura A, Vecchi\u00e9 A, Wang TS, Lee E, Cremer PC, Carey B, et al. Targeting GM-CSF in COVID-19 pneumonia: rationale and strategies. Front Immunol Frontiers Media SA. 2020;11:1625.","journal-title":"Front Immunol. Frontiers Media S.A."},{"key":"2017_CR46","doi-asserted-by":"publisher","first-page":"102816","DOI":"10.1016\/j.amsu.2021.102816","volume":"69","author":"EA Ghizlane","year":"2021","unstructured":"Ghizlane EA, Manal M, Abderrahim EK, Abdelilah E, Mohammed M, Rajae A, et al. Lymphopenia in Covid-19: a single center retrospective study of 589 cases. Ann Med Surg. 2021;69:102816 (Elsevier).","journal-title":"Ann Med Surg."},{"key":"2017_CR47","doi-asserted-by":"crossref","unstructured":"Tavakolpour S, Rakhshandehroo T, Wei EX, Rashidian M. Lymphopenia during the COVID-19 infection: What it shows and what can be learned. Immunol Lett [Internet]. Elsevier; 2020 [cited 2022 Jun 15];225:31. Available from: \/pmc\/articles\/PMC7305732\/","DOI":"10.1016\/j.imlet.2020.06.013"},{"key":"2017_CR48","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3389\/fcimb.2020.00425","volume":"10","author":"K Frank","year":"2020","unstructured":"Frank K, Paust S. Dynamic natural killer cell and T cell responses to influenza infection. Front Cell Infect Microbiol Frontiers Media SA. 2020;10:425.","journal-title":"Front Cell Infect Microbiol Frontiers Media S.A."},{"key":"2017_CR49","doi-asserted-by":"crossref","unstructured":"Fathi N, Rezaei N. Lymphopenia in COVID\u201019: Therapeutic opportunities. Cell Biol Int [Internet]. Wiley-Blackwell; 2020 [cited 2022 Jun 15];44:1792\u20137. Available from: \/pmc\/articles\/PMC7283672\/","DOI":"10.1002\/cbin.11403"},{"key":"2017_CR50","doi-asserted-by":"publisher","unstructured":"Liu Y, Tan W, Chen H, Zhu Y, Wan L, Jiang K, et al. Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19. BMC Infect Dis [Internet]. BioMed Central Ltd; 2021 [cited 2022 Jun 15];21:1\u201310. Available from: https:\/\/bmcinfectdis.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/s12879-021-05792-7","DOI":"10.1186\/s12879-021-05792-7"},{"key":"2017_CR51","doi-asserted-by":"crossref","unstructured":"Gao YM, Xu G, Wang B, Liu BC. Cytokine storm syndrome in coronavirus disease 2019: A narrative review. J Intern Med [Internet]. Wiley-Blackwell; 2021 [cited 2022 Jun 16];289:147\u201361. Available from: \/pmc\/articles\/PMC7404514\/","DOI":"10.1111\/joim.13144"},{"key":"2017_CR52","unstructured":"World Health Organization. Severe Acute Respiratory Syndrome (SARS) [Internet]. [cited 2023 Feb 7]. Available from: https:\/\/www.who.int\/health-topics\/severe-acute-respiratory-syndrome#tab=tab_1"},{"key":"2017_CR53","doi-asserted-by":"publisher","first-page":"7379","DOI":"10.1016\/j.vaccine.2007.08.011","volume":"25","author":"H Shi","year":"2007","unstructured":"Shi H, Liu XF, Zhang X, Chen S, Sun L, Lu J. Generation of an attenuated H5N1 avian influenza virus vaccine with all eight genes from avian viruses. Vaccine. 2007;25:7379\u201384.","journal-title":"Vaccine"},{"key":"2017_CR54","doi-asserted-by":"crossref","unstructured":"Morris G, Bortolasci CC, Puri BK, Marx W, O\u2019Neil A, Athan E, et al. The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all? Cytokine [Internet]. Elsevier; 2021 [cited 2022 Jun 16];144:155593. Available from: \/pmc\/articles\/PMC8149193\/","DOI":"10.1016\/j.cyto.2021.155593"},{"key":"2017_CR55","doi-asserted-by":"crossref","unstructured":"Ragab D, Salah Eldin H, Taeimah M, Khattab R, Salem R. The COVID-19 Cytokine Storm; What We Know So Far. Front Immunol [Internet]. Frontiers Media SA; 2020 [cited 2022 Jun 16];11:1446. Available from: \/pmc\/articles\/PMC7308649\/","DOI":"10.3389\/fimmu.2020.01446"},{"key":"2017_CR56","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41581-022-00642-4","volume":"19","author":"N Murakami","year":"2023","unstructured":"Murakami N, Hayden R, Hills T, Al-Samkari H, Casey J, Del Sorbo L, et al. Therapeutic advances in COVID-19. Nat Rev Nephrol. 2023;19:38\u201352 (Springer US).","journal-title":"Nat Rev Nephrol"},{"key":"#cr-split#-2017_CR57.1","unstructured":"Zhang W, Zhao Y, Zhang F, Wang Q, Li T, Liu Z, et al. The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China. Clin Immunol [Internet]. Elsevier"},{"key":"#cr-split#-2017_CR57.2","unstructured":"2020 [cited 2022 Jun 16];214:108393. Available from: \/pmc\/articles\/PMC7102614\/"},{"key":"2017_CR58","doi-asserted-by":"publisher","first-page":"622","DOI":"10.7326\/M20-6739","volume":"174","author":"H Al-Samkari","year":"2021","unstructured":"Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, et al. Thrombosis, bleeding, and the observational effect of early therapeutic anticoagulation on survival in critically ill patients with COVID-19. Ann Intern Med United States. 2021;174:622\u201332.","journal-title":"Ann Intern Med United States"},{"key":"2017_CR59","doi-asserted-by":"crossref","unstructured":"Kim JS, Lee JY, Yang JW, Lee KH, Effenberger M, Szpirt W, et al. Immunopathogenesis and treatment of cytokine storm in COVID-19. Theranostics [Internet]. Ivyspring International Publisher; 2021 [cited 2022 Jun 16];11:316. Available from: \/pmc\/articles\/PMC7681075\/","DOI":"10.7150\/thno.49713"},{"key":"2017_CR60","doi-asserted-by":"crossref","unstructured":"Zhou Q, Chen V, Shannon CP, Wei XS, Xiang X, Wang X, et al. Interferon-\u03b12b Treatment for COVID-19. Front Immunol [Internet]. Frontiers Media S.A.; 2020 [cited 2022 Dec 23];11:1061. Available from: \/pmc\/articles\/PMC7242746\/","DOI":"10.3389\/fimmu.2020.01061"},{"key":"2017_CR61","doi-asserted-by":"crossref","unstructured":"Bailly C, Vergoten G. Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome? Pharmacol Ther [Internet]. Elsevier; 2020 [cited 2022 Nov 11];214:107618. Available from: \/pmc\/articles\/PMC7311916\/","DOI":"10.1016\/j.pharmthera.2020.107618"},{"key":"#cr-split#-2017_CR62.1","doi-asserted-by":"crossref","unstructured":"Zanza C, Romenskaya T, Manetti AC, Franceschi F, La Russa R, Bertozzi G, et al. Cytokine Storm in COVID-19: Immunopathogenesis and Therapy. Med 2022, Vol 58, Page 144 [Internet]. Multidisciplinary Digital Publishing Institute","DOI":"10.3390\/medicina58020144"},{"key":"#cr-split#-2017_CR62.2","unstructured":"2022 [cited 2022 Nov 11];58:144. Available from: https:\/\/www.mdpi.com\/1648-9144\/58\/2\/144\/htm"},{"key":"2017_CR63","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.1016\/j.cell.2021.03.051","volume":"184","author":"JSY Ho","year":"2021","unstructured":"Ho JSY, Mok BWY, Campisi L, Jordan T, Yildiz S, Parameswaran S, et al. TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. Cell. 2021;184:2618-2632.e17 (Elsevier B.V.).","journal-title":"Cell"},{"key":"2017_CR64","doi-asserted-by":"crossref","unstructured":"Nemchand P, Tahir H, Mediwake R, Lee J. Cytokine storm and use of anakinra in a patient with COVID-19. BMJ Case Reports CP [Internet]. BMJ Specialist Journals; 2020 [cited 2022 Jun 16];13:e237525. Available from: https:\/\/casereports.bmj.com\/content\/13\/9\/e237525","DOI":"10.1136\/bcr-2020-237525"},{"key":"2017_CR65","doi-asserted-by":"crossref","unstructured":"Gupta S, Leaf DE. Tocilizumab in COVID-19: some clarity amid controversy. Lancet [Internet]. Elsevier; 2021 [cited 2022 Jun 16];397:1599\u2013601. Available from: http:\/\/www.thelancet.com\/article\/S0140673621007121\/fulltext","DOI":"10.1016\/S0140-6736(21)00712-1"},{"key":"2017_CR66","doi-asserted-by":"crossref","unstructured":"Luo P, Liu Y, Qiu L, Liu X, Liu D, Li J. Tocilizumab treatment in COVID\u201019: A single center experience. J Med Virol [Internet]. Wiley-Blackwell; 2020 [cited 2023 Feb 7];92:814. Available from: \/pmc\/articles\/PMC7262125\/","DOI":"10.1002\/jmv.25801"},{"key":"2017_CR67","doi-asserted-by":"crossref","unstructured":"Mariette X, Hermine O, Tharaux PL, Resche-Rigon M, Steg PG, Porcher R, et al. Effectiveness of Tocilizumab in Patients Hospitalized With COVID-19: A Follow-up of the CORIMUNO-TOCI-1 Randomized Clinical Trial. JAMA Intern Med [Internet]. American Medical Association; 2021 [cited 2023 Feb 7];181:1241\u20133. Available from: https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2780021","DOI":"10.1001\/jamainternmed.2021.2209"},{"key":"2017_CR68","doi-asserted-by":"crossref","unstructured":"Mehta P, Ciurtin C, Scully M, Levi M, Chambers RC. JAK inhibitors in COVID-19: need for vigilance regarding increased inherent thrombotic risk. Eur Respir J [Internet]. European Respiratory Society; 2020 [cited 2022 Jun 16];56. Available from: https:\/\/erj.ersjournals.com\/content\/early\/2020\/07\/02\/13993003.01919-2020","DOI":"10.1183\/13993003.01919-2020"},{"key":"2017_CR69","doi-asserted-by":"crossref","unstructured":"Rubin R. Baricitinib Is First Approved COVID-19 Immunomodulatory Treatment. JAMA [Internet]. American Medical Association; 2022 [cited 2023 Feb 8];327:2281\u20132281. Available from: https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2793470","DOI":"10.1001\/jama.2022.9846"},{"key":"2017_CR70","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1093\/cid\/ciaa879","volume":"72","author":"BK Titanji","year":"2020","unstructured":"Titanji BK, Farley MM, Mehta A, Connor-Schuler R, Moanna A, Cribbs SK, et al. Use of baricitinib in patients with moderate to severe coronavirus disease 2019. Clin Infect Dis. 2020;72:1247\u201350. https:\/\/doi.org\/10.1093\/cid\/ciaa879.","journal-title":"Clin Infect Dis"},{"key":"2017_CR71","doi-asserted-by":"publisher","unstructured":"Lin Z, Niu J, Xu Y, Qin L, Ding J, Zhou L. Clinical efficacy and adverse events of baricitinib treatment for coronavirus disease-2019 (COVID-19): A systematic review and meta-analysis. J Med Virol [Internet]. John Wiley & Sons, Ltd; 2022 [cited 2023 Feb 8];94:1523\u201334. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/full\/https:\/\/doi.org\/10.1002\/jmv.27482","DOI":"10.1002\/jmv.27482"},{"key":"2017_CR72","doi-asserted-by":"crossref","unstructured":"Bartoli A, Gabrielli F, Alicandro T, Nascimbeni F, Andreone P. COVID-19 treatment options: a difficult journey between failed attempts and experimental drugs. Intern Emerg Med [Internet]. Nature Publishing Group; 2021 [cited 2022 Nov 15];16:281. Available from: \/pmc\/articles\/PMC7781413\/","DOI":"10.1007\/s11739-020-02569-9"},{"key":"2017_CR73","doi-asserted-by":"crossref","unstructured":"Al-Kuraishy HM, Al-Gareeb AI, Al-hussaniy HA, Al-Harcan NAH, Alexiou A, Batiha GES. Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality. Int Immunopharmacol [Internet]. Elsevier; 2022 [cited 2022 Nov 15];104:108516. Available from: \/pmc\/articles\/PMC8733219\/","DOI":"10.1016\/j.intimp.2021.108516"},{"key":"2017_CR74","doi-asserted-by":"crossref","unstructured":"Turner BM. Epigenetic responses to environmental change and their evolutionary implications. Philos Trans R Soc B Biol Sci [Internet]. The Royal Society; 2009 [cited 2022 Jun 15];364:3403. Available from: \/pmc\/articles\/PMC2781845\/","DOI":"10.1098\/rstb.2009.0125"},{"key":"2017_CR75","doi-asserted-by":"publisher","unstructured":"Kubota T, Miyake K, Hirasawa T. Epigenetic understanding of gene-environment interactions in psychiatric disorders: A new concept of clinical genetics. Clin Epigenetics [Internet]. BioMed Central; 2012 [cited 2022 Jun 15];4:1\u20138. Available from: https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/1868-7083-4-1","DOI":"10.1186\/1868-7083-4-1"},{"key":"2017_CR76","doi-asserted-by":"crossref","unstructured":"Deans C, Maggert KA. What Do You Mean, \u201cEpigenetic\u201d? Genetics [Internet]. Oxford University Press; 2015 [cited 2022 Jun 15];199:887. Available from: \/pmc\/articles\/PMC4391566\/","DOI":"10.1534\/genetics.114.173492"},{"key":"#cr-split#-2017_CR77.1","doi-asserted-by":"crossref","unstructured":"Salgado-Albarr\u00e1n M, Navarro-Delgado EI, Del Moral-Morales A, Alcaraz N, Baumbach J, Gonz\u00e1lez-Barrios R, et al. Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection. npj Syst Biol Appl 2021 71 [Internet]. Nature Publishing Group","DOI":"10.1038\/s41540-021-00181-x"},{"key":"#cr-split#-2017_CR77.2","unstructured":"2021 [cited 2022 Jun 15];7:1-14. Available from: https:\/\/www.nature.com\/articles\/s41540-021-00181-x"},{"key":"2017_CR78","doi-asserted-by":"crossref","unstructured":"Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, et al. Cell entry mechanisms of SARS-CoV-2. Proc Natl Acad Sci U S A [Internet]. Proc Natl Acad Sci U S A; 2020 [cited 2022 Jun 16];117. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32376634\/","DOI":"10.1073\/pnas.2003138117"},{"key":"#cr-split#-2017_CR79.1","doi-asserted-by":"crossref","unstructured":"Huang Y, Yang C, Xu X feng, Xu W, Liu S wen. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin 2020 419 [Internet]. Nature Publishing Group","DOI":"10.1038\/s41401-020-0485-4"},{"key":"#cr-split#-2017_CR79.2","unstructured":"2020 [cited 2022 Jun 16];41:1141-9. Available from: https:\/\/www.nature.com\/articles\/s41401-020-0485-4"},{"key":"2017_CR80","doi-asserted-by":"publisher","unstructured":"Ni W, Yang X, Yang D, Bao J, Li R, Xiao Y, et al. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. Crit Care [Internet]. BioMed Central; 2020 [cited 2022 Jun 16];24:1\u201310. Available from: https:\/\/ccforum.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/s13054-020-03120-0","DOI":"10.1186\/s13054-020-03120-0"},{"key":"2017_CR81","doi-asserted-by":"crossref","unstructured":"Peron JPS, Nakaya H. Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE). Clinics [Internet]. Faculdade de Medicina \/ USP; 2020 [cited 2022 Jun 16];75:1\u20136. Available from: http:\/\/www.scielo.br\/j\/clin\/a\/QDXYJBQk6YyLpfGNgBKtxHQ\/?lang=en","DOI":"10.6061\/clinics\/2020\/e1912"},{"key":"2017_CR82","doi-asserted-by":"crossref","unstructured":"Daniel G, Paola AR, Nancy G, Fernando SO, Beatriz A, Zulema R, et al. Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility. Infect Genet Evol [Internet]. Infect Genet Evol; 2022 [cited 2022 Nov 8];104. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/36038007\/","DOI":"10.1016\/j.meegid.2022.105357"},{"key":"2017_CR83","doi-asserted-by":"publisher","unstructured":"Serfozo P, Wysocki J, Gulua G, Schulze A, Ye M, Liu P, et al. Ang II (Angiotensin II) Conversion to Angiotensin-(1\u20137) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent. Hypertens (Dallas, Tex 1979) [Internet]. NLM (Medline); 2020 [cited 2022 Jun 16];75:173\u201382. Available from: https:\/\/www.ahajournals.org\/doi\/abs\/https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.119.14071","DOI":"10.1161\/HYPERTENSIONAHA.119.14071"},{"key":"2017_CR84","doi-asserted-by":"crossref","unstructured":"Verdecchia P, Cavallini C, Spanevello A, Angeli F. The pivotal link between ACE2 deficiency and SARS-CoV-2 infection. Eur J Intern Med [Internet]. Elsevier; 2020 [cited 2022 Jun 16];76:14. Available from: \/pmc\/articles\/PMC7167588\/","DOI":"10.1016\/j.ejim.2020.04.037"},{"key":"2017_CR85","doi-asserted-by":"crossref","unstructured":"Roshanravan N, Ghaffari S, Hedayati M. Angiotensin converting enzyme-2 as therapeutic target in COVID-19. Diabetes Metab Syndr [Internet]. Elsevier; 2020 [cited 2022 Jun 16];14:637. Available from: \/pmc\/articles\/PMC7214324\/","DOI":"10.1016\/j.dsx.2020.05.022"},{"key":"2017_CR86","doi-asserted-by":"crossref","unstructured":"Kalupahana NS, Massiera F, Quignard-Boulange A, Ailhaud G, Voy BH, Wasserman DH, et al. Overproduction of Angiotensinogen from adipose Tissue Induces adipose Infammation, Glucose Intolerance, and Insulin Resistance. Obesity (Silver Spring) [Internet]. NIH Public Access; 2012 [cited 2022 Jun 16];20:48. Available from: \/pmc\/articles\/PMC4465436\/","DOI":"10.1038\/oby.2011.299"},{"key":"2017_CR87","doi-asserted-by":"crossref","unstructured":"Ahmad SF, Ansari MA, Zoheir KMA, Bakheet SA, Korashy HM, Nadeem A, et al. Regulation of TNF-\u03b1 and NF-\u03baB activation through the JAK\/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation. Immunobiology [Internet]. Immunobiology; 2015 [cited 2022 Jun 16];220:889\u201398. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/25666529\/","DOI":"10.1016\/j.imbio.2015.01.008"},{"key":"2017_CR88","doi-asserted-by":"crossref","unstructured":"Deng J, Wang DX, Deng W, Li CY, Tong J. The effect of endogenous angiotensin II on alveolar fluid clearance in rats with acute lung injury. Can Respir J [Internet]. Hindawi Limited; 2012 [cited 2022 Jun 16];19:311. Available from: \/pmc\/articles\/PMC3473006\/","DOI":"10.1155\/2012\/951025"},{"key":"2017_CR89","doi-asserted-by":"crossref","unstructured":"Abu-Farha M, Al-Mulla F, Thanaraj TA, Kavalakatt S, Ali H, Abdul Ghani M, et al. Impact of Diabetes in Patients Diagnosed With COVID-19. Front Immunol [Internet]. Frontiers Media SA; 2020 [cited 2022 Jun 16];11. Available from: \/pmc\/articles\/PMC7736089\/","DOI":"10.3389\/fimmu.2020.576818"},{"key":"2017_CR90","doi-asserted-by":"crossref","unstructured":"Gemmati D, Bramanti B, Serino ML, Secchiero P, Zauli G, Tisato V. COVID-19 and individual genetic susceptibility\/receptivity: Role of ACE1\/ACE2 genes, immunity, inflammation and coagulation. might the double x-chromosome in females be protective against SARS-COV-2 compared to the single x-chromosome in males? Int J Mol Sci. MDPI AG; 2020;21.","DOI":"10.3390\/ijms21103474"},{"key":"2017_CR91","doi-asserted-by":"crossref","unstructured":"Ciaglia E, Vecchione C, Puca AA. COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women and Children. Front Pediatr. Frontiers Media S.A.; 2020;8:206.","DOI":"10.3389\/fped.2020.00206"},{"key":"2017_CR92","doi-asserted-by":"crossref","unstructured":"Goc A, Niedzwiecki A, Rath M. Polyunsaturated \u03c9-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry. Sci Rep [Internet]. Sci Rep; 2021 [cited 2022 May 23];11. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33664446\/","DOI":"10.1038\/s41598-021-84850-1"},{"key":"2017_CR93","doi-asserted-by":"crossref","unstructured":"Xu J, Mukerjee S, Cristiane CR, Carvalho-Galv\u00e3o A, Cruz JC, Balarini CM, et al. A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems. Front Physiol [Internet]. Frontiers Media SA; 2016 [cited 2022 Jun 16];7:469. Available from: \/pmc\/articles\/PMC5067531\/","DOI":"10.3389\/fphys.2016.00469"},{"key":"2017_CR94","doi-asserted-by":"crossref","unstructured":"Lima RS, Rocha LPC, Moreira PR. Genetic and epigenetic control of ACE2 expression and its possible role in COVID\u201019. Cell Biochem Funct [Internet]. Wiley-Blackwell; 2021 [cited 2022 Jun 16];39:713\u201326. Available from: \/pmc\/articles\/PMC8239811\/","DOI":"10.1002\/cbf.3648"},{"key":"2017_CR95","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.htct.2021.07.006","volume":"44","author":"S Shibeeb","year":"2022","unstructured":"Shibeeb S, Khan A. ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review. Hematol Transfus Cell Ther. 2022;44:70\u20135 (Elsevier).","journal-title":"Hematol Transfus Cell Ther."},{"key":"2017_CR96","doi-asserted-by":"crossref","unstructured":"Goel R, Bloch EM, Pirenne F, Al-Riyami AZ, Crowe E, Dau L, et al. ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 Working Group. Vox Sang [Internet]. Vox Sang; 2021 [cited 2022 Jun 16];116:849\u201361. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33578447\/","DOI":"10.1111\/vox.13076"},{"key":"#cr-split#-2017_CR97.1","unstructured":"Moore LD, Le T, Fan G. DNA Methylation and Its Basic Function. Neuropsychopharmacol 2013 381 [Internet]. Nature Publishing Group"},{"key":"#cr-split#-2017_CR97.2","unstructured":"2012 [cited 2022 Jun 16];38:23-38. Available from: https:\/\/www.nature.com\/articles\/npp2012112"},{"key":"2017_CR98","doi-asserted-by":"crossref","unstructured":"Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Lian N, et al. The impact of COPD and smoking history on the severity of COVID\u201019: A systemic review and meta\u2010analysis. J Med Virol [Internet]. Wiley-Blackwell; 2020 [cited 2022 Jun 16];92:1915\u201321. Available from: \/pmc\/articles\/PMC7262275\/","DOI":"10.1002\/jmv.25889"},{"key":"2017_CR99","doi-asserted-by":"crossref","unstructured":"Godoy-Tena G, Barmada A, Morante-Palacios O, de la Calle-Fabregat C, Martins-Ferreira R, Ferret\u00e9-Bonastre AG, et al. Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines. Genome Med [Internet]. Genome Med; 2022 [cited 2022 Dec 24];14. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/36443794\/","DOI":"10.1186\/s13073-022-01137-4"},{"key":"2017_CR100","doi-asserted-by":"crossref","unstructured":"Barturen G, Carnero-Montoro E, Mart\u00ednez-Bueno M, Rojo-Rello S, Sobrino B, Porras-Perales \u00d3, et al. Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection. Nat Commun [Internet]. Nat Commun; 2022 [cited 2023 Jan 4];13. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35933486\/","DOI":"10.1038\/s41467-022-32357-2"},{"key":"2017_CR101","doi-asserted-by":"crossref","unstructured":"Bowler S, Papoutsoglou G, Karanikas A, Tsamardinos I, Corley MJ, Ndhlovu LC. A machine learning approach utilizing DNA methylation as an accurate classifier of COVID-19 disease severity. Sci Rep [Internet]. Sci Rep; 2022 [cited 2022 Dec 25];12. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/36261477\/","DOI":"10.1038\/s41598-022-22201-4"},{"key":"2017_CR102","doi-asserted-by":"crossref","unstructured":"Foolchand A, Mazaleni S, Ghazi T, Chuturgoon AA. A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin D. Int J Mol Sci [Internet]. Int J Mol Sci; 2022 [cited 2022 Dec 23];23. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/36293144\/","DOI":"10.3390\/ijms232012292"},{"key":"2017_CR103","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3389\/fcimb.2020.00290","volume":"10","author":"L Pruimboom","year":"2020","unstructured":"Pruimboom L. Methylation pathways and SARS-CoV-2 lung infiltration and cell membrane-virus fusion are both subject to epigenetics. Front Cell Infect Microbiol Frontiers Media SA. 2020;10:290.","journal-title":"Front Cell Infect Microbiol Frontiers Media S.A."},{"key":"2017_CR104","doi-asserted-by":"publisher","unstructured":"Gujral P, Mahajan V, Lissaman AC, Ponnampalam AP. Histone acetylation and the role of histone deacetylases in normal cyclic endometrium. Reprod Biol Endocrinol [Internet]. BioMed Central; 2020 [cited 2022 Jun 16];18:1\u201311. Available from: https:\/\/rbej.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/s12958-020-00637-5","DOI":"10.1186\/s12958-020-00637-5"},{"key":"2017_CR105","doi-asserted-by":"publisher","first-page":"5310","DOI":"10.1038\/sj.onc.1210599","volume":"26","author":"XJ Yang","year":"2007","unstructured":"Yang XJ, Seto E. HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene. 2007;26:5310\u20138.","journal-title":"Oncogene"},{"key":"2017_CR106","doi-asserted-by":"crossref","unstructured":"Yan C, Boyd DD. Histone H3 Acetylation and H3 K4 Methylation Define Distinct Chromatin Regions Permissive for Transgene Expression. Mol Cell Biol [Internet]. American Society for Microbiology (ASM); 2006 [cited 2022 Jun 16];26:6357. Available from: \/pmc\/articles\/PMC1592829\/","DOI":"10.1128\/MCB.00311-06"},{"key":"2017_CR107","doi-asserted-by":"crossref","unstructured":"Takahashi Y, Hayakawa A, Sano R, Fukuda H, Harada M, Kubo R, et al. Histone deacetylase inhibitors suppress ACE2 and ABO simultaneously, suggesting a preventive potential against COVID-19. Sci Rep [Internet]. Nature Publishing Group; 2021 [cited 2022 Jun 16];11:3379. Available from: \/pmc\/articles\/PMC7873266\/","DOI":"10.1038\/s41598-021-82970-2"},{"key":"2017_CR108","doi-asserted-by":"crossref","unstructured":"Jit BP, Qazi S, Arya R, Srivastava A, Gupta N, Sharma A. An immune epigenetic insight to COVID-19 infection. Epigenomics [Internet]. Epigenomics; 2021 [cited 2022 Dec 25];13:465\u201380. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33685230\/","DOI":"10.2217\/epi-2020-0349"},{"key":"2017_CR109","doi-asserted-by":"crossref","unstructured":"Shi L, Tu BP. Acetyl-CoA and the Regulation of Metabolism: Mechanisms and Consequences. Curr Opin Cell Biol [Internet]. NIH Public Access; 2015 [cited 2022 Jun 16];33:125. Available from: \/pmc\/articles\/PMC4380630\/","DOI":"10.1016\/j.ceb.2015.02.003"},{"key":"2017_CR110","doi-asserted-by":"crossref","unstructured":"Clarke NE, Belyaev ND, Lambert DW, Turner AJ. Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress. Clin Sci (Lond) [Internet]. Clin Sci (Lond); 2014 [cited 2022 Dec 23];126:507\u201316. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/24147777\/","DOI":"10.1042\/CS20130291"},{"key":"2017_CR111","doi-asserted-by":"crossref","unstructured":"P KM, Sivashanmugam K, Kandasamy M, Subbiah R, Ravikumar V. Repurposing of histone deacetylase inhibitors: A promising strategy to combat pulmonary fibrosis promoted by TGF-\u03b2 signalling in COVID-19 survivors. Life Sci [Internet]. Life Sci; 2021 [cited 2022 Jun 16];266. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33316266\/","DOI":"10.1016\/j.lfs.2020.118883"},{"key":"2017_CR112","doi-asserted-by":"publisher","unstructured":"Veerabathiran R, Ragunath B, Kaviarasan V, Mohammed V, Ahmed SSSJ. Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity. [cited 2022 Nov 15]; Available from: https:\/\/doi.org\/10.1186\/s42269-021-00540-y","DOI":"10.1186\/s42269-021-00540-y"},{"key":"2017_CR113","doi-asserted-by":"crossref","unstructured":"Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, et al. TGF\u03b2-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. J Cell Sci [Internet]. Company of Biologists; 2019 [cited 2022 Jun 16];132. Available from: \/pmc\/articles\/PMC6826010\/","DOI":"10.1242\/jcs.233486"},{"key":"2017_CR114","doi-asserted-by":"crossref","unstructured":"Saito S, Zhuang Y, Suzuki T, Ota Y, Bateman ME, Alkhatib AL, et al. Translational Research in Acute Lung Injury and Pulmonary Fibrosis: HDAC8 inhibition ameliorates pulmonary fibrosis. Am J Physiol - Lung Cell Mol Physiol [Internet]. American Physiological Society; 2019 [cited 2022 Jun 16];316:L175. Available from: \/pmc\/articles\/PMC6383499\/","DOI":"10.1152\/ajplung.00551.2017"},{"key":"2017_CR115","doi-asserted-by":"publisher","unstructured":"Barnes PJ. How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol [Internet]. John Wiley & Sons, Ltd; 2006 [cited 2022 Jun 16];148:245\u201354. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/full\/https:\/\/doi.org\/10.1038\/sj.bjp.0706736","DOI":"10.1038\/sj.bjp.0706736"},{"key":"2017_CR116","doi-asserted-by":"publisher","unstructured":"Fang WF, Chen YM, Lin CY, Huang HL, Yeh H, Chang YT, et al. Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression. J Inflamm (United Kingdom) [Internet]. BioMed Central Ltd.; 2018 [cited 2022 Jun 16];15:1\u201311. Available from: https:\/\/journal-inflammation.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/s12950-018-0179-6","DOI":"10.1186\/s12950-018-0179-6"},{"key":"2017_CR117","doi-asserted-by":"crossref","unstructured":"Leus NGJ, Zwinderman MRH, Dekker FJ. Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-\u03baB-mediated inflammation. Curr Opin Chem Biol [Internet]. Europe PMC Funders; 2016 [cited 2022 Jun 16];33:160. Available from: \/pmc\/articles\/PMC5019345\/","DOI":"10.1016\/j.cbpa.2016.06.019"},{"key":"2017_CR118","doi-asserted-by":"crossref","unstructured":"Kawabe Y, Mori J, Morimoto H, Yamaguchi M, Miyagaki S, Ota T, et al. ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue. Am J Physiol Endocrinol Metab [Internet]. 2019 [cited 2022 Dec 23];317:1140\u20139. Available from: http:\/\/www.ajpendo.org","DOI":"10.1152\/ajpendo.00311.2019"},{"key":"2017_CR119","doi-asserted-by":"crossref","unstructured":"Beacon TH, Delcuve GP, Davie JR. Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus1. Genome [Internet]. Genome; 2021 [cited 2022 Dec 25];64:386\u201399. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33086021\/","DOI":"10.1139\/gen-2020-0124"},{"key":"2017_CR120","doi-asserted-by":"crossref","unstructured":"Sawalha AH, Zhao M, Coit P, Lu Q. Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients. Clin Immunol [Internet]. Clin Immunol; 2020 [cited 2022 Dec 25];215. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32276140\/","DOI":"10.1016\/j.clim.2020.108410"},{"key":"2017_CR121","doi-asserted-by":"crossref","unstructured":"Shweta S, Krishna KS. Valproic acid in prevention and treatment of COVID-19. Int J Respir Pulm Med. Clinmed journals. 2020;7.","DOI":"10.23937\/2378-3516\/1410138"},{"key":"2017_CR122","doi-asserted-by":"publisher","unstructured":"Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Ant\u00f3n-Pl\u00e1garo C, et al. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science (80- ) [Internet]. American Association for the Advancement of Science; 2020 [cited 2022 Jun 16];370:861\u20135. Available from: https:\/\/www.science.org\/doi\/https:\/\/doi.org\/10.1126\/science.abd3072","DOI":"10.1126\/science.abd3072"},{"key":"2017_CR123","doi-asserted-by":"crossref","unstructured":"Liu K, Zou R, Cui W, Li M, Wang X, Dong J, et al. Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2. ACS Pharmacol Transl Sci [Internet]. American Chemical Society; 2020 [cited 2022 Jun 16];3:1361\u201370. Available from: \/pmc\/articles\/PMC7671100\/","DOI":"10.1021\/acsptsci.0c00163"},{"key":"2017_CR124","doi-asserted-by":"crossref","unstructured":"Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun [Internet]. Elsevier; 2020 [cited 2022 Jun 17];87:18. Available from: \/pmc\/articles\/PMC7146689\/","DOI":"10.1016\/j.bbi.2020.03.031"},{"key":"#cr-split#-2017_CR125.1","unstructured":"Syahrul S, Maliga HA, Ilmawan M, Fahriani M, Mamada SS, Fajar JK, et al. Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: incidence, risk factors, and pathogenesis - a systematic review and meta-analysis. F1000Research [Internet]. Faculty of 1000 Ltd"},{"key":"#cr-split#-2017_CR125.2","unstructured":"2021 [cited 2022 Jun 17];10. Available from: \/pmc\/articles\/PMC7934095\/"},{"key":"2017_CR126","doi-asserted-by":"crossref","unstructured":"Dietz KC, Casaccia P. HDAC inhibitors and neurodegeneration: at the edge between protection and damage. Pharmacol Res [Internet]. NIH Public Access; 2010 [cited 2022 Jun 17];62:11. Available from: \/pmc\/articles\/PMC2871984\/","DOI":"10.1016\/j.phrs.2010.01.011"},{"key":"2017_CR127","doi-asserted-by":"publisher","unstructured":"Mohamed MFA, Abuo-Rahma GE-DA, Hayallah AM, Aziz MA, Nafady A, Samir E. Molecular docking study reveals the potential repurposing of histone deacetylase inhibitors against Covid-19. Int J Pharm Sci Res [Internet]. 2020;11:4261\u201370. Available from: https:\/\/www.embase.com\/search\/results?subaction=viewrecord&id=L632820375&from=export%0Ahttp:\/\/dx.doi.org\/https:\/\/doi.org\/10.13040\/IJPSR.0975-8232.11(9).4261-70","DOI":"10.13040\/IJPSR.0975-8232.11(9).4261-70"},{"key":"2017_CR128","doi-asserted-by":"crossref","unstructured":"Takahashi Y, Hayakawa A, Sano R, Fukuda H, Harada M, Kubo R, et al. Histone deacetylase inhibitors suppress ACE2 and ABO simultaneously, suggesting a preventive potential against COVID-19. Sci Rep [Internet]. Nature Publishing Group; 2021 [cited 2022 Jun 17];11:3379. Available from: \/pmc\/articles\/PMC7873266\/","DOI":"10.1038\/s41598-021-82970-2"},{"key":"2017_CR129","doi-asserted-by":"crossref","unstructured":"Teodori L, Sestili P, Madiai V, Coppari S, Fraternale D, Rocchi MBL, et al. MicroRNAs Bioinformatics Analyses Identifying HDAC Pathway as a Putative Target for Existing Anti\u2010COVID\u201019 Therapeutics. Front Pharmacol. Frontiers Media S.A.; 2020;11:1729.","DOI":"10.3389\/fphar.2020.582003"},{"key":"2017_CR130","doi-asserted-by":"crossref","unstructured":"Suryawanshi RK, Koganti R, Agelidis A, Patil CD, Shukla D. Dysregulation of Cell Signaling by SARS-CoV-2. Trends Microbiol [Internet]. Elsevier; 2021 [cited 2022 Jun 17];29:224. Available from: \/pmc\/articles\/PMC7836829\/","DOI":"10.1016\/j.tim.2020.12.007"},{"key":"2017_CR131","doi-asserted-by":"crossref","unstructured":"Lara-Ure\u00f1a N, Garc\u00eda-Dom\u00ednguez M. Relevance of BET Family Proteins in SARS-CoV-2 Infection. Biomolecules [Internet]. Biomolecules; 2021 [cited 2022 Jun 17];11. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/34439792\/","DOI":"10.3390\/biom11081126"},{"key":"2017_CR132","doi-asserted-by":"crossref","unstructured":"Stanifer ML, Pervolaraki K, Boulant S. Differential Regulation of Type I and Type III Interferon Signaling. Int J Mol Sci [Internet]. Multidisciplinary Digital Publishing Institute (MDPI); 2019 [cited 2022 Jun 17];20. Available from: \/pmc\/articles\/PMC6471306\/","DOI":"10.3390\/ijms20061445"},{"key":"2017_CR133","doi-asserted-by":"crossref","unstructured":"Mishra PM, Verma NC, Rao C, Uversky VN, Nandi CK. Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis. Prog Mol Biol Transl Sci [Internet]. Elsevier; 2020 [cited 2022 Jun 17];174:1. Available from: \/pmc\/articles\/PMC7129803\/","DOI":"10.1016\/bs.pmbts.2020.03.001"},{"key":"2017_CR134","doi-asserted-by":"crossref","unstructured":"Kee J, Thudium S, Renner DM, Glastad K, Palozola K, Zhang Z, et al. SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature [Internet]. Nature; 2022 [cited 2022 Dec 23];610:381\u20138. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/36198800\/","DOI":"10.1038\/s41586-022-05282-z"},{"key":"2017_CR135","unstructured":"Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature [Internet]. Nature; 2020 [cited 2022 Jun 17];583:459\u201368. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32353859\/"},{"key":"2017_CR136","doi-asserted-by":"crossref","unstructured":"Xu P, Ye S, Li K, Huang M, Wang Q, Zeng S, et al. NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2. J Exp Clin Cancer Res [Internet]. J Exp Clin Cancer Res; 2019 [cited 2022 Jun 17];38. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/31805977\/","DOI":"10.1186\/s13046-019-1448-9"},{"key":"#cr-split#-2017_CR137.1","doi-asserted-by":"crossref","unstructured":"Berndsen CE, Wolberger C. New insights into ubiquitin E3 ligase mechanism. Nat Struct Mol Biol 2014 214 [Internet]. Nature Publishing Group","DOI":"10.1038\/nsmb.2780"},{"key":"#cr-split#-2017_CR137.2","unstructured":"2014 [cited 2022 Jun 17];21:301-7. Available from: https:\/\/www.nature.com\/articles\/nsmb.2780"},{"key":"2017_CR138","doi-asserted-by":"crossref","unstructured":"Cai W, Yang H. The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions. Cell Div [Internet]. BioMed Central; 2016 [cited 2022 Jun 17];11:7. Available from: \/pmc\/articles\/PMC4878042\/","DOI":"10.1186\/s13008-016-0020-7"},{"key":"#cr-split#-2017_CR139.1","doi-asserted-by":"crossref","unstructured":"Salgado-Albarr\u00e1n M, Navarro-Delgado EI, Del Moral-Morales A, Alcaraz N, Baumbach J, Gonz\u00e1lez-Barrios R, et al. Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection. npj Syst Biol Appl 2021 71 [Internet]. Nature Publishing Group","DOI":"10.1038\/s41540-021-00181-x"},{"key":"#cr-split#-2017_CR139.2","unstructured":"2021 [cited 2022 Jun 17];7:1-14. Available from: https:\/\/www.nature.com\/articles\/s41540-021-00181-x"},{"key":"2017_CR140","doi-asserted-by":"crossref","unstructured":"Beacon TH, Su RC, Lakowski TM, Delcuve GP, Davie JR. SARS-CoV-2 multifaceted interaction with the human host. Part II: Innate immunity response, immunopathology, and epigenetics. IUBMB Life [Internet]. IUBMB Life; 2020 [cited 2022 Jun 17];72:2331\u201354. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32936531\/","DOI":"10.1002\/iub.2379"},{"key":"2017_CR141","doi-asserted-by":"publisher","first-page":"198631","DOI":"10.1016\/j.virusres.2021.198631","volume":"308","author":"S Paul","year":"2022","unstructured":"Paul S, Bravo V\u00e1zquez LA, Reyes-P\u00e9rez PR, Estrada-Meza C, Aponte Alburquerque RA, Pathak S, et al. The role of microRNAs in solving COVID-19 puzzle from infection to therapeutics: a mini-review. Virus Res. 2022;308:198631 (Elsevier).","journal-title":"Virus Res"},{"key":"2017_CR142","doi-asserted-by":"publisher","first-page":"854","DOI":"10.3389\/fgene.2020.00854","volume":"11","author":"A Samaddar","year":"2020","unstructured":"Samaddar A, Gadepalli R, Nag VL, Misra S. The enigma of low COVID-19 fatality rate in India. Front Genet Frontiers Media SA. 2020;11:854.","journal-title":"Front Genet Frontiers Media SA."},{"key":"2017_CR143","doi-asserted-by":"crossref","unstructured":"Sarma A, Phukan H, Halder N, Madanan MG. An in-silico approach to study the possible interactions of miRNA between human and SARS-CoV2. Comput Biol Chem [Internet]. Comput Biol Chem; 2020 [cited 2022 Jun 16];88. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32771962\/","DOI":"10.1016\/j.compbiolchem.2020.107352"},{"key":"2017_CR144","doi-asserted-by":"crossref","unstructured":"Khan MAAK, Islam ABMMK. SARS-CoV-2 Proteins Exploit Host\u2019s Genetic and Epigenetic Mediators for the Annexation of Key Host Signaling Pathways. Front Mol Biosci. Frontiers Media S.A.; 2021;7:509.","DOI":"10.3389\/fmolb.2020.598583"},{"key":"2017_CR145","doi-asserted-by":"crossref","unstructured":"Miao Y, Fan L, Li JY. Potential Treatments for COVID-19 Related Cytokine Storm - Beyond Corticosteroids. Front Immunol [Internet]. Frontiers Media SA; 2020 [cited 2022 Nov 15];11:1445. Available from: \/pmc\/articles\/PMC7308586\/","DOI":"10.3389\/fimmu.2020.01445"},{"key":"2017_CR146","doi-asserted-by":"crossref","unstructured":"Yasmin R, Siraj S, Hassan A, Khan AR, Abbasi R, Ahmad N. Epigenetic regulation of inflammatory cytokines and associated genes in human malignancies. Mediators Inflamm [Internet]. Mediators Inflamm; 2015 [cited 2022 Nov 15];2015. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/25814785\/","DOI":"10.1155\/2015\/201703"},{"key":"2017_CR147","doi-asserted-by":"crossref","unstructured":"Das D, Bihari Jena A, Banerjee A, Kumar Radhakrishnan A, Duttaroy AK, Pathak S. Can plant-derived anti-HIV compounds be used in COVID-19 cases? Med Hypotheses [Internet]. Med Hypotheses; 2022 [cited 2022 Nov 15];166:110926. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35935095\/","DOI":"10.1016\/j.mehy.2022.110926"},{"key":"2017_CR148","doi-asserted-by":"crossref","unstructured":"Roshni J, Vaishali R, Ganesh KS, Dharani N, Alzahrani KJ, Banjer HJ, et al. Multi-target potential of Indian phytochemicals against SARS-CoV-2: A docking, molecular dynamics and MM-GBSA approach extended to Omicron B.1.1.529. J Infect Public Health [Internet]. J Infect Public Health; 2022 [cited 2022 Nov 15];15:662\u20139. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35617830\/","DOI":"10.1016\/j.jiph.2022.05.002"},{"key":"2017_CR149","doi-asserted-by":"crossref","unstructured":"Mills RJ, Humphrey SJ, Fortuna PRJ, Lor M, Foster SR, Quaife-Ryan GA, et al. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. Cell [Internet]. Cell; 2021 [cited 2022 Nov 15];184:2167\u20132182.e22. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33811809\/","DOI":"10.1016\/j.cell.2021.03.026"},{"key":"2017_CR150","doi-asserted-by":"publisher","unstructured":"Nehme Z, Pasquereau S, Herbein G. Control of viral infections by epigenetic-targeted therapy. Clin Epigenetics 2019 111 [Internet]. BioMed Central; 2019 [cited 2022 Nov 15];11:1\u201317. Available from: https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/s13148-019-0654-9","DOI":"10.1186\/s13148-019-0654-9"},{"key":"2017_CR151","doi-asserted-by":"crossref","unstructured":"Bravo-V\u00e1zquez LA, Medina-R\u00edos I, M\u00e1rquez-Gallardo LD, Reyes-Mu\u00f1oz J, Serrano-Cano FI, Pathak S, et al. Functional Implications and Clinical Potential of MicroRNAs in Irritable Bowel Syndrome: A Concise Review. Dig Dis Sci [Internet]. Dig Dis Sci; 2022 [cited 2022 Nov 15];1\u201316. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35507132\/","DOI":"10.1007\/s10620-022-07516-6"},{"key":"2017_CR152","doi-asserted-by":"crossref","unstructured":"Herbein G. An epigenetic signature to fight COVID-19. EBioMedicine [Internet]. Elsevier; 2021 [cited 2022 Nov 15];67. Available from: \/pmc\/articles\/PMC8116817\/","DOI":"10.1016\/j.ebiom.2021.103385"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-023-02017-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-023-02017-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-023-02017-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T06:04:49Z","timestamp":1700633089000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-023-02017-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,12]]},"references-count":165,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["2017"],"URL":"https:\/\/doi.org\/10.1007\/s15010-023-02017-8","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,12]]},"assertion":[{"value":"29 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the literature.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"<b>N<\/b>ot applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}