{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:39:37Z","timestamp":1762090777974,"version":"build-2065373602"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s15010-023-02081-0","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T08:02:35Z","timestamp":1691568155000},"page":"1855-1861","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antiviral treatment of COVID-19: which role can clinical parameters play in therapy evaluation?"],"prefix":"10.1007","volume":"51","author":[{"given":"Yannis R.","family":"H\u00fcbner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Spuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schlabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gereon J.","family":"Rieke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Breitschwerdt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"van Bremen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian P.","family":"Strassburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Gonzalez-Carmona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Christian","family":"Wasmuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen K.","family":"Rockstroh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Boesecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte B.","family":"Monin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"2081_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-023-01994-0","author":"L Pilgram","year":"2023","unstructured":"Pilgram L, Appel KS, Ruethrich MM, Koll CEM, Vehreschild MJGT, de Miranda SMN, Hower M, Hellwig K, Hanses F, Wille K, Haselberger M, Spinner CD, Vom Dahl J, Hertenstein B, Westhoff T, Vehreschild JJ, Jensen BO, Stecher M. Use and effectiveness of remdesivir for the treatment of patients with covid-19 using data from the Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS): a multicentre cohort study. Infection. 2023. https:\/\/doi.org\/10.1007\/s15010-023-01994-0.","journal-title":"Infection"},{"key":"2081_CR2","unstructured":"Therapeutics and COVID-19: living guideline, 14 July 2022. Geneva: World Health Organization; 2022 (WHO\/2019-nCoV\/therapeutics\/2022.4). Licence: CC BY-NC-SA 3.0 IGO."},{"key":"2081_CR3","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1007\/s11606-022-07511-7","volume":"37","author":"M Rubio-Rivas","year":"2022","unstructured":"Rubio-Rivas M, Mora-Luj\u00e1n JM, Formiga F, Ar\u00e9valo-Ca\u00f1as C, Lebr\u00f3n Ramos JM, Villalba Garc\u00eda MV, Fonseca Aizpuru EM, D\u00edez-Manglano J, Arnalich Fern\u00e1ndez F, Romero Cabrera JL, Garc\u00eda Garc\u00eda GM, Pesqueira Fontan PM, Vargas N\u00fa\u00f1ez JA, Freire Castro SJ, Loureiro Amigo J, Pascual P\u00e9rez MLR, Alcal\u00e1 Pedrajas JN, Encinas-S\u00e1nchez D, Mella P\u00e9rez C, Ena J, Gracia Guti\u00e9rrez A, Esteban Giner MJ, Varona JF, Mill\u00e1n N\u00fa\u00f1ez-Cort\u00e9s J, Casas-Rojo JM, SEMI-COVID-19 Network. WHO ordinal scale and inflammation risk categories in COVID-19 comparative study of the severity scales. J Gen Intern Med. 2022;37:1980\u20137. https:\/\/doi.org\/10.1007\/s11606-022-07511-7.","journal-title":"J Gen Intern Med"},{"key":"2081_CR4","unstructured":"https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/clinical-care\/underlyingconditions.html. Accessed 03 May 2023."},{"key":"2081_CR5","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1056\/NEJMc2031670","volume":"383","author":"T Aydillo","year":"2020","unstructured":"Aydillo T, Gonzalez-Reiche AS, Aslam S, van de Guchte A, Khan Z, Obla A, Dutta J, van Bakel H, Aberg J, Garc\u00eda-Sastre A, Shah G, Hohl T, Papanicolaou G, Perales MA, Sepkowitz K, Babady NE, Kamboj M. Shedding of viable SARS-CoV-2 after immunosuppressive therapy for cancer. N Engl J Med. 2020;383:2586\u20138. https:\/\/doi.org\/10.1056\/NEJMc2031670.","journal-title":"N Engl J Med"},{"key":"2081_CR6","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1002\/sim.59844","volume":"33","author":"PC Austin","year":"2014","unstructured":"Austin PC. The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. Stat Med. 2014;33:1242\u201358. https:\/\/doi.org\/10.1002\/sim.59844.","journal-title":"Stat Med"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-023-02081-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-023-02081-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-023-02081-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:07:10Z","timestamp":1700651230000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-023-02081-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["2081"],"URL":"https:\/\/doi.org\/10.1007\/s15010-023-02081-0","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"type":"print","value":"0300-8126"},{"type":"electronic","value":"1439-0973"}],"subject":[],"published":{"date-parts":[[2023,8,9]]},"assertion":[{"value":"22 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Yannis R. H\u00fcbner declares on conflicts of interest. Nikolai Spuck declares on conflicts of interest. Moritz Berger declares on conflicts of interest. Stefan Schlabe had a stipend from the German Centre for Infectious Diseases Research (DZIF); he received congress fees and travel expenses from Gilead, Abbvie and Johnson&Johnson and funding from the German Research Society (DFG) for initiation of an African-German research project; he holds Fonds-based shares from BionTech.. Gereon J. Rieke declares on conflicts of interest. Sven Breitschwerdt declares on conflicts of interest. Kathrin van Bremen declares on conflicts of interest. Christian P. Strassburg declares on conflicts of interest. Maria A. Gonzalez-Carmona has contributed to advisory boards for Roche, Eisai. BMS, MSD and AZ. M.B.M. received travel expenses and honoraria from Gilead, Pfizer and Virology Education. Jan-Christian Wasmuth declares on conflicts of interest. J\u00fcrgen K. Rockstroh has received honoraria for lectures and\/or consultancies from Abivax, Galapagos, Gilead, Merck, Janssen, Theratechnologies and ViiV. Christoph Boesecke received honoraria for lectures and\/or consultancies from AbbVie, Gilead, Janssen, MSD, ViiV as well as funding from Dt. Leberstiftung, DZIF, Hector Stiftung, NEAT ID. Malte B. Monin received received honoraria for lectures, travel expenses and\/or consultancies from Pfizer, Gilead Sciences, AstraZeneca, NovaVax and Virology Education. However, these activities have no potential conflicts of interest with the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed in accordance with the Declaration of Helsinki. Due to the retrospective study design, ethical approval and\/or patient information was not required according to the North Rhine-Westphalian legislation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}