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With unprecedented speed, the global scientific community has generated pivotal insights into the pathogen and the host response evoked by the infection. However, deeper characterization of the pathophysiology and pathology remains a high priority to reduce morbidity and mortality of coronavirus disease 2019 (COVID-19).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>NAPKON-HAP is a multi\u2010centered prospective observational study with a long\u2010term follow\u2010up phase of up to 36\u00a0months post-SARS-CoV-2 infection. It constitutes a central platform for harmonized data and biospecimen for interdisciplinary characterization of acute SARS-CoV-2 infection and long-term outcomes of diverging disease severities of hospitalized patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Primary outcome measures include clinical scores and quality of life assessment captured during hospitalization and at outpatient follow-up visits to assess acute and chronic morbidity. Secondary measures include results of biomolecular and immunological investigations and assessment of organ-specific involvement during and post-COVID-19 infection. NAPKON-HAP constitutes a national platform to provide accessibility and usability of the comprehensive data and biospecimen collection to global research.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>NAPKON-HAP establishes a platform with standardized high-resolution data and biospecimen collection of hospitalized COVID-19 patients of different disease severities in Germany. With this study, we will add significant scientific insights and provide high-quality data to aid researchers to investigate COVID-19 pathophysiology, pathology, and chronic morbidity.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-023-02057-0","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T16:01:33Z","timestamp":1689091293000},"page":"93-104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany 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OAC reports grants or contracts from Amplyx, Basilea, BMBF, Cidara, DZIF, EU-DG RTD (101037867), F2G, Gilead, Matinas, MedPace, MSD, Mundipharma, Octapharma, Pfizer, Scynexis; consulting fees from Abbvie, Amplyx, Biocon, Biosys, Cidara, Da Volterra, Gilead, IQVIA, Janssen, Matinas, MedPace, Menarini, Molecular Partners, MSG-ERC, Noxxon, Octapharma, Pardes, Pfizer, PSI, Scynexis, Seres; honoraria for lectures from Abbott, Abbvie, Al-Jazeera Pharmaceuticals, Astellas, Gilead, Grupo Biotoscana\/United Medical\/Knight, Hikma, MedScape, MedUpdate, Merck\/MSD, Mylan, Noscendo, Pfizer, Shionogi; payment for expert testimony from Cidara; participation on a Data Safety Monitoring Board or Advisory Board from Actelion, Allecra, Cidara, Entasis, IQVIA, Janssen, MedPace, Paratek, PSI, Pulmocide, Shionogi, The Prime Meridian Group; A patent at the German Patent and Trade Mark Office (DE 10 2021 113 007.7); stocks from CoRe Consulting, EasyRadiology; other interests from DGHO, DGI, ECMM, ISHAM, MSG-ERC, Wiley. ME received funding from DFG under Germany\u2019s Excellence Strategy-EXC-2049-390688087, Collaborative Research Center ReTune TRR 295-424778381, BMBF, DZNE, DZHK, EU, Corona Foundation, and Fondation Leducq; ME reports grants from Bayer and fees paid to the Charit\u00e9 from Abbot, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, BMS, Daiichi Sankyo, GSK, Sanofi, Covidien, Novartis, Pfizer, all outside the submitted work. HS received advisor honoraria from Janssen, AstraZeneca, Sanofi, Atriva. PUH reports grants from German Ministry of Research and Education, European Union, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin Chamber of Physicians, German Parkinson Society, University Hospital W\u00fcrzburg, Robert Koch Institute, German Heart Foundation, Federal Joint Committee (G-BA) within the Innovationfond, German Research Foundation, Bavarian State, German Cancer Aid, Charit\u00e9-Universit\u00e4tsmedizin Berlin (within Mondafis; supported by an unrestricted research grant to the Charit\u00e9 from Bayer), University G\u00f6ttingen (within FIND-AF randomized; supported by an unrestricted research grant to the University G\u00f6ttingen from Boehringer-Ingelheim), University Hospital Heidelberg (within RASUNOA-prime; supported by an unrestricted research grant to the University Hospital Heidelberg from Bayer, BMS, Boehringer-Ingelheim, Daiichi Sankyo), outside the submitted work. PK reports grants or contracts from German Federal Ministry of Research and Education (BMBF) B-FAST (Bundesweites Forschungsnetz Angewandte Surveillance und Testung) and NAPKON (Nationales Pandemie Kohorten Netz, German National Pandemic Cohort Network) of the Network University Medicine (NUM) and the State of North Rhine-Westphalia; Consulting fees Ambu GmbH, Gilead Sciences, Mundipharma Resarch Limited, Noxxon N.V. and Pfizer Pharma; honoraria for lectures from Akademie f\u00fcr Infektionsmedizin e.V., Ambu GmbH, Astellas Pharma, BioRad Laboratories Inc., Datamed GmbH, European Confederation of Medical Mycology, Gilead Sciences, GPR Academy Ruesselsheim, HELIOS Kliniken GmbH, Lahn-Dill-Kliniken GmbH, medupdate GmbH, MedMedia, MSD Sharp & Dohme GmbH, Pfizer Pharma GmbH, Scilink Comunicaci\u00f3n Cient\u00edfica SC and University Hospital and LMU Munich; Participation on an Advisory Board from Ambu GmbH, Gilead Sciences, Mundipharma Resarch Limited and Pfizer Pharma; a pending patent currently reviewed at the German Patent and Trade Mark Office (DE 10 2021 113 007.7); other non-financial interests from Elsevier, Wiley and Taylor & Francis online outside the submitted work. OC received honoraria for lectures and\/or scientific advice from Fortbildungskolleg, Janssen, Lundbeck, Limes Klinikgruppe, Neuraxpharm, and Peak Profiling Research Funding from the German Research Foundation (OT 209\/7-3; 14-1, 19-1, EXC 2049), the European Commission (IMI2 859366), the German Federal Ministry of Education and Research (KS2017-067), and the Berlin Institute of Health (B3010350). DP received support for attending ECCMID 2021 from Advanz Pharma Germany. PR reports lecture fees from Pfizer, BMS, CSL Behring and Gilead and served as an Advisory Board Member for Pfizer and Gilead. SR reports honoraria for lectures from Med Update GmbH, Pfizer, and Falk Foundation. GR reports personal fees from Astra Zeneca, Atriva, Boehringer Ingelheim, GSK, Insmed, MSD, Sanofi, Novartis and Pfizer for consultancy during advisory board meetings. GR reports personal fees from Astra Zeneca, Berlin Chemie, BMS, Boehringer Ingelheim, Chiesi, Essex Pharma, Grifols, GSK, Insmed, MSD, Roche, Sanofi, Solvay, Takeda, Novartis, Pfizer and Vertex for lectures. WS received consulting fees from United Therapeutics, Tiakis Biotech AG, Liquidia, Pieris Pharmaceuticals, Abivax, Pfizer. FT received travel support from Actelion, Berlin Chemie, Boehringer Ingelheim, Chiesi, Novartis, Mundipharma and TEVA as well as speaker or consultation fees from AstraZeneca, Berlin Chemie, Boehringer Ingelheim, Bristol-Myers Squibb, Chiesi, Fisher & Paykel, GlaxoSmithKline, Roche, Novartis, OM Pharma and Sanofi-Aventis. IV received research grants from the German Research Foundation (DFG): DFG\/KFO309, project ID: 284237345; P5 and EXC 2026, project ID: 390649896, from the Federal Ministry of Education and Research: DZL\/ALI 1.5 und 3.4 and form the von Behring R\u00f6ntgen Foundation: project 66-LV07. JJV has personal fees\u00a0from Merck\/MSD, Gilead, Pfizer, Astellas\u00a0Pharma, Basilea, German Centre\u00a0for\u00a0Infection Research (DZIF), University Hospital Freiburg\/Congress\u00a0and\u00a0Communication, Academy\u00a0for\u00a0Infectious\u00a0Medicine, University Manchester, German Society for\u00a0Infectious\u00a0Diseases (DGI), \u00c4rztekammer Nordrhein, University Hospital Aachen, Back Bay Strategies, German Society for Internal Medicine (DGIM),\u00a0Shionogi,\u00a0Molecular Health, Netzwerk\u00a0Universit\u00e4tsmedizin, Janssen, NordForsk, Biontech, APOGEPHA and\u00a0grants\u00a0from Merck\/MSD, Gilead, Pfizer, Astellas\u00a0Pharma, Basilea, German Centre\u00a0for\u00a0Infection Research (DZIF), German Federal Ministry\u00a0of Education and Research (BMBF), Deutsches Zetrum f\u00fcr Luft- und Raumfahrt (DLR), University of Bristol, Rigshospitalet\u00a0Copenhagen. MJGTV has received research grants from 3M, Astellas Pharma, Biontech, DaVolterra, Evonik, Gilead Sciences, Glycom, Immunic, MaaT Pharma, Merck\/MSD, Organobalance, Seres Therapeutics, Takeda Pharmaceutical, as well as speaker fees and\/or consulting fees from Alb Fils Kliniken GmbH, Arderypharm, Astellas Pharma, Basilea, Bio-M\u00e9rieux, DaVolterra, Farmak International Holding GmbH, Ferring, Gilead Sciences, Immunic AG, MaaT Pharma, Merck\/MSD, Pfizer, Roche, Organobalance, SocraTec R&D GmbH, Tillots Pharma. MvLT has received travel grants and honoraria from Celgene, Gilead, Chugai, Janssen, Novartis, Amgen, Takeda, BMS, Medac, Oncopeptides, Merck, CDDF, Pfizer, medac, thermofisher, AstraZeneca; is a consultant for Celgene, Gilead, Oncopeptides, MSD, 4DPharma, Janssen, Shionogi, and received research funding from BMBF, Deutsche Jose Carreras Leuk\u00e4mie-Stiftung, IZKF Jena, DFG, Novartis, Gilead, Deutsche Krebshilfe, Celgene, Oncopeptides, Deutsche Forschungsgemeinschaft. MW received grants or contracts from Deutsche Forschungsgemeinschaft, Bundesministerium f\u00fcr Bildung und Forschung, Deutsche Gesellschaft f\u00fcr Pneumologie, European Respiratory Society, Marie Curie Foundation, Else Kr\u00f6ner Fresenius Stiftung, Capnetz Stiftung, Bayer Health Care and Biotest; consulting fees from Insmed Germany, Pantherna, Pherecydes, Aptarion, Glaxo Smith Kline, Inflarx, Biotest and payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Astra Zeneca, Insmed Germany, Chiesi, Novartis, Actelion, Boehringer Ingelheim, Glaxo Smith Kline, Biotest and Bayer Health Care. All other authors report no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol and its amendments were reviewed and approved by the Charit\u00e9 Ethics Committee (EA2\/066\/20, EA2\/226\/21) as well as local ethics committees at each participating study center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}