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SARS-CoV-2- antibodies were measured and data on SARS-CoV-2 infections, vaccinations, health and socioeconomic factors as well as caregiver-reported evaluation on their children\u2019s health and psychological status were assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>497 children aged 2\u201317\u00a0years were included. Three groups were analyzed: 183 pre-schoolchildren aged 2\u20134\u00a0years, 176 schoolchildren aged 5\u201311\u00a0years and 138 adolescents aged 12\u201318\u00a0years. Positive antibodies against the S- or N-antigen of SARS-CoV-2 were detected in 86.5% of all participants (70.0% [128\/183] of pre-schoolchildren, 94.3% of schoolchildren [166\/176] and 98.6% of adolescents [136\/138]). Among all children, 40.4% (201\/497) were vaccinated against COVID-19 (pre-schoolchildren 4.4% [8\/183], schoolchildren 44.3% [78\/176] and adolescents 83.3% [115\/138]). SARS-CoV-2 seroprevalence was lowest in pre-school. Health status and quality of life reported by the parents were very positive at the time of the survey (Summer 2022).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Age-related differences on SARS-CoV-2 sero-immunity could mainly be explained by differences in vaccination rates based on the official German vaccination recommendations as well as differences in SARS-CoV-2 infection rates in the different age groups. Health status and quality of life of almost all children were very good independent of SARS-CoV-2 infection and\/or vaccination.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>German Registry for Clinical Trials Identifier W\u00fcrzburg: DRKS00025546 (registration: 11.09.2021), Bochum: DRKS00022434 (registration:07.08.2020), Dresden: DRKS 00022455 (registration: 23.07.2020).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-023-02052-5","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T19:21:16Z","timestamp":1686079276000},"page":"1531-1539","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["SARS-CoV-2 sero-immunity and quality of life in children and adolescents in relation to infections and vaccinations: the IMMUNEBRIDGE KIDS cross-sectional study, 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Reinhard Berner is member of the Corona Expert Counsel of the German government, the Expert Advisory Board on pandemic Acute Respiratory Infections of the Robert Koch Institute, pandemic working group of the Standing committee on Vaccination (STIKO), medical pandemic counsel of the German Medical Association, scientific advisory board of the working group \u201clong-COVID-syndrome\u201d of the German Medical Association, task force Corona for the German Society of Pediatrics and Adolescent Medicine (DGKJ). Berit Lange has received the following grants: egePan Unimed (grant number 01KX2021), NUM COVIM 1.0 (grant number 01KX2021), PREPARED (grant number 01KX2021), RESPINOW (grant number MV2021-012), OptimAgent (grant number MV2021-014). Berit Lange is speaker for the \u201cModeling Network for Severe Infectious Diseases\u201d, vice-president of the German Society of Epidemiology (DGEpi) and member of the internal advisory board of the German Center for Infection Research and member of the steering committee of TBNet. Andre Karch has received funding associated with the SARS-CoV-2 pandemic and other infectious epidemiology-related questions from the German Research Foundation, the German Federal Ministry of Education and Research, the German Federal Ministry of Health, the Robert Koch Institute, the \u201cLandeszentrum Gesundheit Nordrhein-Westfalen\u201d, \u201cNieders\u00e4chsische Vorab\u201d of the Volkswagen Foundation as well as innovation fund of the German federal Joint Committee.Hendrik Streeck has received fees for a discussion round considering \u201cscience communication\u201d from Johnson&Johnson and is part of the scientific advisory board of AstraZeneca and Seqirus without receiving financial compensation. All other authors disclose no further conflicts of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}