{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:12:27Z","timestamp":1777353147804,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Helmholtz-Zentrum f\u00fcr Infektionsforschung GmbH (HZI)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection and severe course of COVID-19 for the German population in summer 2022, there was a lack of systematically collected population-based data allowing for the assessment of the protection level in real time.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In the IMMUNEBRIDGE project, we harmonised data and biosamples for nine population-\/hospital-based studies (total number of participants <jats:italic>n<\/jats:italic>\u2009=\u200933,637) to provide estimates for protection levels against SARS-CoV-2 infection and severe COVID-19 between June and November 2022. Based on evidence synthesis, we formed a combined endpoint of protection levels based on the number of self-reported infections\/vaccinations in combination with nucleocapsid\/spike antibody responses (\u201cconfirmed exposures\u201d). Four confirmed exposures represented the highest protection level, and no exposure represented the lowest.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Most participants were seropositive against the spike antigen; 37% of the participants\u2009\u2265\u200979\u00a0years had less than four confirmed exposures (highest level of protection) and 5% less than three. In the subgroup of participants with comorbidities, 46\u201356% had less than four confirmed exposures. We found major heterogeneity across federal states, with 4\u201328% of participants having less than three confirmed exposures.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Using serological analyses, literature synthesis and infection dynamics during the survey period, we observed moderate to high levels of protection against severe COVID-19, whereas the protection against SARS-CoV-2 infection was low across all age groups. We found relevant protection gaps in the oldest age group and amongst individuals with comorbidities, indicating a need for additional protective measures in these groups.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-023-02071-2","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T15:05:33Z","timestamp":1690988733000},"page":"139-153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022\/2023 winter season: the IMMUNEBRIDGE project"],"prefix":"10.1007","volume":"52","author":[{"given":"Berit","family":"Lange","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika K.","family":"Jaeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Harries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"R\u00fccker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Streeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Blaschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Petersmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Toepfner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max J.","family":"Hassenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren","family":"Dreier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabell","family":"von Holt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Budde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Bartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Ortmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Andr\u00e9","family":"Kurosinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Berner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Borsche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Brandhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Budde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Deckena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine","family":"Engels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Fenzlaff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"H\u00e4rtel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Hovardovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Katalinic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Kehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Kohls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Lieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin M.","family":"Meyer-Schlinkmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Pischon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Rosenkranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"R\u00fcbsamen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Schattschneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Schlegtendal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Schlinkert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Schmidbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Schulze-Wundling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"St\u00f6rk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Tiemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Liese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folke","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick F.","family":"Ottensmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens-Peter","family":"Reese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Heuschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Karch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"2071_CR1","first-page":"753","volume":"119","author":"S Beermann","year":"2022","unstructured":"Beermann S, D\u00f6rr M, Grill E, Karch A, Lange B, Zeeb H. Coronapandemie: Die Rolle epidemiologischer Forschung in Gesundheitskrisen. Dtsch Arztebl. 2022;119:753\u20136.","journal-title":"Dtsch Arztebl"},{"key":"2071_CR2","doi-asserted-by":"publisher","first-page":"957","DOI":"10.3390\/idr13040088","volume":"13","author":"F Brinkmann","year":"2021","unstructured":"Brinkmann F, Diebner HH, Matenar C, Schlegtendal A, Spiecker J, Eitner L, et al. Longitudinal rise in seroprevalence of SARS-CoV-2 infections in children in western germany\u2014a blind spot in epidemiology? Infect Dis Rep. 2021;13:957\u201364.","journal-title":"Infect Dis Rep"},{"key":"2071_CR3","doi-asserted-by":"publisher","first-page":"e2231798-e","DOI":"10.1001\/jamanetworkopen.2022.31798","volume":"5","author":"G Engels","year":"2022","unstructured":"Engels G, Forster J, Streng A, R\u00fccker V, Rudolph P, Pietsch F, et al. Acceptance of different self-sampling methods for semiweekly SARS-CoV-2 testing in asymptomatic children and childcare workers at german day care centers: a nonrandomized controlled trial. JAMA Netw Open. 2022;5:e2231798-e.","journal-title":"JAMA Netw Open"},{"key":"2071_CR4","first-page":"824","volume":"118","author":"D Gornyk","year":"2021","unstructured":"Gornyk D, Harries M, Gl\u00f6ckner S, Strengert M, Kerrinnes T, Heise J-K, et al. SARS-CoV-2 seroprevalence in germany: a population-based sequential study in seven regions. Dtsch Arztebl Int. 2021;118:824.","journal-title":"Dtsch Arztebl Int"},{"key":"2071_CR5","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1055\/a-1630-7601","volume":"83","author":"FA Eichner","year":"2021","unstructured":"Eichner FA, Gelbrich G, Wei\u00dfbrich B, D\u00f6lken L, Kurzai O, Deckert J, et al. Seropr\u00e4valenz von COVID-19 und psychosoziale Auswirkungen in der Allgemeinbev\u00f6lkerung: Ergebnisse des STAAB-COVID-One Programms. Gesundheitswesen. 2021;83:965\u201375.","journal-title":"Gesundheitswesen"},{"key":"2071_CR6","doi-asserted-by":"publisher","unstructured":"Schulze-Wundling K, Ottensmeyer PF, Meyer-Schlinkmann KM, et al. Immunity Against SARS-CoV-2 in the German Population [published online ahead of print, 2023 May 12]. Dtsch Arztebl Int. 2023;(Forthcoming):arztebl.m2023.0072. https:\/\/doi.org\/10.3238\/arztebl.m2023.0072.","DOI":"10.3238\/arztebl.m2023.0072"},{"key":"2071_CR7","doi-asserted-by":"publisher","first-page":"5016","DOI":"10.1126\/sciadv.abm5016","volume":"8","author":"C Klein","year":"2022","unstructured":"Klein C, Borsche M, Balck A, F\u00f6h B, Rahm\u00f6ller J, Peters E, et al. One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: a model for population-based monitoring of infection risk. Sci Adv. 2022;8:5016.","journal-title":"Sci Adv"},{"key":"2071_CR8","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s10654-022-00890-5","volume":"37","author":"AGK Peters","year":"2022","unstructured":"Peters AGK, Goettlicher S, Ahrens W, Albrecht M, Bamberg F, Baernighausen T, et al. Framework and baseline examination of the German National Cohort (NAKO). Eur J Epidemiol. 2022;37:1107.","journal-title":"Eur J Epidemiol"},{"key":"2071_CR9","doi-asserted-by":"publisher","unstructured":"Neuhauser H, Buttmann-Schweiger N, Ellert U, Fiebig J, H\u00f6vener C, Offergeld R, Pr\u00fctz F, Sarganas G, Schaade L, Schaffrath Rosario A, Thamm R, Zimmermann M, Poethko-M\u00fcller C: Seroepidemiologische Studien zu SARS-CoV-2 in Stichproben der Allgemeinbev\u00f6lkerung und bei Blut-spenderinnen und Blutspendern in Deutschland \u2013Ergebnisse bis August 2021 Epid Bull 2021;37:3\u201312. https:\/\/doi.org\/10.25646\/8999.","DOI":"10.25646\/8999"},{"key":"2071_CR10","doi-asserted-by":"publisher","unstructured":"Berndt JC, T, Hasenauer, J, Karch, A, Kheifetz, Y, Kirsten, H, Krueger,et al. A. Szenarien f\u00fcr den Verlauf der SARS-CoV-2-Pandemie im Winter 2022\/23 - Ergebnisse eines Workshops des Modellierungsnetzes f\u00fcr schwere Infektionskrankheiten (Modellierungsnetz). Zenodo, 2022. https:\/\/doi.org\/10.5281\/zenodo.7126032.","DOI":"10.5281\/zenodo.7126032"},{"key":"2071_CR11","doi-asserted-by":"publisher","unstructured":"Lange B, Jaeger V, R\u00fccker V, Hassenstein MJ, Harries M, Berner R, et al. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorl\u00e4ufigen Ergebnissen an die Modellierungskonsortien der BMBF-gef\u00f6rderten Modellierungsplattform. Zenodo. 2022. https:\/\/doi.org\/10.5281\/zenodo.6968574.","DOI":"10.5281\/zenodo.6968574"},{"key":"2071_CR12","doi-asserted-by":"publisher","unstructured":"Lange B, J\u00e4ger, V, R\u00fccker, V, Harries, M, Hassenstein, MJ, Dreier M, et al. 2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorl\u00e4ufigen Ergebnissen an das Modellierungsnetz f\u00fcr schwere Infektionskrankheiten. Zenodo, 2022. https:\/\/doi.org\/10.5281\/zenodo.7177592.","DOI":"10.5281\/zenodo.7177592"},{"key":"2071_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12889-022-13666-z","volume":"22","author":"A Balck","year":"2022","unstructured":"Balck A, F\u00f6h B, Borsche M, Rahm\u00f6ller J, Vollstedt E-J, Waldeck F, et al. Protocol of the Luebeck longitudinal investigation of SARS-CoV-2 infection (ELISA) study\u2013a prospective population-based cohort study. BMC Public Health. 2022;22:1\u20139.","journal-title":"BMC Public Health"},{"key":"2071_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s15010-023-02052-5","volume":"2023","author":"G Engels","year":"2022","unstructured":"Engels G, Oechsle AL, Schlegtendal A, et al. SARS-CoV-2 sero-immunity and quality of life in children and adolescents in relation to infections and vaccinations: the IMMUNEBRIDGE KIDS cross-sectional study. Infection. 2022;2023:1\u20139. https:\/\/doi.org\/10.1007\/s15010-023-02052-5.","journal-title":"Infection."},{"key":"2071_CR15","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","volume":"12","author":"E Von Elm","year":"2014","unstructured":"Von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg. 2014;12:1495\u20139.","journal-title":"Int J Surg"},{"issue":"5","key":"2071_CR16","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10654-014-9890-7","volume":"29","author":"German National Cohort (GNC) Consortium","year":"2014","unstructured":"German National Cohort (GNC) Consortium. The German National Cohort: aims, study design and organization. Eur J Epidemiol. 2014;29(5):371\u201382. https:\/\/doi.org\/10.1007\/s10654-014-9890-7.","journal-title":"Eur J Epidemiol."},{"key":"2071_CR17","unstructured":"Destatis - Statistisches Bundesamt. https:\/\/www-genesis.destatis.de\/genesis\/online?operation=previous&levelindex=0&step=0&titel=&levelid=1689661127749&acceptscookies=false"},{"key":"2071_CR18","doi-asserted-by":"crossref","unstructured":"Lumley T (2004) Analysis of complex survey samples. J Stat Softw 9(1):1\u201319. R package verson 2.2.","DOI":"10.18637\/jss.v009.i08"},{"key":"2071_CR19","doi-asserted-by":"publisher","first-page":"385","DOI":"10.32614\/RJ-2017-019","volume":"9","author":"L Lahti","year":"2017","unstructured":"Lahti L, Huovari J, Kainu M, Biecek P. Retrieval and analysis of eurostat open data with the eurostat package. The R Journal. 2017;9:385.","journal-title":"The R Journal"},{"key":"2071_CR20","unstructured":"Commission E. Eurostat. TERCET Flat Files 2021 [Available from: https:\/\/gisco-services.ec.europa.eu\/tercet\/flat-files."},{"key":"2071_CR21","unstructured":"R Core Team R. R: A language and environment for statistical computing. R foundation for statistical computing Vienna, Austria; 2018."},{"key":"2071_CR22","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1101\/2022.12.30.22284061","volume":"83","author":"M Harries","year":"2022","unstructured":"Harries M, J\u00e4ger V, Rodiah I, Hassenstein MJ, Ortmann J, Dreier M, et al. Bridging the gap-estimation of 2022\/2023 SARS-CoV-2 healthcare burden in Germany based on multidimensional data from a rapid epidemic panel. medRxiv. 2022;83:965. https:\/\/doi.org\/10.1101\/2022.12.30.22284061.","journal-title":"medRxiv"},{"key":"2071_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-022-32404-y","volume":"13","author":"RC Barnard","year":"2022","unstructured":"Barnard RC, Davies NG, Jit M, Edmunds WJJNC. Modelling the medium-term dynamics of SARS-CoV-2 transmission in England in the Omicron era. Nat Commun. 2022;13:1\u201315.","journal-title":"Nat Commun"},{"key":"2071_CR24","unstructured":"RKI. Corona-Monitoring bundesweit \u2013 Welle 2 (aktualisierte Version vom 14.12.2022). 2022; accessed at https:\/\/www.rki.de\/DE\/Content\/Gesundheitsmonitoring\/Studien\/lid\/Factsheet-CoMoBu-Welle-2.pdf?__blob=publicationFile."},{"key":"2071_CR25","unstructured":"Kleeblattprinzip: 93 Corona\u00adintensivpatienten verlegt, das Konzept funktioniert: Deutsches \u00c4rzteblatt; 2021 [Available from: https:\/\/www.aerzteblatt.de\/nachrichten\/129956\/Kleeblattprinzip-93-Coronaintensivpatienten-verlegt-das-Konzept-funktioniert."},{"key":"2071_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2807\/esm.11.04.00614-en","volume":"11","author":"D Faensen","year":"2006","unstructured":"Faensen D, Claus H, Benzler J, Ammon A, Pfoch T, Breuer T, et al. SurvNet@ RKI\u2013a multistate electronic reporting system for communicable diseases. Eurosurveillance. 2006;11:7\u20138.","journal-title":"Eurosurveillance"},{"key":"2071_CR27","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s10654-022-00880-7","volume":"37","author":"O Kuss","year":"2022","unstructured":"Kuss O, Becher H, Wienke A, Ittermann T, Ostrzinski S, Schipf S, et al. Statistical Analysis in the German National Cohort (NAKO)\u2013specific aspects and general recommendations. Eur J Epidemiol. 2022;37:429.","journal-title":"Eur J Epidemiol"},{"key":"2071_CR28","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.7326\/M22-1300","volume":"175","author":"D Follmann","year":"2022","unstructured":"Follmann D, Janes HE, Buhule OD, Zhou H, Girard B, Marks K, et al. Antinucleocapsid antibodies after SARS-CoV-2 infection in the blinded phase of the randomized, placebo-controlled mRNA-1273 COVID-19 vaccine efficacy clinical trial. Ann Intern Med. 2022;175:1258\u201365.","journal-title":"Ann Intern Med"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-023-02071-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-023-02071-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-023-02071-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:09:20Z","timestamp":1706177360000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-023-02071-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["2071"],"URL":"https:\/\/doi.org\/10.1007\/s15010-023-02071-2","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,2]]},"assertion":[{"value":"6 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"CK serves as a medical advisor to Centogene and Retromer Therapeutics and has received speaking honoraria from Desitin and Bial.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The responsible ethics committees of individual studies approved all study-related analyses: GUIDE: 202\/22 approved by the Ethics Committee of the Medical Faculty of the Rheinische Friedrich-Wilhelm-University Bonn. ELISA: University of L\u00fcbeck (Az. 20\u2013150). NAKO: The study is continuously approved by the responsible local ethics committees of the German Federal States where all study centers are located in (original ethics approvals of the leading ethics committee of the Bayerische Landes\u00e4rztekammer (protocol code 13023, Approval Date: 27 March 2013 and 14 February 2014 (rectification of documents, study protocol, consent form)). An external ethics advisory board has been established that accompanies NAKO over the full study period. A 'Code of Ethics' of NAKO (Ethikkodex) has been developed and the study is under steady surveillance by the ethics committees of the regional study centers []. STAAB: Ethics committee of the Medical Faculty of the University W\u00fcrzburg (STAAB: #98\/13). MuSPAD: Ethics committee of Hannover Medical School (9086_BO_S_2020 for MuSPAD), Dresden paedSAXCOVID: Ethics Committee of the Technische University (TU) Dresden (BO-EK-156042020). Bochum CorKID: Ethics Committee of the Ruhr University Bochum (Nr. 20-6927_7). W\u00fcrzburg W\u00fc-KITa-CoV: W\u00fcrzburg, Kennzeichen 105\/21. IMMUNEBRIDGE_ED: Ethics Committee of University Medical Center G\u00f6ttingen (21\/6\/22).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The aggregated data for this study will be made available to other academic researchers. The minimum dataset includes study site information, assay information, sample type, demographic information, self-administered diagnostic anamneses and lab results (NC, S Spike, IGRA and NAb). Institutions can apply for the data via serohub@helmholtz-hzi.de. Data were provided to the modelling network for severe infectious diseases in Germany (MONID []).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and materials"}}]}}