{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:54:18Z","timestamp":1784332458680,"version":"3.55.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p><jats:italic>Candida auris<\/jats:italic>, an emerging multidrug-resistant yeast, has been reported worldwide. In Italy, the first case was reported in 2019. We describe the first case of <jats:italic>C. auris<\/jats:italic>, imported from Greece, in Milan, using whole genome sequencing to characterise mutations associated with antifungal resistance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>On October 2022 an 80-year-old Italian man was hospitalised in Greece. In the absence of clinical improvement, the patient was transferred to our hospital, in Italy, where blood culture resulted positive for <jats:italic>C. auris<\/jats:italic>. Despite therapy, the patient died of septic shock. In a phylogenetic analysis the genome was assigned to Clade I with strains from Kenya, United Arab Emirates and India. D1\/D2 region resulted identical to a Greek strain, as for many other strains from different World regions, highlighting the diffusion of this strain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Importation of <jats:italic>C. auris<\/jats:italic> from abroad has been previously described. We report the first case of <jats:italic>C. auris<\/jats:italic> imported into Italy from Greece, according to phylogenetic analysis. This case reinforces the need for monitoring critically ill hospitalised patients also for fungi and addresses the need for the standardisation of susceptibility testing and strategies for diagnosis and therapy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-024-02232-x","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T09:12:10Z","timestamp":1711962730000},"page":"1633-1638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["First imported case of Candida auris infection in Milan, Italy: genomic characterisation"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1935-8750","authenticated-orcid":false,"given":"Sara Giordana","family":"Rimoldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Nodari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-006X","authenticated-orcid":false,"given":"Alberto","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Tamoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Longobardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Salari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Galimberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Rizzardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Catena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0569-9407","authenticated-orcid":false,"given":"Spinello","family":"Antinori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-4792","authenticated-orcid":false,"given":"Francesco","family":"Comandatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-8660","authenticated-orcid":false,"given":"Maria Rita","family":"Gismondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"issue":"13","key":"2232_CR1","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.2147\/IDR.S249864","volume":"5","author":"M Ademe","year":"2020","unstructured":"Ademe M, Girma F. Candida auris: from multidrug resistance to pan-resistant strains. Infect Drug Resist. 2020;5(13):1287\u201394. https:\/\/doi.org\/10.2147\/IDR.S249864. (PMID:3 2440165; PMCID: PMC7211321).","journal-title":"Infect Drug Resist"},{"issue":"46","key":"2232_CR2","doi-asserted-by":"publisher","first-page":"2200846","DOI":"10.2807\/1560-7917.ES.2022.27.46.2200846","volume":"27","author":"A Kohlenberg","year":"2022","unstructured":"Kohlenberg A, Monnet DL, Plachouras D, Candida auris survey collaborative group; Candida auris survey collaborative group includes the following national experts. Increasing number of cases and outbreaks caused by Candida auris in the EU\/EEA, 2020 to 2021. Euro Surveill. 2022;27(46):2200846. https:\/\/doi.org\/10.2807\/1560-7917.ES.2022.27.46.2200846.","journal-title":"Euro Surveill"},{"key":"2232_CR3","unstructured":"Centers for Disease Control and Prevention. Increasing Threat of Spread of Antimicrobial-resistant Fungus in Healthcare Facilities. CDC Newsroom Releases. Mar 2023. https:\/\/www.cdc.gov\/media\/releases\/2023\/p0320-cauris.html. Accessed 23 Jan 2024"},{"issue":"4","key":"2232_CR4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.7326\/M22-3469","volume":"176","author":"M Lyman","year":"2023","unstructured":"Lyman M, Forsberg K, Sexton DJ, Chow NA, Lockhart SR, Jackson BR, et al. Worsening Spread of Candida auris in the United States, 2019 to 2021. Ann Intern Med. 2023;176(4):489\u201395. https:\/\/doi.org\/10.7326\/M22-3469. (Epub 2023 Mar 21 PMID: 36940442).","journal-title":"Ann Intern Med"},{"issue":"4","key":"2232_CR5","doi-asserted-by":"publisher","first-page":"106558","DOI":"10.1016\/j.ijantimicag.2022.106558","volume":"59","author":"A Ceballos-Garzon","year":"2022","unstructured":"Ceballos-Garzon A, Garcia-Effron G, Cordoba S, Rodriguez JY, Alvarez-Moreno C, Pape PL, Parra-Giraldo CM, Morales-L\u00f3pez S. 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J Clin Med. 2023;12(5):1912. https:\/\/doi.org\/10.3390\/jcm12051912.","journal-title":"J Clin Med"},{"issue":"2","key":"2232_CR8","doi-asserted-by":"publisher","first-page":"e03364","DOI":"10.1128\/mBio.03364-19","volume":"11","author":"NA Chow","year":"2020","unstructured":"Chow NA, Mu\u00f1oz JF, Gade L, Berkow EL, Li X, Welsh RM, et al. Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses. MBio. 2020;11(2):e03364\u2013e3419. https:\/\/doi.org\/10.1128\/mBio.03364-19. (PMID: 32345637; PMCID: PMC7188998).","journal-title":"MBio"},{"key":"2232_CR9","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3390\/jof7020140","volume":"7","author":"V Di Pilato","year":"2021","unstructured":"Di Pilato V, Codda G, Ball L, Giacobbe DR, Willison E, Mikulska M, et al. Molecular epidemiological investigation of a nosocomial cluster of C. auris: evidence of recent emergence in Italy and ease of transmission during the COVID-19 Pandemic. J Fungi (Basel). 2021;7:140. https:\/\/doi.org\/10.3390\/jof7020140. (PMID: 33672021; PMCID: PMC7919374).","journal-title":"J Fungi (Basel)."},{"key":"2232_CR10","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000347","author":"F Gona","year":"2020","unstructured":"Gona F, Comandatore F, Battaglia S, et al. Comparison of core-genome MLST, coreSNP and PFGE methods for Klebsiella pneumoniae cluster analysis. Microb Genom. 2020. https:\/\/doi.org\/10.1099\/mgen.0.000347.","journal-title":"Microb Genom"},{"issue":"9","key":"2232_CR11","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","volume":"30","author":"A Stamatakis","year":"2014","unstructured":"Stamatakis A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics. 2014;30(9):1312\u20133. https:\/\/doi.org\/10.1093\/bioinformatics\/btu033. (Epub 2014 Jan 21. 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Emerg Microbes Infect. 2022;11(1):1867\u201375. https:\/\/doi.org\/10.1080\/22221751.2022.2100280.","journal-title":"Emerg Microbes Infect"},{"key":"2232_CR16","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/jof9040430","volume":"9","author":"CA Alvarez-Moreno","year":"2023","unstructured":"Alvarez-Moreno CA, Morales-Lopez S, Rodriguez GJ, et al. The mortality attributable to candidemia in C. auris is higher than in other Candida species: myth or reality? J Fungi (Basel). 2023;9:430.","journal-title":"J Fungi"},{"key":"2232_CR17","doi-asserted-by":"publisher","first-page":"921","DOI":"10.3390\/jof8090921","volume":"8","author":"M Mikulska","year":"2022","unstructured":"Mikulska M, Magnasco L, Signori A, Sepulcri C, Dettori S, Tutino S, et al. Sensitivity of serum B-D-glucan in candidemia according to Candida species epidemiology in critically ill patients admitted to the Intensive care Unit. J Fungi (Basel). 2022;8:921.","journal-title":"J Fungi"},{"key":"2232_CR18","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00779-21","volume":"60","author":"BL Freitas","year":"2022","unstructured":"Freitas BL, Leach L, Chaturvedi V, Chaturvedi S. Reverse transcription-quantitative real-time PCR (RT-qPCR) assay for the rapid enumeration of live Candida auris cells from the health care environment. J Clin Microbiol. 2022;60: e0077921. https:\/\/doi.org\/10.1128\/JCM.00779-21. (Epub 2021 Dec 8. PMID: 34878804; PMCID: PMC8849214).","journal-title":"J Clin Microbiol"},{"key":"2232_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.757835","volume":"7","author":"EK Dennis","year":"2021","unstructured":"Dennis EK, Chaturvedi S, Chaturvedi V. So many diagnostic tests, so little time: review and preview of Candida auris testing in clinical and public health laboratories. Front Microbiol. 2021;7: 757835. https:\/\/doi.org\/10.3389\/fmicb.2021.757835. 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Italian Ministry of Health. https:\/\/www.trovanorme.salute.gov.it\/norme\/renderNormsanPdf?anno=2023&codLeg=95361&parte=1%20&serie=null. 0019076\u201319\/06\/2023-DGPRE-DGPRE-P."}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-024-02232-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-024-02232-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-024-02232-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T18:49:40Z","timestamp":1722365380000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-024-02232-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["2232"],"URL":"https:\/\/doi.org\/10.1007\/s15010-024-02232-x","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]},"assertion":[{"value":"4 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All clinical samples and data were collected during routine patient care. No personal information, photos or images are contained in the study. Any potentially identifying data has been appropriately anonymized or pseudonymized.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Because of the lethal disease course, no informed consent could be obtained from the patient. The case report does not contain any pictures that could identify the patient. The patient\u2019s identity is anonymized.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}